The crypto market pulled back slightly today, with Bitcoin falling from its recent all-time high of $126,000 to around $121,200, before stabilizing near $121,553. The decline triggered widespread liquidations, totaling over $659 million across longs and shorts — with $500 million of that wiped from long positions in just 24 hours and now the question is: where to find the best altcoins to buy during this dip? DISCOVER: Plasma (XPL) Crypto: Partners With Trust Wallet, Bottom Is In? Ethereum also slid over ...

编辑丨王多鱼 排版丨水成文 尽管前体信使 RNA （pre-mRNA） 外显子的反向剪接是由经典的剪接体机制进行的低效加工，但这种反向剪接会在全基因组范围内产生 环状 RNA （circRNA） ，其序列与来自相同基因位点的线性 RNA 几乎完全相同，只是在反向剪接连接 （BSJ） 位点有所不同。 重要的是，越来越多的证据表明，一些 circRNA 通过不同的分子作用模式在基因表达调控中发挥着重要作用。这些作用包括调节转录、干扰 mRNA 剪接、作 为"海绵"吸附 miRNA 或蛋白质、影响翻译以及被翻译为多肽。一些高表达的 circRNA 已被证实参与维持静止的造血干细胞、调控细胞生长和癌症进展、影响大 脑功能和神经元发育以及调控先天免疫反应。 这些发现增加了人类转录组的复杂性和多样性。 此外， 可变环化 （ alternative circularization， AC） 导致 单个基因位点产生多个 circRNA，这 进一步扩大了 circ RN A 的功能复杂性，造就了不同细胞系和 组织中 circRNA 表达的独特图谱。然而，大多数通过可变环化产生的 circRNA 的功能，仍然未知。 在这项新研究 ...

Company Overview - Guangdong Hongjing Optoelectronics Technology Co., Ltd. specializes in the R&D, design, production, and sales of optical lenses and camera modules since its establishment in 2012 [1] - Main products include optical lenses and camera modules for smart cars and emerging consumer markets, with applications in smart cockpits, intelligent driving, smart homes, and panoramic/sport cameras [1] Financial Performance - In the first half of 2025, the company achieved a revenue of CNY 701.14 million, representing a year-on-year growth of 55.72% [1] - Net profit attributable to shareholders was CNY 75.52 million, with a year-on-year increase of 10.22% [1] - Revenue breakdown: - Panoramic/sport camera business: 49.66% - Smart home business: 22.80% - Smart car business: 18.90% - New business: 7.55% [1] Customer Base - Established a diverse customer base in the smart car sector, supplying to brands like Chery, Changan, Xiaopeng, and SAIC through partners such as Desay SV and Hikvision [2] - In the smart home sector, the company is a key supplier for mid-to-high-end brands like Ring and Blink in the European and American markets [2] - Long-term partnership with Ying Shi Innovation in the panoramic/sport camera field [2] Collaboration with Ying Shi Innovation - Collaboration began in 2015, driven by mutual needs and market potential [3] - In 2022, the company developed a leading 48-megapixel panoramic camera lens and module, which received positive market feedback [3] Profitability Analysis - Overall gross margin for the first half of 2025 was 24.43% [4] - Gross margins by product: - Smart car optical lenses: 25.12% - Emerging consumer optical lenses: 46.06% - Emerging consumer camera modules: 15.48% [4] - Camera modules have lower gross margins due to reliance on externally sourced components [4] Future Development Outlook - The company aims to implement a "3+N" product strategy over the next 3-5 years, focusing on increasing market share in smart cars, smart homes, and panoramic/sport cameras [6] - Plans to expand into emerging fields such as AI hardware, machine vision, industrial inspection, and medical applications [6]

Core Viewpoint - The article emphasizes the importance of selecting the right floor when purchasing a property, highlighting that certain "golden floors" can enhance living quality and asset appreciation over time [1][3]. Group 1: Golden Floors - The "next-to-top floor" (also known as the "Phoenix floor") offers a balance of privacy, light, and views while avoiding the extreme temperatures of the top floor [5][7]. - Floors 4, 5, and 6 are considered ideal due to their accessibility, comfort, and safety, making them suitable for families with children and elderly members [9][11]. - Ground floors with gardens provide a private outdoor space, enhancing the living experience and convenience for older residents [13][17]. Group 2: Height Considerations - Floors between the 10th and 20th levels are identified as the "golden section," balancing light, ventilation, and safety, making them highly desirable [16][20]. - Top floors with attics can transform the living experience by providing additional functional space, which can be used for various purposes, thus increasing the property's value [22][24]. Group 3: Overall Benefits - The five types of "golden floors" collectively aim to provide a more comfortable, safe, and valuable living environment, ultimately enhancing both emotional and financial well-being for homeowners [25].

