Group 1 - The Chinese government is supporting the high-quality development of innovative drugs by providing up to 10 million yuan in funding for eligible projects, including first-class innovative drugs, second-class improved new drugs, and biosimilars [1] - Chinese pharmaceutical companies are transitioning from raw material producers to innovative drug manufacturers, with their share in global drug research and development nearing 30%, while the share of US companies has decreased to approximately 48% [4] - The number of Chinese innovative drugs included in global conference abstracts has reached a record high this year, indicating a growing recognition of China's contributions to drug development [4] Group 2 - In the first half of this year, US and Chinese pharmaceutical companies completed 14 licensing deals worth $18.3 billion, highlighting increasing collaboration between the two markets [4] - The expiration of patents for blockbuster drugs before 2030 is creating opportunities for collaboration between US and Chinese pharmaceutical companies, as US firms need to replenish their drug development pipelines [4] - The high costs associated with drug development in the US present challenges, further opening the door for partnerships with Chinese companies [4]

Core Viewpoint - Jiangsu Hengrui Medicine Co., Ltd. has announced the completion of the third lock-up period for its 2022 employee stock ownership plan, with specific conditions for unlocking portions of the shares based on performance metrics [1][4][5]. Summary by Sections Employee Stock Ownership Plan Progress - The 2022 employee stock ownership plan was approved during meetings held on August 19, 2022, and September 8, 2022 [1][2]. - A total of 12 million shares were transferred to the employee stock ownership plan account at a price of 4.97 yuan per share [2]. - The first meeting of the plan's participants was held on November 7, 2022, where a management committee was established to oversee the plan [3]. Lock-up Period and Unlocking Conditions - The employee stock ownership plan has three unlocking phases: 40% after 12 months, 30% after 24 months, and 30% after 36 months [4][5]. - The third lock-up period ended on November 7, 2025, and the management committee will manage the rights of the participants based on market conditions [5]. Performance Assessment for Unlocking - Company-level performance metrics include sales revenue from innovative drugs, the number of new molecular entity IND approvals, and the number of NDA applications accepted [6][7]. - For the third unlocking phase, the company achieved over 32 billion yuan in cumulative innovative drug revenue, more than 33 IND approvals, and over 21 NDA applications, meeting the 100% unlocking criteria [6]. Subsequent Arrangements Post Unlocking - After the third lock-up period, the management committee will handle the rights of the participants according to the employee stock ownership plan [7][8]. New Employee Stock Ownership Plan - The company has initiated a new employee stock ownership plan for 2025, with 13.51 million shares transferred at a price of 30.95 yuan per share, representing 0.20% of the total share capital [10][11]. - The new plan will also have three unlocking phases similar to the previous plan, with performance assessments determining the actual unlocking ratios [11]. Clinical Trial Approvals - The company has received approval for clinical trials of SHR-4610 injection, an innovative anti-tumor drug, and HRS-2430 injection, a general anesthetic, indicating ongoing investment in R&D [19][24]. - The total R&D investment for SHR-4610 is approximately 7.36 million yuan, while HRS-2430 has seen an investment of about 24.6 million yuan [21][25].

Investment Rating - The report assigns an "Outperform" rating for BeiGene, indicating an expected total return over the next 12-18 months that exceeds the relevant market benchmark by more than 10% [16]. Core Insights - In Q3 2025, BeiGene achieved revenue of USD 1.4 billion, a year-on-year increase of 41%, and a quarter-on-quarter increase of 7.7% from USD 1.3 billion in Q2 2025. The U.S. market contributed USD 743 million, reflecting an 8.5% increase from the previous quarter. GAAP operating profit was USD 163 million, up 73.4% quarter-on-quarter [5][6]. - Management has updated its full-year guidance for 2025, projecting total revenue between USD 5.1 billion and USD 5.3 billion, with GAAP operating expenses expected to be between USD 4.1 billion and USD 4.3 billion [5][6]. Revenue Breakdown - Global revenue for Zanubrutinib reached USD 1.0 billion, representing a 51% year-on-year increase and a 5.3% quarter-on-quarter increase. In the U.S., revenue was USD 740 million, up 47% year-on-year and 8% quarter-on-quarter. European revenue was USD 160 million, a 68% year-on-year increase and an 8.7% quarter-on-quarter increase [2][6]. - Tislelizumab revenue in Q3 2025 was USD 190 million, reflecting a 17% year-on-year increase but a slight decline of 1.5% quarter-on-quarter [6]. Clinical Development Progress - Sonrotoclax (BCL2 inhibitor) received Breakthrough Therapy Designation for RR MCL, and patient enrollment for a potential registrational Phase 2 study in RR WM has been completed [7]. - BGB-16673 (BTK CDAC) has initiated a global Phase 3 trial against pirtobrutinib in R/R CLL, with patient enrollment currently underway [7]. - BGB-45035 (IRAK4 CDAC) has started a Phase 2 trial for moderate-to-severe rheumatoid arthritis, with patient enrollment initiated [7]. Expected R&D Milestones - BGB-43395 (CDK4 inhibitor) plans to initiate a Phase 3 trial in 1L HR+/HER2- breast cancer in H1 2026 [8]. - BGB-16673 (BTK CDAC) expects data readout in R/R CLL in H1 2026 to support an accelerated approval application [8]. - Sonrotoclax plans to initiate patient enrollment for a Phase 3 trial combining with BTK inhibitor versus acalabrutinib + venetoclax in H1 2026, and a Phase 3 trial in multiple myeloma in H2 2026 [8].

