交银国际研究 公司更新 医药 2024 年 8 月 1 日 收盘价 目标价 潜在涨幅 港元 29.45 港元 40.40↑ +37.2% 和黄医药 (13 HK) 1H24 呋喹替尼海外销售强劲，盈亏平衡路径逐步清晰，上调目标价 1H24 肿瘤/免疫业务超预期，呋喹替尼美国市场快速上量：肿瘤/免疫业务 收入 1.69 亿美元（同比-53%，主因去年同期计入武田合作的一次性首付款 收入），超此前Visible Alpha卖方一致预期。肿瘤产品收入增长59%（+64% @CER）至 1.28 亿美元，主要得益于呋喹替尼美国销售快速放量：1H24 销 售达1.31亿美元，公司计入合作收入约0.43亿美元；其中2Q销售约8,000 万美元，环比 1Q 5,000 万美元显著提升。三款核心品种的中国销售额继续 稳 步 增 长 ： 呋 喹/ 索 凡/ 赛 沃 分 别+8%/+12%/+18% （ +13%/+17% /+22% @CER）至 0.61 亿/0.25 亿/0.26 亿美元。公司维持 2024 全年肿瘤/免疫业务 收入 3-4 亿美元的指引，并根据 1H24 情况和 2H 潜在里程碑收款节奏（欧 洲上市和日本 ...

2 Aug 2024 CMB International Global Markets | Equity Research | Company Update Hutchmed (13 HK) Fruquintinib's overseas sales beat HCM's oncology/immunology product revenue reached US$128mn in 1H24 (+59.6% YoY), including US$43mn revenue recognised from fruquintinib's sales outside China. The consolidated revenue from oncology/immunology including R&D services and Takeda collaboration revenue, reached US$169mn in 1H24, representing 48% of the midpoint of the FY24 guidance range of US$300-400mn. In 2Q24, fru ...

Investment Rating - The report maintains an "outperform" rating for Hutchmed (China) Limited with a target price of HKD 51.33 per share, reflecting a slight increase from the previous target of HKD 51.01 [6][14]. Core Insights - Hutchmed reported total revenue of USD 305.7 million for H1 2024, a decrease of 43% year-on-year, with oncology product revenue driven by overseas sales of fruquintinib reaching USD 42.8 million [3][12]. - The company expects oncology/immunology consolidated revenue for 2024 to remain between USD 300 million and USD 400 million, with potential for growth based on the positive sales trend of fruquintinib and upcoming regulatory milestones [4][13]. - The report highlights significant cost control measures, with R&D expenditure down 34% and SG&A expenses down 15%, contributing to a net profit of USD 25.8 million in H1 2024 [3][12]. Summary by Sections Financial Performance - Total revenue for H1 2024 was USD 305.7 million, with a significant drop of 43% compared to the previous year. The revenue from fruquintinib's overseas sales was USD 42.8 million, contributing to a 59% increase in oncology product revenue [3][12]. - The cost of goods sold (COGS) was USD 180.1 million, down 14%, while R&D expenses were USD 95.3 million, accounting for 74.5% of oncology product revenue [3][12]. Sales and Market Outlook - Fruquintinib's overseas sales are showing strong growth, with Q1 and Q2 2024 sales reported at 78 billion yen and 119 billion yen respectively, indicating a quarter-on-quarter growth of 53% in Q2 [4][13]. - The company is optimistic about achieving breakeven by the end of 2025, driven by continued growth in fruquintinib sales and effective cost management [4][12]. Pipeline and Future Prospects - Hutchmed is expanding its pipeline with savolitinib expected to submit a New Drug Application (NDA) by the end of 2024, which could become the company's second product approved for overseas commercialization [5][13]. - The innovative pipeline includes several promising candidates targeting hematological conditions, with ongoing clinical trials and positive results expected to drive future growth [5][13].

大家早上好欢迎参加和黄医药2024年中期业绩发布会我是和黄医药投资关系部的主管吴嘉俊我们公司的详细的业绩和演示稿PPT已经在昨天晚上上载于我们的官网大家也可以在香港交易所网页上面下载在开始之前先要举个温馨提示 所有听众现在是在静音模式今天的内容我们首先会由管理层做一个业绩的这个讲解之后会有一个答问的环节麻烦大家将你的名字和你公司的名称都填好让我们之后在发问的时候可以正确的读出你的名字最后请大家留意一下我们演示稿PPT的第二页里面有我们的免责声明 本公告所在自本集团表现和经营业织都属于历史的信息过往的表现并不保证本集团之未来业织谢谢大家的留意好那现在我们正式开始首先请我们和黄医药执行董事首席执行官兼首席科学官苏卫国博士开始今天我们中期业绩发布会苏总请 谢谢David各位投资界的朋友大家上午好欢迎大家参加和皇一样2024上半年的半年报发布会那么像David刚才说的我们详细的业绩报告已经在昨天晚上公布那么今天跟我一起参加这个发布会了 我先简单介绍一下江丽成是我们的CFO那么原则志George Yuan商业化部门的负责人那么简单介绍一下George可能意内的朋友对George也非常了解George可以说是总流产品业务 ...

