Core Viewpoint - Boron Neutron Capture Therapy (BNCT) is a promising new radiation therapy that aims to effectively kill cancer cells while minimizing damage to healthy cells, representing a significant advancement over traditional radiation methods [1][2]. Group 1: Technology Overview - BNCT is a binary targeted therapy that involves two main steps: injecting a non-toxic boron-10 compound that accumulates in cancer cells, followed by neutron irradiation that triggers a nuclear reaction to release high-energy particles, effectively damaging cancer cell DNA [1][2]. - The "blast radius" of BNCT is less than 10 micrometers, which is smaller than the diameter of a cancer cell, resulting in minimal harm to normal tissues [2]. Group 2: Historical Context and Development - The concept of BNCT was introduced in the 1930s, with subsequent research focused on its feasibility for cancer treatment [2]. - Historically, strong neutron beams for BNCT were produced using nuclear reactors, which posed challenges for hospital applications. However, advancements in accelerator neutron source technology in the 21st century have made it safer and more cost-effective for clinical use [2]. Group 3: Technological Breakthroughs - The research team has achieved three major technological breakthroughs: 1. Development of a high-power, stable accelerator neutron source system that meets the requirements for proton beam flow [3]. 2. Creation of a second-generation boron compound with improved synthesis efficiency, reduced production costs, and enhanced quality and efficacy [3]. 3. Development of a domestic BNCT treatment planning system (TPS) that accurately analyzes and predicts treatment outcomes [3]. - These advancements position the country among the global leaders in BNCT research and development, with plans to initiate clinical trials by the end of the year [3].

Core Viewpoint - Boron Neutron Capture Therapy (BNCT) is a promising new radiation therapy that aims to effectively kill cancer cells while minimizing damage to healthy cells, representing a significant advancement over traditional radiation methods [1][2]. Group 1: Technology Overview - BNCT is a binary targeted therapy that involves two main steps: injecting a non-toxic boron-10 compound that accumulates in cancer cells, followed by precise neutron irradiation to induce a nuclear reaction that destroys cancer cell DNA [1][2]. - The effective range of BNCT is less than 10 micrometers, which is smaller than the diameter of a cancer cell, resulting in minimal damage to normal tissues and reduced side effects compared to conventional treatments [2]. Group 2: Historical Context and Development - The concept of BNCT was introduced in the 1930s, but practical application faced challenges due to the need for suitable boron compounds and stable neutron sources [2]. - In the 21st century, Japan advanced BNCT technology by developing accelerator neutron sources that are safer and more cost-effective than traditional nuclear reactors, enabling successful treatments for various tumors [2]. Group 3: Technological Breakthroughs - The research team has achieved three major technological breakthroughs: 1. Development of a high-power, stable accelerator neutron source system that meets the requirements for proton beam flow [3]. 2. Creation of a second-generation boron compound with improved synthesis efficiency, reduced production costs, and enhanced quality and efficacy [3]. 3. Development of a domestic BNCT treatment planning system (TPS) that accurately analyzes and predicts treatment outcomes using a proprietary Monte Carlo particle transport program [3]. - The successful integration of these components positions the country among the global leaders in BNCT technology, with plans to initiate clinical trials by the end of the year [3].

2025年7月2日，NMPA公布了创新医疗器械特别审查申请审查结果公示（2025年第6号），有 14款产品 进入创新通道。其中包括， 国科中子医疗科技有限公司 申请的 硼中子俘获治疗系统 。 美国 布鲁克海文国家实验室、意大利帕维亚大学等 机构开展BNCT临床研究，累计治疗超千例患者，但设备普及率低。 2006年，中国科学院高能物理研究所在中国国家"973"计划支持下启动BNCT相关研究，积累了 离子源及射频四极加速器（RFQ） 的设计与制造经验，为国产 BNCT设备的开发奠定了基础。 # 研发背景 硼中子俘获治疗（BNCT） 是一种新兴的精准放射疗法，被誉为 继手术、传统放疗、化疗和免疫疗法之后的"第五种癌症治疗方法" 。 BNCT针对传统治疗（如X射线、手术）难以根治的癌症（如 脑胶质瘤、头颈癌、黑色素瘤 ）具有显著优势。全球每年新增脑胶质瘤病例 约30万 ，头颈癌 约90万 ，BNCT的精准靶向特性满足了这些难治性癌症的治疗需求。 全球BNCT市场2023年规模约数亿美元，预计 2030年CAGR达10%-15% ，主要集中于日本、美国、欧洲。 日本 住友重工和Stella Pharma 于2020年推 ...

Core Insights - The event marked the third anniversary of the public open day at the Songshan Lake Materials Laboratory, attracting over 1,500 participants, setting a new record for public engagement in science [1] Group 1: Scientific Presentations - Two science reports were presented, including one by researcher Zou Chao on Boron Neutron Capture Therapy (BNCT), a precise cancer treatment method that targets tumor cells using boron-containing drugs [3] - Zou highlighted that BNCT is recognized as "cell-level radiotherapy," utilizing boron-10 isotopes to destroy cancer cells while protecting surrounding healthy tissue [3][5] Group 2: Public Engagement and Interaction - The event featured interactive experiments, allowing participants to engage with various scientific demonstrations, including a showcase of an electric all-terrain vehicle and demonstrations of superconductivity [6] - The public was invited to experience hands-on experiments, emphasizing the importance of engaging children in science from a young age [10] Group 3: Research and Development Focus - The open day showcased several research teams focusing on strategic basic research, industrial applications, and public technology platforms, highlighting advanced domestic equipment such as high-temperature superconducting coating devices [8] - The event included a demonstration of a scanning tunneling microscope capable of observing atoms at a scale of 0.1 nanometers, emphasizing the laboratory's commitment to cutting-edge research [8]