Financial Data and Key Metrics Changes - The company reported revenue of $9 million for Q3 2025, an increase from approximately $7 million in the same quarter of the previous year, primarily from research fees related to partnered programs [9] - Research and development expenses for the quarter were $55 million, an increase of about $14 million compared to the same quarter last year, driven by specific investments of $15 million in two internal programs [10] - The net loss for the quarter was approximately $57 million, compared to a loss of about $51 million in the same quarter of the previous year, resulting in a loss of $0.19 per share [10][11] - The company ended the quarter with approximately $680 million in available liquidity, including $520 million in cash and cash equivalents and $160 million in committed government funding [4][12] Business Line Data and Key Metrics Changes - The company initiated one additional partner-initiated program in Q3 2025, bringing the cumulative total to 103 programs with downstream participation [7] - The cumulative total of molecules that have reached the clinic remained at 18, including both the company's own pipeline and those led by partners [7][8] Market Data and Key Metrics Changes - The company is transitioning from a partnership model to focusing on internal drug development, with the first two programs now in clinical development [16] - The company aims to advance at least one more development candidate into IND enabling studies by the end of the year [4][25] Company Strategy and Development Direction - The company has completed its transition from a platform company to a clinical-stage biotech, with a focus on advancing its internal pipeline [4] - The appointment of Dr. Sarah Nunberg as Chief Medical Officer is seen as a strategic move to enhance clinical development capabilities [5][17] - The company is confident in its ability to fund pipeline investments well beyond the next three years [12] Management's Comments on Operating Environment and Future Outlook - Management acknowledged that the progress of partner-initiated programs has been slower than anticipated, with some programs taking up to six years to move into clinical development [16] - The company is encouraged by the progress of its clinical trials and expects to provide updates on its pipeline in the coming year [21][36] Other Important Information - The company has received commitments for funding from the Government of Canada's Strategic Innovation Fund and the Government of British Columbia, which are not reflected on the balance sheet [11][12] - The company is focused on advancing its two lead programs through their phase I clinical studies while building a strong pre-clinical pipeline [12] Q&A Session Summary Question: How to think about partner-initiated programs in the clinic? - Management noted that the partner-initiated programs have been stagnant since 2024, but they expect some to move forward into clinical development, albeit at a slower pace than initially anticipated [16] Question: Why was now the appropriate time to bring Dr. Nunberg in as CMO? - Management indicated that the transition to drug development on their own behalf necessitated the need for a senior executive with clinical development experience [17] Question: What is the data disclosure strategy for the phase I 635 study? - Management expects to make a single disclosure after completing the proof of concept part, likely around mid-next year, focusing on safety and efficacy [21] Question: How is enrollment going in the phase I trial for 575? - Management confirmed that enrollment is proceeding as expected and is on track [24] Question: What are the benefits of 635 versus existing hormonal treatments for hot flashes? - Management clarified that 635 is being developed as an alternative to menopausal hormone therapy, targeting women who cannot use MHT due to contraindications or adverse events [31]

