作为全球科创领域最具公信力和影响力的年度盛事之一，2 0 2 5 福布斯中国科创人物评选已正 式拉开帷幕，该评选旨在发掘中国科创领域的标杆人物，展现其卓越贡献，激励更多人才投身 科创事业。 中国国际科技促进会母基金分会会长、母基金研究中心创始人、水木资本董事长唐劲草获聘出 任本届福布斯中国科创人物评委。 福布斯官方微信公众号于6月2 6日发布的文章如下： 福布斯中国科创人物评选作为科创领域年度权威标杆评选，致力发掘以全球化、颠覆性视野重 塑产业格局的商业领袖、科学先锋、跨界定义者。在这里，中国企业家领袖、世界 5 0 0强掌舵 者、独角兽缔造者及科学巨擘共铸"环球科创核心圈"，掌握技术革命话语权，贯通万亿级创新 生态，引领人类新纪元。 回顾 2 0 2 4年福布斯中国科创人物评选，"影响力"类别 入选者旗下企业总市值突破 1 0万亿元， 累计专利超万项 ；" 革新力"类别 入选企业总市值达千亿级，融资规模数百亿 ， 几乎都是已 上市公司、拟上市公司、独角兽或准独角兽企业。 过去一年，中国科技创新呈现蓬勃发展态势，各领域领军企业取得突破性进展。 2 0 2 4年入选 的企业类代表横跨 人工智能、智能制造、航空航 ...

Core Viewpoint - The 16th Davos Forum highlighted the profound changes in the global economic, political, and security landscape, emphasizing the rise of trade protectionism and geopolitical conflicts impacting global supply chains and economic fragmentation [2]. Group 1: Economic Challenges and Responses - The disruption of supply chains is a global issue, necessitating China's contribution to stabilizing the entire industrial and supply chain [2]. - China should transform the pressures from trade wars into opportunities for industrial restructuring and upgrading [2]. - The need for traditional industries in China to undergo further transformation and upgrading over the next decade was emphasized [2]. Group 2: Strategic Emerging Industries - Seven major strategic emerging industries must achieve qualitative improvements to gradually dominate global markets, including new-generation information technology, biotechnology, new materials, and new energy vehicles [3]. - Future industries should receive targeted support and guidance, particularly in AI technology and life sciences [4]. Group 3: Global Economic Recovery - Many companies face difficulties in global expansion, which could significantly impact global economic recovery and growth [4]. - The turning point for the global economy may arise from significant setbacks, leading countries to return to correct economic paths [4]. - According to the theory of comparative advantage, countries should leverage their strengths to produce high-quality, cost-effective products, forming a beneficial global supply chain [4].

Core Viewpoint - The article emphasizes the importance of plasmid extraction in life sciences, highlighting its relevance for professionals ranging from students to scientists and its critical role in molecular-level work [1][2]. Summary by Sections Essential Knowledge Points - A qualified plasmid consists of several key components, including the origin of replication (Ori), antibiotic resistance genes, multiple cloning sites (MCS), promoters/enhancers, terminators, and poly(A) signals [5][10][11][12]. - Understanding how to read plasmid maps is crucial, focusing on the location of Ori, selection markers, MCS, and the size of foreign DNA inserts [14][15][19][20]. - The principles of plasmid extraction involve separating plasmid DNA from chromosomal DNA and proteins, utilizing methods like alkaline lysis [21][24][26][28][29]. Common Methods for Plasmid Extraction - Plasmid extraction methods include alkaline lysis, boiling lysis, and silica membrane adsorption, each with specific advantages and disadvantages [37][39][40][45][46]. - Alkaline lysis is the most common method, effective for various E. coli strains, but can damage DNA if not performed correctly [41][43]. - Boiling lysis is quick and simple but may yield lower purity and stability [45]. - Silica membrane adsorption is widely used for its high purity and efficiency, though it can be more costly [46][47]. Considerations for Plasmid Extraction - Proper bacterial culture conditions are essential, including selecting appropriate strains and media, and controlling growth parameters [63][64]. - Careful handling during cell lysis and purification is necessary to avoid contamination and ensure high-quality plasmid DNA [65][66][67]. - Using nuclease-free materials and reagents is critical to prevent DNA degradation [68][69]. Methods to Improve Plasmid Extraction Concentration - Strategies to enhance plasmid DNA concentration include optimizing lysis conditions, ensuring complete enzymatic treatment, and increasing initial cell quantities [70][71][72][74]. - Proper sample storage and equipment maintenance are also important for achieving higher yields [75][77]. Small-Scale Plasmid Preparation - Plasmids are circular DNA molecules that can replicate independently within bacterial cells, making them ideal for gene cloning [78][79]. - The alkaline lysis method is commonly used for small-scale plasmid preparation, allowing for the removal of proteins and RNA [80][81]. - The extraction process typically involves bacterial growth, harvesting, lysis, and purification steps [82][83]. Common Issues and Solutions in Plasmid Extraction - Problems such as excessive bacterial culture volume or inadequate lysis can lead to low yields and purity, requiring adjustments in protocol [97][98].

