恒瑞医药（600276）(600276.SH)发布公告，近日，公司收到国家药品监督管理局(以下简称"国家药监 局")下发的《受理通知书》，公司注射用甲苯磺酸瑞马唑仑的药品上市许可申请获国家药监局受理。 甲苯磺酸瑞马唑仑属于苯二氮类药物，是一种短效GABAa受体激动剂。甲苯磺酸瑞马唑仑通过与 GABAa受体结合，抑制神经元活动，从而产生镇静麻醉作用。甲苯磺酸瑞马唑仑的优势在于起效快、 苏醒时间短、对呼吸及心血管系统影响小。德国PAIONAG公司研发的苯磺酸瑞马唑仑，2020年1月在日 本获批上市，2020年10月在美国获批上市，2020年7月在中国获批上市。经查询，苯磺酸瑞马唑仑2024 年全球销售额合计约为5,922万美元。截至目前，注射用甲苯磺酸瑞马唑仑相关项目累计研发投入约 18,400万元。 ...

智通财经APP讯，恒瑞医药(600276.SH)发布公告，近日，公司收到国家药品监督管理局(以下简称"国家 药监局")下发的《受理通知书》，公司注射用甲苯磺酸瑞马唑仑的药品上市许可申请获国家药监局受 理。 甲苯磺酸瑞马唑仑属于苯二氮类药物，是一种短效GABAa受体激动剂。甲苯磺酸瑞马唑仑通过与 GABAa受体结合，抑制神经元活动，从而产生镇静麻醉作用。甲苯磺酸瑞马唑仑的优势在于起效快、 苏醒时间短、对呼吸及心血管系统影响小。德国PAIONAG 公司研发的苯磺酸瑞马唑仑，2020年1月在 日本获批上市，2020 年10月在美国获批上市，2020年7月在中国获批上市。经查询，苯磺酸瑞马唑仑 2024年全球销售额合计约为5,922万美元。截至目前，注射用甲苯磺酸瑞马唑仑相关项目累计研发投入 约18,400万元。 ...

Investment Rating - The industry investment rating is "Positive" and is maintained [6]. Core Viewpoints - The report highlights that Renfu Pharmaceutical is undergoing a core restructuring, focusing on optimizing assets and enhancing innovation capabilities. The company has established itself as a leader in the anesthetics market, particularly with its Yichang Renfu subsidiary, which holds a dominant position in the fentanyl series [3][11]. - The report emphasizes the continuous growth of Renfu's product lines, with a significant number of products achieving over 100 million yuan in sales. The company is also expanding its research and development efforts, particularly in oral formulations and pain management applications [17][21]. - The report notes that the pharmaceutical and biotechnology sector has seen a 1.9% increase this week, outperforming the CSI 300 index by 0.21 percentage points, with the medical R&D outsourcing sector showing the largest gains [4][38]. Summary by Sections 1. Renfu Pharmaceutical: Core Restructuring and Innovation Pipeline - Renfu Pharmaceutical is advancing its core restructuring strategy, focusing on optimizing its asset portfolio and enhancing innovation. The company has established a strong foundation in the anesthetics market through its Yichang Renfu subsidiary, which leads the fentanyl series with approximately 90% market share [3][11]. - The company has a robust pipeline of innovative drugs, including pUDK-HGF, which has completed Phase III clinical trials for severe lower limb ischemia, and several differentiated innovative pipelines targeting pain, solid tumors, and inflammatory bowel disease [3][22]. 2. Market Performance - The pharmaceutical and biotechnology sector has increased by 1.9% this week, ranking 19th among 31 sub-industries. The medical R&D outsourcing sector experienced the highest growth at 8.29% [4][38]. - The report indicates that Renfu Pharmaceutical's commercial capabilities are reflected in its sales performance, with 16 products exceeding 100 million yuan in sales in 2024, showcasing the company's strong market presence [17][18]. 3. Investment Recommendations - Recommended stocks in the pharmaceutical and biotechnology sector include Heng Rui Pharmaceutical, East China Pharmaceutical, Sanofi Pharmaceutical, Renfu Pharmaceutical, and others. The report also highlights key players in the CXO and research service sectors [5].