Financial Data and Key Metrics Changes - Total revenues for Q3 2025 were $27.5 million, consisting of $25.7 million from Gemyto and $1.8 million from Zesturi, with Gemyto sales showing a 13% year-over-year growth when excluding CreateX sales from the previous year [22][24] - Net loss for Q3 2025 was $33.3 million, or $0.69 per share, compared to a net loss of $23.7 million, or $0.51 per share in Q3 2024 [24] - Cash, cash equivalents, and marketable securities totaled $127.4 million as of September 30, 2025 [24] Business Line Data and Key Metrics Changes - Gemyto generated net product revenue of $25.7 million, reflecting a 13% increase in underlying demand revenue over the same period in 2024 [6][22] - Zesturi sales were $1.8 million in Q3 2025, with a preliminary demand revenue estimate of $4.5 million for October, indicating strong early momentum [15][22] Market Data and Key Metrics Changes - Zesturi addresses an estimated $5 billion annual market, with expectations to become a standard of care and deliver over $1 billion in peak revenue [5][6] - The company has secured broad coverage across major payers, with Zesturi now accessible to over 95% of covered lives, approximately 296 million eligible patients [16] Company Strategy and Development Direction - The company is focused on the ongoing commercialization of Zesturi and Gemyto, with Zesturi being the primary growth driver [3][4] - A permanent product-specific J code for Zesturi is expected to take effect on January 1, 2026, which is anticipated to accelerate adoption [19][20] - The company plans to submit a New Drug Application (NDA) for UGN-103 in the second half of 2026, with potential approval anticipated in 2027 [8][10] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the long-term potential for Zesturi, citing positive physician feedback and increasing patient enrollment forms [4][5] - The company acknowledged logistical and operational challenges affecting the conversion of patient enrollment forms to actual patient dosing but expects improvements as practices gain experience [18][32] - Management emphasized the importance of the upcoming permanent J code in simplifying reimbursement and reducing barriers to adoption [19][20] Other Important Information - R&D expenses for Q3 2025 were $14 million, primarily driven by costs associated with the phase 3 Utopia trial for UGN-103 [22] - Selling, general, and administrative expenses increased to $37.6 million, driven by Zesturi commercial preparation activities and expansion of the sales force [23] Q&A Session Summary Question: Can you explain the timing for revenue recording and remittance? - Management indicated that the average lag time between patient enrollment form submission and patient dosing is currently 45-60 days, with expectations for gradual improvement as practices gain experience [31][33] Question: What visibility is there into physicians waiting for the permanent J code? - Management noted that many physicians are interested in prescribing Zesturi but are waiting for the permanent J code to take effect [36][40] Question: How are patient enrollment forms tracking month over month? - Management reported steady growth in patient enrollment forms, with some weeks showing equal or greater numbers compared to Gemyto [45][48] Question: What is the expected impact of the J code on lag time for patient dosing? - Management anticipates that the lag time will gradually decrease, potentially reaching below 30 days as practices become more familiar with the process [58][61] Question: Will additional capital be needed in 2026? - Management expressed confidence in their current cash position and operational plans, believing they can reach profitability without needing additional capital [70]

Financial Data and Key Metrics Changes - Total product revenue for Q3 2025 exceeded $74 million, representing a 40% increase year over year [4] - The company raised the lower end of its full-year total revenue guidance to a range of $285-$290 million, indicating a 42% increase at the midpoint compared to 2024 [4][12] - Gross margin improved to 85%, driven primarily by an improved product mix [11] - For the first time in the company's history, it reported quarterly net income [9][11] Business Line Data and Key Metrics Changes - Recorlev generated revenue of $37 million in Q3, a year-over-year increase of 109%, with the average number of patients on therapy growing by 108% [5][10] - Gvoke delivered revenue of more than $25 million, up nearly 10% from the same period last year, driven by a 5% increase in total prescriptions [6][10] - Keveyis achieved quarterly revenue of approximately $12 million, supported by new patient additions [6][10] Market Data and Key Metrics Changes - The company continues to expand its prescriber base for Recorlev, reflecting strong demand in the hypercortisolemia and Cushing's syndrome market [5][7] - The average number of patients on therapy for Keveyis increased, indicating a healthy pace of new patient starts [10] Company Strategy and Development Direction - The company is focused on expanding its commercial footprint to capture significant opportunities for Recorlev while strengthening operational capabilities for scalable growth in 2026 and beyond [7] - The strategic expansion includes nearly doubling the sales and patient support teams [7] - The company is advancing its pipeline with XP-8121, a once-weekly subcutaneous form of levothyroxine, with plans to initiate a phase three clinical trial in the second half of 2026 [7][8] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the ongoing demand for therapies and the company's ability to deliver strong performance [9][12] - The company anticipates continued growth for Recorlev, with expectations of it becoming a billion-dollar product [21] - Management emphasized the importance of maintaining positive adjusted EBITDA while making incremental investments in growth opportunities [12][24] Other Important Information - The company is committed to remaining adjusted EBITDA positive despite increased spending on R&D and SG&A [12][24] - Management highlighted the importance of a disciplined approach to investments in technology and infrastructure to support future growth [29] Q&A Session Summary Question: Impact of expanded sales force on Recorlev productivity - The sales force for Recorlev was increased by 50%, and productivity is expected to ramp up in the first half of the year [15][16] Question: Discontinuation rates for Recorlev - There have been no significant changes in dropout rates, with new patient starts overwhelming any metrics [19][20] Question: Competitive dynamics with potential new entrants - Management views the potential approval of competitors as an opportunity to expand the market for hypercortisolemia treatments [40][41] Question: Plans to target general practitioners for Recorlev - The company plans to expand its commercial footprint to include general practitioners as part of its data-driven approach [41][42] Question: Durability of the Keveyis franchise - The company continues to see strong performance from Keveyis, with ongoing efforts to support patient treatment and retention [45]

