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超93亿美元!siRNA赛道升温,中国药企竞速全球
(原标题:超93亿美元!siRNA赛道升温,中国药企竞速全球) 21世纪经济报道记者 韩利明 继2024年1月达成两项潜在价值41.65亿美元的独家许可合作后,舶望制药(Argo Biopharma)与诺华 (NYSE: NVS)在心血管治疗领域的合作再度升级。 根据新的协议内容,舶望制药授予诺华两款处于早研阶段分子的中国以外权益的选择权,用于治疗重度 高甘油三酯血症 (sHTG) 和混合型血脂异常,以及就BW-00112 (ANGPTL3) 产品的优先谈判权。该产品 目前在美国和中国处于II期临床试验阶段,后续将由舶望制药主导开展联合用药的临床试验。 此外,针对另一款处于临床前研究阶段的siRNA(小分子干扰核糖核酸)候选药物,舶望制药授予诺华 独家中国地区以外许可,并包含在美国和中国分享损益 (P&L) 的互惠选择权,该产品预计2026年将启 动I期临床试验。 基于此,舶望制药将获得1.6亿美元的预付款,并可能获得潜在的里程碑和期权付款以及商业销售的分 级特许权使用费,总潜在里程碑价值高达52亿美元。此外,诺华已初步意向参与舶望制药的下轮股权融 资,但具体参与(包括投资金额与时间)仍需履行例行尽职调查、并 ...
九洲药业(603456):经营业绩修复向好,CDMO业务稳健增长
Investment Rating - The investment rating for the company is "Buy" and the rating has been maintained [4][7]. Core Views - The company's operating performance is recovering positively, with a strong growth in CDMO (Contract Development and Manufacturing Organization) business [2][3]. - The company reported a revenue of 2.871 billion yuan for the first half of 2025, a year-on-year increase of 3.86%, and a net profit attributable to the parent company of 526 million yuan, up 10.70% year-on-year [2]. - The cash flow from operating activities showed significant improvement, reaching 845 million yuan, a year-on-year increase of 164.50% [2]. Summary by Sections Financial Performance - In the first half of 2025, the company achieved a revenue of 2.871 billion yuan, with CDMO business sales revenue at 2.291 billion yuan, growing 16.27% year-on-year [2][3]. - The API (Active Pharmaceutical Ingredient) and intermediate business revenue was 523 million yuan, down 28.48% year-on-year, but the gross margin improved by 2.07 percentage points to 23.26% [2][6]. - The company expects a net profit attributable to the parent company of 933 million yuan in 2025, with an EPS of 0.97 yuan per share [7]. Business Development - The CDMO project pipeline continues to expand, with new customer acquisitions progressing smoothly [3][5]. - As of June 30, 2025, the company has 38 launched projects and 1,086 projects in clinical phases, showing significant growth compared to 2024 [3]. - The TIDES division and related technology platforms are rapidly developing, with plans for capacity expansion to meet increasing demand [5]. Market Outlook - The company is well-positioned to benefit from the growth in the global market for peptides and conjugated drugs, with expectations for continued project acquisition [5]. - The forecast for net profit from 2025 to 2027 is 933 million, 1.076 billion, and 1.156 billion yuan respectively, indicating a positive growth trajectory [7].