Core Insights - The conversation highlights the evolving understanding of biology, particularly the role of genes and DNA, challenging traditional views that consider them as the sole controllers of life [4][9][10] Group 1: Understanding of Genes and DNA - The author Philip Ball argues that genes and DNA should be viewed as "molecular resources" that cells utilize based on their environment rather than as strict instructions governing all biological processes [9][10] - The historical perspective of genes as a "code" directing all biological functions is deemed outdated, with a shift towards understanding the complex interactions within cells [8][9] - The concept of "selfish genes" is critiqued, suggesting that it oversimplifies the intricate regulatory mechanisms at play in biological systems [12][19] Group 2: Medical Implications - Ball emphasizes the need for a more holistic approach to medicine, moving beyond genetic-level interventions for diseases that may not primarily stem from genetic issues [10][11] - The discussion points out that many common diseases are influenced by higher-level biological processes rather than solely by genetic factors [10][11] - The author suggests that current medical practices often resemble trial-and-error methods rather than being based on a deep understanding of biological mechanisms [11][12] Group 3: Complexity of Biological Systems - The conversation addresses the complexity of cellular environments, likening them to crowded nightclubs rather than orderly factories, highlighting the chaotic interactions among molecules [27][29] - The role of biomolecular condensates in cellular processes is introduced, emphasizing the importance of understanding these structures for effective medical interventions [24][26] - The need for advanced imaging techniques, such as cryo-electron microscopy, is discussed as a means to better visualize and understand cellular dynamics [27][29] Group 4: Emergence and Agency in Biology - The concept of "agency" in biological systems is explored, suggesting that organisms, including cells, exhibit decision-making capabilities that go beyond mere genetic programming [30][32] - Ball argues that understanding the agency of living organisms is crucial for comprehending the essence of life, distinguishing it from non-living entities [32][34] - The discussion touches on the philosophical implications of human decision-making and its divergence from evolutionary imperatives, indicating a complex interplay between instinct and conscious choice [34][36] Group 5: Future Directions in Biological Research - The potential of AI in biological research is acknowledged, particularly in predicting gene regulation and understanding complex biological phenomena [21][23] - However, concerns are raised about the limitations of AI in providing mechanistic explanations for biological processes, emphasizing the need for a deeper understanding of underlying mechanisms [23][24] - The conversation concludes with a call for better narratives in biology that reflect its complexity and the agency of living systems, moving away from simplistic explanations [49][50]

Core Viewpoint - The "2025 International Genomics Conference Ophthalmology Conference (ICGEYE) and CGT Innovation and Industry Transformation Summit" will be held in Shenyang from October 31 to November 1, 2025, aiming to promote high-quality development in China's precision medical industry and eye health sector [1] Group 1 - The conference is co-hosted by Liaoning He Eye Hospital Group Co., Ltd., Liaoning He Medical College, He Eye Industry Group, and the Eye Gene Bank [1] - The event will focus on the cross-disciplinary integration of cell and gene therapy (CGT) and ophthalmology, facilitating the transformation of major scientific achievements and enhancing talent exchange [1] - The conference will feature four cutting-edge forums and will cover topics such as genetics, stem cells, ophthalmology, artificial intelligence, big data, and biomedicine [1] Group 2 - The conference aims to create a multi-dimensional platform for cross-disciplinary dialogue, industry-finance connection, and popular science communication [1] - The event seeks to promote innovative development and share intelligent achievements among participants [1]

Core Concept - The article discusses the concept of the "triple helix" proposed by R.C. Lewontin, emphasizing the interaction and influence among genes, organisms, and the environment [1][8]. Group 1: Genetic Determinism Debate - Lewontin criticizes genetic determinism, arguing that the human genome differs by less than 0.1%, yet it is misused to explain social inequalities such as wealth, intelligence, and crime [5][6]. - He asserts that the environment is not merely a container but is actively shaped by organisms, which select and modify their surroundings [5][8]. - The completion of the Human Genome Project, according to Lewontin, will not achieve its intended purpose of identifying disease-causing genes through DNA comparison [5][6]. Group 2: Responses from Richard Dawkins - Richard Dawkins responds to Lewontin's critiques, clarifying that he never claimed genes determine everything, but rather that genetic differences can explain phenotypic variations [6]. - Dawkins emphasizes the directionality of evolution, countering Lewontin's and Gould's views on randomness in evolution by citing examples like the speed of cheetahs [6]. - He argues that moral responsibility should not be outsourced to science, maintaining a distinction between scientific conclusions and their political implications [6]. Group 3: Impact on Biological Sciences - The debate between Lewontin and Dawkins has had a lasting impact on the field of biology, with new perspectives emerging, such as those presented by behavior geneticist Kathryn Harden in her book "The Gene Lottery" [7]. - Harden attempts to find a middle ground, acknowledging the significant role of genes while also recognizing the influence of luck and the potential for social policies to mitigate genetic impacts [7]. - However, Lewontin remains critical of this middle ground, insisting that the interactions among genes, environment, and randomness are too complex to disentangle [7][8]. Group 4: Science as a Social Institution - Lewontin argues that science is not an isolated pursuit of truth but a social institution influenced by political and economic factors [10][11]. - The direction of scientific research is often driven by societal needs and interests, rather than purely by the quest for knowledge [10][12]. - Cultural and ideological contexts shape scientific inquiry, affecting research focus and methodologies across different societies [11][12]. Group 5: Historical Context and Future Implications - Historical examples illustrate the close relationship between biology and political ideologies, such as the use of Darwinian theory in imperialism and eugenics [12]. - The ongoing developments in biological sciences, particularly in the context of the COVID-19 pandemic, raise questions about the political implications of scientific advancements [12].

Group 1 - The research team, including Dr. Dai Guangzheng from Liaoning He University, published a paper in the journal "npj Digital Medicine" on the feasibility of using a portable slit lamp combined with AI algorithms to identify narrow anterior chamber angles (NACA) for early screening of primary angle-closure glaucoma (PACG) [1] - Glaucoma is a leading cause of irreversible blindness globally, and traditional screening methods are not suitable for large-scale community screening due to various limitations [1] - The developed portable slit lamp system is compact and easy to operate, addressing issues of high costs and portability associated with traditional equipment, showcasing the potential of AI in eye disease screening [1] Group 2 - He Eye Hospital Group, as an innovative digital eye health ecosystem, supports the research and aims to leverage its advantages in the eye health industry chain to promote intelligent, precise, and inclusive eye health services [2] - The company plans to utilize cutting-edge technologies such as AI, genetics, and stem cells to ensure that technological innovations benefit the public and improve overall health outcomes [2]