Core Viewpoint - Hutchison China MediTech Limited (HCM) announced the latest updates on several research studies of its self-developed compounds, which will be presented at major upcoming oncology conferences in 2025 [1] Group 1: Upcoming Presentations - Results from the first human clinical trial of the anti-CD47 monoclonal antibody HMPL-A83 for the treatment of advanced solid tumors will be presented at the ESMO Asia Congress in Singapore from December 5 to 7, 2025 [1] - The results of the FRUSICA-2 registration study's Phase II portion, which examines fruquintinib in combination with sintilimab for second-line treatment of locally advanced or metastatic renal cell carcinoma, will also be shared at the same ESMO Asia Congress [1] - Additionally, results from a Phase II/III study of surufatinib combined with camrelizumab and chemotherapy for first-line treatment of metastatic pancreatic cancer will be presented at the conference [1]

Core Viewpoint - Hutchison China MediTech Limited (HCM) announced the latest and updated data from several studies of its self-developed compounds, which will be presented at the European Society for Medical Oncology (ESMO) Asia Congress in Singapore and the American Society of Hematology (ASH) Annual Meeting in Orlando in December 2025 [1] Group 1: Clinical Trials and Presentations - The first human clinical trial results of the anti-CD47 monoclonal antibody HMPL-A83 for the treatment of advanced solid tumors will be presented at the 2025 ESMO Asia Congress [1] - Results from the FRUSICA-2 registration study's Phase II portion, which examines fruquintinib in combination with sintilimab for second-line treatment of locally advanced or metastatic renal cell carcinoma, will also be disclosed at the 2025 ESMO Asia Congress [1] - The Phase II portion results of a study combining surufatinib with camrelizumab and chemotherapy for first-line treatment of metastatic pancreatic cancer will be presented at the same congress [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不 對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 HUTCHMED (China) Limited 和黃醫藥（中國）有限公司 （於開曼群島註冊成立的有限公司） （股份代號：13） 自願性公告 和黃醫藥將於2025年歐洲腫瘤內科學會 (ESMO) 亞洲年會和 2025年美國血液學會 (ASH) 年會公佈臨床數據 和黃醫藥（中國）有限公司（簡稱「和黃醫藥」或 「HUTCHMED」）今日宣佈和黃醫藥自主研發的化合物的數項研 究的最新及更新後的數據將於2025年12月5日至7日在新加坡召開的歐洲腫瘤內科學會（ESMO）亞洲年會，以及 2025年12月6日至9日在美國奧蘭多召開的美國血液學會（ASH）年會上公佈。 | 摘要標題 | 報告人/ 主要作者 報告詳情 | | | --- | --- | --- | | 奧希替尼聯合賽沃替尼用於治療EGFR突變伴MET過表達和/或奧希替尼治療後進展 | Se-Hoon Lee | 982P | | 的晚期非小細胞肺癌: S ...

Core Insights - HUTCHMED will present new and updated data from several studies at the upcoming ESMO Asia Congress 2025 and ASH Annual Meeting, showcasing its commitment to advancing cancer therapies [1][2][3] Group 1: Upcoming Presentations - A first-in-human study of HMPL-A83, an anti-CD47 monoclonal antibody, will be presented, focusing on advanced solid tumors [2] - The phase II results of the FRUSICA-2 study, evaluating the combination of fruquintinib and sintilimab for renal cell carcinoma, will also be shared [2] - Surufatinib's phase II results in combination with camrelizumab and chemotherapy for metastatic pancreatic cancer will be reported [2] Group 2: Specific Study Details - HMPL-A83 presentation details include a mini oral session on December 7, 2025, led by Ye Guo [2] - Fruquintinib's results will be presented by Shanshan Wang on December 5, 2025, in a proffered paper session [2] - Surufatinib's study will be displayed as a poster by Shukui Qin [2] Group 3: Additional Studies - Several investigator-initiated studies will also be presented, including combinations of fruquintinib with other treatments for metastatic colorectal cancer [3] - The final analysis of the ESLIM-01 study on sovleplenib for chronic primary immune thrombocytopenia will be presented at the ASH Annual Meeting [3] Group 4: Product Information - Fruquintinib is a selective oral inhibitor of VEGFRs, co-developed by HUTCHMED and Eli Lilly, marketed as ELUNATE in China [4] - HMPL-A83 is a humanized anti-CD47 monoclonal antibody that disrupts cancer cells' immune evasion [5] - Savolitinib is a selective MET tyrosine kinase inhibitor developed by AstraZeneca and HUTCHMED, marketed as ORPATHYS [6] - Surufatinib is an oral angio-immuno kinase inhibitor marketed as SULANDA in China [7] - Sovleplenib is a selective small molecule inhibitor targeting Syk, with potential applications in B-cell lymphomas [8]

