科创板IPO排队超两年，百奥赛图（北京）医药科技股份有限公司（以下简称"百奥赛图"）终于迎来了上会机会，上交所上市审核委员会 定于9月24日召开2025年第38次上市审核委员会审议会议，审议百奥赛图的首发事项。 招股书显示，百奥赛图成立于2009年，是一家临床前CRO以及生物技术企业。公司基于自主开发的基因编辑技术提供各类创新模式动物以 及临床前阶段的医药研发服务，并利用其自主开发的RenMice全人抗体小鼠平台，针对人体内近千个潜在药物靶点进行规模化药物发现与 开发（以下简称"千鼠万抗"），并将有潜力的抗体分子对外转让、授权或合作开发。 百奥赛图方面向北京商报记者表示，"千鼠万抗"计划自2020年启动，已实现阶段性成果。针对千余个靶点形成了近百万个抗体结合表位的 分子序列"货架"。商业化模式包括抗体分子序列授权/转让、合作开发，以及RenMice小鼠对外授权和抗体制备服务，公司可获取首付款、 里程碑付款及销售分成。目前，公司已与德国默克、吉利德、IDEAYA、Neurocrine、翰森制药、华润生物、荣昌生物、ADC Therapeutics 等数十家国内外知名药企达成合作。这表明"千鼠万抗"已成为公司对外 ...

Summary of the Conference Call for Heber Pharmaceuticals Company Overview - Heber Pharmaceuticals is leveraging the capabilities of Nona Biotech for hematopoietic development and business development (BD) collaborations, entering a harvest period in 2025 with significant highlights including licensing agreements and high-quality transactions with companies like Winword and AZ [2][5] Financial Performance - In the first half of the year, Heber Pharmaceuticals achieved a net profit of 500 million RMB, maintaining positive profitability since 2023 [2][5] Strategic Partnerships - AstraZeneca (AZ) has strategically invested 9% in Heber Pharmaceuticals, becoming the largest shareholder, which optimizes the company's equity structure and supports long-term stable development [2][6] - Heber has established collaborations with major multinational companies such as AZ and Pfizer, showcasing its platform's efficient conversion capabilities [4][13] Core Technology and Product Pipeline - The core technology of Heber Pharmaceuticals is based on the Hubermix platform, which allows for the development of complex molecules with low immunogenicity and effective penetration through complex barriers. Only three companies globally possess similar platforms [2][7] - The self-immune pipeline is a key development direction, with the FCRN target having submitted a New Drug Application (NDA), expected to be approved in the second half of this year or early next year, marking the company's first commercial product [2][10] Clinical Trials and Product Development - The TSLP target product 9,378 has initiated the first administration for asthma indications overseas, being the first long-acting TSLP target in clinical trials for asthma globally, with a dosing interval of 3 to 6 months [2][12] - Heber's oncology pipeline is rich, including multiple targets such as CTIL-4, B7H7, and CCR8, with data readouts expected for the 18.2CD3 TCE project in the second half of next year [2][13] Business Development Achievements - Nona Biotech has successfully delivered 17 projects in collaboration with well-known pharmaceutical companies, contributing to Heber's high-quality molecule production [3][15] - Heber's business development performance is notable, with 17 transactions completed, totaling 10 billion USD, which will significantly contribute to future commercialization and financial statements [4][5] Management and Governance - The management team, led by founder Wang Jinsong, possesses extensive industry experience, contributing to an efficient and professional organizational structure [6] - Wang Jinsong holds approximately 8-9% of the shares, providing stability for the company's long-term development [6] Legal and Patent Issues - Heber's subsidiary in Anqing is currently involved in a patent infringement lawsuit in the U.S. concerning 600 infringement cases, following a 2.5 billion USD investment in 2021 [8] Future Outlook - Heber Pharmaceuticals is expected to reach a revenue peak of 500 to 1 billion USD, with ongoing pipeline development and delivery expected to maintain high research and development efficiency [17] - The platform's value and business development capabilities are highly anticipated, with future data readouts expected to validate the clinical benefits of the platform products [18][19]