Core Viewpoint - The article discusses the development of a self-wrapping, bioresorbable neural interface that addresses the challenges of peripheral nerve injury treatment through innovative design and functionality [2][17]. Group 1: Challenges in Current Treatments - Current clinical treatments for nerve injuries face challenges such as limited precision, long-term stability, and minimally invasive options due to individual differences and complex inflammatory responses [2]. - Traditional nerve interfaces rely on rigid devices or wired connections, which hinder their application in chronic nerve repair [2]. Group 2: Development of the SWB Neural Interface - Researchers from Fudan University and Dalian University of Technology proposed a self-wrapping bistable neural interface inspired by the design of "pop rings," which can adapt to different diameters of peripheral nerves [3]. - The device features a stress gradient-driven ultra-thin SiNx bilayer structure that transitions from a flat state to a three-dimensional curled structure, providing gentle and stable coverage of nerves [3][7]. Group 3: Functional Integration and Mechanism - The neural interface integrates a MXene photothermal layer and a drug-loaded module, enabling wireless near-infrared-triggered photothermal therapy combined with drug release for precise control over the nerve repair process [3][11]. - Systematic mechanical modeling and finite element simulations confirmed the reliability and biocompatibility of the device, demonstrating its effectiveness in a rat sciatic nerve injury model [3][14]. Group 4: Experimental Validation - In vivo experiments showed that the SWB neural interface significantly improved nerve function recovery in a rat model over a four-week intervention period, with the combination of drug release and photothermal stimulation yielding the best results [14]. - The study included control experiments to assess the effectiveness of different treatment modalities, confirming the superiority of the combined therapy approach [14]. Group 5: Biocompatibility and Absorbability - The SWB neural interface was designed with biocompatibility and biodegradability in mind, reducing the need for secondary surgeries due to material retention [16]. - Accelerated degradation tests and cytotoxicity assessments indicated that the materials used in the device are safe for cellular proliferation and survival [16]. Group 6: Conclusion and Future Implications - The research presents a novel neural interface that combines adaptive three-dimensional structures, bioresorbable properties, and wireless multimodal therapy capabilities, paving the way for precise treatment of localized peripheral nerve injuries [17].

1月8日，中央音乐学院通过官方微信公众号发布声明：日前，我校发现有微信用户"中央音乐学院考级 办杨老师"(微信号:BG151108)在未经我校授权情况下，以我校名义宣传2025"艺数未来"数字教育艺术成 果展示展演活动，我校在此郑重声明如下：上述活动与我校无任何关系，我校不对上述活动承担任何责 任，亦自始未对微信用户"中央音乐学院考级办杨老师"（微信号:BG151108）及上述活动进行过任何授 权。 近日，北京大学、清华大学、西南交通大学等多所高校接连发布声明，对各类虚假招生信息、违规活 动、违规使用学校名称及标识等行为进行辟谣。 最新一例来自中央音乐学院。 2025年12月9日，西南交通大学发布声明称，该校正在开展学校名称授权使用的专项清理工作，发现部 分社会企业擅自使用"西南交通大学""西南交大"或使用带有特定指向该校的校名组合字样作为企业名 称，误导公众认为其与西南交通大学存在关联关系。学校称，上述行为已严重侵害该校合法权益，应当 承担由此产生的全部法律责任。 2025年12月19日，复旦大学终身教育处发布声明称，近期，有社会机构、个人冒用复旦大学名义散布研 学营、冬令营等虚假信息开展违规招生。根据教育 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 2026 年伊始，国际顶尖学术期刊 Nature 上线了 35 篇研究论文，其中 14 篇来自华人学者 （包括通讯作者和第一作者） 。 1 月 7 日，香港 香港中文大学 吕海荣 、 香港科技大学 全杨健 作为共同通讯作者，在 Nature 期刊发表了题为： Electrochemical defluorinative Matteson- type homologation （ 电化学脱氟马特森型同系化反应 ） 的研究论文 【1】 。 1 月 7 日， 伦斯勒理工学院 Meng Xiangyi 作为第一作者，在 Nature 期刊发表了题为： Surface optimization governs the local design of physical networks （ 表面优化控制着物理网络的局部设计） 的研究论文 【2】 。 1 月 7 日， 马萨诸塞大学医学院 翁志萍 作为通讯作者，在 Nature 期刊发表了题为： An expanded registry of candidate cis-regulatory elements （ 候选顺 式调控元件的 ...

