新华社北京11月21日电 《经济参考报》11月21日刊发文章《触摸"十五五"产业脉搏丨思维现实加 速"链接" 脑机接口迈入产业化快车道》。文章称，在资本市场上，脑机接口正成为投资者的关注焦 点。不仅相关板块今年以来最高涨幅超过60%，创投方面的相关投资额也实现大幅度增长。资本热捧背 后，是脑机接口技术研发的全链条推进，应用案例的持续涌现，以及产业链的加速完善。 "十五五"期间，在政府、企业、科研机构等各方合力推动下，脑机接口这一连接思维与现实的人机交互 关键技术，有望撬动百亿级产业规模，为医疗、消费等领域带来深刻变革。 研发和临床全链条推进 不久前，中国科学院深圳先进技术研究院团队联合东华大学团队，成功研发出如头发丝般纤细、柔软可 拉伸的神经纤维电极——神经蠕虫（NeuroWorm）。 记者了解到，植入式脑机接口技术因电极直接与神经元"对话"，可实现更高的监测精度与更丰富的功 能。然而，传统植入式电极植入后不仅无法动态调整植入位置，也无法对周边环境作出响应性调整。而 NeuroWorm这样的"动态电极"可以在兔子颅内"游走"，根据需要主动更换监测目标。 中国科学院深圳先进技术研究院研究员刘志远表示，该研究首次 ...

Core Insights - The article highlights the growing interest in brain-computer interface (BCI) technology within the capital market, with related sectors experiencing a maximum increase of over 60% this year, and significant growth in venture capital investments [1] - The "14th Five-Year Plan" period is expected to catalyze a hundred billion-level industry scale for BCI, driven by collaboration among government, enterprises, and research institutions [1] R&D and Clinical Advancements - A team from the Shenzhen Institute of Advanced Technology and Donghua University has developed a new type of neural electrode called NeuroWorm, which is flexible and can dynamically adjust its position within the brain [2] - The first clinical implantation of a domestically developed BCI chip, "Han-Chip," was successfully completed, leading to significant improvements in a patient's motor functions after surgery [2][3] - The success of the "Han-Chip" implantation marks a critical advancement in the clinical application of domestic BCI technology [3] Policy Support and Industry Development - The development of BCI technology is significantly supported by government policies, including a July 2023 initiative aimed at enhancing innovation in the BCI industry, with a goal for the industry to rank among the world's top by 2030 [3][4] - Policies encouraging the development of small and medium enterprises are expected to deepen technological specialization and create a self-sustaining industry ecosystem [4] Market Potential and Investment Trends - The BCI market is projected to reach tens of billions of dollars, with estimates suggesting it could exceed $10 billion by 2030, and potentially reach $145 billion by 2040 in the medical application sector [6] - The BCI sector has seen a 50% increase in stock prices this year, with a peak increase of 63.22% [6] Future Outlook - The BCI industry is anticipated to experience significant breakthroughs during the "14th Five-Year Plan," moving beyond prototype demonstrations to achieve large-scale applications in medical rehabilitation and other urgent social needs [7] - Key technological challenges remain, but rapid advancements are being made to address issues such as electrode longevity and high-channel communication technology [7]

Group 1: Alzheimer's Disease Treatment Innovations - A new nano-drug strategy has been proposed by a research team from Sichuan University and the Catalonia Institute for Bioengineering, which cleared nearly 50% of amyloid-beta (Aβ) in Alzheimer's model mice within 2 hours and sustained cognitive recovery for up to 6 months [5][11]. - The traditional approach focused on directly removing Aβ, but the real issue is the failure of the brain's waste clearance system, particularly the low-density lipoprotein receptor-related protein 1 (LRP1) [6][7]. - The new strategy aims to repair the waste clearance system rather than just removing the waste, utilizing a designed nano-carrier (A₄₀-POs) that enhances LRP1's function [8][10]. Group 2: Brain-Machine Interface Breakthroughs - A new type of flexible, stretchable neural electrode called "NeuroWorm" has been developed, which can move within the brain or muscle tissue, allowing for dynamic monitoring of physiological signals [12][15]. - This innovation represents a paradigm shift from static electrodes to dynamic, controllable devices that can provide long-term monitoring of neural activity [15]. Group 3: Chronic Pain Mechanisms - Research has identified a specific type of neuron (Y1R neurons) in the parabrachial nucleus of the brain that remains active during chronic pain, providing insights into potential new therapies for chronic pain management [16][18]. - The study reveals that the brain has an intrinsic pain modulation mechanism, where survival needs can suppress chronic pain signals, suggesting that behavioral interventions may also influence pain perception [20][21].

上海证券指出，我国脑机接口领域迈入高速发展阶段，行业规范不断完善，新的技术突破持续涌现。中 国科学院深圳先进技术研究院联合东华大学科研团队成功研发出"神经蠕虫"（NeuroWorm），这项技术 标志着生物电子接口从静态走向动态、从被动记录走向主动智能探测的范式转变。该技术不仅为脑机接 口开辟了新路径，还在肌肉内实现了长期植入与稳定工作，为外骨骼控制、康复辅助以及人机协同提供 了新可能。此外，国家药监局最新批准发布了《采用脑机接口技术的医疗器械术语》医疗器械行业标 准，明确了核心术语及定义，有助于破解行业术语不统一、概念不规范等基础性难题，为研发生产和科 学监管提供关键技术依据，对规范行业秩序、促进产业健康发展具有重要意义。 医疗ETF（159828）跟踪的是中证医疗指数（399989），该指数从中国A股市场中选取涉及医疗器械、 医疗服务等领域的上市公司证券作为指数样本，以反映医疗主题相关上市公司证券的整体表现。中证医 疗指数成分股主要集中在医药生物行业，同时涵盖少量计算机和美容护理行业证券，整体呈现中小市值 特征。 （文章来源：每日经济新闻） ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在 脑机接口 等神经接口系统中， 电极 是连接电子设备和生物神经系统的核心界面传感器，是脑机接口中"接口"的核心所在。 然而，当前植入式电极均是" 静态 "的，植入后只能"固定位置、局限采集"，还在免疫反应中"被动挨打"乃至传导失效，这严重制约了脑机接口的应用和未来发 展。 2025 年 9 月 17 日， 中国科学院深圳先进技术研究院 刘志远 研究员、 徐天添 研究员、 韩飞 副研究员和东华大学 严威 教授合作，在国际顶尖学术期刊 Na ture 上发表了题为：： A movable long-term implantable soft microfibre for dynamic bioelectronics 的研究论文。 研究团队受到 蚯蚓 在土壤中灵活运动和分段感知能力的启发，成功开发出了一种 柔性、可驱动、可长期植入的纤维电极—— 神经蠕虫 （ NeuroWorm ） ，标 志着生物电子接口 （脑机接口、人机接口） 从静态走向动态、从被动记录走向主动智能探测的范式转变。 为实现具有分布式传感能力的柔性动态电极，从自然界汲取灵感是一个前景广阔的方向。自然界中， ...