Core Viewpoint - The research published in Science reveals that the insufficient expression of the Aldh1a2 gene leads to inadequate synthesis of retinoic acid (RA), which is the core mechanism behind the failure of ear regeneration in higher mammals like mice. Activating this gene or supplementing with RA can enable ear regeneration in mice [2][3][8]. Group 1: Research Findings - The study identifies Aldh1a2 gene expression deficiency as a critical factor in the failure of ear regeneration in mice, linking it to insufficient RA synthesis [3][8]. - By activating the Aldh1a2 gene or providing external RA, the research demonstrated successful regeneration of the ear in mice after injury [13][14]. - The research utilized advanced techniques such as single-cell RNA sequencing and spatiotemporal omics technology to compare regenerative processes between species with and without ear regeneration capabilities [7][15]. Group 2: Evolutionary Insights - The study highlights evolutionary differences, noting that rabbits, which can regenerate their ears, have multiple active enhancers near the Aldh1a2 gene that are not present in mice, leading to lower expression levels of this gene in the latter [11][17]. - The loss of enhancer activity in the evolutionary lineage of mice and rats explains their inability to regenerate ear tissue after injury [11][17]. - The research provides a theoretical basis for exploring organ reconstruction and regeneration in humans by understanding the mechanisms behind the loss of regenerative capabilities in higher mammals [15].

Group 1 - The Chinese automotive industry, particularly domestic brands, will not be affected by the US tariffs as their exports to the US are minimal and they do not sell in the US market [2] - The market share of Chinese domestic brands in Russia remains high at 55%, indicating limited pressure from export reductions [2] Group 2 - Jack Ma attended the 21st "Ali Day" event, encouraging Alibaba employees to maintain their entrepreneurial spirit and continue innovating [3] Group 3 - The Chinese Academy of Traditional Chinese Medicine released evaluation standards for large-scale pre-trained models in the field of traditional medicine, establishing a quantitative assessment system [4] Group 4 - In April 2025, the national industrial producer price index decreased by 2.7% year-on-year and 0.4% month-on-month, with the average for January to April showing a 2.4% decline compared to the previous year [4] - In April 2025, the national consumer price index decreased by 0.1% year-on-year, with urban prices stable and rural prices down by 0.3% [5] Group 5 - The first "embodied intelligent rehabilitation demonstration base" was established in Shanghai, focusing on the application of intelligent robots in rehabilitation medical scenarios [6][7] Group 6 - China Energy Construction Corporation launched the first "hundred-megawatt" flywheel energy storage project in Shanxi, marking a significant development in energy storage technology [8] Group 7 - Apple announced price reductions for the iPhone 16 Pro and Pro Max models, with the Pro Max dropping by $160 and the Pro by $176, likely in preparation for the upcoming 618 shopping festival [9] Group 8 - The "AIDA Mediterranean" cruise ship made its inaugural voyage from Shenzhen, with plans to operate unique routes covering Hong Kong, Japan, Vietnam, and the Philippines [10] Group 9 - The first intelligent inspection robot for freight railways was deployed in Hebei, enhancing the smart capabilities of China's freight railway system [11] Group 10 - Japanese beef exports to the US are facing challenges due to increased tariffs, with one company potentially needing to raise prices by over 50% if tariffs are implemented [12] - India is willing to reduce its average tariff gap with the US from nearly 13% to below 4% to negotiate a trade agreement with the Trump administration [13] Group 11 - The negative effects of US tariff policies are impacting American agriculture, with large agricultural companies reporting difficulties in product exports and imports of essential supplies [15] Group 12 - Panasonic announced plans to cut 10,000 jobs globally, including 5,000 in Japan, and will terminate unprofitable business lines [16] Group 13 - Tesla has halted the sale of the extended battery pack for the Cybertruck, refunding customers who had previously paid a deposit [17] Group 14 - The mobility service brand of SAIC Motor, Xiangdao Mobility, completed a C-round financing of over 1.3 billion yuan, marking a significant milestone [18] - The domestic exoskeleton robot technology platform company, Aoshark Intelligent, completed a multi-million yuan B-round financing to accelerate the mass production of consumer-grade exoskeleton robots [18] Group 15 - Wuxi Yelong Precision Machinery Co., Ltd. withdrew its IPO application after more than a year of being on hold [19] - Hangzhou Tongshifu Cultural (Group) Co., Ltd. submitted an IPO application to the Hong Kong Stock Exchange, with 招银国际 as the sole sponsor [20]