2025 年 10 月 20 日 证券研究报告 行业周报 行业评级： | 报告期：2025.10.9-2025.10.19 | | | --- | --- | | 投资评级 | 看好 | | 评级变动 | 维持评级 | 分析师： huchenxi@gwgsc.com 执业证书编号：S0200518090001 联系电话：010-68085205 分析师 魏钰琪 weiyuqi@gwgsc.com 执业证书编号：S0200525060001 联系电话：010-68099389 公司地址：北京市丰台区凤凰嘴街 2 号院 1 号楼中国长城资产大厦 16 层 医药生物行业双周报 2025 年第 21 期总第 144 期 政策规范临床研究路径 重磅创新成果集中亮相 2025ESMO 大会 行业回顾 本报告期医药生物行业指数跌幅为 3.65%，在申万 31 个一级行业中 位居第 21，跑输沪深 300 指数（-2.73%）。从子行业来看，中药、 线下药店涨幅居前，涨幅分别为 1.90%、0.88%；医疗研发外包、医 疗设备跌幅居前，跌幅分别为 11.40%、5.54%。 行业走势： 估值方面，截至 2025 年 10 月 ...

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index experienced a decline of 2.72%, ranking 23rd among 31 primary industries, underperforming the CSI 300 index which declined by 2.62% [4][16] - The industry valuation as of September 30, 2025, is a PE (TTM overall method, excluding negative values) of 31.23x, down from 31.79x in the previous period, indicating a downward trend and below the average [21] - The top three sub-industries in terms of PE (TTM overall method, excluding negative values) are vaccines (55.74x), medical devices (41.29x), and hospitals (39.51x), with the median at 33.19x, while pharmaceutical circulation has the lowest valuation at 14.34x [21] Industry Review - The report highlights that during the reporting period, 51 listed companies in the pharmaceutical and biotechnology sector had a net reduction in shareholders amounting to 2.435 billion yuan, with 14 companies increasing their holdings by 681 million yuan and 37 companies reducing their holdings by 3.116 billion yuan [4] - The report emphasizes the importance of upcoming clinical data and the strong fundamentals of companies ahead of the ESMO 2025 conference, which is expected to showcase significant clinical research results from various domestic pharmaceutical companies [7][8] Important Industry News - AstraZeneca plans to list on the New York Stock Exchange [6] - The report mentions the approval of a new oral SERD drug by Eli Lilly, marking it as the second such drug approved globally [8][45] - The approval of the first domestic quadrivalent HPV vaccine in China is expected to expand the coverage population and potentially be priced lower than imported versions [8][50][52]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [2] Core Views - The pharmaceutical and biotechnology industry index increased by 1.03% during the reporting period, outperforming the CSI 300 index which rose by 0.56% [3][16] - The industry valuation as of September 12, 2025, shows a PE (TTM overall method, excluding negative values) of 31.79x, up from 31.41x in the previous period, indicating an upward trend but still below the average [4][22] - Recent academic conferences and industry dynamics highlight the strength and resilience of China's innovative drug development capabilities [7][8] Industry Trends - The top-performing sub-industries include other biological products and medical research outsourcing, with increases of 4.17% and 3.64% respectively, while traditional Chinese medicine and hospitals saw declines of 1.36% and 1.23% [3][16] - A total of 48 listed companies in the pharmaceutical and biotechnology sector experienced a net reduction in shareholder holdings amounting to 3.686 billion yuan, with 6 companies increasing their holdings by 406 million yuan and 42 companies reducing by 4.092 billion yuan [4] Important Industry News - The NMPA has optimized the review and approval process for clinical trials of innovative drugs, aiming to enhance the efficiency of clinical research [26][27] - Sanofi's Teplizumab has been approved by the NMPA as the first innovative drug to delay the progression of type 1 diabetes [37][38] - The U.S. government is considering strict restrictions on Chinese pharmaceuticals, which may impact the industry [49][50] Investment Recommendations - Investors are advised to focus on companies with differentiated advantages in innovative pipelines, particularly in oncology, autoimmune, and metabolic disease areas [8] - Companies with international standard clinical and data capabilities, as well as those with mature license-out capabilities and global collaboration resources, are also recommended for investment [8]