本报讯（记者 孙云）今天上午，上海量子城市时空创新基地一期工程在复兴岛上正式开工，为杨浦区 2026年104项重大工程按下了启动键。在今天上午举行的2026年杨浦区重大项目落地、重大工程推进会 暨重大工程开工仪式上，杨浦区宣布，7项重大工程今天集中开工，总建筑面积29.16万平方米，总投资 130.85亿元，涵盖科创载体、商办及住宅、高校建设和市政配套等领域，包括复旦大学江湾校区数学科 学楼、同济大学四平路校区综合运动馆、国京路道路新建工程等。同时，一批重大项目集中签约落地， 将通过项目落地见效带动产业能级跃升。 为聚焦培育发展新质生产力、推动科技创新和产业创新深度融合，2026年，杨浦区将推进一批重点都市 工业和科技创新项目，一批重大工程则将发挥"扩投资、稳增长、载功能"的引擎作用，坚持"谋定快 动、立说立行"，强化清单化推进、节点化管理、责任化落实，同时把优化营商环境贯穿项目全生命周 期，更大力度提升企业获得感。一批重大基础设施、重大产业、重大公共服务、重大城市更新、重大高 校、重大管线以及重点都市工业、重点科技创新等建设突击队在活动中获授旗，将进一步聚力攻坚，推 动量子城市时空创新基地等项目尽快建成。 ...

Core Viewpoint - Neoadjuvant immune checkpoint blockade (NICB) therapy has become a first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), significantly improving progression-free survival for patients. However, the pathological complete response (pCR) rate is ≤40%, indicating a need to elucidate the mechanisms of resistance to NICB to optimize treatment outcomes [3][7]. Group 1 - A recent study identified a subset of senescent EGR1+ B cells associated with poor pathological responses in ESCC patients undergoing NICB therapy, highlighting the role of these cells in treatment failure [8][11]. - EGR1 is a key transcription factor regulating B cell senescence, and the presence of EGR1+ B cells serves as a predictive marker for poor prognosis across multiple cohorts [8][11]. - The senescent B cells drive chronic inflammation in the tumor microenvironment (TME) through a senescence-associated secretory phenotype (SASP), which induces immunosuppressive TREM2+ tumor-associated macrophages (TAMs), ultimately inhibiting anti-tumor immune responses [8][11]. Group 2 - Fisetin, a natural flavonoid found in various fruits and vegetables, has been shown to alleviate B cell senescence and enhance the efficacy of NICB therapy [10][14]. - The study emphasizes that targeting B cell senescence could be a viable strategy to improve the effectiveness of NICB in treating ESCC [14].

蓝皮书显示，上海博物馆事业在2024年继续保持高质量发展态势。截至2024年底，上海全市备案博物馆 数量达171座，较2023年新增7座，平均每14.5万人拥有一座博物馆，设施网络持续完善。更为重要的 是，博物馆的运营质量与公共服务水平显著提升：免费开放博物馆比例高达82.46%；国家一、二、三 级博物馆占比达19.30%；社会力量兴办的博物馆占据半壁江山，占比达50.90%，展现了多元共建的活 力。 中新网上海1月1日电 (记者 陈静)记者1日获悉，在沪发布的《上海市博物馆在地贡献度蓝皮书(2024 年)》(下称：蓝皮书)显示，博物馆已超越传统的收藏、展示机构，成为驱动上海城市软实力与综合实力 提升的"新引擎"。它不仅通过直接消费拉动经济("消费力")，更通过知识传播、美学熏陶、身份建构、 国际对话产生深远的社会与文化影响("吸引力")，最终与城市发展形成互利共生的良性生态。 蓝皮书以丰富案例展现了上海博物馆界通过业态创新、科技融合与国际合作，将文化"流量"转化为城 市"增量"的生动实践。"现象级大展"驱动消费新样本。上海博物馆"金字塔之巅：古埃及文明大展"创下 纪录，接待观众超125万人次，近七成来自外省 ...

Core Viewpoint - Zhongjie Resources has established a partnership with Fudan University to create a joint laboratory focused on research and development related to industrial sewing machines and advanced technologies, including robotics [2] Group 1: Partnership and Collaboration - The company’s wholly-owned subsidiary, Zhejiang Zhongjie Sewing Technology Co., Ltd., is collaborating with Fudan University to explore cutting-edge technologies in the industrial sewing field [2] - The joint laboratory aims to research and develop equipment related to industrial sewing machines, leveraging Fudan University's engineering and applied technology expertise [2] Group 2: Project Status and Development - Currently, the joint project is in the early stages of research and technical exploration, specifically focusing on the development of a robot for loading and unloading templates in sewing machines [2] - The project has not yet produced any market-ready products, is not in mass production, and has not generated any direct sales revenue [2] Group 3: Market and Operational Factors - The successful operation of the joint laboratory project is influenced by various factors, including industry policies, technological levels, management capabilities, and market judgments [2] - The company’s stock price fluctuations are a reflection of multiple factors, including macroeconomic conditions, industry cycles, market sentiment, and the company's fundamentals [2]