Financial Data and Key Metrics Changes - Total revenue increased by 11% in the first nine months of 2025, driven by strong demand for innovative medicines [6][11] - Core EPS rose by 15%, reflecting robust underlying business momentum [14] - Alliance revenue surged by 41%, primarily due to growth from Enhertu and Tezspire [11] - Core gross margin was reported at 83%, with expectations of a slight decrease for the full year due to various factors [12][15] Business Line Data and Key Metrics Changes - Oncology franchise revenue grew by 16%, with Tagrisso achieving $1.9 billion in sales, marking a 10% increase year-on-year [17][19] - Biopharmaceuticals revenue reached $17.1 billion, reflecting an 8% growth, with significant contributions from Fasenra and Tezspire [31] - Rare disease medicines grew by 6% to $6.8 billion, driven by strong demand for Ultomiris and Koselugo [40] Market Data and Key Metrics Changes - U.S. revenues increased by 19%, while emerging markets outside of China saw a 21% growth [7] - The U.S. is projected to account for around 50% of total revenue by 2030 [9] - China’s revenue growth is anticipated to be affected by stock compensation costs and year-end hospital budget capping [16] Company Strategy and Development Direction - The company aims to achieve $80 billion in revenue by 2030, supported by a rich pipeline of upcoming product launches and regulatory approvals [8][45] - A landmark agreement with the U.S. government aims to provide clarity around pricing and safeguard biopharmaceutical innovation [9] - Continued investment in R&D is planned, with a focus on high-value pipeline opportunities and expanding global manufacturing capacity [15][36] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company’s ability to navigate regulatory changes and maintain growth momentum [49] - The company anticipates strong revenue momentum in growth brands to continue, despite potential headwinds from product exclusivity losses [15][52] - Positive results from multiple pivotal studies are expected to reshape clinical practice and drive future growth [23][29] Other Important Information - The company is expanding its manufacturing footprint in the U.S. and has broken ground on a new facility in Virginia [10] - AstraZeneca ordinary shares will be listed on the New York Stock Exchange from February next year, enhancing capital access [10] Q&A Session Summary Question: What is the risk of residual activity from the administration regarding pricing? - Management addressed concerns by stating that the agreement with the U.S. government covers key points and they do not expect further issues [49] Question: Is the $10 billion catalyst potential part of the $80 billion ambition? - The $10 billion is part of the $80 billion peak-year revenue potential, contributing to the overall 2030 goal [50] Question: What is the comfort level regarding 2026 margin consensus? - Management indicated that while there are pushes and pulls, they remain committed to investing in growth brands and maintaining strong margins [51][52]