Core Insights - The ITP drug treatment market in China is projected to grow, reaching 2.4 billion yuan in 2024, an increase of 200 million yuan from 2023, and is expected to reach approximately 2.8 billion yuan in 2025 [1][3][4] - Eltrombopag, a novel oral small molecule TPO receptor agonist, has shown excellent efficacy in treating ITP, significantly expanding treatment options for patients [1][4][7] - The sales of Eltrombopag in hospitals reached 376 million yuan in 2023, with an estimated 430 million yuan for the entire year of 2024 [1][4] ITP Drug Treatment Industry Pathway - ITP, or Immune Thrombocytopenic Purpura, is primarily treated with corticosteroids as the first-line therapy, while second-line treatments include platelet-stimulating drugs [2][4] - The incidence of ITP in adults in China is estimated at 5 to 10 per 100,000, with a projected 130,400 patients in 2024 [2][3] ITP Drug Treatment Industry Development Status - The ITP drug treatment market has been expanding, with a notable increase in treatment options due to ongoing research into the disease's pathophysiology [4][6] - The market is characterized by a growing number of patients and an increasing demand for effective treatments [2][3] ITP Drug Treatment Industry Chain - The upstream of the ITP drug treatment industry includes active pharmaceutical ingredients (APIs), chemical raw materials, and related equipment, while the midstream focuses on drug manufacturing [4][6] ITP Drug Treatment Competitive Landscape - Major companies in the domestic ITP drug market include Jiangsu Aosaikang Pharmaceutical, Jiangsu Hengrui Medicine, and Shenyang Sanofi Pharmaceutical, among others [2][6] - Several companies have received approval for Eltrombopag, indicating a competitive environment for generic versions of the drug [6][7] ITP Drug Treatment Development Trends - The treatment of ITP is moving towards targeted and precision medicine, with new therapies showing potential in regulating key immune nodes [7] - Future research may explore the combination of Eltrombopag with existing therapies to enhance treatment outcomes and achieve long-term remission for patients [7]

Summary of the Conference Call for Hodgman Company Industry and Company Overview - The conference call pertains to Hodgman Company, a biopharmaceutical firm focused on oncology and autoimmune disease treatments, with a significant presence in both the Chinese and global markets [2][3][4]. Key Points and Arguments Product Pipeline and Performance - **Orpathys**: A carbonic anhydrase inhibitor for lung cancer, currently commercialized in China, with a Phase III clinical trial in collaboration with AstraZeneca expected to yield data in mid-2026, aiming for global approval by 2027 [2][3]. - **Cavatak**: A colorectal cancer treatment with sales of approximately $616 million in the first half of 2025, showcasing Hodgman's strength in the Chinese market and global competitiveness [3]. - **Tequila**: A top-selling oncology drug, recently approved for metastatic colorectal cancer, with expected growth driven by markets in Europe and Japan. It has received approval for endometrial cancer in China and is under investigation for second-line kidney cancer, anticipated to be approved by late 2026 [2][8]. - **SAFFRON Trial**: A Phase II clinical trial for a second-line EGFR mutation non-small cell lung cancer drug, with results expected in mid-2026. If successful, it could lead to U.S. approval around 2027, targeting patients with c-MET gene amplification [10][11]. Financial Guidance and Market Strategy - The company has adjusted its revenue guidance downward due to weak sales in the first half of 2025, attributed to increased competition and infrastructure restructuring for compliance, which has temporarily impacted sales activities [5][6]. - Despite short-term challenges, Hodgman anticipates improved performance in the second half of 2025, driven by recovery in the Chinese market [5][6]. ATTC Platform - The ATTC (Antibody-Targeted Therapy Conjugate) platform is a novel treatment modality that uses small molecule targeted drugs instead of chemical toxins, aiming to reduce toxicity and enhance selectivity. Currently in Phase I trials, it shows significant potential for future applications [4][6]. - Hodgman is actively seeking partnerships to advance the ATTC platform, with interest from multinational pharmaceutical companies [7]. Market Opportunities and Challenges - The Chinese market remains crucial for Hodgman, but competition is fierce, with lower prices and limited profit margins. The company is focusing on expanding its presence in higher-margin markets like the U.S., Europe, and Japan [5][6]. - The potential market size for the second-line EGFR mutation treatment in the U.S. and China is estimated at around $1 billion, with Hodgman aiming to capture significant market share through ongoing trials and approvals [11][12]. Other Important Insights - Hodgman has a strong balance sheet and stable revenue from its commercialized products, positioning it well for future growth [4][13]. - The company is optimistic about the ITP inhibitor project, which is expected to resubmit data in mid-2026 for potential approval in 2027, marking its entry into the autoimmune disease market [12]. This summary encapsulates the critical aspects of Hodgman Company's conference call, highlighting its product pipeline, financial outlook, strategic initiatives, and market positioning.

