Core Viewpoint - Boron Neutron Capture Therapy (BNCT) is a promising new radiation therapy that aims to effectively kill cancer cells while minimizing damage to healthy cells, representing a significant advancement over traditional radiation methods [1][2]. Group 1: Technology Overview - BNCT is a binary targeted therapy that involves two main steps: injecting a non-toxic boron-10 compound that accumulates in cancer cells, followed by neutron irradiation that triggers a nuclear reaction to release high-energy particles, effectively damaging cancer cell DNA [1][2]. - The "blast radius" of BNCT is less than 10 micrometers, which is smaller than the diameter of a cancer cell, resulting in minimal harm to normal tissues [2]. Group 2: Historical Context and Development - The concept of BNCT was introduced in the 1930s, with subsequent research focused on its feasibility for cancer treatment [2]. - Historically, strong neutron beams for BNCT were produced using nuclear reactors, which posed challenges for hospital applications. However, advancements in accelerator neutron source technology in the 21st century have made it safer and more cost-effective for clinical use [2]. Group 3: Technological Breakthroughs - The research team has achieved three major technological breakthroughs: 1. Development of a high-power, stable accelerator neutron source system that meets the requirements for proton beam flow [3]. 2. Creation of a second-generation boron compound with improved synthesis efficiency, reduced production costs, and enhanced quality and efficacy [3]. 3. Development of a domestic BNCT treatment planning system (TPS) that accurately analyzes and predicts treatment outcomes [3]. - These advancements position the country among the global leaders in BNCT research and development, with plans to initiate clinical trials by the end of the year [3].

Core Viewpoint - Boron Neutron Capture Therapy (BNCT) is a promising new radiation therapy that aims to effectively kill cancer cells while minimizing damage to healthy cells, representing a significant advancement over traditional radiation methods [1][2]. Group 1: Technology Overview - BNCT is a binary targeted therapy that involves two main steps: injecting a non-toxic boron-10 compound that accumulates in cancer cells, followed by precise neutron irradiation to induce a nuclear reaction that destroys cancer cell DNA [1][2]. - The effective range of BNCT is less than 10 micrometers, which is smaller than the diameter of a cancer cell, resulting in minimal damage to normal tissues and reduced side effects compared to conventional treatments [2]. Group 2: Historical Context and Development - The concept of BNCT was introduced in the 1930s, but practical application faced challenges due to the need for suitable boron compounds and stable neutron sources [2]. - In the 21st century, Japan advanced BNCT technology by developing accelerator neutron sources that are safer and more cost-effective than traditional nuclear reactors, enabling successful treatments for various tumors [2]. Group 3: Technological Breakthroughs - The research team has achieved three major technological breakthroughs: 1. Development of a high-power, stable accelerator neutron source system that meets the requirements for proton beam flow [3]. 2. Creation of a second-generation boron compound with improved synthesis efficiency, reduced production costs, and enhanced quality and efficacy [3]. 3. Development of a domestic BNCT treatment planning system (TPS) that accurately analyzes and predicts treatment outcomes using a proprietary Monte Carlo particle transport program [3]. - The successful integration of these components positions the country among the global leaders in BNCT technology, with plans to initiate clinical trials by the end of the year [3].

当抽象的高端放射治疗技术遇上全息投影和AR游戏，会碰撞出怎样的火花？近日，东莞南方医科大学 第十附属医院（东莞市人民医院）硼中子治疗中心推出2.0版BNCT（硼中子俘获治疗）科普装置，通过 全息柜动态模型与AR沙盘互动游戏，将尖端抗癌技术转化为公众尤其是青少年可参与的沉浸式体验。 "我们的核心目标是让源自'国之重器'的尖端抗癌技术变得直观易懂。"黄荻阐述了设计理念。 据介绍，硼中子俘获治疗（BNCT）是一种新型的二元靶向肿瘤放射治疗技术。通过将含硼靶向药物与 中子照射相结合，精准杀伤肿瘤细胞，同时最大限度地减少对周围正常组织的损伤。 东莞市人民医院BNCT设备是目前粤港澳大湾区唯一的中子治疗设备，是中国散裂中子源这一"国之重 器"的重大科技成果转化项目，拥有完全自主知识产权，致力于提升我国在恶性肿瘤研究方面的基础科 研和临床治疗水平。 更值得关注的是，依托此装置打造的"BNCT科普基地"即将启用。 指尖轻点屏幕，中子治癌技术"活"起来 在中心内，项目研发人员黄荻演示了装置的核心部分。一座全息柜动态模型启动后，柜内悬浮的动态影 像360度清晰地展示了BNCT治疗的完整流程：射频四级场加速器加速质子后撞击旋转锂靶 ...