每经AI快讯，宜明昂科-B(01541.HK)涨超5%，截至发稿，涨5.11%，报4.94港元，成交额834.81万港 元。 （文章来源：每日经济新闻） ...

宜明昂科-B(01541)涨超5%，截至发稿，涨5.11%，报4.94港元，成交额834.81万港元。 值得一提的是，据宜明昂科公众号披露，近日，宜明昂科团队一行三人出席了第44届摩根大通医疗健康 年会，公司创始人、董事长、CEO兼CSO田文志博士在Biotech Showcase全面介绍了公司发展状况及重 要项目进展。田文志博士携公司高管团队在会议期间密集约见了十余家跨国药企及生物技术公司，并在 会后已与多家潜在合作伙伴建立深度沟通，反馈积极，2026年有望达成实质性进展，为公司管线全球化 注入新动能。 消息面上，1月21日晚，宜明昂科发布公告称，公司于2025年12月31日成功完成IMM01(替达派西普)用 于慢性粒-单核细胞白血病(CMML)一线治疗的III期临床试验的104例患者招募，预期将于2026年3月底 前完成中期分析所需的132例患者招募。此外，公司计划于2026年底递交preBLA申请，其在动脉粥样硬 化领域的Ib/II期研究也将推进至概念验证阶段。截至公告日期，董事会确认集团的业务营运及临床开发 维持正常，且集团的业务营运及财务状况并无重大不利变动。 ...

消息面上，1月21日晚，宜明昂科发布公告称，公司于2025年12月31日成功完成IMM01(替达派西普)用 于慢性粒-单核细胞白血病(CMML)一线治疗的III期临床试验的104例患者招募，预期将于2026年3月底 前完成中期分析所需的132 例患者招募。此外，公司计划于2026年底递交preBLA申请，其在动脉粥样 硬化领域的Ib/II期研究也将推进至概念验证阶段。截至公告日期，董事会确认集团的业务营运及临床开 发维持正常，且集团的业务营运及财务状况并无重大不利变动。 值得一提的是，据宜明昂科公众号披露，近日，宜明昂科团队一行三人出席了第44届摩根大通医疗健康 年会，公司创始人、董事长、CEO兼CSO田文志博士在Biotech Showcase™ 全面介绍了公司发展状况及 重要项目进展。田文志博士携公司高管团队在会议期间密集约见了十余家跨国药企及生物技术公司，并 在会后已与多家潜在合作伙伴建立深度沟通，反馈积极，2026年有望达成实质性进展，为公司管线全球 化注入新动能。 智通财经APP获悉，宜明昂科-B(01541)涨超5%，截至发稿，涨5.11%，报4.94港元，成交额834.81万港 元。 ...

宜明昂科-B(01541)发布公告，本公司于2025年12月31日成功完成IMM01(替达派西普)用于慢性粒-单核 细胞白血病(CMML)一线治疗的III期临床试验的104例患者招募，并预期将于2026年3月底前完成中期分 析所需的132 例患者招募。截至本公告日期，董事会确认本集团的业务营运及临床开发维持正常，且本 集团的业务营运及财务状况并无重大不利变动。 本集团拥有IMM01(替达派西普)的全球知识产权及商业化权利。截至本公告日期，就IMM01(替达派西 普)而言，本集团拥有一个专利家族，其中包括在中国、美国、日本及欧盟的已授权专利。 本集团的核心产品IMM01(替达派西普)是创新靶向CD47的分子。该款产品是中国首个进入临床阶段的 SIRPα-Fc融合蛋白。具有免疫球蛋白G1 (IgG1) Fc的 IMM01(替达派西普)能够通过双重作用机制充分激 活巨噬细胞 — 同时通过干扰CD47/SIRPα相互作用阻断"别吃我"信号，并通过激活巨噬细胞的Fc-gamma (Fcγ)受体传递"吃我"信号。此外，IMM01(替达派西普)的CD47结合结构域经过特别改造能够避免与人 体红细胞(RBC)结合。凭藉差异化 ...