HUTCHMED (China) Conference Call Summary Company Overview - **Company**: HUTCHMED (China) (NasdaqGS:HCM) - **Event**: Jefferies Global Healthcare Conference - **Date**: November 17, 2025 Key Points Industry and Company Pipeline - HUTCHMED is a globally commercialized biotech company with a focus on oncology products, including FRUZAQLA, a colorectal cancer drug with half-year sales of approximately $160 million [2][3] - The company is also advancing ORPATHYS, a c-Met inhibitor for lung cancer, with expectations for U.S. approval by 2027 following successful phase three trials [3][4] Financial Performance and Guidance - The company has revised its 2025 oncology revenue guidance to a range of $270 million to $350 million due to competitive pressures and restructuring of sales infrastructure [9][10] - HUTCHMED has been profitable since 2023, driven by sales and milestone payments from its products [3][4] Strategic Focus - HUTCHMED prioritizes growth in both China and global markets, leveraging its R&D capabilities and partnerships with multinational pharmaceutical companies [6][7] - The company has opted to partner with established firms for global distribution rather than relying solely on its sales team [8] ATTC Platform Development - The ATTC (Antibody Targeted Therapy Conjugate) platform is a key focus, offering a chemo-free alternative to traditional ADCs, potentially reducing toxicity and improving selectivity [4][11] - Human trials for the ATTC platform are set to begin soon, with strong interest from multinational pharma for potential partnerships [12][18] Product Launches and Market Opportunities - FRUZAQLA has been successfully launched globally, with significant growth expected from Europe and Japan [21][22] - The company is also working on expanding FRUZAQLA's indications in China, with potential approvals for kidney cancer expected in the second half of next year [24][25] Competitive Landscape - HUTCHMED faces increasing competition in the oncology space, particularly in China, where generic products are emerging [9][10] - The company is focused on differentiating its products, such as targeting c-Met-amplified patients in lung cancer, which have worse prognoses [29][30] Future Milestones - Key upcoming milestones include the approval of FRUZAQLA for kidney cancer in China and the readout of phase three trial data for ORPATHYS in the first half of next year [25][28] - The company aims to enhance its market position through strategic partnerships and aggressive clinical strategies [19][20] Additional Insights - HUTCHMED is optimistic about the potential of its ATTC platform to revitalize previously shelved small molecule drugs, expanding its pipeline and market reach [14][15] - The company is also developing a SYK inhibitor for ITP, with a target approval and launch in China by 2027 [33][34] Conclusion HUTCHMED is positioned for growth with a robust pipeline and strategic partnerships, focusing on innovative therapies in oncology while navigating a competitive landscape. The upcoming milestones and the development of the ATTC platform are critical for the company's future success.

Core Viewpoint - The performance of Hutchison China MediTech (HCM) has lagged behind the overall market despite the significant rise in the Hong Kong healthcare sector, with its stock price showing only a 36.36% increase year-to-date compared to the sector's peak of 102.6% [1][2]. Market Performance - HCM's stock price has been volatile, particularly after the release of its mid-year report, which showed a revenue decline of 9.2% to $278 million, despite a significant profit increase due to the sale of non-core assets [2][3]. - Following the mid-year report, HCM's stock experienced a sharp decline of 15.99% in a single day, with trading volume reaching a record high of 70.29 million shares, indicating increased market panic and a shift in investor sentiment [3][5]. Investor Sentiment - The recent trading data indicates a shift in investor behavior, with significant net buying from certain brokers, while others have been net sellers, reflecting a divided market view on HCM's future prospects [6][7]. - The stock's price-to-earnings ratio (PE) is currently at 5.64, significantly lower than the industry average of 28.32, suggesting potential for a technical rebound in the short term [6]. Sales Performance - HCM's core innovative drugs have seen substantial sales declines in the domestic market, with revenues for its main products dropping between 30% to 50% [2][8]. - In contrast, overseas sales for its key drug, Elunate (fuquintinib), have increased by 25% to $163 million, indicating stronger performance in international markets [9]. Pipeline and Future Prospects - HCM is focusing on its new drug candidate HMPL-A251, which has shown promising preclinical results and is expected to enter clinical development by the end of the year [10][11]. - The company is attempting to shift market attention towards its antibody-drug conjugate (ADC) research, which has garnered industry interest, although immediate stock price catalysts may be limited [11].