Core Insights - The understanding of aging is evolving from a linear perspective to a dynamic interplay of genetics, lifestyle, and environmental exposure, with significant individual differences in organ age among peers [1] - The market is shifting from vague concepts of overall youthfulness to targeted organ-specific care, addressing core pain points such as liver detoxification, collagen loss in skin, and testosterone decline in men [2] Group 1: Company Innovations - LAIFE, a Boston-based life sciences AI formulation brand, is leveraging AI technology to decode the molecular mechanisms of organ aging, transitioning from "experience medicine" to "computational medicine" [2][3] - The RevOrgan AI formulation platform developed by LAIFE utilizes deep learning algorithms and organ aging models to create dynamic formulations, significantly reducing R&D time and enhancing product efficacy and stability [3][5] Group 2: Product Development - LAIFE has established a product matrix that includes various targeted formulations such as LAIFE "乐净肺" for lung health, LAIFE "乐轻肝" for liver support, and LAIFE "红宝瓶II" for ovarian health, addressing aging from multiple dimensions [5] - The AI system employed by LAIFE can dynamically simulate metabolic responses in organs, allowing for precise selection and optimization of ingredients through high-performance computing [5] Group 3: Research and Development - LAIFE's research foundation is supported by its parent company, RegenerativeBio, which integrates AI with biotechnology to enhance product precision and effectiveness [7] - The team at RegenerativeBio includes top scientists from prestigious institutions, ensuring rigorous testing and validation of LAIFE's products to meet international standards [7] Group 4: Future of Aging Science - LAIFE is pioneering a new paradigm in aging science, transforming aging from an inevitable fate into a decodable and potentially reversible process, enabled by advanced AI computational capabilities [9] - The company is actively promoting the integration of AI in aging research, hosting conferences and supporting academic initiatives to advance the field [7][9]

Group 1 - The forum focused on new trends in bilateral investment and industrial cooperation between China and Germany, attracting over a hundred representatives from various industries including automotive manufacturing, chemical materials, life sciences, intelligent manufacturing, and green energy [1][4] - Shandong province aims to create a market-oriented, law-based, and international business environment to attract more German enterprises for investment, emphasizing the complementary industrial structures between Shandong and North Rhine-Westphalia [4][5] - The forum highlighted that China remains Germany's largest source of imports and the second-largest trading partner globally, with strong bilateral investment momentum particularly in advanced sectors such as electronics, automotive, machinery, chemical pharmaceuticals, green transition, intelligent manufacturing, and digitalization [5][6] Group 2 - North Rhine-Westphalia is identified as the region with the highest concentration of Chinese investments in Germany, benefiting from its advantageous location and industrial foundation, which continues to attract high-quality investment projects [5][6] - The city of Binzhou has developed five major trillion-level industrial clusters and leads the province in technological innovation investment intensity, welcoming deep participation from German enterprises, especially from North Rhine-Westphalia, in its industrial transformation and international cooperation [6] - The roundtable discussion emphasized the ongoing attractiveness of the Chinese market for German enterprises, particularly in sectors like new energy and pharmaceutical innovation, despite the "China+1" supply chain adjustment phenomenon [6][7]

