近日，记者从信用中国获悉，天津中瑞药业股份有限公司因安全生产违法被武清区应急管理局罚款1.5万元。 违法事实为：安全设备的安装不符合国家标准。 | | | | 信用信息 ▼ 天津中瑞药业股份有限公司 | | | 搜索 | | --- | --- | --- | --- | --- | --- | --- | | 信息公示 信用动态 | 信用立法 政策法规 | | 信用承诺 | 城市信用 | | 走进信用 | | 天津中瑞药业股份有限公司 | 存续 守信激励对象 | | | | | | | 统一社会信用代码: 91120000758130319M | | | | | | | | 重要提示: | 信息进行信用修复,可按照行政处罚信息信用修复流程指引提出信用修复申请。 2.本查询结果仅依现有数据展示相关信息,供社会参考使用。使用相关信息的单位和个人应对信息使用行为的合法性负责。 3."信用中国"网站公示信息与认定单位公示信息不一致的，以认定单位相关系统公示信息为准。 | 1.如认为所展示信息存在指误、造局、公开期限不符合规定以及其他侵犯信息主体合法权益的，可按照信用信息异议审诉指南提出异议审诉，如需对相关行政处罚 ...

上周(8月11日至15日)，化工指数与石油指数出现两极分化，化工指数全线上扬，石油指数全线下跌。 从现货市场看，涨幅前五名的石化产品分别为液氯上涨29.05%、电池级碳酸锂上涨18.57%、工业级碳 酸锂上涨14.53%、叶酸上涨6.38%、烟酰胺上涨5.00%；跌幅前五名的石化产品分别为丁酮下跌8.91%、 有机硅DMC下跌8%、有机硅D4下跌7.69%、生胶下跌7.41%、合成氨下跌6.95%。 从资本市场看，涨幅前五名的上市化企分别为双一科技上涨41.17%、凯美特气上涨34.73%、宏和科技 上涨33.09%、唯科科技上涨31.54%、新瀚新材上涨31.43%；跌幅前五名的上市化企分别为至正股份下 跌13.04%、东华能源下跌11.49%、仁智股份下跌10%、丰山集团下跌8.51%、河化股份下跌8.20%。 （罗阿华） 转自：中国化工报 化工板块方面，化工原料指数累计上涨2.81%、化工机械指数累计上涨1.53%、化学制药指数累计上涨 3.70%、农药化肥指数累计上涨1.03%；石油板块方面，石油加工指数累计下跌1.10%、石油开采指数累 计下跌1.22%、石油贸易指数累计下跌1.02%。 上周，国际 ...

Core Findings - A team from the University of California, Irvine discovered that a combination of Vitamin B3 (niacinamide) and the active component in green tea, EGCG, can rejuvenate aging brain cells and effectively clear harmful protein accumulations associated with Alzheimer's disease [1][2] - The research published in the latest issue of "Aging Science" indicates that this combination significantly enhances the levels of GTP, a key energy molecule in brain cells, and improves the ability to clear β-amyloid proteins, which are characteristic of Alzheimer's disease [1][3] Mechanism of Action - The study utilized a gene-encoded fluorescent sensor named GEVAL to monitor GTP dynamics in neurons of aged Alzheimer's model mice, revealing a continuous decline in GTP levels with age, particularly in mitochondria, which severely impacts autophagy, the process of clearing damaged components [1] - Neurons treated with niacinamide and EGCG showed GTP levels restored to those of younger cells, leading to improved energy metabolism, activation of key proteins responsible for cellular transport, and efficient clearance of β-amyloid aggregates, thereby reducing oxidative stress associated with neurodegeneration [2] Implications for Treatment - The findings suggest that the combination of these two natural dietary supplements may serve as a new tool in combating cognitive decline and Alzheimer's disease [3]

