Financial Results - Revenues for Q1-25 were $88,076, an increase of $1,472 or 2% compared to Q1-24, driven by growth in key promoted products, partially offset by declines in mature products and currency depreciation in select LATAM countries [7][13] - Gross margin decreased to $34,866 or 40% of revenues from $41,699 or 48% in the same period last year, primarily due to hyperinflation accounting in Argentina [7][19] - Operating loss was $5,537 compared to an operating income of $2,660 in Q1-24 [11][25] - Net income was $2,185, a significant improvement from a net loss of $4,546 in the prior year [25] - Adjusted revenues were $87,979, reflecting a 3% increase, and $6,631 or 8% on a constant currency basis [7][13] Corporate Developments - The company entered into an asset purchase agreement to acquire the Paladin business for $100,000, with an additional $20,000 for inventory, and potential future payments of up to $15,000 based on sales milestones [7][36] - A working capital line of credit of USD 40,000 was obtained from Citibank, with USD 35,000 withdrawn [6][37] - The company in-licensed Onicit IV for distribution in Mexico, Brazil, and select LATAM countries, and submitted Tavalisse for ANMAT approval in Argentina [8][33][35] Shareholder Updates - Shareholders re-elected members to the Board of Directors, including Jonathan Ross Goodman and Samira Sakhia [9] Financial Outlook - The company reaffirmed its financial guidance for 2025, expecting revenues between $390 million to $405 million and adjusted EBITDA to be approximately 13% of revenues [38]

Core Viewpoint - Incyte Corporation reported strong first-quarter 2025 results, with adjusted earnings and revenues exceeding expectations, driven by the performance of its lead drug Jakafi and the launch of Opzelura [1][3][4]. Financial Performance - Adjusted earnings per share for Q1 2025 were $1.16, surpassing the Zacks Consensus Estimate of $1.01 and up from 58 cents in the same quarter last year [1]. - Total revenues reached $1.05 billion, a 20% increase year over year, exceeding the Zacks Consensus Estimate of $1 billion [1]. - Jakafi generated revenues of $709.4 million, a 24% increase from the previous year, driven by a 10% rise in paid demand, and also beating the Zacks Consensus Estimate of $661.1 million [3]. - Opzelura cream sales were $118.7 million, up 38% year over year, although it fell short of the Zacks Consensus Estimate of $127 million [4]. - Newly approved Zynyz generated $3 million in sales, significantly up from the previous year and exceeding the Zacks Consensus Estimate of $1.9 million [5]. Product Performance - Iclusig net product revenues were $29.5 million, down 3% year over year but above the Zacks Consensus Estimate of $28.7 million [5]. - Pemazyre sales were $18.4 million, reflecting a 4% year-over-year increase but missing the Zacks Consensus Estimate of $21.6 million [5]. - Minjuvi revenues totaled $29.6 million, a 24% increase year over year, but below the Zacks Consensus Estimate of $33.4 million [6]. - Axatilimab-csfr (Niktimvo) recorded $13.6 million in sales following its launch in Q1 2025 [7]. Guidance and Future Outlook - The company raised its 2025 Jakafi revenue guidance to a range of $2.95-$3 billion, up from the previous range of $2.93-$2.98 billion [15]. - Opzelura net product revenues are expected to be between $630-$670 million in 2025 [15]. - Adjusted research and development expenses are projected to be in the range of $1.78-$1.81 billion, while adjusted selling, general and administrative expenses are expected to be between $1.16-$1.19 billion [16]. Cash Position - As of March 31, 2025, the company had cash, cash equivalents, and marketable securities totaling $2.4 billion, an increase from $2.2 billion as of December 31, 2024 [13].

Core Insights - Incyte reported $1.05 billion in revenue for Q1 2025, a 19.5% year-over-year increase, with an EPS of $1.16 compared to $0.64 a year ago [1] - The revenue exceeded the Zacks Consensus Estimate of $1.01 billion by 4.66%, and the EPS also surpassed the consensus estimate of $1.01 by 14.85% [1] Revenue Performance - Net product revenues for Pemazyre were $18.44 million, below the average estimate of $21.62 million, representing a 4.3% year-over-year increase [4] - Total product revenues reached $922.27 million, exceeding the average estimate of $876.70 million, with a year-over-year change of 26.4% [4] - Iclusig generated $29.54 million in net product revenues, slightly above the average estimate of $28.67 million, but a 2.6% decrease year-over-year [4] - Minjuvi/Monjuvi reported $29.55 million, below the average estimate of $33.43 million, with a year-over-year increase of 23.8% [4] - Opzelura's net product revenues were $118.71 million, below the average estimate of $126.95 million, reflecting a 38.5% year-over-year increase [4] - Jakafi generated $709.41 million, surpassing the average estimate of $661.10 million, with a 24.1% year-over-year increase [4] - Zynyz reported $3.01 million, exceeding the average estimate of $1.92 million [4] Royalty Revenues - Jakavi's royalty revenues were $92.15 million, below the average estimate of $97.41 million, with a 2.9% year-over-year increase [4] - Total product royalty revenues reached $130.62 million, below the average estimate of $139.49 million, reflecting a 3.7% year-over-year increase [4] - Olumiant's royalty revenues were $30.80 million, below the average estimate of $34.90 million, with a 0.7% year-over-year change [4] - Tabrecta generated $6.41 million, exceeding the average estimate of $5.93 million, with a 22.5% year-over-year increase [4] Stock Performance - Incyte's shares returned -1.7% over the past month, compared to the S&P 500 composite's -0.8% change [3] - The stock currently holds a Zacks Rank 3 (Hold), indicating potential performance in line with the broader market in the near term [3]

MONTREAL, March 26, 2025 (GLOBE NEWSWIRE) -- Knight Therapeutics Inc., (TSX:GUD) ("Knight"), a pan-American (ex-US) specialty pharmaceutical company, announced today the launch of Minjuvi® (tafasitamab) by its Mexican affiliate, Grupo Biotoscana de Especialidad S.A. de C.V. Minjuvi® in combination with lenalidomide, followed by Minjuvi® monotherapy, is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), who are not eligible for autologous stem cel ...