Core Viewpoint - The FDA has approved Gilead's lenacapavir, a twice-yearly antiviral injection for HIV prevention, which could significantly impact global public health and help in the fight against the HIV epidemic [2][5]. Product Efficacy and Impact - Lenacapavir has shown the ability to virtually eliminate new HIV infections when administered every six months, outperforming existing daily pills and monthly injections [3][12]. - In clinical trials, the injection demonstrated a 99.9% efficacy rate, with only two infections among over 2,000 patients, proving to be 89% more effective than Gilead's daily pill Truvada [12][13]. Market Potential and Pricing - Analysts estimate lenacapavir could achieve peak sales of around $4 billion globally for both prevention and treatment [7]. - The current price for lenacapavir, under its treatment brand Sunlenca, exceeds $42,200 per year, but it could potentially be produced for as low as $26 to $40 annually [6]. Access and Distribution - Gilead plans to align the pricing of lenacapavir for HIV prevention with existing branded PrEP options, which are around $2,000 per month for daily pills [8]. - The company has licensed six generic manufacturers to produce lower-cost versions of the injection for 120 low- and lower-middle-income countries, and will supply doses for up to 2 million people at no profit before generics are available [9]. Challenges to Implementation - Proposed cuts to federal funding for HIV prevention, particularly affecting Medicaid, pose a significant threat to access for underserved populations [14][15]. - The potential reduction in funding could destabilize HIV prevention efforts and make it harder to distribute Gilead's injection effectively [16][17].

People look at iPhones at the Apple Fifth Avenue store in New York City, U.S., May 23, 2025.Apple has plans to make a folding iPhone starting next year, reliable analyst Ming-Chi Kuo said on Wednesday.Kuo said that Apple's folding phone could have a display made by Samsung Display, which is planning to produce as many as 8 million foldable panels for the device next year. However, other components haven't been finalized, including the device's hinge, Kuo wrote. He expects it to have "premium pricing."Kuo is ...

Scale AI's Interim CEO Jason Droege said in a memo on Wednesday that the artificial intelligence startup is not changing course following Meta's multibillion-dollar investment in the company last week."Unlike some other recent tech deals you might have heard about in the AI space, this is not a pivot or a winding down," Droege wrote in a post directed at customers, employees and investors.Meta has a 49% stake in Scale after its $14.3 billion investment, though the social media company will not have any voti ...

U.S. Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. and Secretary of Education Linda McMahon attend a Make America Healthy Again (MAHA) Commission event, in the East Room of the White House in Washington, D.C., U.S., May 22, 2025.A key, revamped government panel of vaccine advisors appointed by Health and Human Services Secretary Robert F. Kennedy Jr. will soon vote on a shot preservative that contains mercury, which is safely used in some flu jabs but has been incorrectly linked to autism ...

Jeremy Allaire, CEO of Circle Internet Group, the issuer of one of the world's biggest stablecoins, and Circle co-founder Sean Neville pose outside the New York Stock Exchange (NYSE), on the day of the company's IPO in New York City, U.S., June 5, 2025.Shares of Circle and Coinbase rallied on Wednesday, as Wall Street cheered the Senate's passage of the GENIUS Act, which would establish a federal framework for U.S. dollar-pegged stablecoins. Circle, the issuer of the USDC stablecoin, rose 22% following the ...

OpenAI is winding down its work with Scale AI, the artificial intelligence startup that received a multibillion-dollar investment from Meta earlier this month and saw its founder join the social media company to lead an AI effort.Scale is best known for its work helping major tech companies, including OpenAI, prepare data they use to train cutting-edge AI models. But OpenAI has been pulling back from the startup over the last six to 12 months, according to an OpenAI spokesperson.OpenAI has been looking to w ...

Residents of New York City will soon start seeing Waymo cars cruising the avenues. But at least for now, a human will be in the driver's seat.Alphabet's self-driving car unit announced on Wednesday that it plans to drive vehicles manually in New York, marking the first step toward potentially cracking the largest U.S. city. Waymo said it applied for a permit with the New York City Department of Transportation to operate autonomously with a trained specialist behind the wheel in Manhattan."While we won't be ...

Amazon's Zoox robotaxi unit is ramping up vehicle production at a new facility in Hayward, California.Amazon-owned autonomous vehicle startup Zoox on Wednesday opened a sprawling new manufacturing facility in the San Francisco Bay Area, paving the way for more robotaxi production as it plans a commercial rollout of its fleet later this year.The company will use the site in Hayward, California, to increase its robotaxi fleet significantly. The facility is currently producing one robotaxi per day, but Zoox sa ...

Rolls of steel are seen before the US president speaks during a rally at US Steel - Irvin Works in the Pittsburgh suburb of West Mifflin, Pennsylvania, on May 30, 2025.U.S. Steel shares stopped trading on the New York Stock Exchange on Wednesday after Japan's Nippon Steel completed its acquisition of the iconic American industrial name. President Donald Trump has insisted for weeks that the companies would form a "partnership" in which U.S. Steel would remain American owned. But the New York Stock Exchange ...

Core Viewpoint - Nintendo's newly launched Switch 2 console has generated significant consumer interest and excitement, leading to a record high in the company's stock price and a substantial increase in market capitalization [1][2]. Sales Performance - Nintendo sold 3.5 million units of the Switch 2 within the first four days of its launch, indicating strong demand [3]. - The company has forecasted sales of 15 million units for the fiscal year ending March 2026, although analysts believe this estimate may be conservative [3]. Stock Market Impact - Nintendo's shares have increased by 46% this year, adding approximately $39 billion to the company's market value [2]. - Since the launch of the original Switch in March 2017, Nintendo's stock has surged nearly 470%, resulting in an increase of over $81 billion in market capitalization [6]. Historical Context - The original Switch console, launched in 2017, has sold over 152 million units, making it Nintendo's second-most successful console [4]. - The hybrid nature of the Switch, allowing for both TV and portable play, has contributed to its popularity [4]. Strategic Advantages - Nintendo has leveraged its strong franchises, including Super Mario, Zelda, and Pokemon, to enhance the success of its consoles [5]. - The company has also expanded its intellectual property into movies and theme parks, further boosting its core video game products [5].