Core Insights - AbbVie has effectively managed its transition post-Humira, with strong sales from newer immunology drugs, Rinvoq and Skyrizi, mitigating the impact of Humira's erosion [1][8] Sales Performance - Skyrizi sales increased by 62% year-over-year to $4.42 billion, while Rinvoq sales rose by 41% to $2.03 billion, driven by strong volume growth and market share gains, particularly in the inflammatory bowel disease (IBD) segment [2][8] - AbbVie expects combined sales of Skyrizi and Rinvoq to exceed $25 billion in 2025, with Skyrizi's sales guidance raised to $17.1 billion and Rinvoq on track for approximately $8.2 billion [3][8] Market Position and Competition - AbbVie faces competition in the immunology space from Johnson & Johnson, which markets Stelara and Tremfya, and Eli Lilly, which has recently expanded its portfolio with the FDA approval of Omvoh for UC and CD [5][6] Valuation and Estimates - AbbVie shares are trading at a premium, with a price/earnings (P/E) ratio of 14.58, slightly above the industry average of 14.28 and higher than its five-year mean of 12.61 [10] - Bottom-line estimate movements for 2025 and 2026 have shown mixed trends over the past week, with slight revisions in estimates [12]

Core Viewpoint - Eli Lilly and Company's stock has declined 15.7% over the past year due to a first-quarter earnings miss, guidance cut, and positive developments at rival Novo Nordisk, alongside broader economic challenges [1][10]. Group 1: Company Performance - Lilly's cardiometabolic division is its strongest segment, driven by the success of GLP-1 therapies Mounjaro and Zepbound, which together account for approximately 48% of total revenues [3][4]. - Despite slower-than-expected sales in the second half of 2024, Mounjaro and Zepbound saw a resurgence in the first quarter of 2025 due to new international market launches and improved supply [5][6]. - Lilly anticipates continued growth for Mounjaro and Zepbound through expanded international uptake and deeper market penetration in the U.S. [6][7]. Group 2: Product Pipeline and Future Growth - Lilly has secured approvals for several new therapies, including Omvoh, Jaypirca, Ebglyss, and Kisunla, which are expected to contribute to revenue growth in 2025 [10][11]. - The company is also advancing its pipeline in obesity, diabetes, and cancer, with several key mid and late-stage data readouts expected this year [12]. - Lilly is diversifying beyond GLP-1 drugs by expanding into cardiovascular, oncology, and neuroscience areas, including recent M&A deals to enhance its pipeline [13]. Group 3: Competitive Landscape - The obesity market is projected to reach $100 billion by 2030, with Lilly and Novo Nordisk currently dominating the space [14]. - Mounjaro and Zepbound face competition from Novo Nordisk's semaglutide products and emerging candidates from companies like Amgen and Viking Therapeutics [15][17]. - Other pharmaceutical companies are also entering the obesity market, which could challenge Lilly's and Novo Nordisk's market positions [18]. Group 4: Financial Outlook - Lilly expects 2025 revenues to be between $58 billion and $61 billion, indicating a year-over-year growth of approximately 32% [30]. - The company's stock has increased by over 400% in the past five years, primarily due to successful drug launches and a strong pipeline [29]. - Despite a high valuation with a price/earnings ratio of 29.54 compared to the industry average of 15.04, Lilly's stock is trading below its five-year mean [23].

Core Insights - AbbVie has effectively managed the loss of exclusivity for Humira by launching two new immunology drugs, Skyrizi and Rinvoq, with significant sales expected in the upcoming quarterly report [1][3][8] Group 1: Drug Performance and Sales Expectations - Skyrizi and Rinvoq have been launched across major indications previously covered by Humira, including a new indication for atopic dermatitis, showing strong performance particularly in inflammatory bowel disease (IBD) [2] - AbbVie anticipates combined sales of $6 billion for Skyrizi and Rinvoq in the second quarter, with individual estimates of $4 billion for Skyrizi and $2 billion for Rinvoq [3][8] Group 2: Expansion in Other Therapeutic Areas - AbbVie is also expanding its oncology and neuroscience portfolios, adding new therapies such as Epkinly, Elahere, and Emrelis, bringing its total oncology therapies to five [4] - The neuroscience segment has seen growth driven by increased uptake of migraine treatments, Ubrelvy and Qulipta [4] Group 3: Competitive Landscape - The immunology market is highly competitive, with key players like Johnson & Johnson and Eli Lilly also expanding their portfolios. Johnson & Johnson is focusing on Tremfya after Stelara lost patent exclusivity [5] - Eli Lilly has recently received FDA approval for Omvoh, marking its entry into the IBD market, which enhances its immunology offerings [6] Group 4: Valuation and Market Performance - AbbVie shares have outperformed the industry year to date, trading at a price/earnings (P/E) ratio of 14.21, slightly below the industry average of 15.01 [7][10] - The bottom-line estimate for AbbVie in 2025 remains at $12.28, with a slight increase in the 2026 estimate from $14.05 to $14.06 [11]

