成都康华生物（维权）制品股份有限公司（以下简称"康华生物"）于近期发布2024年年度报告，各项财 务数据呈现出不同程度的变化。其中，研发费用大幅下降47.81%，筹资活动产生的现金流量净额变动 幅度更是高达 -6528.79%，这些显著变化值得投资者深入关注。 关键财务指标解读 营收下滑，市场竞争或成主因 2024年，康华生物营业收入为1,431,876,597.94元，相较于2023年的1,577,395,401.05元，下降了9.23%。 从业务板块来看，生物制品业务收入为1,325,731,889.52元，占营业收入比重92.59%，但较上年同期下 降15.93%；其他业务收入106,144,708.42元，占比7.41%，同比增长22,494.27% ，不过因其基数较小，对 整体营收影响有限。 分地区来看，各主要地区收入大多呈下降趋势。如华东地区收入552,092,855.84元，同比下降15.12%； 华中地区收入228,075,736.74元，同比下降21.03%。境外收入增长显著，达到106,240,500.00元，同比增 长4,657.11%，但目前占比相对较小。公司营收下降，或与市场竞争加剧 ...

Core Viewpoint - The company reported a significant decline in revenue and net profit for 2024, with revenue decreasing by 59.25% to 2.245 billion yuan and net profit dropping by 91.49% to 106 million yuan [1]. Industry Analysis - The vaccine sector experienced a substantial revenue decline of 84.69%, totaling 606 million yuan, while the in vitro diagnostics (IVD) business saw a revenue increase of 4.91%, reaching 1.609 billion yuan [2]. - In the IVD sector, the company has completed the layout of high, medium, and low throughput instruments, including three fully automated chemiluminescence immunoassay analyzers and 115 corresponding reagents, addressing various clinical testing needs [2]. - The company is advancing a high-throughput fully automated biochemical analyzer, WanBC2800, to enhance its product line and meet diverse user demands [2]. - A new nucleic acid detection product based on microfluidic technology is under development, promising rapid testing processes and improved efficiency [2]. - The IVD segment achieved nearly double-digit growth despite policy impacts, with notable increases in reagent consumables such as chemiluminescence reagents (up 19%) and tuberculosis detection reagents (up 50%) [3]. Product Development - The company is focusing on vaccine development, particularly the nine-valent HPV vaccine, which is progressing well through clinical trials and is on track for commercialization [5][6]. - The company is also advancing several other vaccine candidates, including a 20-valent pneumonia conjugate vaccine and a recombinant herpes zoster vaccine, with various stages of clinical trials and regulatory submissions ongoing [6]. International Market Expansion - The company is actively promoting its bivalent HPV vaccine, Cecolin®, for inclusion in national immunization programs across multiple countries, including Thailand and Nicaragua [8]. - New markets have been added, with countries like Angola, Tunisia, Burundi, and Pakistan incorporating the vaccine into their immunization plans, and several procurement orders have been secured [8].

Core Viewpoint - The company is a leading biopharmaceutical enterprise in China, specializing in the research, development, production, and sales of human vaccines, with a mission to create accessible and high-quality innovative vaccine products for global health [2][3]. Company Overview - The company has developed a comprehensive portfolio of vaccines, including the 13-valent pneumococcal conjugate vaccine and the HPV vaccine, maintaining a leading market share in China since their launch [3][4]. - The company has exported its vaccine products to 22 countries and regions, contributing significantly to public health both domestically and internationally [2]. Product Sales - In 2024, the company achieved sales revenue of 2.54 billion yuan from its self-developed vaccines, accounting for 90.10% of total revenue, despite increasing competition in the global vaccine market [7]. - The 13-valent pneumococcal conjugate vaccine continues to hold the top market share in China, while the dual-valent HPV vaccine focuses on government procurement projects to enhance accessibility for young girls [7]. Product Production and Approval - The company successfully produced and approved 24,639,153 doses of its vaccines in 2024, ensuring a stable market supply while balancing inventory and sales [8]. New Product Development and Registration - The company invested 24.82% of its revenue in R&D in 2024, focusing on innovative vaccine development through collaboration with academic institutions and research organizations [9]. - The company is advancing several vaccine candidates, including the mRNA vaccine for COVID-19 variants, which has completed necessary clinical trials and is in the process of registration [10][11]. Export and International Cooperation - The company achieved overseas business revenue of 570 million yuan in 2024, marking a 98% year-on-year increase, with significant exports to new markets such as Afghanistan and Burkina Faso [12]. - The company’s dual-valent HPV vaccine received WHO prequalification, enhancing its procurement eligibility for international organizations [13]. Industrialization and Management Improvement - The company completed the construction of its production expansion project and implemented a digital management system for its entire product line, enhancing operational efficiency [16]. - The company is optimizing its governance structure and internal controls to support sustainable development and risk management [18][19]. Financial Data and Shareholder Information - The company has completed share buybacks and capital reductions, enhancing shareholder returns without significantly impacting its operational capabilities [30][27].

