Summary of Conference Call Records Industry Overview - The pharmaceutical sector showed strong performance in 2025, with the Guohai Pharmaceutical Index indicating a significant annual increase. However, 2026 is expected to present a more balanced market with multiple sub-sectors such as innovative drugs, CRO (Contract Research Organizations), traditional Chinese medicine, medical devices, and pharmacy distribution being favored [1][2][3]. Key Insights and Arguments - **Innovative Drugs**: The sector remains promising, with a strategic theme for 2026 titled "Innovative Drugs Going Global: From Initial Year to Major Year." The importance of Clinical Development Plans (CDP) is emphasized, recommending companies like Sanofi, Innovent Biologics, and KANGFANG Biopharma, while also highlighting KANGDE and Aidi Pharmaceutical [1][5]. - **CRO Sector**: The domestic CRO sector is viewed positively, benefiting from improved overseas demand and expectations of interest rate cuts by the Federal Reserve. Domestic demand is also expected to improve due to innovative drugs going global and better financing conditions [1][13]. - **Traditional Chinese Medicine**: The sales side is gradually recovering, with expectations for a strong start in Q1 2026. The sector is seen as having significant market share growth potential due to its consumer-oriented nature [1][16]. - **Retail Pharmacy**: The retail pharmacy sector is positioned for growth, with positive same-store sales data from leading chains. The sector is expected to benefit from the expansion of commercial health insurance and changes in basic medical insurance policies [1][14][15]. Notable Developments - **KANGDE**: The company has its dual formulation and three indications included in the medical insurance for the first time, expected to see significant volume in 2026. Aidi Pharmaceutical is also making strides in HIV treatment, with products expected to renew at original prices and maintain growth [1][7][12]. - **Claudin 18.2 ADC**: This product, owned by AstraZeneca, is set for global new drug application submission, indicating strong growth potential [1][9][10]. - **Surgical Robots**: The market for surgical robots is rapidly developing, with significant breakthroughs in overseas orders. Companies like Jingfeng Medical and MicroPort are performing well, with MicroPort ranking second globally in terms of order volume [1][17][18]. Challenges and Opportunities - **Domestic Drug Commercialization**: Domestic drugs face challenges in commercialization but are expected to enter hospitals after being included in medical insurance. The convenience of new formulations like KANGYUE's pre-filled syringe is highlighted [1][8]. - **Commercial Health Insurance**: The commercial health insurance sector is showing significant growth potential, with new policies expected to expand coverage for innovative products [1][19]. - **Basic Medical Insurance Changes**: Recent changes in basic medical insurance policies, including inter-provincial pooling and long-term care insurance, are anticipated to release medical demand and alleviate financial pressures [1][20][21]. Conclusion - The pharmaceutical industry is poised for a diverse and balanced growth trajectory in 2026, with various sub-sectors showing promise. Key players in innovative drugs, CRO, and retail pharmacy are expected to benefit from favorable market conditions and policy changes, while challenges in commercialization and competition remain.

Core Viewpoint - The company reported a slight revenue increase in 1H25, driven by strong sales growth of its core product, Tuoyi, while reducing its net loss compared to the previous year [1]. Group 1: Financial Performance - The company's revenue for 1H25 reached 1.168 billion yuan, representing a year-on-year growth of 46% [1]. - The net loss attributable to shareholders was 413 million yuan, which is a reduction in loss by 232 million yuan compared to the previous year [1]. Group 2: Product Development and Market Trends - Tuoyi's sales in the domestic market amounted to 954 million yuan in 1H25, showing a year-on-year increase of 42% [1]. - Tuoyi has received approval for 12 indications in China and is approved in 40 countries and regions, indicating a growing global commercialization value [1]. - The company expects accelerated global sales of Tuoyi as new indications enter the market and more countries approve its commercialization [1]. Group 3: Pipeline and Clinical Research - The company is focusing on the potential of its PD-1/VEGF dual antibody, JS207, which is currently in Phase II clinical trials for various cancers [2]. - The DKK1 monoclonal antibody has shown promising clinical data and is also in Phase II clinical trials, leading in global research progress [2]. - The company has established a pipeline covering over 50 innovative products across five therapeutic areas, with nearly 30 products in clinical research [2]. Group 4: Profit Forecast and Valuation - The company has adjusted its 2025 profit forecast from a loss of 662 million yuan to a loss of 917 million yuan, and introduced a 2026 forecast of a loss of 315 million yuan [3]. - The target price has been raised by 101.0% to 36.98 HKD, indicating a potential upside of 21.1% from the current stock price [3].

Summary of the Conference Call for XinNuoWei Company Overview - XinNuoWei has acquired Giant Stone Biotech, gaining an ADC platform with proprietary intellectual property, enhancing its innovation transformation [2][3] - The company was established in 2006, initially focusing on caffeine raw materials, and went public in 2019 [4] Key Products and Developments - **EGFR ADC (SYS6,010)**: - A flagship product targeting third-generation TKI-resistant EGFR mutant non-small cell lung cancer, expected to launch by 2027 [2][11] - Clinical data shows an ORR of 88.9% in second-line mutation patients and 34.2% in third-line patients, with good safety profiles [2][12] - Received multiple FDA fast track designations and breakthrough therapy qualifications [11][12] - **Claudin 18.2 ADC**: - Currently in Phase III clinical trials, showing an ORR of 47.1% in gastric cancer patients, with good safety, aiming for first-line treatment in combination with chemotherapy [2][14][15] - **Nectin-4 ADC**: - Planned to enter Phase III clinical trials in the second half of 2025, focusing on head and neck squamous cell carcinoma [2][15] - **MRNA Platform**: - Achieved breakthroughs with its LNP delivery system, avoiding international patent restrictions and reducing immunogenicity, with multiple MRNA vaccines in clinical development [2][16] Financial Performance and Projections - XinNuoWei's revenue projections are 2.392 billion yuan for 2025 and 2.765 billion yuan for 2026, supported by a strong pipeline and cash flow from existing products [3] - The company has a stable cash flow business, with rapid market entry of biosimilars like PD-1 and others, contributing to financial stability [5][17] Strategic Support and Structure - XinNuoWei is primarily controlled by the publicly listed Shiyao Group, which holds 75% of its shares, providing strong support in production, R&D, and commercialization [7][9] - The management team is experienced, with many members having long tenures at Shiyao Group or its subsidiaries [7] Acquisition and Growth Strategy - The company announced a cash increase of 1.87 billion yuan to acquire 51% of Giant Stone Biotech, expected to complete in January 2024 [6] - Plans to strengthen its innovative drug pipeline through further acquisitions, despite terminating a previous acquisition of Shiyao Baike to protect shareholder interests [6] Market Position and Competitive Advantage - XinNuoWei's ADC platform is characterized by excellent stability and uniformity, utilizing mainstream conjugation technologies and unique enzyme-based conjugation methods [10] - The company’s ADC products are positioned to compete effectively in the market, leveraging the strong sales team from Shiyao Group [15] Overall Assessment - XinNuoWei is positioned for significant growth through its innovative drug pipeline and stable cash flow from existing products, supported by Shiyao Group's resources [18] - The company is recognized as a high-potential enterprise in the biopharmaceutical sector, with a dual-driven development strategy [18]