Summary of 4D Molecular Therapeutics Conference Call Company Overview - **Company**: 4D Molecular Therapeutics (FDMT) - **Focus**: Gene therapy portfolio, specifically targeting neovascular diseases and cystic fibrosis Key Programs 1. **4,150 for Neovascular Diseases** - Targets wet AMD and diabetic eye disease - Currently in two Phase III trials (FORFORNTA I and FORFORNTA II) - Strong enthusiasm and enrollment observed - Recent survey indicated 50% of physicians view gene therapy as the most exciting novel approach for wet AMD - Expected completion of enrollment for FORFORNTA I in Q1 2026, with a 52-week endpoint anticipated in 2027 [3][4] 2. **4,710 for Cystic Fibrosis** - An aerosol-delivered vector for cystic fibrosis patients, particularly those not amenable to modulators - Currently in a Phase I dose-finding study - Initial doses were found to be overdosed; adjustments made to lower doses for better physiological expression - Expected readouts on lung function and quality of life in Q4 2025 [4][38] Clinical Trial Insights - **4,150 Program** - Strong dose response observed in Phase I and II trials, with treatment burden reduction between 83% to 94% - Safety profile is robust, with less than 3% transient inflammation reported [6][7] - Changes from Phase II to Phase III include refined patient population and minor tweaks to reinjection criteria to enhance safety and efficacy [12][14] - **4,710 Program** - High expression levels observed initially, but adjustments made to avoid overdosing - Focus on long-term data from patients at various dose levels, with follow-up ranging from 3 to 18 months [39][44] - Emphasis on multiple endpoints including FEV1, Lung Clearance Index, and quality of life metrics [46][50] Market Position and Strategy - The company is well-positioned with cash reserves extending into 2028, allowing for continued development of its gene therapy programs [3] - The focus is on large market opportunities rather than rare diseases, reflecting a strategic shift in the pharmaceutical landscape [62] Regulatory Considerations - The company aims to align with FDA and EMA guidelines, particularly regarding trial designs and patient populations [20][23] - Emphasis on demonstrating significant reductions in treatment burden to meet regulatory expectations [36][37] Future Directions - Potential for collaborations in gene therapy, but with a focus on maintaining the integrity of their own product development [62] - Plans for post-approval studies to assess real-world efficacy and safety of their therapies [26][27] Conclusion 4D Molecular Therapeutics is advancing its gene therapy programs with promising data and a strategic focus on large market opportunities. The company is committed to refining its clinical trials and ensuring alignment with regulatory expectations to maximize the potential of its innovative therapies.

Product Features & Benefits - Samsung Galaxy S25 FE is priced at $650 [1] - The phone supports 45W wired charging, reaching 65% charge in 30 minutes [1] - The phone features a 4,900 mAh battery, the largest in an FE phone [1] - The new model is 11% lighter (190 grams) and 8% thinner compared to the previous FE model [2] Design & Accessories - The S25 FE lacks internal magnets but supports magnetic accessories with a compatible case [2]

| 证券代码：603585 | 证券简称：苏利股份 | 公告编号：2025-066 | | --- | --- | --- | | 转债代码：113640 | 转债简称：苏利转债 | | 江苏苏利精细化工股份有限公司 2025 年半年度主要经营数据公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 | 主要产品 | 平均售价 | 上年同期 | 变动比率 | | --- | --- | --- | --- | | | （万元/吨） | （万元/吨） | （%） | | 农药及农药中间体 | 3.36 | 3.38 | -0.59 | | 阻燃剂及阻燃剂中间体 | 3.68 | 3.46 | 6.36 | 三、主要原材料的价格变动情况（不含税） | 主要原材料 | 平均采购价 | 上年同期 | 变动比率 | | --- | --- | --- | --- | | | （万元/吨） | （万元/吨） | （%） | | 溴素 | 2.01 | 1.87 | 7.49 | | 间二甲苯 | 0.82 | 0.84 | -2.3 ...

