Financial Performance & Guidance - BRINSUPRI achieved preliminary unaudited U S net revenues of approximately $144 6 million in Q4 2025 and $172 7 million for the full year 2025[23] - ARIKAYCE generated worldwide revenue of approximately $433 8 million in FY 2025, representing a 19 3% increase year-over-year[27] - The company anticipates ARIKAYCE revenue to be between $450 million and $470 million for the full year 2026[28] Clinical Development Programs - The company expects topline data readout from the Phase 3 ENCORE trial for ARIKAYCE in March/April 2026, potentially leading to label expansion[30, 31] - Phase 3 trials for TPIP in PAH, PPF, and IPF are expected to initiate in early and the second half of 2026 respectively[13, 38] - Topline data readout from the Phase 2 CEDAR trial for brensocatib in Hidradenitis Suppurativa is expected in Q2 2026[46, 50] Pipeline Expansion - The company plans to file Investigational New Drug (IND) applications for RA and IBD in the second half of 2026[13, 50] - IND filing for Stargardt is anticipated in 2026[13, 59] - Phase 2 programs in ILD and moderate to severe asthma are planned for INS1148[13, 40] Commercial Expansion - BRINSUPRI is expected to launch in the EU and UK, pending regulatory approval[13, 44] - BRINSUPRI is also anticipated to launch in Japan, pending regulatory approval[13, 44] Cash Position - The company reported a cash position of $1 7 billion as of September 30, 2025[62]

Ascendis Pharma A/S J.P. Morgan Healthcare Conference San Francisco January 2026 This presentation also contains estimates and other statistical data made by independent parties and by us relating to market size and other data about our industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such data and estimates. In addition, projections, assumptions and estimates of our future performance and the future performance of the markets in which w ...

公司简称：博瑞传播 证券代码：600880 编号：临 2026-001 号 成都博瑞传播股份有限公司 关于股票交易异常波动公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 重要风险提示： 经自查，公司目前生产经营活动一切正常，内外部经营环境、行业政策等均 未发生重大变化，不存在应披露而未披露的重大信息。 （二）重大事项情况 经公司自查，并经向公司控股股东成都传媒集团函证核实，截至本公告披露 日，除公司已披露、公开的事项外，公司、控股股东不存在其他影响公司股价异 常波动的重大事项，包括但不限于涉及公司的重大资产重组、股份发行、收购、 债务重组、业务重组、资产剥离、资产注入、股份回购、股权激励、破产重整、 重大业务合作、引进战略投资者等重大事项。 （三）媒体报道、市场传闻、热点概念情况 公司未发现需要澄清或回应的媒体报道或市场传闻。截至本公告披露日，公 司相关 GEO 业务营业收入为 0，暂未产生实质性收益。 （四）业绩波动风险 一、股票交易（异常）波动的具体情况 公司股票于 2026 年 1 月 8 日、1 月 9 日 ...

关于公司持股 5%以上股东协议转让股份过户完成的 公告 持股 5%以上的股东中外运集装箱运输有限公司保证向本公司提供的信息内 容真实、准确、完整、没有虚假记载、误导性陈述或重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 证券代码：600179 证券简称：安通控股 公告编号：2026-001 安通控股股份有限公司 二、协议转让完成股份过户登记 重要内容提示： 2025 年 7 月 11 日，安通控股股份有限公司（以下简称"安通控股"、"公 司"）持股 5%以上股东中外运集装箱运输有限公司（以下简称"中外运集运"） 与中国化工资产管理有限公司（以下简称"中化资管"）签署《股份转让协议》， 中化资管同意将其持有的安通控股 82,908,988 股（占公司总股本的 1.9593%） 无限售流通股通过协议转让的方式转让给中外运集运，每股转让价格为 3.20 元， 交易总对价 265,308,761.60 元。 本次协议转让交易已于 2025 年 12 月 9 日取得了国务院国有资产监督管 理委员会（以下简称"国资委"）出具的《国务院国资委关于安通控股股份有限 公司国有股东非公开协议转让所 ...