Group 1 - The company, Changjiang Life Science Technology, has announced promising early results from preclinical laboratory tests of a novel cancer vaccine targeting TROP2, a cell surface glycoprotein overexpressed in various cancers such as breast, lung, pancreatic, and colorectal cancers [1] - TROP2 plays a critical role in cell proliferation, metastasis, and invasion, making it a potential therapeutic target in oncology due to its high expression in cancer cells and minimal presence in normal tissues [1] - The TROP2 cancer vaccine candidate utilizes innovative circular RNA (circRNA) and fusion protein constructs, demonstrating significant tumor growth inhibition in preclinical studies involving over 170 mice, with complete tumor growth suppression observed in all breast cancer studies [1] Group 2 - The incidence of breast cancer, particularly triple-negative breast cancer (TNBC), is rising sharply in Asia, affecting many young women, with higher rates and severity compared to Western countries [2] - The company believes that the TROP2 cancer vaccine shows unprecedented anti-cancer efficacy based on mouse studies and aims to advance it to clinical research stages to provide new treatment options for patients [2] - The company has filed patent applications for the circRNA and fusion protein TROP2 cancer vaccine with the Hong Kong Intellectual Property Department and a provisional patent application with the U.S. Patent and Trademark Office [2] Group 3 - The company has applied to the Stock Exchange for the resumption of trading of its shares starting from 9:00 AM on April 11, 2025 [3]

同时2025年公司在销售团队持续推广、人群疫苗接种意识进一步提高下，我们预计公司破伤风疫苗将继 续实现增长。 盈利预测：我们预计2025-2027 年收入分别为7/8/10 亿元。 风险提示：销售不及预期的风险；竞争格局恶化风险；在研产品进度不及预期的风险。 金葡菌疫苗处于临床III 期，有望2025年上市。公司重组金葡菌疫苗临床 III 期已完成5000 余例入组，产 品有望在2025 年实现上市。预计2030 年我国闭合性骨折手术人数约134 万，其中80%感染者接种疫 苗，产品上市后将有望带动公司业绩快速放量。同时公司正积极布局病毒类疫苗，三价、四价流感病毒 裂解疫苗（MDCK 细胞）已获得临床试验批准。 破伤风疫苗收入占比仍然较高。分产品来看，公司破伤风疫苗实现收入首次突破5亿元，销量为336.4 万 支（+6.9%），公司破伤风疫苗在外伤门诊、犬伤门诊以及血制品企业三大渠道实现稳定放量，外伤渠 道比例处于持续提升当中。 事件：公司发布 2024年年报，实现营业收入5.9亿元，同比提高18.7%；实现归属于母公司股东净利润 0.2 亿元，同比提高18.2%；实现扣非后归母净利润0.1 亿元，同比增长2 ...

近期欧林生物（688319）发布2024年年报，证券之星财报模型分析如下： 营收与利润 尽管盈利能力有所提升，但公司的三费（销售费用、管理费用、财务费用）占营收比例仍高达 67.82%，虽然同比下降了1.28个百分点，但这一比例仍然较高。值得注意的是，财务费用同比增加了 113.91%，主要原因是报告期内公司贷款规模增加。 现金流状况 公司经营活动产生的现金流量净额为负，每股经营性现金流为-0.02元，同比减少了122.13%。这主要是 由于研发投入付现支出增加所致。此外，货币资金为2.24亿元，同比减少了38.09%，主要原因是支付临 床费用及进行固定资产投资。 应收账款 应收账款为5.66亿元，同比增长了15.30%。应收账款与利润的比例达到了2728.74%，显示出公司在应收 账款管理方面存在一定压力。 资产与负债 有息负债为3.61亿元，同比增长了54.88%，表明公司负债水平有所上升。固定资产同比增长了50.24%， 主要原因是3、4号楼生产厂房转入固定资产。 欧林生物（688319）在2024年的营业总收入达到5.89亿元，较去年同期增长了18.69%。归母净利润为 2075.76万元，同比增长1 ...