医药生物/化学制药 公 司 研 究 和黄医药（00013.HK） 2024 年 08 月 01 日 呋喹替尼海外销量超预期，公司进入全球收获期 ——公司信息更新报告 投资评级：买入（维持） 余汝意（分析师） yuruyi@kysec.cn 证书编号：S0790523070002 | --- | --- | |--------------------|---------------| | 日期 | 2024/8/1 | | 当前股价(港元) | 29.450 | | 一年最高最低(港元) | 35.900/19.000 | | 总市值(亿港元) | 256.62 | | 流通市值(亿港元) | 256.62 | | 总股本(亿股) | 8.71 | | 流通港股(亿股) | 8.71 | | 近 3 个月换手率(%) | 21.51 | 肿瘤产品收入维持高增长，公司有望 2024 年后实现持续盈利 2024H1 公司实现营收 21.8 亿元，同比下滑 42.64%；扣非归母净利润 1.84 亿元， 同比下滑 84.69%，公司收入和利润同比下滑主要是受武田首付款、里程碑及研 发服务费用影响。公司核心业务肿瘤产品 ...

Investment Rating - Buy (Maintained) [3] Core Views - The company's growth momentum continues with sufficient cash reserves [2] - The company's tumor/immunotherapy business achieved comprehensive revenue of $168.7 million in H1 2024, driven by a 59% increase in tumor product revenue [2] - FRUZAQLA® (fruquintinib) achieved $130.5 million in US sales in H1 2024, demonstrating strong market demand and commercial appeal [2] - The company reiterated its 2024 financial guidance for tumor/immunotherapy business comprehensive revenue of $300-400 million, reflecting confidence in its development [2] - The company has 15 key late-stage registration trials initiated, ongoing, or under review [2] - Cost control efforts have been effective, with net expenses decreasing to $279.9 million in H1 2024 from $364.3 million in the same period last year [2] Financial Performance - Total revenue for H1 2024 was $305.7 million, compared to $532.9 million in H1 2023 [2] - Net income for H1 2024 was $25.8 million, with cash reserves of $802.5 million [2] - Revenue cost decreased by 14% YoY to $180.1 million, and R&D expenses decreased by 34% YoY to $95.3 million [2] - The company forecasts 2024/2025/2026 revenues of $890 million, $1.255 billion, and $1.575 billion, respectively [5] - Net profit attributable to the parent company is projected to be $134 million, $237 million, and $351 million for 2024, 2025, and 2026, respectively [5] Product Development - FRUZAQLA® was approved in the EU and has submitted marketing authorization applications in over a dozen countries and regions [2] - Solpalitinib's new drug application was accepted in January 2024 and included in priority review [2] - The company plans to submit a new drug application for savolitinib for non-small cell lung cancer in the US by the end of the year [2] - Applications for expanding the use of ORPATHYS® and ELUNATE® in China, as well as new drug or new indication applications for TAVALISSE®, have been accepted [2] - The company has added projects targeting Menin and CD38 to its hematology product portfolio [2] Valuation Metrics - The company's P/E ratios for 2024, 2025, and 2026 are projected at 25.53, 14.45, and 9.77, respectively [6] - P/B ratios for the same period are forecasted at 3.97, 3.12, and 2.37 [6] - EV/EBITDA ratios are expected to be 17.51, 11.09, and 7.61 for 2024, 2025, and 2026, respectively [6] Market Performance - The company's 52-week stock price range is HK$35.90 to HK$19.00 [4] - The 52-week P/E range is 38.38 to -131.92, and the P/B range is 5.30 to 2.72 [4] - The stock has gained 28.04% over the past 52 weeks [4]