| 证券代码：688135 | 证券简称：利扬芯片 | 公告编号：2026-005 | | --- | --- | --- | | 转债代码：118048 | 转债简称：利扬转债 | | 广东利扬芯片测试股份有限公司 关于控股股东、实际控制人减持股份结果公告 本公司董事会、全体董事及相关股东保证本公告内容不存在任何虚假记载、 误导性陈述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律 责任。 重要内容提示： 2025 年 10 月 25 日，公司于上海证券交易所（www.sse.com.cn）披露了《关 于控股股东、实际控制人减持股份计划公告》（公告编号：2025-055），股东黄江 先生计划于 2025 年 11 月 17 日至 2026 年 2 月 16 日期间，通过集中竞价交易、 大宗交易方式减持公司股份数量合计不超过 6,000,000 股，即不超过公司总股本 的 2.9513%。 本次减持期间，公司股东通过集中竞价交易方式减持的，自减持计划公告披 露之日起 15 个交易日后的 3 个月内进行，且在任意连续 90 个自然日内减持股份 的总数不超过公司股份总数的 1.00%；通过大宗交易方式 ...

Core Insights - Current mortgage rates are averaging just below 6%, with the 30-year fixed mortgage rate at 5.91% and the 15-year fixed rate at 5.36% [1][18] Current Mortgage Rates - The national average for the 30-year fixed mortgage rate is 5.91% [18] - The 15-year fixed mortgage rate averages 5.36% [18] - Adjustable-rate mortgages (ARMs) such as the 5/1 ARM are currently at 6.17% [18] Refinance Rates - Mortgage refinance rates are generally higher than purchase rates, but this is not always the case [3] - Current refinance rates include a 30-year fixed at 5.99% and a 15-year fixed at 5.43% [6] Monthly Payments - For a $300,000 mortgage at a 30-year term with a 5.91% rate, the monthly payment would be approximately $1,781, totaling $341,279 in interest over the loan's life [8] - A $300,000 mortgage at a 15-year term with a 5.36% rate results in a monthly payment of $2,429, with total interest paid being $137,224 [10] Adjustable-Rate Mortgages - ARMs typically start with lower rates than fixed-rate mortgages but can increase after the initial period [11] - The 5/1 ARM locks in the rate for the first five years before adjusting annually [11] Factors for Lower Rates - Lenders offer lower rates to borrowers with higher down payments, excellent credit scores, and low debt-to-income ratios [14] - Options to buy down interest rates include paying for discount points at closing or temporary buydowns [15][16] Future Rate Predictions - The Mortgage Bankers Association (MBA) forecasts the 30-year mortgage rate to be around 6.4% through 2026 [20] - Fannie Mae predicts rates will remain above 6% next year, with a slight dip to 5.9% in Q4 2026 [20]

Core Insights - The Federal Reserve has cut the federal funds rate three times in 2025, leading to a decline in deposit account rates, making it crucial for savers to seek high-yield savings accounts to maximize interest earnings [1] Group 1: Savings Account Rates - High-yield savings accounts can offer interest rates as high as 4% APY, significantly above the national average [2][3] - As of January 12, 2026, the highest savings account rate available from partners is 4% APY, offered by institutions like SoFi, Valley Bank Direct, and Barclays [3] - The national average savings account rate is currently just 0.39%, while 1-year CDs average 1.63%, indicating a substantial gap between average and top rates [5] Group 2: Online Banks vs. Traditional Banks - Most top savings rates are provided by online banks, which have lower overhead costs compared to traditional banks, allowing them to offer higher rates and lower fees [4] - Despite recent rate cuts by the Federal Reserve, traditional savings accounts and CDs are still offering some of the highest interest rates seen in over a decade [4] Group 3: Choosing a Savings Account - When selecting a savings account, it is essential to compare rates and consider factors such as minimum balance requirements, customer service, ATM access, and digital banking tools [6][7] - Ensuring that the savings account is insured by the FDIC or NCUA is critical for protecting deposits in case of institutional failure [7]

