从整体来看，当前创新药产业正迎来政策推动、需求爆发的双重利好，二者正共同激活新药研发需求， 并进一步传导至产业链上游的CXO板块。 智通财经APP获悉，创新药领域呈现三大趋势：国际化2.0纵深发展，2025年license-out交易数达103个、 首付款84.5亿美元创历史新高，自主出海企业享受估值溢价；政策支持力度空前，医保谈判效率提升并 首次设立商保创新药目录；技术驱动持续突破，ADC、IO双抗、GLP-1减重、小核酸药物多点开花。 招银国际认为，资本市场融资活动恢复，创新药出海交易规模扩张，国内创新药研发需求回暖，加上美 国进入降息周期，CXO企业下半年业绩表现有望复苏，招银国际预期已授权的创新药管线在海外的临 床发展可成为创新药板块最重要催化剂。 Wind资讯数据显示，在A股CXO板块29家上市公司中，有20家公司实现前三季度营收同比增长。 中信建投证券发布研究报告称，创新药领域呈现三大趋势：国际化2.0纵深发展，2025年license-out交易 数达103个、首付款84.5亿美元创历史新高，自主出海企业享受估值溢价；政策支持力度空前，医保谈 判效率提升并首次设立商保创新药目录；技术驱动持续突破 ...

26H1 催化丰富、CDK4 抑制剂重点转向一线 Bcl2 抑制剂索托克拉：预计26H1 启动ZS 固定剂量方案对比AV方案的III 期试验，ASH 数据来看有望成 为BIC；BTK CDAC/BGB-16673：预计26H1 读出用于后线CLL 的II 期潜在关键试验数据； CDK4 抑制剂/BGB-43395：预计26H1 启动用于1L BC 的III 期试验（不再开发2L）； 事件 公司公布2025 年三季报，25Q1-Q3 收入为276.0 亿元（+44.2%），归母净利润为11.4 亿元（去年同期 为-36.9 亿元），扣非归母净利润为9.7 亿元（去年同期为-39.9 亿元）。25Q3 收入为100.8 亿元 （+41.1%），归母净利润为6.9 亿元（去年同期为-8.1 亿元），扣非归母净利润为7.1 亿元（去年同期 为-8.7 亿元）。公司同时将全年收入指引从此前的50-53 亿美元调整至51-53 亿美元、全年GAAP 经营利 润为正的指引不变。 核心观点 25Q3 泽布替尼突破10 亿美元， 费用环比稳中略降前三季度拆分来看，泽布替尼全球收入达27.8 亿美元 （+53.2%），其中美国1 ...

买入|维持 证券研究报告：医药生物 | 公司点评报告 发布时间：2025-11-21 股票投资评级 个股表现 -10% 2% 14% 26% 38% 50% 62% 74% 86% 98% 2024-11 2025-01 2025-04 2025-06 2025-09 2025-11 百济神州 医药生物 资料来源：聚源，中邮证券研究所 公司基本情况 | 最新收盘价（元） | 298.80 | | --- | --- | | 总股本/流通股本（亿股）15.41 / 1.15 | | | 总市值/流通市值（亿元）4,604 / 344 | | | 52 周内最高/最低价 | 326.08 / 155.01 | | 资产负债率(%) | 43.6% | | 市盈率 | -82.09 | | 第一大股东 | Amgen Inc.,安进公司 | 研究所 分析师:盛丽华 SAC 登记编号:S1340525060001 Email:shenglihua@cnpsec.com 分析师:陈灿 SAC 登记编号:S1340525070001 Email:chencan@cnpsec.com 百济神州(688235) 盈利稳步提升 ...

Investment Rating - The report maintains a positive outlook on the overseas pharmaceutical sector, particularly focusing on innovative drugs and industry chain opportunities, with an investment rating of "Overweight" [1][6]. Core Insights - Multiple policies are supporting the development of the innovative drug industry, with domestic innovative drug transactions reaching historical highs in both value and quantity. The sector's valuation has rebounded from a low point, and leading companies are achieving profitability through increased commercial sales and licensing income [6][8]. - Companies like BeiGene are experiencing significant growth, with global sales exceeding $1 billion in Q3 2025, marking a 51% year-on-year increase. The company anticipates a positive GAAP operating profit for the full year 2025, raising its revenue guidance to $5.1-5.3 billion [1][6]. - Innovent Biologics is expanding its pipeline with a dual focus on oncology and non-oncology products, expecting to achieve positive non-IFRS net profit and EBITDA in 2024, with continued growth projected for 2025 [2][6]. - The report highlights the increasing R&D investments by leading pharmaceutical companies, which are enhancing their innovative pipelines and accelerating their transformation towards innovation [3][7]. Summary by Sections Section 1: Overseas Pharmaceuticals - The report emphasizes the focus on innovative drugs and the opportunities within the industry chain for 2026, noting the historical highs in transaction amounts and numbers for domestic innovative drugs going overseas [6][8]. - BeiGene's overseas sales are highlighted, with Q3 2025 global sales surpassing $1 billion and a significant year-on-year profit turnaround [1][6]. - Innovent Biologics is noted for its strategic partnerships and expected profitability in the coming years [2][6]. Section 2: Pharma Sector - Leading companies are rapidly increasing their R&D investments, which is expected to strengthen their innovative pipelines and global competitiveness [3][7]. - Companies like Hansoh Pharmaceutical and China Biologic Products are projected to see substantial growth in their innovative product revenues, with significant contributions expected in the coming years [3][7]. Section 3: CXO Sector - The report indicates a recovery in investment and financing for innovative drugs, which is likely to drive early-stage R&D investments and boost demand [8]. - Emerging fields such as peptides and ADCs are expected to open new growth opportunities, with a recommendation to focus on companies like WuXi AppTec and WuXi Biologics [8].