Investment Rating - The investment rating for the company is "Accumulate" [1][3][7] Core Views - The company has shown steady revenue growth with a 32.73% year-on-year increase in revenue for the first half of 2025, reaching 353 million yuan [3] - The net profit attributable to the parent company for the same period was 25 million yuan, reflecting a significant year-on-year growth of 54.99% [3] - The company has successfully established a comprehensive service platform and maintains high R&D investment, which supports its growth potential [6][7] Financial Performance - In the first half of 2025, the company achieved a revenue of 353 million yuan, with quarterly revenues of 169 million yuan in Q1 and 183 million yuan in Q2, marking an 8.19% quarter-on-quarter increase [3] - The company’s net profit margin improved, with sales gross margins of 28.39% and 27.51% in Q1 and Q2 respectively, compared to 20.61% and 26.84% in the same periods of 2024 [3] - The company’s operating cash flow turned positive, reaching 39 million yuan in the first half of 2025 [3] Business Segments - The drug discovery segment generated 186 million yuan, accounting for 52.67% of total revenue, with a year-on-year growth of 17.41% [3] - The commercial production segment saw revenue of 123 million yuan, representing 35.00% of total revenue, with a remarkable growth rate of 55.89% [3] - The process research and development segment contributed 29 million yuan, with a growth rate of 30.13% [3] Market Expansion - The company experienced significant growth in new orders and customer acquisition, with Q2 new orders in the service segment reaching 246 million yuan, a 98.77% increase from Q1 [4] - The number of new customers in the service segment increased by 35.29% in Q2, while the commercial production segment added 20% more customers [4] R&D and Technology Platforms - The company invested 19 million yuan in R&D in the first half of 2025, representing 5.39% of its revenue [5] - The CADD/AIDD technology platform has supported 95 new drug projects, with 7 projects entering clinical trials [5] - The DiOrion platform has expanded its capabilities, enhancing drug discovery efficiency and supporting complex molecular types [5] Profit Forecast - The company’s projected net profits for 2025-2027 are 639 million yuan, 817 million yuan, and 979 million yuan respectively, with corresponding EPS of 0.46, 0.59, and 0.70 yuan [6][10]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index increased by 0.39% during the reporting period, ranking 26th among 31 primary industries, underperforming the CSI 300 index which rose by 7.01% [4][14] - The industry shows resilience despite a slight decline in overall revenue and net profit for A-share pharmaceutical companies in the first half of the year, with stable gross profit margins [6] - The CXO sector has returned to high prosperity with significant growth in performance, while the chemical preparation sector shows a mixed performance [6] - The report highlights the approval of several innovative drugs, including Novartis' "Acrux" for IgA nephropathy and the first oral HER2 inhibitor "Zongertinib" by Boehringer Ingelheim [5][41] Industry Review - The pharmaceutical and biotechnology industry PE (TTM, excluding negative values) is at 31.41x, slightly down from 31.38x in the previous period, indicating a valuation below the average [20] - The top three sub-industries by PE are vaccines (56.18x), hospitals (42.24x), and medical devices (40.66x), while pharmaceutical circulation has the lowest valuation at 14.06x [20] - In the reporting period, 29 listed companies in the pharmaceutical and biotechnology sector experienced a net reduction in shareholder holdings amounting to 1 billion CNY [4] Important Industry News - The CDE released a draft guideline for single-arm clinical trials to support the regular approval of anti-tumor drugs [25] - Novartis' IgA nephropathy drug "Acrux" received NMPA approval, marking it as the first of its kind in China [28] - The approval of the new generation ALK inhibitor "Dirocitinib" by Xuan Bamboo Biotech for treating ALK-positive non-small cell lung cancer [36] - The approval of the ADC "Datopotamab deruxtecan" for treating HR-positive, HER2-negative breast cancer [39] Investment Recommendations - The report suggests focusing on investment opportunities in the chemical preparation sector, particularly innovative drugs, and the CXO sector due to their clear long-term growth logic [6]