Core Viewpoint - The Hong Kong stock market has seen a significant rise in the healthcare sector, with the Hang Seng Healthcare Index reaching a maximum increase of 102.6% this year, although it has since corrected to a still substantial 70.57% increase. In contrast, Hutchison China MediTech (HCM) has underperformed, with a maximum increase of only 36.36% and a recent drop to just 5.19% [1] Market Performance - HCM's stock price has fluctuated between the middle and upper Bollinger Bands since early April, reflecting the overall bullish trend in the Hong Kong innovative drug sector. However, the release of its mid-year report on August 7 marked a turning point, leading to a decline in market sentiment [2] - Following the mid-year report, HCM's stock plummeted by 15.99% on August 8, with trading volume reaching a record high of 70.29 million shares, indicating increased market panic and a significant shift in investor sentiment [3] Investor Behavior - The trading behavior of HCM's stock has shown signs of speculative trading rather than long-term holding, with notable fluctuations in trading volume and price changes on specific dates [3] - Recent data indicates that major banks and investment firms have shifted their positions, with significant net buying from Bank of China and other channels, while major sellers include HSBC and Citibank [4] Financial Performance - HCM reported a revenue of $278 million for the first half of 2025, a decrease of 9.2% year-on-year. However, net profit surged to $455 million, a 16.6-fold increase, primarily due to the sale of non-core joint venture stakes. Despite this, sales of its three main innovative drugs fell sharply by 30-50%, leading to a 22% decline in proprietary product sales [2][6] Product Pipeline and Future Prospects - HCM's core products have faced significant domestic market challenges, with sales of Elunate, Sulanda, and Orpathys declining by 29%, 50%, and 41% respectively due to increased competition and market pressures [6] - Despite domestic setbacks, HCM's overseas sales, particularly for Elunate, have shown growth, with a 25% increase to $163 million, indicating potential for recovery in international markets [6][7] - The company is focusing on new product development, with the recent acceptance of HMPL-A251 for clinical trials, which combines targeted therapies and may offer new treatment options [7][8]

Core Viewpoint - Huadong Medicine (00013) has significant potential in its innovative pipeline, with a "Buy" rating maintained by Huayuan Securities, projecting total revenues of $567 million, $676 million, and $816 million for 2025-2027 [1] Group 1: Event Highlights - Huadong Medicine shared key R&D and business progress during an investor meeting on October 31, 2025, focusing on advancements in innovative cancer and immune disease treatments, including its next-generation Antibody-Drug Conjugate (ATTC) platform and late-stage pipeline candidates [1] Group 2: Breakthrough ATTC Platform and Pipeline Potential - The ATTC platform is a proprietary cancer precision therapy drug development platform that connects monoclonal antibodies with patented targeted small molecule payloads, aiming for superior anti-tumor activity and safety compared to traditional Antibody-Drug Conjugates (ADC) [2] - The first potential pipeline from this platform is HMPL-A251, a PAM-HER2ATTC that combines a highly selective and potent PI3K/PIKK inhibitor as the payload with a humanized anti-HER2 IgG1 antibody via a cleavable linker, showing promising anti-tumor efficacy and tolerability in preclinical studies [2] - Based on preclinical data, Huadong Medicine plans to advance HMPL-A251 into clinical development starting at the end of 2025 [2] Group 3: Ongoing Late-Stage Projects - The FRUSICA-2 study of fruquintinib combined with sintilimab for second-line treatment of renal cell carcinoma will present data at the 2025 ESMO conference, showing a median progression-free survival (mPFS) of 22.2 months and an overall response rate (ORR) of 60.5% [3] - The SANOVO China Phase III study for savolitinib in first-line treatment of EGFR-mutant non-small cell lung cancer with MET overexpression has completed patient recruitment, while the SAFFRON global Phase III study for second-line treatment is progressing well, expected to complete recruitment by the end of 2025 [3] - The study of surufatinib for pancreatic cancer, in combination with carrelizumab, albumin-bound paclitaxel, and gemcitabine, is progressing well, with Phase II results to be announced at an upcoming scientific meeting [3] - The Chinese registration Phase II study of HMPL-453 for advanced intrahepatic cholangiocarcinoma has completed recruitment, with plans to submit a new drug application in the first half of 2026 [3]