智通财经APP获悉，中信建投发布研报称，中国医药产业迈入"创新兑现+全球布局"的关键阶段，人口 与内需基数、全产业链制造能力构成核心支撑，企业积极探索多元化的出海路径。面对全球竞争与政策 深化，行业需"立足于内、创新引领、开拓于外"，对内强化供应链安全与合规能力，对外深化多元化出 海布局。展望2026年，重点把握创新商业化、全球化突破、政策优化带来的新增量及行业并购整合的机 遇。 中信建投主要观点如下： 出海的价值重塑：多维突破，构建全球化新格局 ①创新药：BD常态化，迈入国际化2.0时代;②产业链：国内和海外需求回暖;③原料药：化解短期扰 动，向特色原料药/ CDMO转型;④器械：开拓海外市场，创新器械自主销售与BD并行;⑤血制品/疫苗： 静丙海外注册、疫苗出海模式多元。 2026年投资展望：价值重塑，静待花开 ①创新主线：创新药(ADC、二代IO、小核酸、减重)、创新器械(AI医疗、脑机接口等)。②出海主线： 具备全球临床数据与国际化能力的创新药企、积极开拓海外市场的器械公司。③边际变化主线：1)政策 红利：医疗设备更新等;2)供求改善：CXO行业订单复苏、上游物料国产替代及海外销售。④整合主 线：器械细 ...

Core Viewpoint - Zejing Pharmaceutical is planning to launch an IPO on the Hong Kong Stock Exchange to enhance its international brand recognition and competitiveness, despite currently being unprofitable and facing financial pressures [1][2][3]. Financial Performance - As of Q3 2025, Zejing's debt-to-asset ratio reached 61.87%, the highest since Q3 2020, significantly exceeding the industry average of 34.36% by 27.51 percentage points [2][5]. - The company's liquidity ratios have declined, with the current ratio falling from 1.953 in Q3 2024 to 1.850 in Q3 2025, and the quick ratio decreasing from 1.831 to 1.721 in the same period [2]. - Operating cash flow has turned negative, with a net cash flow of -16.73 million yuan in the first three quarters of 2025, a 125.11% decrease from 66.65 million yuan in the same period of 2024 [2][5]. Revenue and Profitability - Despite revenue growth from 27.66 million yuan in 2020 to 533 million yuan in 2024, the company continues to report losses, with net losses of 319.2 million yuan in 2020 and narrowing to 93.42 million yuan in the first three quarters of 2025 [5][6]. - Sales expenses have consistently exceeded 50% of revenue, contributing to ongoing losses, with sales expenses rising from 35.07 million yuan in 2020 to 33.20 million yuan in 2025 [6]. Strategic Initiatives - The company aims to accelerate its internationalization strategy, having received FDA clinical trial approvals for multiple products, including ZG0895, which is in the I/II clinical trial phase [9][10]. - Zejing's previous attempt to internationalize through the acquisition of Gensun Pharmaceuticals resulted in continuous losses, leading to the decision to deregister Gensun to streamline operations and reduce costs [10]. Market Context - The global oncology drug market is projected to reach $649.7 billion by 2034, with a compound annual growth rate of 9.0% from 2024 to 2034, indicating significant growth potential for companies in this sector [6]. - The Chinese innovative drug market is experiencing rapid internationalization, with total foreign licensing amounts nearing $100 billion in 2025, highlighting the competitive landscape [7][9].

| 指数 | 收盘 | | 涨跌（％） | | | --- | --- | --- | --- | --- | | 名称 | （点） | 1 日 | 5 日 | 1 月 | | 上证指数 | 3940 | -0.81 | 2.61 | -1.57 | | 深证综指 | 2486 | -1.04 | 3.71 | -1.26 | | 风格指数 (％) | 昨日 | 近 1 个月 | 近 6 个月 | | --- | --- | --- | --- | | 大盘指数 | -0.53 | 1.15 | 17.53 | | 中盘指数 | -1.16 | 1.45 | 26.1 | | 小盘指数 | -0.94 | 4.27 | 23.91 | | 涨幅居前 行业(％) | 昨日 | 近 1 个月 | 近 6 个月 | | --- | --- | --- | --- | | 广告营销 | 3.99 | 15.01 | 16.32 | | 数字媒体 | 3.41 | 5.75 | 10.21 | | 互联网电商 | 2.28 | -0.02 | 7.06 | | 渔业 | 2.02 | 20.85 | 26.74 | | ...