Core Insights - Nicotinamide, an important member of the B-vitamin family, has diversified applications in the food, pharmaceutical, and cosmetic industries, driven by its nutritional enhancement and functional characteristics [1][15] - The market size of the nicotinamide industry in China is projected to reach approximately 2.535 billion yuan in 2024, with a year-on-year growth of 17.26% [1][15] - The industry is expected to benefit from the ongoing "Healthy China" strategy and the increasing consumer demand for functional products, indicating a broader development space in the future [1][15] Industry Overview - Nicotinamide, also known as niacinamide, is a white crystalline powder with a molecular weight of 122.125, primarily used in clinical settings for the prevention and treatment of various health issues [3] - The industry can be segmented into food-grade, cosmetic-grade, pharmaceutical-grade, and feed-grade nicotinamide, with varying concentrations available [3] Production Methods - Three main production methods for nicotinamide include oxidation of β-methylpyridine to niacin, dehydration of niacin with ammonium hydroxide, and a reaction involving niacin, boric acid, and ammonia [5][11] Applications and Benefits - Nicotinamide is recognized for its anti-acne, anti-inflammatory, whitening, and anti-aging properties, making it a popular ingredient in skincare products [7][8] - In the pharmaceutical sector, it is crucial for treating conditions related to niacin deficiency, while in cosmetics, it enhances skin barrier function and moisture retention [9][12] Industry Chain - The nicotinamide industry chain includes upstream raw material supply, midstream production and processing, and downstream applications in pharmaceuticals, cosmetics, and food [9] - Key raw materials include 3-cyanopyridine, niacin, ammonia, and solvents, with production methods involving chemical synthesis or fermentation [9] Market Dynamics - The global nicotinamide industry exhibits a tiered competitive landscape, with leading companies like Lonza, Vantiv, and Brother Technology dominating the market [17][19] - Brother Technology is identified as a leading domestic player, focusing on the production and sales of nicotinamide and niacin products across various sectors [19][21] Future Trends - The industry is shifting towards high-value products, with a focus on technological innovation and product upgrades to enhance purity and bioavailability [26][28] - The application of nicotinamide is expanding into new areas such as oral beauty products and functional foods, driven by consumer trends and interdisciplinary research [27][28]

Investment Rating - The report maintains a recommendation for the chemical industry, indicating a positive outlook for the sector [5]. Core Insights - The report highlights significant price increases in isobutyraldehyde and TDI, suggesting potential high growth in Q2 performance for specific companies [4]. - The overall chemical sector saw a 0.80% increase in the first week of July, lagging behind the Shanghai Composite Index by 0.60 percentage points [13]. - The dynamic PE for the chemical sector is reported at 24.98 times, which is lower than the average PE of 33.31 times since 2015 [13]. Industry Performance - In the first week of July, 24 sub-industries within the chemical sector experienced growth, with the top five performers being fiberglass (+17%), compound fertilizers (+3.2%), other plastic products (+3.08%), fluorochemicals and refrigerants (+2.97%), and tires (+2.66%) [17]. - Conversely, seven sub-industries declined, with synthetic leather (-4%), petroleum trading (-2.19%), inorganic salts (-1.91%), petroleum processing (-0.57%), and textile chemicals (-0.54%) being the worst performers [17]. Price and Spread Trends - The report lists the top five products with the highest weekly price increases: dichloropropane-white (+8.82%), isobutyraldehyde (+7.2%), TDI (+7.02%), butanone (+6.39%), and sulfur iron ore (+3.82%) [23]. - The top five products with the largest price declines include liquid chlorine (-86.51%), aniline (-7.67%), acetone (-6.69%), propylene oxide (-6.53%), and niacinamide (-6.35%) [23]. - Among the 75 products analyzed for price spreads, the top five with the highest increases were DMF spread (+24.73%), soft foam polyether spread (+21.54%), acetone hydrogenation isopropanol spread (+17.26%), polybutadiene rubber spread (+16.69%), and hard foam polyether spread (+14.62%) [42]. Inventory Changes - Significant inventory changes were noted, with polyester filament increasing by 36.09%, while other notable changes included a decrease in the inventory of chlorpyrifos (-19.05%) and an increase in ethylene glycol (+15.61%) [60]. Recommended Companies - The report suggests focusing on companies expected to see substantial quarter-over-quarter growth in Q2, specifically mentioning Zhongchumai, Sully Co., and Haigong Coatings, as well as Guangxin Materials, which is anticipated to pass certification [4].

