特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我们的推送。 建立高效 液相色谱 法测定从化乌橄榄中 6 种酚类物质的分析方法 作者：黄锦波 谱瑞（广州）检测技术有限公司，广州 510000 摘要 : 目的为建立高效 液相色谱 法测定从化乌橄榄中 6 种酚类物质的分析方法。称取 0.5g 从化乌橄榄干粉经过异 丙醇溶解，超声 30min ，固相萃取柱净化后，经滤膜过滤上机测试；选择 Ecl ipse XDB-C18 色谱柱为分离柱，采 用二极管阵列检测器，优化前处理条件及仪器测试条件，以达到最佳的分离条件。结果表明：没食子酸、羟基酪醇、橄 榄苦苷、榄香素在浓度为 10-2000 μ g/ l ，矢车菊素 -3-o- 葡糖苷与表没食子儿茶素没食子酸酯（ EGCG ） 在 浓度 20-200 μ g/ l 内，其峰面积均呈良好线性关系（ R 均＞ 0.995 ） ；没 食 子 酸 ，羟 基 酪 醇 ， 橄 榄 苦 苷 ， 榄香 素，矢车菊素 -3-o- 葡糖苷，表没食子儿茶素没食子酸酯（ EGCG ）的检出限（ 3S/N ）分别为 2.09mg/ kg ， ...

Core Findings - A team from the University of California, Irvine discovered that a combination of Vitamin B3 (niacinamide) and the active component in green tea, EGCG, can rejuvenate aging brain cells and effectively clear harmful protein accumulations associated with Alzheimer's disease [1][2] - The research published in the latest issue of "Aging Science" indicates that this combination significantly enhances the levels of GTP, a key energy molecule in brain cells, and improves the ability to clear β-amyloid proteins, which are characteristic of Alzheimer's disease [1][3] Mechanism of Action - The study utilized a gene-encoded fluorescent sensor named GEVAL to monitor GTP dynamics in neurons of aged Alzheimer's model mice, revealing a continuous decline in GTP levels with age, particularly in mitochondria, which severely impacts autophagy, the process of clearing damaged components [1] - Neurons treated with niacinamide and EGCG showed GTP levels restored to those of younger cells, leading to improved energy metabolism, activation of key proteins responsible for cellular transport, and efficient clearance of β-amyloid aggregates, thereby reducing oxidative stress associated with neurodegeneration [2] Implications for Treatment - The findings suggest that the combination of these two natural dietary supplements may serve as a new tool in combating cognitive decline and Alzheimer's disease [3]