Core Viewpoint - Euroseas Ltd. has signed a contract for the construction of two additional modern fuel-efficient 4,300 teu container vessels, scheduled for delivery in March and May of 2028, with a total consideration of approximately $59.25 million for each vessel [1][2]. Company Overview - Euroseas Ltd. operates in the container shipping market and was formed on May 5, 2005, under the laws of the Republic of the Marshall Islands, consolidating the ship-owning interests of the Pittas family, which has been in the shipping business for over 150 years [5][6]. - The company trades on the NASDAQ Capital Market under the ticker ESEA [5]. Fleet Profile - Euroseas currently has a fleet of 22 vessels, including 15 feeder containerships and 7 intermediate containerships, with a total cargo capacity of 67,494 teu [7]. - After the sale of M/V Marcos V and the delivery of four intermediate containership newbuildings in 2027 and 2028, the fleet will consist of 25 vessels with a total carrying capacity of 78,344 teu [7]. Strategic Insights - The company is committed to growing and modernizing its fleet by investing in eco intermediate-sized containerships, a segment characterized by a low orderbook and an aging existing fleet, which is viewed as a sound investment strategy [2]. - The current charter arrangements secure revenue for the company in the coming years, positioning it to capitalize on future market opportunities and create long-term value for shareholders [2].

Core Insights - D-Wave Quantum Inc. has experienced over 1,000% stock growth in the past year, driven by rising interest in quantum computing [2] - The company is well-positioned to capitalize on the transition from research to commercial applications in quantum computing [10] Group 1: Growth Catalysts - The quantum computing industry is moving towards commercial applications, with D-Wave's quantum annealing technology effective in sectors like logistics, finance, drug discovery, and AI [3] - D-Wave's cloud-based quantum computing services present a significant revenue opportunity, allowing customers to access quantum capabilities without heavy capital investments [4] - Government investments in quantum research and development create opportunities for D-Wave to secure long-term contracts, ensuring consistent revenue streams [4] Group 2: Technological Advancements - D-Wave's latest 4,400-qubit processor marks a significant technological advancement, reinforcing its leadership in quantum annealing technology [5] - The Advantage2 quantum system, designed for complex optimization and AI tasks, showcases improvements in qubit connectivity, coherence, and energy efficiency [5] Group 3: Competitive Landscape - D-Wave's first-mover advantage in commercial quantum computing has led to stronger client relationships and advanced technology infrastructures [13] - The scalability of D-Wave's technology is evident, with successive generations showing significant improvements in qubit performance [13] Group 4: Market Context - The current environment, characterized by rising computational demands and substantial government spending, mirrors the early phases of the internet and AI revolutions [11] - D-Wave's established technology positions it to capture significant value as the quantum computing market evolves [11]

Core Viewpoint - The article discusses the IPO acceptance of Hebei Caike New Materials Technology Co., Ltd. on the Beijing Stock Exchange, aiming to raise 210 million yuan for various expansion and upgrade projects, including the production of key chemical materials [1][7]. Summary by Sections Company Overview - Hebei Caike New Materials Technology Co., Ltd. was established in 2005 and became a joint-stock company in 2021, focusing on the R&D, production, and sales of fine chemical products. It is recognized as a national-level specialized and innovative "little giant" enterprise [7]. Financial Performance - The company's projected revenues for 2022, 2023, and 2024 are approximately 360 million yuan, 380 million yuan, and 450 million yuan, respectively. Net profits are expected to be 83.14 million yuan, 84.86 million yuan, and 115.64 million yuan, with gross profit margins increasing from 30.61% to 36.11% over the same period [9]. Production Capacity and Utilization - Current production capacities include 15,000 tons/year of DMS, 4,500 tons/year of DMSS, and 2,000 tons/year of DATA. The company also produces 5,000 tons/year of DMAS. The capacity utilization rates for DMS, DMSS, DATA, and DMAS have shown significant improvement from 2022 to 2024, with DMSS reaching 98.22% and DATA exceeding 100% in 2024 [8][10]. Product Expansion Plans - The company plans to expand its production capacity for DMS, DMSS, and DATA, including a new project to produce 500 tons/year of BPDA, a key monomer for high-end electronic-grade polyimide films. This expansion is expected to enhance the company's competitive position in the high-end polyimide monomer market, which is currently dominated by international giants [2][4]. Market Position - The high-end polyimide monomer market is primarily led by companies like DuPont and Mitsubishi Chemical, with domestic competitors including Hebei Hailihengyuan New Materials and Shanghai Guchuang Chemical New Materials. The article highlights the active financing of some domestic players, indicating a growing interest in this sector [4][5].