Core Viewpoint - The whitening ingredient tranexamic acid is experiencing a resurgence in the skincare market, moving from a previously overlooked status to becoming a popular choice among brands and consumers [1][5][20]. Ingredient Trends - Traditional whitening ingredients like niacinamide, arbutin, and alpha hydroxy acids dominate the market, while tranexamic acid, once popularized by Shiseido, has seen a revival due to new research validating its efficacy [1][5]. - In Q1 2024, tranexamic acid entered the top 10 list of popular cosmetic ingredients, marking a significant increase from its previous ranking of 15 in the same period last year [5][6]. Market Growth - The number of registered products containing tranexamic acid has surged, with 918 new registrations in 2024 and a compound annual growth rate exceeding 80% over the past three years [6][8]. - By May 2025, over 3,000 products featuring tranexamic acid were registered, reflecting a year-on-year growth of over 100% [6][8]. Brand Strategies - Major brands are increasingly incorporating tranexamic acid into their product lines, with companies like OLAY and domestic brands like Proya launching new products featuring this ingredient [14][15]. - The competitive landscape in the whitening market is intensifying, with brands seeking innovative narratives to differentiate their offerings amid a saturated market [13][20]. Research and Development - Procter & Gamble's recent research highlights the mechanism by which tranexamic acid inhibits melanin production, providing a scientific basis for its use in whitening products [10][12]. - The study indicates that tranexamic acid can stabilize melanocytes, preventing excessive melanin transfer to skin cells, thus enhancing its whitening effects [12][13]. Consumer Engagement - The rise of "ingredient-focused" consumers has led to increased discussions about tranexamic acid on social media platforms, indicating growing consumer interest and awareness [17][18]. - However, the lack of a standout product in the market is seen as a barrier to tranexamic acid's widespread adoption, with brands needing to innovate to capture consumer attention [18][19]. Future Outlook - The potential for tranexamic acid to become a leading whitening ingredient hinges on overcoming challenges related to its skin absorption and stability [18][19]. - Innovations such as microneedling combined with tranexamic acid are being explored to enhance its efficacy and safety in topical applications [18][19]. - The cost of tranexamic acid remains a factor, with current prices significantly higher than those of established ingredients like niacinamide, which may limit its market penetration [19][20].

Core Viewpoint - The article discusses a study published in Nature Metabolism that highlights the potential of Nicotinamide to accelerate recovery in mild to moderate COVID-19 patients and its role in modulating gut microbiota changes associated with the virus [2][12]. Group 1: Nicotinamide and COVID-19 - Nicotinamide is essential for the production of NAD+, a key coenzyme in cellular energy metabolism, which decreases during viral infections, particularly COVID-19 [5]. - The study indicates that during acute inflammation caused by SARS-CoV-2, tryptophan metabolism is enhanced, leading to increased kynurenine levels, which is a critical intermediate in the NAD+ synthesis pathway [5]. - COVID-19 is closely linked to gut microbiota dysbiosis, characterized by reduced microbial diversity and beneficial species, which is associated with increased inflammation and immune dysregulation [5]. Group 2: Research Findings - Previous research showed that tryptophan helps maintain gut microbiota homeostasis, and supplementation with Nicotinamide has strong, microbiota-dependent anti-inflammatory effects [6]. - The study developed a pH-dependent matrix tablet formulation for Nicotinamide, designed to release in the lower small intestine and colon, ensuring systemic supply and targeting gut microbiota [6]. - The COVit-2 trial involved 900 symptomatic COVID-19 patients and demonstrated that 57.6% of those treated with Nicotinamide recovered from physical decline by week 2, compared to 42.6% in the placebo group [7]. Group 3: Clinical Implications - The changes in gut microbiome characteristics correlated with clinical efficacy, suggesting that Nicotinamide can regulate fecal microbiota changes associated with SARS-CoV-2 infection [8]. - Follow-up after 6 months indicated that those who responded to Nicotinamide treatment had a lower incidence of post-COVID syndrome compared to the placebo group [8]. - Throughout the study, no safety risks related to Nicotinamide treatment were reported [8].

全球股市一天跌没 20 万亿元 巴菲特一笔交易赚超过 1500 亿美元 马斯克说支持特朗普不代表赞同他做的一切 关注《晚点财经》并设为星标，第一时间获取每日商业精华。 全球股市一天跌没 20 万亿元 2024 年 8 月 5 日，星期一，全球所有主要股市齐跌。根据我们的不完全统计，日本、韩国、中国、欧洲 和美国至少损失超过 20 万亿元市值。 市场其实担心衰退已好一阵子。上周五日经指数就创下 1987 年黑色星期一以来最大跌幅。信心不知何 故地在周末开始加速崩塌。巴菲特出人意料地大卖股票也许击碎了市场残存信心。现在市场恐慌，他已 备好近 2 万亿元现金储备。 周一黑色的情绪是从亚洲股市开始。日经 225 指数重挫 12.4%，韩国综合股价指数盘中熔断、收跌 8.77%。A 股和港股恒生指数不到 2% 的跌幅好于绝大多数市场。欧洲股市是在北京时间下午开盘的， 跌幅介于 2% 到 4%。 期间国际黄金一度上涨超过 1%，但随着更多在欧美市场交易的投资人加入，金价转跌。 到了北京时间晚上九点半，美股标普 500 和纳斯达克指数开盘分别跌超 4% 和 6%。其中，标普 500 指 数在开盘头 1 分钟就跌去近 1.9 ...