Core Insights - Eli Lilly and Company (LLY) has reached a significant support level, making it an attractive option for investors from a technical standpoint, with the stock breaking through its 50-day simple moving average (SMA), indicating a potential short-term bullish trend [1][9] - The company's cardiometabolic business, particularly the success of its diabetes drug Mounjaro and weight loss medicine Zepbound, has become a key driver of revenue [3][4] - Despite some challenges, Lilly expects substantial revenue growth in 2025, driven by Mounjaro, Zepbound, and other new drug approvals [31][32] Company Performance - LLY's stock has traded below its 50-day average since early May due to an earnings miss and guidance cut, but it has recently shown signs of recovery [2][9] - Mounjaro and Zepbound generated combined sales of $6.15 billion in Q1 2025, accounting for approximately 48% of the company's total revenues [4][9] - The company expects 2025 revenues to be between $58 billion and $61 billion, reflecting a 32% year-over-year growth [31][32] Product Pipeline and Growth Drivers - Lilly has launched Mounjaro in new international markets, including China, India, and Mexico, which is expected to drive future sales growth [6][11] - The FDA approved Zepbound for a second indication, which could further enhance sales [7] - Lilly's pipeline includes several promising candidates in obesity, diabetes, and cancer, with key mid and late-stage data readouts expected this year [11][12] Competitive Landscape - The obesity market is projected to expand to $100 billion by 2030, leading to increased competition, particularly from Novo Nordisk and other companies developing GLP-1-based therapies [14][15] - Mounjaro and Zepbound face competition from Novo Nordisk's semaglutide medicines and other emerging candidates from companies like Amgen and Viking Therapeutics [15][16] Financial Metrics and Valuation - Lilly's stock has risen 5.6% this year, outperforming the industry and S&P 500 [22][24] - The stock currently trades at a price/earnings ratio of 31.34, higher than the industry average of 15.51, but below its 5-year mean of 34.54 [26][29] - Estimates for Lilly's 2025 earnings have declined recently, but the company still shows solid growth prospects [29][32]

Core Insights - AbbVie anticipates a return to strong revenue growth in 2025, following the loss of U.S. exclusivity for Humira, which saw a nearly 50% year-over-year sales decline to $1.12 billion in Q1 2025 [1][7] - The ex-Humira platform experienced over 21% year-over-year growth in Q1 2025, driven by the performance of newer immunology drugs, Skyrizi and Rinvoq [2][7] - AbbVie raised its sales guidance by approximately $900 million, now targeting $24.7 billion in combined sales from Skyrizi and Rinvoq for 2025 [3][7] Ex-Humira Growth - Skyrizi and Rinvoq are leading the growth in AbbVie's ex-Humira revenue, particularly in the inflammatory bowel disease (IBD) market, which includes ulcerative colitis (UC) and Crohn's disease (CD) [2][3] - Strong market growth and the potential for new indications for Rinvoq are expected to further drive sales [3] Competitive Landscape - The immunology market is highly competitive, with Johnson & Johnson's Stelara and Tremfya as key competitors, especially after Stelara lost U.S. exclusivity [4] - Eli Lilly is also expanding its immunology portfolio with the recent FDA approval of Omvoh for UC and CD indications [5] Valuation and Performance - AbbVie shares have outperformed the industry year-to-date, trading at a price/earnings (P/E) ratio of 14.48, slightly below the industry average of 15.12 [6][9] - The Zacks Consensus Estimate for 2025 earnings has slightly decreased from $12.30 to $12.28 per share, while the estimate for 2026 has increased from $13.97 to $14.05 [10]

