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PD(L)1*VEGF双抗
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三生制药(01530):首次覆盖:主营业务稳健,迈向PD-1VEGF的星辰大海
Investment Rating - The report initiates coverage on 3S BIO with an "OUTPERFORM" rating and a target price of HK$45.50, indicating a positive outlook for the company's stock performance [1][2][7]. Core Insights - The company's core business is robust, with innovative products expected to drive future growth. Key products include TPO, EPO, and the leading hair loss treatment brand Mandi, which dominate their respective markets [2][9]. - The company has a strong pipeline with over 30 projects in development, including four innovative drugs currently undergoing NDA approval, which are anticipated to contribute significantly to revenue growth [2][12]. - The partnership with Pfizer for the PD-1×VEGF dual antibody SSGJ-707 is expected to reshape the global valuation landscape, with peak global sales projected to reach between US$11.3 billion and US$13.4 billion [3][6][31]. Summary by Sections Business Overview - 3S BIO has established itself as a leading biopharmaceutical company in China, focusing on nephrology, hematology, oncology, and other therapeutic areas. The company has shown steady revenue growth from RMB 55.9 billion in 2020 to an estimated RMB 91.1 billion in 2024 [9][12]. - The company’s core products, including TPO and EPO, maintain leading market shares of 67% and 42% respectively, ensuring a solid cash flow foundation [2][11]. Product Pipeline - The innovative pipeline includes promising candidates such as SSS06 (long-acting erythropoietin) and IL-17A monoclonal antibody, with peak sales potential estimated at RMB 7-10 billion [2][12]. - The company has also introduced new products in the consumer healthcare sector, targeting the growing market for hair loss treatments, with Mandi achieving sales of RMB 1.34 billion in 2024 [15]. Strategic Partnerships - The collaboration with Pfizer for SSGJ-707, a PD-1×VEGF dual antibody, is a significant milestone, with Pfizer paying US$1.25 billion upfront and potential milestone payments of US$4.8 billion, highlighting the product's anticipated market potential [31][33]. - The dual antibody is positioned to capture a substantial share of the oncology market, projected to exceed US$200 billion, as it demonstrates superior efficacy compared to existing PD-1 monoclonal antibodies [18][22]. Financial Projections - Revenue projections for 2025-2027 are estimated at RMB 19.18 billion, RMB 11.90 billion, and RMB 14.05 billion respectively, with net profits expected to reach RMB 9.36 billion, RMB 2.73 billion, and RMB 3.33 billion [7][9]. - The report employs a discounted cash flow (DCF) model with a WACC of 10% and a perpetual growth rate of 3.5%, supporting the target price of HK$45.50 per share [7].
三生制药(01530):PD1VEGF双抗的全球之路
Investment Rating - The report maintains a rating of "Buy" for the company [9]. Core Insights - The report highlights the potential of SSGJ-707 in the global market, emphasizing its promising clinical data and the strategic partnership with Pfizer, which is expected to enhance its market presence [2][3]. Summary by Sections 1. PD(L)1*VEGF Dual Antibodies as New SOC - PD(L)1 monoclonal antibodies have become the standard treatment for various cancers, with a projected market size of $100 billion by 2029. The PD(L)1*VEGF dual antibodies are expected to replace PD(L)1 monoclonal antibodies in many indications, potentially covering a market exceeding $200 billion [13][19]. 2. SSGJ-707's BIC Potential - SSGJ-707, a PD1*VEGF dual antibody developed by the company, has shown superior efficacy in early clinical trials compared to competitors. It is currently in Phase II trials for various cancers, including NSCLC and CRC, and is expected to enter Phase III trials soon [25][29]. 3. Global Market Entry via Pfizer - The partnership with Pfizer, which includes a record upfront payment of $1.25 billion and milestone payments totaling $4.8 billion, positions SSGJ-707 for significant market penetration. Pfizer's established oncology business is expected to leverage SSGJ-707 to expand its treatment offerings [32][35]. 4. Financial Projections - The company forecasts revenues of RMB 191.78 billion, RMB 118.95 billion, and RMB 140.51 billion for 2025, 2026, and 2027, respectively. Net profits are projected to be RMB 102.14 billion, RMB 28.08 billion, and RMB 35.08 billion for the same years [9][10]. 5. Clinical Development Pipeline - The company plans to launch 13 new drug assets between 2025 and 2027, enhancing its portfolio in hematology, immunology, nephrology, and dermatology. This expansion is expected to contribute significantly to revenue growth [9][10]. 6. Competitive Landscape - The report discusses the competitive advantages of SSGJ-707, including its superior binding affinity and efficacy in clinical trials compared to other PD(L)1*VEGF dual antibodies, which positions it favorably in the oncology market [25][29]. 7. Market Potential and Patient Coverage - The dual antibody is anticipated to cover over 1.4 million patients in previously unaddressed indications, significantly expanding its market potential [21][24]. 8. Strategic Collaborations - The collaboration with Pfizer is expected to facilitate rapid clinical development and market access for SSGJ-707, particularly in indications where Pfizer has existing assets [44]. 9. Valuation and Target Price - The report utilizes a DCF valuation method to raise the target price to HKD 46.71, reflecting the company's growth potential in the PD(L)1*VEGF market [9].