2003年11月，宫颈癌晚期的梅艳芳在红磡体育馆唱了八夜，竭力在《夕阳之歌》末尾喊出ByeBye，一个 月后猝然离世，享年40岁。 "所有宫颈癌患者的死亡是不必要的。" 但它产能有限，跨国批签发手续复杂，2017年到2018年，默沙东的四价和九价HPV疫苗才借智飞生物 的代理在中国姗姗上市，一度成为"疫苗茅"，排号动辄需要两年，打了上针可能没有下针，喂肥了一大 批黄牛党和诈骗犯。 这本该是个医学技术创新带动全民幸福的故事。可 没承想，默沙东联合澳洲和中国的科学家们历时 25 年 研制出的疫苗，费了 11年 进入中国，却在这 个全球宫颈癌高发大国卖 了 7年 就哑火。 在今年的2月4号，默沙东宣布暂停向中国市场供应HPV疫苗——并非美国人又想卡我们的脖子，而是单 纯因为卖不动了。而在代理商智飞的仓库里， 囤积的HPV疫苗一度高达4千万支。 相比狂犬病3个月就能看出疯没疯，高危型HPV病毒像颗地雷，感染后可能自行消失，也可能在20年后 突然爆发。 可以说，在感染HPV的概率上，有过性行为的人首次实现了男女平等。 梅艳芳去世3年后，2006年，美国医药巨头默沙东研制出世界首款HPV四价疫苗，可预防4种常见的 HPV ...

专注高端疫苗，以在中国取代传统疫苗和进口疫苗。 本文为IPO早知道原创 作者｜Stone Jin 微信公众号｜ipozaozhidao 据IPO早知道消息，江苏中慧元通生物科技股份有限公司（以下简称"中慧元通"）于2025年1月23 日正式向港交所递交招股说明书，拟主板挂牌上市，中信证券和招银国际担任联席保荐人。 成立于2015年的中慧元通专注创新疫苗及采用新技术方法的传统疫苗的研发、制造及商业化，尤其 聚焦高端疫苗，以在中国取代传统疫苗和进口疫苗，并将自己的竞争优势扩展至国际市场 。 | 產品 | 適應症 | 研發 | 臨床前 | IND批准 | | 臨床 | | NDA批准 | 預計近期里程碑 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | | | 1期 川期 | | 川期 | | | | | 流感(3歲 | 自研 | | | | | | | 於2025年第四季度 完成批准後安全性 | | 四價流感 病毒亞單位 | 及以上) | | | | | | | | 研究 | | 疫苗* | 流感(6至 | 自研 | | ...

证券简称： 康乐卫士 证券代码： 833575 北京康乐卫士生物技术股份有限公司 BEIJING HEALTH GUARD BIOTECHNOLOGY INC. 北京市北京经济技术开发区荣昌东街 7 号 A2 幢 201、202 北京康乐卫士生物技术股份有限公司招股说明书（注册稿） 本公司的发行申请尚未经中国证监会注册。本招股说明书申报稿不具有据以发行股票的法律效 力，投资者应当以正式公告的招股说明书全文作为投资决定的依据。 本次股票发行后拟在北京证券交易所上市，该市场具有较高的投资风险。北京证券交易所主要 服务创新型中小企业，上市公司具有经营风险高、业绩不稳定、退市风险高等特点，投资者面临较 大的市场风险。投资者应充分了解北京证券交易所市场的投资风险及本公司所披露的风险因素，审 慎作出投资决定。 保荐机构（主承销商） 广东省深圳市福田区中心三路 8 号卓越时代广场（二期）北座 1-1-1 中国证监会和北京证券交易所对本次发行所作的任何决定或意见，均不表明其对注册申 请文件及所披露信息的真实性、准确性、完整性作出保证，也不表明其对发行人的盈利能力、 投资价值或者对投资者的收益作出实质性判断或者保证。任何与之相 ...