复星医药表示，本次收购完成后，公司将持续有序推进该药品的上市后确证性临床试验，以使该药品尽 快获得国家药品审评部门批准。 （文章来源：每日经济新闻） 本次收购完成后，绿谷医药将纳入复星医药合并报表子公司范围。 值得注意的是，标的公司的主要品种为治疗阿尔茨海默病的甘露特钠胶囊（商品名：九期一）。因注册 批件到期，2024年11月起，甘露特钠胶囊未开展商业化生产。该药品在重新开展商业化生产和销售前， 还需补充完成上市后确证性临床试验并获得国家药品审评部门批准。截至目前，该等上市后确证性临床 试验已在开展中。 12月15日，复星医药（SH600196，股价27.93元，市值745.85亿元）公告称，为丰富公司中枢神经系统 治疗领域的创新产品管线矩阵，其控股子公司复星医药产业与绿谷（上海）医药科技有限公司（以下简 称绿谷医药）及其现有相关股东共同签订相关投资协议，拟出资约14.12亿元控股收购绿谷医药。 ...

Group 1: Company Overview - The company introduced its innovative drug pipeline, focusing on Alzheimer's disease and related research [1] - The Alzheimer's II/III clinical trial is the largest key registration study in China, designed scientifically with dual endpoints (ADAS-Cog and ADCS-ADL) to evaluate cognitive function and daily living abilities [2] Group 2: Alzheimer's Disease Research - The clinical trial employs a multi-center, randomized, double-blind design with placebo and positive drug controls, assessing the drug's impact on disease progression and biomarkers [2] - The drug Huperzine A is a cholinesterase inhibitor showing potential benefits in anti-inflammation, cholinergic regulation, neuroprotection, mitochondrial protection, and antioxidant stress [2] - The controlled-release formulation of Huperzine A aims for rapid onset, reduced adverse reactions, and improved patient compliance with once-daily dosing [2] Group 3: ALS (Amyotrophic Lateral Sclerosis) Development - The company is developing WP205 for ALS, which has received orphan drug designation from the FDA and is patent pending [3] - The company plans to explore the multi-target mechanism of Huperzine A in ALS treatment and has patented core compounds for drug development targeting MCR [3]

Core Viewpoint - Eli Lilly's Alzheimer's drug Kisunla has received support from EU regulators, paving the way for it to become the second drug in Europe to delay the most common cause of dementia [1][2] Group 1: Drug Approval and Market Impact - The European Medicines Agency (EMA) recommended Kisunla for patients with specific gene mutations that may increase the risk of amyloid-related imaging abnormalities (ARIA) [1] - Kisunla's approval in the EU is expected to enhance competition with Eisai and Biogen's Leqembi, which is also limited to patients with a lower risk of ARIA [2] - Bloomberg Intelligence has halved the market size forecast for Alzheimer's drugs by 2030 to $6 billion, with Kisunla projected to generate approximately $2 billion in sales [2] Group 2: Drug Administration and Side Effects - Kisunla is administered once a month, which may offer a convenience advantage over Leqembi, which requires bi-weekly infusions [3] - Both Kisunla and Leqembi are associated with side effects, including potential brain swelling and bleeding risks [2]