Core Insights - Startup Genome's "Global Startup Ecosystem Report 2025" ranks Silicon Valley first, with New York, London, and Tel Aviv following in second to fourth places, while Beijing rises three spots to tie for fifth with Boston, becoming the only Chinese city in the global top five [1][2] Group 1: Performance Metrics - Beijing ranks third globally in performance metrics, fourth in talent and expertise, and fourth in knowledge supply [1] - Beijing's ecosystem value from 2022 to 2024 is projected at $533 billion, significantly higher than the global average of $204 billion [1] - The number of active unicorns in Beijing is 61, compared to a global average of 4 [1] Group 2: Financial Indicators - Software engineer salaries in Beijing are expected to reach $53,500 in 2024, slightly above the global average of $52,000 [1] - Total venture capital in Beijing from 2020 to 2024 is estimated at $64 billion, while the global average is $5.2 billion [1] Group 3: Supporting Factors - The report attributes Beijing's entrepreneurial ecosystem success to strong government support, top-tier universities, and a thriving capital market [2] - Beijing is recognized as a leading technology and innovation center, particularly in AI-driven data analysis, life sciences, and fintech [2] Group 4: Other Chinese Cities - Other Chinese cities included in the report are Shanghai (10th), Shenzhen (17th), Hangzhou (23rd), Hong Kong (27th), and Guangzhou (35th), with all cities except Hong Kong showing improved rankings [2]

编译丨王聪 编辑丨王多鱼 排版丨水成文 饶毅 教授是中国科学和教育领域的杰出改革者。1980 年代，饶毅在美国开启职业生涯，2007 年，他辞去美国西北大学终身教职，全职回国，出任北京大学生命 科学学院院长，他引入了多项举措，使中国生命科学研究重焕生机，其中包括采用终身教职制度和同行评审来评估学者的学术成就。如今， 饶毅 卸任了首都医学 大学校长职务，在北京大学负责一个前沿脑科学研究实验室，并担任其他领导职务。 饶毅 一向以直言不讳著称。2008 年，他放弃美国护照，以抗议前总统乔治·W·布什在 9·11 事件后推行的政策。他还在新冠疫情期间批评了美国的政策，并强 烈反对实验室泄漏论。此外，他还是中国人才引进计划的积极倡导者。 2025 年 6 月 17 日，国际顶尖学术期刊 Nature 发布了一篇对 饶毅 教授的专访 ， Nature 向饶毅询问了他如何看待中国在生命科学领域的作用，以及中国怎样 才能成为生物科技超级大国。 饶毅 教授 中国如何能成为生物科技超级大国？ Nature ：根据《自然》指数，中国在生命科学领域的实力不如在物理科学领域。这是为什么呢？ 只要中国没有类似于美国 NIH 这样的机构， ...

ONS经济统计主管Liz McKeown指出，服务业和制造业产出的减少是导致4月份整体GDP下滑的主要原 因。她还提到，在过去的三个月里，尽管4月份的数据不佳，但总体GDP仍有所增长，这可能是因为一 些商业活动被提前到了年初完成。 此外，4月份法律和房地产行业的表现尤其疲软。这可能是由于在3月份印花税调整后，购房需求集中释 放，导致4月份的需求相对减弱。这种情况表明，短期经济波动有时会受到政策变动的影响，而这些影 响可能会导致某些行业出现周期性的起伏。 （文章来源：新华财经） 财政大臣Rachel Reeves 对这一数据表示失望，但同时强调其即将进行的支出审查计划将有助于推动经 济增长。 英国政府表示，将加大相关领域的政府投资，并以此带动私人投资，从而实现经济增长。未来五年内， 英国将投入156亿英镑，用于改善城市交通基础设施。将在今后几年内投资860亿英镑，用于加速推动英 国增长最快的行业，包括科技、生命科学、先进制造业和国防等。将投入1.87亿英镑，用于学生AI方面 的培训，其中的0.24亿英镑，将作为该项目的旗舰项目的投资，目的是让英国每所中学的学生有机会在 三年内获得新的人工智能技能。到2027年， ...

