格隆汇11月13日丨康希诺生物(06185.HK)宣布，公司开发的吸入用肺结核疫苗(5型腺病毒载体)("吸入用 结核病加强疫苗")近日于印度尼西亚正式启动I期临床试验，并完成I期临床试验首例受试者入组。 目前，卡介苗是全球唯一可用于预防结核病的疫苗，在全球范围内被广泛接种，其对预防婴幼儿结核病 发挥重要作用，但卡介苗保护力会随时间减弱，无法通过加强免疫接种增强疫苗的保护效果。针对此不 足，公司研发了第一代全球创新结核病加强疫苗("结核病加强疫苗")用于卡介苗接种人群，结核病加强 疫苗于加拿大完成了Ia及Ib期临床试验，临床试验数据证明了结核病加强疫苗作为候选疫苗的安全性和 作为卡介苗加强疫苗的有效性，以及黏膜免疫的优越性。 基于吸入用新冠疫苗开发的技术累积，公司建立了完整的吸入药学、质量控制体系，升级第一代产品， 同时增加了抗原组分，开发了吸入用结核病加强疫苗，通过雾化吸入的方式递送，有望可以激发肺部免 疫应答，从而清除结核菌，控制潜伏感染，并可实现预防感染的效果。 ...

基于吸入用新冠疫苗开发的技术累积，公司建立了完整的吸入药学、质量控制体系，升级第一代产品， 同时增加了抗原组分，开发了吸入用结核病加强疫苗，通过雾化吸入的方式递送，有望可以激发肺部免 疫应答，从而清除结核菌，控制潜伏感染，并可实现预防感染的效果。 目前，卡介苗是全球唯一可用于预防结核病的疫苗，在全球范围内被广泛接种，其对预防婴幼儿结核病 发挥重要作用，但卡介苗保护力会随时间减弱，无法通过加强免疫接种增强疫苗的保护效果。针对此不 足，公司研发了第一代全球创新结核病加强疫苗("结核病加强疫苗")用于卡介苗接种人群，结核病加强 疫苗于加拿大完成了Ia及Ib期临床试验，临床试验数据证明了结核病加强疫苗作为候选疫苗的安全性和 作为卡介苗加强疫苗的有效性，以及黏膜免疫的优越性。 格隆汇11月13日丨康希诺生物(06185.HK)宣布，公司开发的吸入用肺结核疫苗(5型腺病毒载体)("吸入用 结核病加强疫苗")近日于印度尼西亚正式启动I期临床试验，并完成I期临床试验首例受试者入组。 ...

Group 1 - The article discusses the significant changes in the global landscape, emphasizing the uncertainty and unpredictability of future events, particularly in the context of geopolitical tensions and economic shifts [5][6][13] - It highlights the historical context of major geopolitical conflicts and their impact on economic centers, noting that such conflicts can lead to new markets and opportunities for growth [7][8] - The article stresses the importance of companies adapting their strategies to global changes, with examples of successful businesses that have diversified their operations internationally to mitigate risks [9][10] Group 2 - Companies are encouraged to focus on customer needs rather than merely competing with rivals, suggesting that understanding and addressing customer demands can lead to a competitive advantage [11][12] - The article provides examples of companies that have successfully navigated challenges by innovating and aligning their products with customer expectations, such as IKEA and ASML [10][11] - It emphasizes the necessity for businesses to establish research and development centers globally to better understand diverse customer bases and foster innovation [12] Group 3 - The article categorizes events into three types: certain events, predictable events based on past experiences, and completely unpredictable events, stressing the need for companies to prepare for uncertainty [13][14] - It discusses the concept of "capital" in business, defining it as both financial resources and the capabilities of entrepreneurs to manage and utilize those resources effectively [21][20] - The importance of having a solid financial foundation and skilled management is highlighted as essential for companies to survive and thrive in uncertain environments [21][19]

Core Viewpoint - Shanghai's community health service centers have initiated flu vaccine inoculation services to prevent flu viruses during the autumn-winter and winter-spring seasons, with a peak in vaccination expected soon [1][2]. Group 1: Vaccination Services - Various brands and types of flu vaccines are being delivered to community health centers, with plans to increase vaccination capacity by adding weekend sessions and dedicated vaccination rooms starting from late September [1]. - The vaccination process is efficient, with residents able to complete registration and inoculation in approximately 5-6 minutes [1]. Group 2: Target Population and Timing - September and October are identified as the "golden time" for flu vaccination, as it takes 2-4 weeks for the body to develop antibodies post-inoculation, aligning with the flu peak [2]. - Key populations recommended for early vaccination include children aged 6 months to 5 years, seniors aged 60 and above, individuals with chronic diseases (asthma, diabetes, heart disease), and professionals frequently in contact with others (healthcare workers, teachers) [2]. Group 3: Vaccine Availability and Demand - Flu vaccines are arriving in various districts, with the first day of vaccination at one center resulting in 17 doses administered [2]. - The flu vaccine availability this year is earlier than in previous years, with the first batch arriving in late July, ensuring supply meets demand [2]. - Historical data indicates that the peak vaccination period is typically in October and November, with current demand still low, allowing for a streamlined process for elderly individuals [2].

Group 1 - The article discusses health recommendations for the upcoming Xiaoman solar term, emphasizing the importance of adapting to seasonal changes to prevent health issues [1] - The National Health Commission held a press conference addressing public concerns about health during this period, focusing on respiratory infections and general wellness [1] Group 2 - To prevent respiratory infectious diseases, maintaining good personal hygiene, regular handwashing, and proper ventilation are crucial [2] - Vaccination is particularly recommended for vulnerable groups such as young children, the elderly, and those with chronic illnesses [2] - Pertussis, caused by Bordetella pertussis, poses a high risk for unvaccinated infants, highlighting the need for timely vaccination [2] Group 3 - Tuberculosis, primarily caused by Mycobacterium tuberculosis, is a significant health concern, with early detection and treatment adherence being essential [3] - Close contacts of newly diagnosed tuberculosis patients should undergo screening to prevent further spread [3] - Vaccination with BCG is advised for eligible children to enhance immunity against tuberculosis [3] Group 4 - During Xiaoman, traditional beliefs suggest avoiding cold foods to protect the body's yang energy, which can be disrupted by excessive consumption of cold items [4] - Recommended foods include those that nourish the spleen and stomach, such as coix seed and lotus seed, while spicy ingredients can help mitigate the effects of cold foods [4] - Sleep quality can be improved by maintaining a regular sleep schedule and creating a conducive sleep environment [4] Group 5 - Achieving a balance between diet and exercise is essential for maintaining a healthy weight, with recommendations for regular meal times and portion control [5] - The importance of consuming whole grains and fresh fruits while limiting sugary drinks is emphasized [5] - Misconceptions about skipping meals for weight loss are addressed, highlighting potential negative effects on metabolism [5] Group 6 - For children and adolescents, proper nutrition is critical for growth and development, with a focus on adequate protein intake and physical activity [6] - Recommendations include engaging in outdoor activities for preschoolers and ensuring at least 60 minutes of moderate to vigorous exercise for older children [6]