Financial Data and Key Metrics Changes - Total revenue increased by 11% in the first nine months of 2025, driven by strong demand for innovative medicines [5][11] - Core EPS rose by 15%, reflecting robust underlying business momentum [5][13] - Core gross margin was 83%, with expectations of a slight decrease for the full year due to various factors [11][12] - Cash flow from operating activities increased by 37% to $12.2 billion [13] Business Line Data and Key Metrics Changes - Oncology franchise grew by 16%, with total revenue reaching $18.6 billion [6][17] - Biopharmaceuticals revenue increased by 8% to $17.1 billion, with notable growth in severe asthma and chronic obstructive pulmonary disease (COPD) segments [30] - Rare disease medicines grew by 6% to $6.8 billion, driven by strong demand in neurology indications [39] Market Data and Key Metrics Changes - U.S. revenues increased by 19%, while emerging markets outside of China saw a 21% growth [6][9] - Alliance revenue surged by 41%, primarily due to growth from Enhertu and Tezspire [11] Company Strategy and Development Direction - The company aims to achieve $80 billion in revenue by 2030, supported by a rich pipeline and multiple regulatory approvals [5][8] - A landmark agreement with the U.S. government aims to provide clarity around pricing and safeguard biopharmaceutical innovation [9] - Continued expansion of global manufacturing capacity, including a new facility in Virginia [10] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the agreement with the U.S. government, expecting it to mitigate risks related to pricing and innovation costs [47] - The company anticipates strong revenue momentum in growth brands to continue, despite potential headwinds from product exclusivity losses [14][51] Other Important Information - The company is in a catalyst-rich period with multiple pivotal data sets expected to reshape clinical practice [43][44] - Significant investments are being made in high-value pipeline opportunities, including oncology and rare diseases [12][30] Q&A Session Summary Question: What is the risk of residual activity from the administration regarding pricing? - Management addressed concerns, stating that the agreement with the U.S. government covers key points and they do not expect further issues [47] Question: Is the $10 billion catalyst potential part of the $80 billion ambition? - Management confirmed that the $10 billion is part of the $80 billion peak-year revenue potential, not a 2030 number [48] Question: What is the level of comfort regarding 2026 margin consensus? - Management indicated that the key headwind for 2026 will be the loss of Farxiga in the U.S. and China, but they remain committed to investing in growth brands [51][52] Question: How does the company view the potential of the CARDIO-TTRansform study? - Management expressed optimism about the study's potential to reshape treatment guidelines for patients with ATTR amyloidosis [62][63]

Core Insights - The company reported a revenue of 10.086 billion yuan for the first three quarters of 2025, representing a year-on-year increase of 14.4%, while the net profit attributable to shareholders decreased by 19.8% to 1.141 billion yuan [1] - The company raised its revenue growth target for 2025 to 12%-16% from the previous 10%-15%, indicating confidence in performance growth [1] Financial Performance - In Q3 2025, the company achieved a revenue of 3.645 billion yuan, a year-on-year increase of 13.4% and a quarter-on-quarter increase of 9.1%, marking a recent high for quarterly revenue [1] - The adjusted net profit margin for Q3 2025 was 10.89%, the best level since Q1 2024, reflecting improved operational efficiency as revenue scales up [1] Business Segment Analysis - The laboratory services segment generated revenue of 6.004 billion yuan in the first three quarters of 2025, with a gross margin of 45.1%, an increase of 0.3 percentage points year-on-year [2] - The CMC segment reported revenue of 2.293 billion yuan, with a gross margin of 32.1%, up 1.3 percentage points year-on-year, and is expected to see further improvements in Q4 2025 [2] Profit Forecast and Valuation - Revenue projections for 2025 to 2027 are set at 14.053 billion yuan, 16.034 billion yuan, and 18.090 billion yuan, with year-on-year growth rates of 14.5%, 14.1%, and 12.8% respectively [3] - Net profit forecasts for the same period are 1.669 billion yuan, 2.140 billion yuan, and 2.565 billion yuan, with growth rates of -6.9%, +28.2%, and +19.9% respectively [3]

Investment Rating - The investment rating for the company is "Buy" [1][3] Core Insights - The company has raised its revenue guidance for 2025, reflecting confidence in growth, with a target increase of 12%-16% compared to the previous 10%-15% [7] - The company's operating quality continues to improve, with significant growth in core business segments and a notable increase in new orders [7] - The financial forecasts for 2025 to 2027 indicate a steady revenue growth trajectory, with expected revenues of 140.53 billion yuan, 160.34 billion yuan, and 180.90 billion yuan respectively [4][7] Summary by Sections Financial Performance - For the first three quarters of 2025, the company achieved a revenue of 100.86 billion yuan, a year-on-year increase of 14.4%, while the net profit attributable to shareholders was 11.41 billion yuan, down 19.8% [7] - The company reported a significant improvement in quarterly performance, with Q3 2025 revenue reaching 36.45 billion yuan, a 13.4% year-on-year increase and a 9.1% quarter-on-quarter increase [7] Business Segments - The laboratory services segment generated revenue of 60.04 billion yuan in the first three quarters of 2025, with a gross margin of 45.1%, reflecting a 0.3 percentage point increase year-on-year [7] - The CMC business segment reported revenue of 22.93 billion yuan, with a gross margin of 32.1%, up 1.3 percentage points year-on-year, indicating potential for further improvement [7] Profitability Forecast - The projected net profit for 2025 is 16.69 billion yuan, with a year-on-year growth rate of -6.9%, followed by a recovery in 2026 and 2027 with growth rates of 28.2% and 19.9% respectively [4][7] - The earnings per share (EPS) is expected to be 0.94 yuan in 2025, increasing to 1.20 yuan in 2026 and 1.44 yuan in 2027 [4][7]