Core Viewpoint - The research highlights the role of extracellular proteins in supporting T cell immunity, particularly in the context of aging and its impact on immune response [2][4][7]. Group 1: Research Findings - The study published in Cell Reports reveals that even healthy elderly individuals with normal albumin levels (>25g/L) may experience limited T cell functionality during acute viral infections due to relatively lower albumin concentrations [2]. - Activated T cells can internalize extracellular proteins like albumin, degrade them in lysosomes, and release free amino acids such as leucine, which are crucial for maintaining mTORC1 activity and cytokine production, thereby enhancing antiviral and antitumor immunity [4][5]. - The transcription factor TFE3 plays a central regulatory role in this process, with its expression being specifically upregulated during T cell activation, promoting lysosomal biogenesis and protein degradation capabilities [4][5]. Group 2: Clinical Implications - The clinical significance of this pathway has been validated in elderly lung cancer patients, where tumor-infiltrating CD8⁺ T cells showed significantly reduced lysosomal degradation capacity and cytokine secretion compared to middle-aged patients [5]. - The study suggests that the activation of mTORC1 is regulated by both rapid signals from extracellular free amino acids and sustained amino acid signals from lysosomal degradation of extracellular proteins, which may influence the differentiation balance between effector T cells and memory T cells [5][7]. - The functional impairment of elderly T cells arises from both intrinsic lysosomal dysfunction and extrinsic declines in plasma albumin levels [5][7].

据"微言教育"微信公众号消息，12月30日，教育部人事司在华东师范大学宣布了教育部党组的任免决 定，马余刚同志任华东师范大学校长、党委副书记，钱旭红同志不再担任华东师范大学校长、党委副书 记职务。教育部人事司主要负责同志出席会议并讲话。上海市教卫工作党委主要负责同志出席会议。 马余刚主要研究方向为中高能及极端相对论的重离子碰撞的实验和理论研究，主要研究核物质的液气相 变和夸克－胶子等离子体相变，反物质原子核的探测与性质；奇异核束物理的实验与理论，主要研究奇 异核结构和性质以及用奇异核束进行的核反应研究；开展激光-核物理，伽马光核物理研究；有关物理 学与复杂性的交叉学科等。 曾获国家自然科学二等奖（2016年度、2001年度）、全球华人物理与天文学会-亚洲成就奖（2015年 度）、上海市自然科学奖一等奖（2014年度）、上海市自然科学奖二等奖（2008年度）、第九届中国青 年科技奖、中国科学院青年科学家、上海市十大"杰出青年"、上海市科技精英、上海市牡丹科学奖、上 海市先进工作者等多项奖励和荣誉。 智通财经记者 邹佳雯 公开资料显示，马余刚，男，汉族，1968年3月生，中共党员，研究生学历，博士学位，教授、博士 ...

流程编辑：袁瑞 原标题：澜湄青创赛组委会举办中越青年对话 来源：中国青年报客户端 据悉，澜湄青创赛是由复旦大学等单位联合举办的青年外交活动，既是面向澜湄六国的高等教育机构和 青年学生、培养六国青年实践素养与治理能力的青年赛事，也是繁荣流域内青年人文交流、为流域各国 治理与发展贡献青年智慧的创新平台，自2016年创办以来，已在中国、老挝、柬埔寨、泰国、越南等地 举办9届赛事，累计吸引3000余人次参与，形成创新创业设计方案530余份。 责任编辑：邱晨辉 梁国胜 中国青年报客户端讯（张虹雨 唐林焕 中青报·中青网记者 王烨捷）12月23日，复旦大学国际关系与公共 事务学院、第十届澜沧江-湄公河流域治理与发展青年创新设计大赛（简称澜湄青创赛）组委会举办中 越青年对话，46名中越青年代表齐聚云端，共同分享在中越人文交流年的收获。 林之澄是复旦大学国际关系与公共事务学院2024级国际政治专业硕士生，目前正在越南河内国家大学越 南学与发展科学研究院交换学习。在分享中，他从地理、文化、制度等维度解读了中越人文交流的先天 优势，通过三个案例将两国的深厚联结具象化为一幅幅生动的图景。 ...