据介绍，在具体实施路径方面，该项目首先将制定规范化的诊疗路径、学科建设细则等标准化文件，从 源头解决诊疗流程不统一的问题；依托"人才送上去+专家走下来"的培训体系，为基层医生和上级专家 提供更多相互交流、借鉴学习的机会，全面提升专科人才诊疗能力；推动医生评估考核标准的统一，对 符合标准的单位拟实施拓展一批合作单位，通过考核激励机制促进人才发展。 本报北京电(朱彩霞)近日，"炎症性肠病规范化诊疗与管理专项能力提升项目"在北京正式启动。会上， 多位专家学者围绕炎症性肠病规范化诊疗、学科建设、能力提升等关键议题展开讨论。 炎症性肠病(IBD)是一种特发性肠道炎症性疾病，包括溃疡性结肠炎和克罗恩病，常见症状有便血、腹 泻、腹痛等。"IBD疾病负担持续攀升，不仅是医疗行业需要应对的挑战，更需要全社会的关注。"该专 项专家组组长、中山大学附属第一医院主任医师陈旻湖表示，希望通过多方协作，推动专科人才培养与 规范化诊疗水平提升，让更多患者享受到更规范、更便捷的诊疗服务。 ...

Core Viewpoint - The study reveals that MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA (mtDNA) during necroptosis, leading to the upregulation of interferon β (Ifnb) expression and inflammation, independent of cell membrane rupture [3][10]. Group 1: Mechanism of Necroptosis - Necroptosis is a pro-inflammatory and lytic form of programmed cell death executed by the MLKL protein, which is phosphorylated by RIPK3, causing membrane rupture and the release of damage-associated molecular patterns (DAMPs) [2]. - Phosphorylated MLKL (pMLKL) also translocates to mitochondria, inducing microtubule-dependent mtDNA release, which activates the cGAS-STING pathway [7][8]. - The integrity of microtubules is essential for the release of mtDNA into the cytoplasm [8]. Group 2: Implications for Inflammatory Bowel Disease (IBD) - In a mouse model of IBD mediated by necroptosis, inhibiting the STING pathway accelerates the resolution of intestinal inflammation [3][10]. - The study enhances understanding of necroptosis and its implications for IBD treatment, suggesting that targeting the cGAS-STING pathway may provide therapeutic benefits [10].

Core Insights - The article highlights the rising prevalence of Inflammatory Bowel Disease (IBD) in China, with current incidence rates ranging from 1.96 to 3.14 per 100,000 people, particularly affecting young adults [1] Misconceptions about IBD - Misconception 1: IBD is merely diarrhea; it includes Ulcerative Colitis (UC) and Crohn's Disease (CD), which are chronic inflammatory conditions affecting the gastrointestinal tract, with symptoms like abdominal pain, weight loss, and severe complications [2] - Misconception 2: IBD is a diet-related disease; while diet can influence symptoms, IBD is linked to genetic susceptibility and immune dysfunction, not directly caused by food [3] - Misconception 3: IBD patients cannot marry or have children; while there is a hereditary risk, many IBD patients successfully have healthy pregnancies with proper medical management [4] - Misconception 4: IBD requires long-term maintenance therapy; abrupt discontinuation of medication can lead to rebound inflammation, with studies showing a 60% five-year remission rate with regular treatment [5] - Misconception 5: IBD inevitably leads to cancer; while uncontrolled inflammation increases cancer risk, regular monitoring and treatment can mitigate this risk [6] - Misconception 6: Surgery can cure IBD; surgery is only for complications and does not eliminate the disease, with a high recurrence rate post-surgery [7] - Misconception 7: IBD patients should avoid exercise; moderate exercise can improve gut motility and quality of life, with recommendations for low-intensity activities [8] - Misconception 8: IBD can only be managed with Western medicine; a combination of Western and alternative therapies can provide a personalized treatment approach [9] - Misconception 9: IBD is an incurable disease; it is now considered a manageable chronic condition, with over 80% clinical remission rates achievable through proper treatment [10] Research and Development - Global research on IBD is advancing rapidly, with innovative treatments like fecal microbiota transplantation and CAR-T cell therapy entering clinical trials in China, potentially leading to breakthroughs in the next decade [11] - The focus is shifting towards precision diagnosis, individualized treatment, and accelerated drug development, aiming for a future where patients can coexist peacefully with IBD [12]