在今年3月被调出港股通名单后，科笛-B(02487)的股价便开始了"过山车行情"。 虽然在退通后的一个月内迅速下探至年内最低点3.64港元，但在4月22披露年报后，科笛又凭借财报展示的扎实基本面迅速止跌，并在市场低估和港股创新 药牛市双重因素推动下，于接下来两个月走出一波2.5倍股价涨幅的拉升行情。 通过叠加恒生医疗保健指数不难看出，4月9日至6月16日这段时间区间内，科笛的股价涨幅斜率表现明显优于指数，但从时间跨度来看，科笛这波主升行情 仅持续至6月16日，而指数则是爬升到9月初才开始逐步调整。 实际上，从4月至今的涨跌表现来看，科笛与指数在走势上存在一定的同频波动，但振幅明显更大，在此过程中，"出通"带来的流动性问题则被一步步放 大。 拉升行情加速港股通资金出清 智通财经APP观察到，今年4月9日，科笛股价触底3.64港元，创下上市以来股价新低，但在随后的1个半月内持续反弹。5月20日，科笛盘中股价最高涨幅达 20%，最高价达到7.62港元，突破退通前的前高股价。也就是说，经过2个多月的股价震荡，科笛股价最终修复了"出通"后全部跌幅。 支撑其股价迅速拉升的原因除了港股医药板块回暖外，年报显示的扎实基本面是 ...

近期，第76届AASLD年会召开，作为全球权威肝脏病学会议之一，我国创新药企在会上表现如何？展 望后市，创新药行业景气度会持续延续吗？（资料参考：证券日报《我国乙肝创新药物临床研究取得突 破性进展》，2025.11.10） 我国创新药企业在会上表现如何？ 1. 中国学者与团队整体表现突出 我国多个研究团队发表AASLD 2025大会报告，发布乙肝基础研究、临床诊治、新药研发、肝癌发病机 制、肝硬化、脂肪肝等肝病领域多方面最新研究成果。多位中国专家获得重要荣誉，年轻学者也屡 获"青年研究者"奖；国内多家医院的年轻医生积极参与学术交流，展现出中国肝病领域雄厚的人才储 备，中国肝病研究在国际舞台上的影响力正在不断提升。（资料参考：上海证券报《我国乙肝创新药物 研究获进展 多项研究成果亮相AASLD》，2025.11.10）；国际肝病《AASLD名家连线丨尤红教授：聚 焦乙肝指南革新、新药研发突破与中国学术力量——大会三大核心亮点》，2025.11.16） 创新药后续景气度如何？ 创新药领域再添重磅研究成果，产业后续景气度会持续吗？综合来看，创新药正受益于多个积极的行业 趋势： 一、出海热潮持续。创新药"出海"已成为 ...

Group 1 - The report emphasizes the rapid development of China's innovative pharmaceuticals, highlighting that the number of clinical trials has reached a global leading position, with a significant increase in new drug approvals [3][5][7] - Chinese pharmaceutical companies are transitioning from a "fast follower" to an "innovation leader" model, actively engaging in cutting-edge fields such as ADC, bispecific antibodies, and mRNA vaccines, with a notable increase in the number of products in late-stage development [8][11][18] - The report identifies two main investment directions: the transformation of biotech companies into biopharma and the revaluation of traditional pharmaceutical companies during their innovation transition, suggesting specific companies to watch in both categories [3][4] Group 2 - China's integration into the global innovative drug value chain is deepening, with a growing number of global multi-center clinical trials led by Chinese companies, indicating a shift in the global drug development landscape [3][24] - The report notes that the contribution of Chinese companies to global clinical trials has significantly increased, with a projection of 1,903 innovative drug clinical trials registered in China by 2024 [7][24] - The report highlights the increasing competitiveness of Chinese companies in high-potential therapeutic areas, particularly in oncology, metabolic diseases, and autoimmune diseases, with substantial market shares in these segments [18][19] Group 3 - The report discusses the rising trend of BD (business development) transactions involving Chinese assets, with a notable increase in transaction amounts and numbers, indicating China's growing influence in the global pharmaceutical innovation landscape [33][44] - It highlights that the majority of license-out projects are now in early stages, reflecting the international interest in early-stage Chinese innovations, particularly in oncology and metabolic therapies [39][44] - The report points out that major multinational corporations (MNCs) are increasingly seeking next-generation blockbuster products from China to fill revenue gaps due to impending patent expirations [62][66]