未知机构:国泰海通医药热门领域重磅交易再起继续推荐创新药板块端午节期-20250603
未知机构· 2025-06-03 01:45
Summary of Conference Call Records Industry Overview - The focus is on the innovative drug sector, particularly in the context of recent significant transactions and developments in the PD(L)1*VEGF and GLP1 fields [1][2]. Key Points and Arguments PD(L)1*VEGF Dual Antibody Developments - 康方生物 and Summit announced top-line data from the global clinical trial HARMONI for Ivosidenib targeting 2L EGFRm, indicating: - The PD(L)1*VEGF dual antibody shows certain effectiveness in the post-EGFRm mutation line, although the median follow-up time is short, necessitating longer follow-up for evaluation [1] - The HARMONI study validates the consistency of clinical results between China and the U.S. [1] - The FDA stated that statistically significant overall survival benefits are necessary to support the submission for market approval, which will influence Summit's timeline for BLA submission [1] - The primary focus remains on the first-line global clinical results for Ivosidenib [1] Collaboration and Licensing Opportunities - BMS and BNTX are collaborating on the development of PD(L)1*VEGF dual antibodies, with BMS committing to: - An upfront payment of $1.5 billion, $2 billion in non-contingent annual payments, potential milestone payments of $7.6 billion, and a 50:50 cost/profit sharing arrangement [2] - The continuous licensing of PD(L)1*VEGF assets reflects MNCs' optimism regarding these types of drugs, suggesting potential for identifying advantageous subpopulations for clinical benefits [2] - Other companies such as ROG and ABBV are also expected to have demand for similar assets, with domestic firms like 荣昌生物, 宜明昂科, 华海药业, 华兰生物, and 神州细胞 making strategic moves in this area [2] GLP1/GIP Dual Agonist Transactions - Regeneron and Hansoh Pharmaceutical reached a deal for the GLP1/GIP dual agonist, with Regeneron paying an upfront fee of $80 million, $1.93 billion in milestones, and a double-digit sales share [2] - The past year has seen ABBV, REGN, and JNJ entering the diabetes and weight loss market, expanding competition against existing players like LLY, NVO, MSD, ROG, and AZN [2] - The ongoing interest from MNCs in the weight loss sector is expected to lead to a resurgence of new drug developments, particularly following data releases from conferences like ADA [2] Recommended Companies - The following companies are recommended for attention: - 恒瑞医药, 华东医药, 联邦制药, 歌礼制药, 来凯医药 [3] Market Trends - There is optimism regarding the Chinese innovative drug sector due to ongoing licensing activities, which are expected to drive a bullish market trend [4] - MNCs have reiterated their interest in Chinese assets during recent earnings calls, reflecting a strong demand for domestic innovative drugs and low policy sensitivity [4] - The continuous licensing of Chinese innovative drugs is anticipated to lead to a revaluation of overseas valuations [4] - Recommended stocks for Pharma revaluation include 恒瑞医药, 华东医药, 三生制药, 联邦制药, 中国生物制药, 石药集团/新诺威, 先声药业, 康哲药业, 科伦药业; for Biotech global competitiveness: 益方生物, 泽璟制药, 一品红, 百利天恒, 科伦博泰生物, 贝达药业, 信达生物, 百济神州, 再鼎医药, 和黄医药 [4]