Core Insights - The 2025 ASCO Annual Meeting will showcase significant research results from domestic innovative drugs, highlighting their potential in oncology treatments [1] Group 1: Clinical Data and Drug Performance - The TROP2 ADC SKB264 from Kelun-Biotech reported a 59.3% overall response rate (ORR) and a 91.4% disease control rate (DCR) in a Phase II trial for non-small cell lung cancer (NSCLC) [2] - The median progression-free survival (mPFS) for the same patient group was 15.0 months, with ORR varying by PD-L1 expression levels: 47.1% for TPS<1%, 68.1% for TPS≥1%, and 77.8% for TPS≥50% [2] - Compared to previous data, the ORR decreased from 72.7% to 59.3% in a larger sample size [2] - SKB264 demonstrated superior efficacy over other PD-1/VEGF dual antibodies, with ORR of 54.5% for SSGJ-707 and 47% for Ivosidenib [3] Group 2: Safety and Adverse Effects - The incidence of grade 3 or higher adverse reactions for SKB264 was 40%, higher than SSGJ-707's 24.1% and Ivosidenib's 29% [3] - However, the discontinuation rate due to adverse effects for SKB264 was 0%, lower than Ivosidenib's 2% and SSGJ-707's 6% [3] Group 3: Comparative Efficacy in EGFR Mutant NSCLC - In a separate study for EGFR mutant NSCLC, SKB264 showed a 45.1% ORR and mPFS of 6.9 months, statistically significant compared to Docetaxel [4] - Despite a decrease in ORR and mPFS in larger sample sizes, SKB264 still outperformed Dato-DXd (43%) and HER3-DXd (35.2%) in efficacy [4] - Other domestic competitors also showed promising results, with Ivosidenib achieving an ORR of 50.6% and BL-B01D1 reaching 52.5% in their respective trials [4][5]

医药生物周报（24 年第 17 周） 优于大市 ASCO 摘要标题整理，25Q1 公募基金医药持仓分析 本周医药板块表现强于整体市场，医疗服务板块领涨。本周全部 A 股上涨 0.95%（总市值加权平均），沪深 300 上涨 0.38%，中小板指上涨 2.13%， 创业板指上涨 1.74%，生物医药板块整体上涨 1.16%，生物医药板块表 现强于整体市场。分子板块来看，化学制药上涨 2.71%，生物制品下跌 0.93%，医疗服务上涨 3.38%，医疗器械上涨 0.17%，医药商业下跌 0.28%，中药下跌 0.50%。医药生物市盈率（TTM）30.67x，处于近 5 年历史估值的 61.96%分位数。 证券研究报告 | 2025年04月30日 多个国产创新药分子将在 ASCO 年会读出重要临床数据。ASCO 会议摘要标 题已于近日挂网，国产创新药产品将在会上展示一系列高质量的研究成 果。多个具有同类首创/同类最佳潜力的国产创新药分子将有数据读出， 包括：信达生物的 PD1xIL2 双抗 IBI363、科伦博泰的 TROP2 ADC SKB264、 百济神州的 CDK2i BG-68501、百利天恒的 EGFRx ...