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乐普生物科技:MRG003的注册性临床研究结果于2025年ASCO年会上公布
news flash· 2025-06-01 10:43
Core Viewpoint - The announcement highlights the promising results of the candidate drug MRG003, an innovative antibody-drug conjugate targeting epidermal growth factor receptor, for the treatment of recurrent or metastatic nasopharyngeal carcinoma, with key clinical trial results to be presented at the 2025 ASCO annual meeting [1] Group 1: Clinical Trial Results - The objective response rate (ORR) for the MRG003 group was 30.2%, compared to 11.5% for the chemotherapy group, with a statistically significant p-value of 0.0025 [1] - Progression-free survival (PFS) was significantly improved in the MRG003 group, with a hazard ratio (HR) of 0.63 and a median PFS of 5.8 months, compared to the chemotherapy group [1] - The median overall survival (OS) for the MRG003 group was 17.1 months, while the chemotherapy group had a median OS of 12 months, with an HR of 0.73 [1]