国泰君安版权所有发送给上海东方财富金融数据服务有限公司.东财接收研报邮箱.ybjieshou@eastmoney.com p1 股票研究 /[Table_Date] 2024.08.01 | --- | --- | --- | --- | |----------|-------------------|----------------------------|--------------------------| | | 丁丹(分析师) | 甘坛焕(分析师) | 付子阳(研究助理) | | | 0755-23976735 | 021-38675855 | 0755-23976666 | | | dingdan@gtjas.com | gantanhuan028803@gtjas.com | fuziyang028496@gtjas.com | | 登记编号 | S0880514030001 | S0880523080007 | S0880123100022 | 本报告导读： 24H1 公司肿瘤产品销售亮眼，呋喹替尼美国销售约 1.3 亿美金，看好海外放量。赛 沃替尼有望年底提交美国 NDA，创新管线进入收获期 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概 不對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 收入增長勢頭持續，現金結餘充裕支持擴展 HUTCHMED (China) Limited 和黃醫藥（中國）有限公司 呋喹替尼全球佈局持續推進，管線進一步拓寬並取得切實進展 （於開曼群島註冊成立的有限公司） 1 / 70 （股份代號：13） 和黃醫藥公佈2024年中期業績及最新業務進展 和黃醫藥（中國）有限公司（簡稱「和黃醫藥」、「本公司」或「我們」）今日公佈截至2024年6月30日止六個月的 財務業績以及提供關鍵臨床項目和商業化發展的最新進展。 公司將於今天中國香港時間晚上8時/英國夏令時間下午1時/美國東部夏令時間上午8時舉行網絡直播（英語場 次），並於2024年8月1日（星期四）中國香港時間上午8時30分舉行中文（普通話）場次。投資者登記後可透過 和黃醫藥網站（www.hutch-med.com/event）參與實時網絡直播。 除另有說明外，所有金額均以美元列示。 • 重申2024年全年腫瘤/免疫業務 ...

Investment Rating - The investment rating for the company is "Buy" (maintained) [3][7]. Core Insights - The company showcased significant progress in its innovative drug pipeline during the R&D Day held on July 9, 2024, highlighting the clinical data and market potential of its candidate drugs [3]. - The company has a strong competitive edge with its innovative pipeline, which includes promising candidates such as Syk inhibitor, Sovanertinib, and HMPL-306, each targeting specific diseases with substantial market potential [4]. - Future catalysts for the company include the anticipated growth in overseas sales of Fuquintinib, ongoing clinical trials for various indications, and expected regulatory approvals that could drive revenue growth [5]. Summary by Sections Company Events - On July 9, 2024, the company held an R&D Day where management shared insights on clinical data and market value of its innovative pipeline, including Syk inhibitor for autoimmune diseases, Sovanertinib for pancreatic cancer, and HMPL-306 for acute myeloid leukemia [3]. Candidate Pipeline Progress - Syk Inhibitor: Demonstrates superior selectivity and safety profile, with ongoing clinical trials showing promising results for ITP and wAIHA [4]. - Sovanertinib: Shows improved progression-free survival (PFS) and overall survival (OS) in combination with PD1 and chemotherapy for pancreatic cancer [4]. - HMPL-306: Targets IDH1/2 mutations in acute myeloid leukemia, with a registration-phase III trial initiated [4]. Future Catalysts - Fuquintinib's overseas sales are expected to grow, with a potential approval in Japan in the second half of 2024 [5]. - The company anticipates new sales growth from domestic approvals for various indications, including gastric cancer and other cancer therapies [5]. - The company has a robust cash position of $886 million as of the end of 2023, supporting its growth strategy [5]. Financial Forecast and Valuation - The company projects total revenue of $300 million to $400 million in 2024, driven by existing product sales and royalties [5]. - Revenue estimates for 2024-2026 are $705 million, $912 million, and $1.185 billion, respectively, with a calculated equity value of HKD 40.9 billion based on DCF analysis [5][6].

[ T able_StockInfo] 2024 年 07 月 10 日 证券研究报告•公司动态跟踪报告 买入 (维持) 当前价:27.00 港元 和黄医药(0013.HK)医疗保健 目标价:34.30 港元 商业化表现靓眼,管线持续释放创新潜力 [Table_Summary 事件:7 月 9 日,] 和黄医药举办研发日交流,管理团队分享和黄医药丰富且创新 的候选药物管线中的部分项目的最新进展,包括索乐匹尼布用于治疗免疫性血小板 减少症的 ESLIM-01 III 期研究,以及用于治疗温抗体型自身免疫性溶血性贫血的 ESLIM-02 II/III 期研究;索凡替尼用于治疗胰腺导管腺癌的 II/III 期研究;以及 HMPL-306 用于治疗急性髓系白血病的 RAPHAEL III 期研究。 呋喹替尼美国商业化推进顺利,获 EMA批准上市。呋喹替尼于 2023年 11 月 9 日获 FDA 批准上市,上市以来到 3 月底美国销售额达 101 亿日元(约合美元 6500 万)。呋喹替尼于 2024年 6月在欧盟获得经治转移性结直肠癌的批准,有 望于 2024年年底前在日本获得经治转移性结直肠癌的批准。呋喹替尼二线 ...