Investment Rating - The investment rating for the company is "Accumulate" [2][6][8] Core Views - The company's performance shows marginal improvement with a rapid increase in new orders. The industry demand is recovering, leading to a significant rise in new contracts [3][4] - The company reported a slight decline in revenue and net profit for the first half of 2025, but the second quarter showed a strong recovery with revenue growth of 1.82% year-on-year and a remarkable net profit increase of 45.17% year-on-year [2][3] - The gross profit margin improved significantly from 16.23% in Q1 to 29.67% in Q2, indicating a recovery in profitability [3] Summary by Sections Financial Performance - In the first half of 2025, the company achieved revenue of 390 million yuan, a year-on-year decrease of 1.08%, and a net profit of 54 million yuan, down 1.40% year-on-year. The second quarter saw revenue of 214 million yuan, up 1.82% year-on-year and 21.06% quarter-on-quarter, with net profit reaching 47 million yuan, up 45.17% year-on-year and 528.73% quarter-on-quarter [2][3] - The company’s total market capitalization is 3.735 billion yuan, with a circulating market value of 3.561 billion yuan [2][6] Order Growth - The company signed new contracts worth 600 million yuan in the first half of 2025, representing a year-on-year increase of 40.12%. The total amount of contracts on hand reached nearly 2 billion yuan, a year-on-year increase of 9.45% [3][4] Profitability and Cost Control - The sales gross margin increased significantly, and the expense ratios remained stable, indicating effective cost control. The management, sales, and financial expense ratios in Q2 were 9.47%, 1.05%, and -0.17%, respectively, all slightly down from Q1 [3]

Investment Rating - The investment rating for the company is "Buy" and the rating has been maintained [1][3][5] Core Views - The company reported strong performance in the first half of 2025, achieving revenue of 2.374 billion yuan, a year-on-year increase of 50.57%, and a net profit attributable to shareholders of 1.051 billion yuan, up 60.22% year-on-year [3][5] - The growth driver for the company's performance is the strong sales of Vomeletin, which generated sales revenue of 2.36 billion yuan in 2021, 7.90 billion yuan in 2022, 19.78 billion yuan in 2023, and is projected to reach 3.506 billion yuan in 2024, with year-on-year growth rates of 235.29%, 150.22%, and 77.27% respectively [3][5] - The company is expanding the indications for Vomeletin, with new treatments expected to be approved as early as next year [3][4] - The commercialization of Golai Reza has begun, which is expected to drive future growth [4][5] Summary by Sections Financial Performance - In the first half of 2025, the company achieved a net profit margin of 44.29%, an increase of 4.10 percentage points from the end of 2024 [4] - The gross profit margin was 96.87%, up 0.9 percentage points from the end of 2024 [4] - Research and development expenses reached 297 million yuan, a 126% increase year-on-year, accounting for 12.50% of revenue [3][4] Future Projections - The company has adjusted its net profit forecasts for 2025-2027 to 2.028 billion yuan, 2.301 billion yuan, and 2.650 billion yuan respectively, with corresponding EPS of 4.51 yuan, 5.11 yuan, and 5.89 yuan [5][9] - The current stock price corresponds to a PE ratio of 25, 22, and 19 for the years 2025, 2026, and 2027 respectively [5][9] Market Position - The company is positioned to leverage its strengths in promoting the RET inhibitor Pralsetinib, alongside the ongoing commercialization of Golai Reza and the rapid growth of Vomeletin [5]

Investment Rating - The investment rating for the company is "Accumulate" [6] Core Views - The company reported a revenue of 1.023 billion yuan for the first half of 2025, representing a year-on-year growth of 9.92%. The net profit attributable to the parent company was 303 million yuan, up 11.34% year-on-year [1][6] - The color sorting machine business accounted for over 70% of total revenue, with a significant increase in gross margin [1] - The company launched the new AI+ intelligent color sorting machine "Meiya Master 4.0," enhancing its market competitiveness [1] - The medical equipment segment stabilized with a revenue of 204 million yuan, maintaining a gross margin of 48.45% [1][5] Financial Performance - The company achieved a net cash flow from operating activities of 393 million yuan, a year-on-year increase of 125.28% [1] - The overall gross margin for the first half of 2025 was 52.14%, an increase of 1.26 percentage points year-on-year [1] - The color sorting machine segment's revenue was 742 million yuan, with a gross margin of 51.87%, up 2.84 percentage points year-on-year [1] - The projected net profits for 2025-2027 are 730 million, 805 million, and 867 million yuan respectively, with corresponding EPS of 0.83, 0.91, and 0.98 yuan per share [6][9] Market Position - The company has established a leading position in the color sorting machine market through continuous innovation and product iteration [1] - The "Meiya Meiya" digital cloud platform for oral health has surpassed 10,000 end users, laying a solid foundation for future growth in the medical business [5]

