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我国科研人员破译动物发育动态调控的“时空密码”
Xin Hua Wang· 2025-06-26 21:34
Core Insights - The collaboration between Hangzhou BGI Life Sciences Research Institute and Southern University of Science and Technology has resulted in the creation of a multimodal dataset that decodes the developmental process of animals, specifically generating a 3D single-cell spatiotemporal multi-omics atlas of the entire developmental cycle of fruit flies [1][2] - The research findings were published in the international academic journal "Cell," highlighting the molecular-level references for biological development and the potential foundation for studying developmental defects and related disease mechanisms [1][2] Group 1 - The research team utilized BGI's proprietary technology to sample fruit fly embryos at critical stages every 0.5 to 2 hours, generating over 3.8 million spatially resolved single-cell transcriptomes [2] - The "Spateo" algorithm was employed to reconstruct a high-precision 3D model, allowing for the precise analysis of spatial dynamics in tissue morphology and gene expression [2] - The study constructed a "differentiation trajectory map" of fruit fly embryonic development, elucidating key molecular mechanisms that determine cell fate [2] Group 2 - The research identified that different embryonic layer cells differentiate along specific pathways, with transcription factors acting as "directors" to activate or inhibit genes, guiding cells to perform specific roles [2] - Multiple previously unidentified transcription factors were found to potentially play critical roles in the nervous, intestinal, and endocrine systems [2] - Understanding the developmental processes and gene regulatory mechanisms in fruit flies, which share approximately 70% of disease-related genes with humans, can aid in exploring significant scientific questions related to life development and provide references for research in human developmental diseases [2]
这些“太空特产”从中国空间站而来 期待科学家破解更多“生命之谜”
Yang Shi Wang· 2025-05-01 10:19
据了解,此次下行的材料类实验样品后续将随返回舱运输回京,包括高强韧钢、月壤加固材料等4类22种。 太空生命科学实验 助力守护人类健康 为什么要在太空开展生命科学实验,这些生命科学实验样品将为我们揭开哪些"生命密码"呢?一起来了解。 央视网消息:4月30日13时08分,神舟十九号载人飞船返回舱在东风着陆场东区成功着陆,中国空间站第八批空间科学实验样品也随神舟 十九号乘组返回地球,生命类科学实验样品于30日晚顺利交付给科学家。 据记者介绍,这次随神舟十九号飞船下行的科学实验样品涉及空间生命科学、材料科学、新技术等多个领域的25个实验项目,总重量约 37.25公斤。在现场交付的实验样品主要是生命类科学实验样品,因为生物活性的特殊要求,这些样品是第一时间从着陆场转运到中国科学院 空间应用中心。现场交付的生命类科学实验样品包括骨细胞和成骨细胞、人支气管上皮细胞、蛋白样品及果蝇等20类,是空间站应用与发展阶 段下行生物样品种类最多的一次。此次下行的果蝇,跟斑马鱼、小白鼠一样是重要的模式生物,人类有约75%的致病基因都可以在果蝇身上找 到同源基因。神舟十九号乘组在轨期间,果蝇在空间站特殊装置内展开了"亚磁-微重力"实验。在 ...
数据透视中国空间站第八批空间科学实验“硕果累累” 果蝇实现“四世同堂”
Yang Shi Wang· 2025-05-01 01:47
央视网消息:4月30日13时08分,神舟十九号载人飞船返回舱在东风着陆场成功着陆,航天员蔡旭哲、宋令东、王浩泽身体状态良好,神 舟十九号载人飞行任务取得圆满成功。 14时02分,三位航天员安全顺利出舱。蔡旭哲重返"天宫"的圆梦征程完美收官,成为目前在舱外执行任务次数最多的中国航天员。两 名"90后"航天员宋令东、王浩泽的首飞之旅圆满完成。 中国空间站第八批实验样品返回交付科学家 中国空间站第八批空间科学实验样品随神舟十九号乘组也已经顺利返回地球。此次返回的究竟有哪些太空实验样品?回来之后,又将展开 哪些后续研究呢?来看总台记者4月30日晚发回的最新报道。 此刻,中国科学院空间应用中心正在进行的就是空间科学实验样品的交接仪式。这次随神舟十九号飞船下行的科学实验样品涉及空间生命 科学、材料科学、新技术等多个领域的25个实验项目,总重量约37.25公斤。 据了解,此次下行的材料类实验样品后续将随返回舱运输回京,包括高强韧钢、月壤加固材料等4类22种。我们也期待科学家们在地面的 后续研究能够取得重要成果,为未来深空探测、人类太空活动提供重要的理论基础和技术支撑。 现场交付的实验样品,主要是生命类科学实验样品,因为生物 ...
涉及25个实验项目 重约37.25公斤 空间站第八批实验样品返回
Core Points - The eighth batch of space science experiment samples has successfully returned to Earth with the Shenzhou 19 crew, involving 25 experimental projects across various fields [1][3] - The total weight of the returned samples is approximately 37.25 kilograms [3] Group 1: Life Science Experiments - The delivered samples primarily consist of life science experiments, including bone cells, bronchial epithelial cells, early embryos of humans and animals, protein samples, and fruit flies, totaling 20 categories [6][8] - These life science samples were prioritized for transport due to their biological activity requirements, marking the largest variety of biological samples returned from the space station [6] Group 2: Fruit Fly Experiments - A notable experiment involved fruit flies that successfully bred in space, achieving "four generations" under microgravity and low magnetic field conditions [11][15] - Fruit flies are significant model organisms in genetic research, with 75% of human disease genes having homologs in fruit flies, contributing to six Nobel Prizes in related studies [13] Group 3: Material Science Experiments - The materials science samples, including high-strength steel and lunar soil reinforcement materials, will be transported back to Beijing for further research [19] - The ongoing research aims to provide important theoretical foundations and technical support for future deep space exploration and human space activities [19]
新华全媒+|大漠长风起 神舟破云归——写在神舟十九号航天员乘组天外凯旋之际
Xin Hua She· 2025-04-30 18:37
新华社酒泉4月30日电 题:大漠长风起 神舟破云归——写在神舟十九号航天员乘组天外凯旋之际 新华社记者李国利、黄一宸、刘艺 4月30日,祖国西北的巴丹吉林沙漠传出喜报—— 神舟十九号载人飞船返回舱安全降落在东风着陆场,为国出征太空半年的蔡旭哲、宋令东、王浩泽3名 航天员安全顺利出舱,健康状态良好。 至此,我国载人航天工程的第14次载人飞行任务圆满成功。 183天,3名航天员在太空中进行了3次出舱活动和6次载荷进出舱任务,创造了航天员单次出舱活动9小 时时长的世界纪录;参与实施了88个空间科学与技术实(试)验项目,覆盖空间生命科学、微重力基础 物理、空间材料科学、航天医学、航天新技术等领域,取得了阶段性成果。 万众一心迎舟归 三十余载勤作桨,飞天万里梦为帆。 中国航天人以长风破浪之姿,在建设航天强国、科技强国的征程上奋勇向前。 4月29日,位于巴丹吉林沙漠的东风着陆场大风呼啸,黄沙漫卷。 为确保航天员生命健康安全和任务圆满成功,原计划在这天实施的神舟十九号载人飞船返回任务,不得 不因气象原因推迟一天。 新华社记者第一时间采访了酒泉卫星发射中心相关部门负责人。 "大风扬沙天气会影响到飞船的姿态控制、返回舱的落点精 ...