Financial Data and Key Metrics Changes - In 2024, the company's full year revenue increased by 32%, reaching $45 billion, with fourth quarter revenue growing by 45% [19] - The company invested nearly $11 billion in R&D, representing about 24% of its revenue, with an 18% year-over-year increase [19] - A new $15 billion share repurchase program was announced, marking the seventh consecutive year of a 15% increase in quarterly dividends [19] Business Line Data and Key Metrics Changes - The performance of Monjaro, Zepbound, and Verzenio significantly contributed to revenue growth [16] - The company launched five new medicines since 2022, including Evolus, Jaypirca, Kisunla, Monjaro, Zepbound, and Omvoh, enhancing patient reach [18] Market Data and Key Metrics Changes - The company expanded its manufacturing capacity to meet increasing demand and opened new facilities, including the Lilly Seaport Innovation Center in Boston and a Lilly Gateway Lab in the UK [20][21] - A major investment in the United States was announced, bringing total manufacturing commitments since 2020 to over $50 billion [21] Company Strategy and Development Direction - The company remains focused on solving serious healthcare problems and aims to deliver life-changing medicines to millions [16] - The long-term balanced growth strategy includes advancements in obesity, diabetes, oncology, neuroscience, and immunology [16] - The company is complementing its pipeline through acquisitions and collaborations, such as acquiring Morphic Therapeutics and partnering with OpenAI [20] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the potential for significant growth from late-stage readouts in 2025 [17] - The company is committed to enhancing supply chain resilience and creating high-paying jobs through its investments [21] - Management emphasized the importance of their workforce and collaborations in achieving their goals [22] Other Important Information - The proposals to amend the articles of incorporation regarding the board structure and voting provisions did not receive the required votes [15] Q&A Session Summary Question: Does the compensation committee use the compensation actually paid total in setting the CEO target total compensation award for the coming year? - Management clarified that the compensation actually paid is not used to set the target compensation, as it reflects a mark-to-market value rather than actual compensation [26][28] Question: How much training is provided to employees to prevent clicking on links resulting in malware or breaks in cybersecurity? - Management confirmed that a comprehensive cybersecurity program is in place, including training to prevent incidents related to malware [29]

Core Viewpoint - Eli Lilly and Company reported mixed first-quarter 2025 results, missing earnings estimates but exceeding revenue expectations, driven by strong sales of its diabetes and weight loss medications [1][2][13]. Financial Performance - Adjusted EPS for Q1 2025 was $3.34, missing the Zacks Consensus Estimate of $3.52, but representing a 29% year-over-year increase [1]. - Total revenues reached $12.73 billion, a 45% increase year-over-year, surpassing the Zacks Consensus Estimate of $12.62 billion [2]. Key Drug Sales - Mounjaro sales were $3.84 billion, up 113% year-over-year, exceeding the Zacks Consensus Estimate of $3.75 billion [3]. - Zepbound generated $2.31 billion in sales, compared to $1.91 billion in the previous quarter, beating the Zacks Consensus Estimate of $2.27 billion [4]. - Trulicity sales fell 25% year-over-year to $1.1 billion, aligning with the Zacks Consensus Estimate [6]. - Jardiance sales increased 48% to $1.01 billion, significantly surpassing the Zacks Consensus Estimate of $675 million [7]. - Taltz generated $761.9 million, up 30% year-over-year, beating the Zacks Consensus Estimate of $663 million [7]. - Verzenio sales were $1.16 billion, a 10% increase year-over-year, but missed the Zacks Consensus Estimate of $1.25 billion [8]. - Emgality revenues dropped 45% to $124.6 million, while Olumiant sales rose 5% to $228.7 million [9]. Guidance and Market Position - The company maintained its 2025 revenue guidance of $58.0 billion to $61.0 billion, indicating a 32% year-over-year growth, but lowered EPS guidance to $20.78 to $22.28 [11][12]. - Competition from Novo Nordisk's semaglutide products is significant, with expectations of strong revenue growth for Novo's offerings [5][16]. - Lilly is investing in obesity treatments and has new molecules in clinical development, including a promising oral GLP-1 agonist [16][18]. Market Reaction - Despite strong sales, Lilly's shares fell nearly 5% in pre-market trading due to the EPS miss and lowered earnings guidance [14]. - CVS Caremark's decision to exclude Zepbound from its preferred drug list may impact sales [14]. - Lilly's stock has increased 16.7% year-to-date, outperforming the industry average of 3.5% [14].

Financial Performance - Total revenue reached $12.7 billion, a 45% increase compared to Q1 2024[11] - Key product revenue surged to $7.5 billion, representing a 119% growth rate[11] - Non-GAAP earnings per share (EPS) increased by 29% to $3.34[11] - The company reaffirms its 2025 revenue guidance of $58.0 billion to $61.0 billion[9] Market Leadership and Expansion - The company gained U.S. incretin analogs market leadership with a 53.3% market share in total prescriptions[9] - Mounjaro U.S. type 2 diabetes incretin analogs TRx share of market (SOM) reached 39% and NBRx SOM 46% at the end of Q1 2025[22] - Zepbound U.S. branded anti-obesity TRx SOM exceeded 60% and NBRx SOM 74% at the end of Q1 2025[22] Strategic Investments and Pipeline Development - The company announced plans to double U.S. manufacturing investments, committing a total of $50 billion since 2020[9] - Research & Development investment reached $2.7 billion, accounting for 8% growth[11] - The company disclosed positive Phase 3 trial results for oral GLP-1, orforglipron, demonstrating statistically significant efficacy and a safety profile consistent with injectable GLP-1 medicines[9] - Jaypirca achieved Q1 2025 sales of $92 million and secured regulatory approval in the EU for relapsed or refractory CLL patients previously treated with a BTK inhibitor[22]