Investment Rating - The investment rating for the company is "Buy" and the rating has been maintained [1][3]. Core Insights - The company reported a revenue of 731 million yuan for the first half of 2025, representing a year-on-year growth of 74.26%. The pharmaceutical sales revenue was 641 million yuan, up 53.47% year-on-year. However, the net profit attributable to shareholders was -30 million yuan, and the net profit after deducting non-recurring gains and losses was -82 million yuan. R&D expenses increased by 6.71% to 450 million yuan [3][9]. - The core product, Acalabrutinib, has shown strong growth with sales reaching 637 million yuan, a year-on-year increase of 52.84%. It has been approved for first-line treatment of CLL/SLL and is expected to drive future sales growth [4][9]. - Tafasitamab has been approved for commercialization, which is anticipated to contribute to revenue growth. The company is preparing for its market launch in Q3 to Q4 of 2025 [4][9]. - The company is advancing its pipeline with multiple clinical trials, including ICP-248 for various indications, which is expected to be a strategic pillar for the company's hematology product line [5][6][9]. - The company is also exploring autoimmune indications for Acalabrutinib, with several clinical trials expected to start in the second half of 2025 [6][9]. - The company has submitted an NDA for ICP-723 and received priority review, which is expected to enhance its solid tumor product pipeline [7][9]. Financial Summary - The company expects revenues of 1.41 billion yuan in 2025, 1.70 billion yuan in 2026, and 2.06 billion yuan in 2027, with net profits projected at -43 million yuan, -36 million yuan, and -24 million yuan respectively [9][11]. - The company maintains a high gross margin, projected at around 86.89% in 2025, with a net profit margin improving from -43.65% in 2024 to -30.29% in 2025 [11][13].

Investment Rating - The investment rating for the company is "Buy" and the rating has been maintained [3][9] Core Views - The company reported a revenue of 21.675 billion yuan for the first half of 2025, representing a year-on-year growth of 3.39%, with a net profit attributable to shareholders of 1.815 billion yuan, up 7.01% year-on-year [3] - The pharmaceutical industrial segment is the core growth engine, achieving a net profit of 1.580 billion yuan, a year-on-year increase of 14.09% [3] - The innovative product business has entered a high-growth phase, with sales and agency service revenue reaching 1.084 billion yuan, a 59% increase year-on-year [3][4] - The company has over 80 innovative drug pipelines under development, with significant investments in R&D [3][4] Summary by Sections Financial Performance - For the first half of 2025, the company achieved a revenue of 21.675 billion yuan, with Q1 and Q2 revenues of 10.736 billion yuan and 10.939 billion yuan respectively, showing growth rates of 3.12% and 3.65% [3] - The pharmaceutical commercial, industrial, and industrial microbiology segments reported revenues of 13.947 billion yuan, 7.317 billion yuan, and 368 million yuan respectively, with growth rates of 2.91%, 9.24%, and 29% [3] Innovative Products - The innovative product revenue surpassed 1 billion yuan, driven by new product approvals and sales, with key products including Nixinna®, Liraglutide®, and CAR-T product Saikeze® [3][4] - The company’s R&D investment reached 1.484 billion yuan in the first half of 2025, a 33.75% increase year-on-year, with direct R&D spending accounting for 15.97% of pharmaceutical industrial revenue [3][4] Market Position and Future Outlook - The company is focusing on expanding its international market presence and integrating into the global pharmaceutical supply chain, with the industrial microbiology segment achieving a revenue of 368 million yuan, a 29% increase year-on-year [7] - The aesthetic medicine segment experienced a revenue of 1.112 billion yuan, showing a decline but with signs of recovery in the second quarter [5][7] - The company expects to maintain a growth trend in its pharmaceutical industrial segment, with projected net profits of 4.028 billion yuan, 4.559 billion yuan, and 5.120 billion yuan for 2025, 2026, and 2027 respectively [9][11]