Core Insights - Today's CD rates are significantly higher than the national average, influenced by the Federal Reserve's interest rate cuts in 2025, which may present a final opportunity to secure these elevated rates with certificates of deposit [1] Group 1: Best CD Rates - As of January 12, 2026, the highest CD rate available is 4.1% APY, offered by LendingClub for an 8-month CD and Sallie Mae Bank for an 11-month CD [2] Group 2: National Average CD Rates - The national average CD rates are considerably lower than the best available rates, with the highest national average interest rate for a 1-year term standing at 1.63% as of December 2025 [3] - Current average CD rates are among the highest seen in nearly two decades, primarily due to the Federal Reserve's strategy to combat inflation by maintaining elevated interest rates [3] Group 3: Finding the Best CD Rates - To secure the best CD rates, it is advisable to shop around and compare rates from various financial institutions, particularly online banks which typically offer more competitive rates due to lower overhead costs [4] - It is essential to check minimum deposit requirements, as higher rates may necessitate larger initial deposits [4] - Reviewing account terms and conditions is crucial, including early withdrawal penalties and auto-renewal policies, with some CDs offering more flexible options like no-penalty withdrawals [4]

Core Insights - Current national average rates for home equity lines of credit (HELOC) and home equity loans (HEL) are decreasing, making second mortgage options more affordable for homeowners [1] - The average HELOC rate is currently 7.25%, down 19 basis points from the previous month, while the average home equity loan rate is 7.56%, a decrease of three basis points [2] Group 1: Rate Trends - The Federal Reserve estimates that homeowners have $36 trillion of equity locked in their homes, indicating a significant opportunity for homeowners to access this equity through second mortgages [4] - HELOC rates are based on an index rate plus a margin, with the current prime rate at 6.75%, leading to potential HELOC rates around 7.50% depending on lender margins [5] - Average national HELOC rates can include introductory rates that may only last for a limited time before becoming adjustable [6] Group 2: Product Comparison - A HELOC allows homeowners to draw from an approved line of credit as needed, while a home equity loan provides a lump sum [3] - Homeowners with low primary mortgage rates may find it advantageous to obtain a HELOC or HEL without sacrificing their favorable mortgage rate [11] - The best HELOC lenders offer low fees and flexible credit lines, while the best home equity loan lenders provide fixed rates for the duration of the repayment period [8][9] Group 3: Financial Implications - For a $50,000 HELOC at a 7.50% interest rate, the monthly payment during the 10-year draw period would be approximately $313, but this rate is variable and may increase during the repayment period [12] - Homeowners can utilize cash drawn from their equity for various purposes, including home improvements and repairs, making this an opportune time to consider a HELOC or HEL [11]

Core Insights - Money market accounts (MMAs) are highlighted as a favorable option for storing cash due to their relatively high interest rates and liquidity [1] - The article discusses the historical fluctuations in MMA rates, particularly in relation to the Federal Reserve's interest rate changes [4][5][6][7] Group 1: Current Trends in Money Market Accounts - Despite a recent decline in rates, some MMAs still offer over 4% APY, making them competitive for savers [3] - Online banks and credit unions are noted to provide the highest MMA rates as of 2026, although a downward trend in rates has begun following recent Fed cuts [8] Group 2: Historical Context - Following the 2008 financial crisis, MMA rates were extremely low, typically ranging from 0.10% to 0.50% due to the Fed's near-zero interest rate policy [5] - The COVID-19 pandemic prompted another round of rate cuts, leading to a significant drop in MMA rates [6] - Starting in 2022, aggressive interest rate hikes by the Fed resulted in historically high deposit rates, with many MMAs offering rates of 4% or higher by late 2023 [7] Group 3: Considerations for Choosing MMAs - When selecting an MMA, factors beyond interest rates, such as minimum balance requirements, fees, and withdrawal limits, are crucial for evaluating overall value [9][10] - Many MMAs require a substantial minimum balance to earn the highest rates, with some accounts demanding $5,000 or more [10] - It is essential to ensure that the chosen account is insured by the FDIC or NCUA, which protects deposits up to $250,000 per institution [11] Group 4: Comparative Rates and Earnings - The national average interest rate for MMAs is currently 0.58%, while the best rates can reach around 4% APY, comparable to high-yield savings accounts [12] - For example, depositing $50,000 in an MMA with a 4.5% APY would yield approximately $2,303 in interest over one year [13] - Currently, no MMAs offer a 5% APY, but some high-yield savings accounts from online banks do [14]