Core Viewpoint - The development of Sanya as a key area in the Hainan Free Trade Port has accelerated over the past five years, focusing on creating a modern industrial system and enhancing its international tourism consumption capabilities, while also emphasizing innovation in agriculture and deep-sea technology [1][2][3][4][5][10]. Group 1: Economic Development and Tourism - Sanya has positioned itself as an international tourism consumption center, leveraging the Hainan Free Trade Port's policies to enhance tourism products and services, resulting in a shift from sightseeing to vacation shopping [2][6]. - The number of international routes from Sanya Phoenix International Airport has expanded to 32, serving 24 overseas cities, with over 1.11 million travelers passing through [2]. - Sanya's duty-free sales account for over 60% of the province's total, significantly boosting tourism consumption [2]. Group 2: Innovation and Technology - Sanya is focusing on agricultural innovation and deep-sea technology, establishing the "South Breeding Silicon Valley" and attracting significant research and development investments [3][4]. - The city has set up six national-level research platforms and over 40 provincial-level platforms, with the breeding industry generating over 10 billion yuan in revenue [3]. - Sanya has attracted 1,206 marine industry enterprises to its high-tech zone, fostering a cluster of deep-sea technology companies [4]. Group 3: Industrial Structure Transformation - Sanya is transitioning from a tourism and real estate-centric economy to a diversified model that includes technology innovation and modern industries, with a projected GDP exceeding 100 billion yuan in 2024 [5][6]. - The city has successfully established two trillion-yuan industrial clusters in modern finance and commerce, with a total of 8,417 enterprises in the park by April 2025 [5][6]. Group 4: Business Environment and Policy Support - Sanya has implemented various measures to optimize its business environment, including a local regulation for improving the business climate and reducing approval times for high-frequency social matters by 31.47% [7][8]. - The city has pioneered a new model for the approval of imported agricultural materials, enhancing the efficiency of agricultural research material imports [8]. Group 5: Future Development and Strategic Goals - Sanya is preparing for the 2025 Free Trade Port closure and expansion, focusing on enhancing its strategic position and ensuring smooth operations [9][10]. - The city has completed seven closure operation projects and is working on expanding its international flight network to strengthen its role as a regional aviation hub [9].

科技创新和产业创新深度融合。创新策源能力持续提升，英歌石科学城创新发展，获批5家全国重 点实验室，新获评雏鹰企业109家、瞪羚企业22家；今年将在动力电池、低空经济、化工新材料、生命 科学领域布局建设大连市首批概念验证中心、中试小试平台，进一步加速科技成果转化。产业集群发展 取得新突破，绿色石化产业集群、工业母机集群获评国家级先进制造业集群。在高端化智能化绿色化转 型上，累计建成142家省级数字化车间和智能工厂、37个省级工业互联网平台，培育130家省级以上绿色 工厂、2个国家级绿色工业园区。新兴产业聚能起势，金普新区氢能产业园开园，大连市加入国家燃料 电池汽车示范城市群，全市布局低空起降点280个，开通3条陆岛直升机航线。 深化改革和扩大开放走深走实。制定实施6.0版营商环境提升方案，推出48项提升举措。"一企一 策"深化国企改革，市属国企资产总额同比增长6.9%，实现营业收入同比增长8.6%。对外开放水平进一 步提升，全市新设外资企业36家、同比增长38.5%。大连自贸片区整合提升加速，国内首单国际航行船 舶保税液化天然气岸基加注业务落户，两架保税融资租赁飞机业务落地，大窑湾保税物流中心运营。大 连市获批 ...