格隆汇1月21日丨宜明昂科-B(01541.HK)宣布，公司于2025年12月31日成功完成IMM01(替达派西普)用 于慢性粒-单核细胞白血病(CMML)一线治疗的III期临床试验的104例患者招募，并预期将于2026年3月 底前完成中期分析所需的132例患者招募。截至本公告日期，董事会确认集团的业务营运及临床开发维 持正常，且集团的业务营运及财务状况并无重大不利变动。 集团拥有IMM01(替达派西普)的全球知识产权及商业化权利。截至本公告日期，就IMM01(替达派西普) 而言，集团拥有一个专利家族，其中包括在中国、美国、日本及欧盟的已授权专利。 集团的核心产品IMM01(替达派西普)是创新靶向CD47的分子。该款产品是中国首个进入临床阶段的 SIRPα-Fc融合蛋白。具有免疫球蛋白G1(IgG1)Fc的IMM01(替达派西普)能够通过双重作用机制充分激活 巨噬细胞—同时通过干扰CD47/SIRPα相互作用阻断「别吃我」信号，并通过激活巨噬细胞的Fc- gamma(Fcγ)受体传递「吃我」信号。此外，IMM01(替达派西普)的CD47结合结构域经过特别改造能够 避免与人体红细胞(RBC)结合。凭藉差异化的分 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因 倚賴該等內容而引致的任何損失承擔任何責任。 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. 宜明昂科生物醫藥技術（上海）股份有限公司 關於IMM01（替達派西普） （於中華人民共和國註冊成立的股份有限公司） （股份代號：1541） 自願公告 有關IMM01（替達派西普）臨床試驗的最新消息 本公告由宜明昂科生物醫藥技術（上海）股份有限公司（「本公司」，連同其附屬 公司統稱「本集團」）自願作出，以告知本公司股東及潛在投資者有關本集團的 最新業務發展情況。 本公司董事（「董事」）會（「董事會」）欣然宣佈，本公司於2025年12月31日成功完 成IMM01（替達派西普）用於慢性粒-單核細胞白血病(CMML)一線治療的III期臨 床試驗的104例患者招募，並預期將於2026年3月底前完成中期分析所需的132 例患者招募。截至本公告日期，董事會確認本集團的業務營運及臨床開發維持 正常，且本集團的業務營運及財務狀況並無 ...

Core Viewpoint - The termination of the collaboration between 宜明昂科-B (1541.HK) and AxionBio highlights the challenges faced by Chinese innovative drug companies in the global market, emphasizing that the choice of partners may be more critical than the technical advantages of the products themselves [5][21][25]. Group 1: Collaboration Details - In August 2024, 宜明昂科-B signed a potential licensing agreement with AxionBio worth over $2 billion, which was seen as a significant step for the company's international expansion [2][18]. - By January 2026, 宜明昂科-B announced the recovery of global rights for its dual-antibody drug IMM2510 and CTLA-4 antibody IMM27M, marking the end of the collaboration [4][21]. - The company retained the $35 million upfront and milestone payments received from AxionBio, indicating a strategic decision rather than a forced exit [5][21]. Group 2: Clinical Development Challenges - The clinical trial progress for IMM2510 was notably slow, with only three patients enrolled in the Phase I trial in the U.S. before the collaboration ended [7][23]. - The FDA approved the clinical trial application for IMM2510 in July 2025, but AxionBio did not administer the first patient until October 2025, resulting in a 15-month delay from the agreement to actual clinical operations [7][23]. Group 3: Market Competition - The PD-(L)1/VEGF dual-antibody market is highly competitive, with 17 drugs currently in clinical trials, all associated with Chinese innovative drug companies [10][27]. - Major players like 康方生物 and 三生制药 have advanced their products to Phase III clinical trials in collaboration with multinational giants, creating a challenging environment for 宜明昂科-B [10][27]. Group 4: Strategic Implications - The decision to regain rights to the assets allows 宜明昂科-B to explore new partnerships and strategies without being constrained by previous agreements, although it also means assuming all associated risks and costs [15][33]. - The company plans to target multinational corporations for future business development while also considering partnerships with mid-sized companies [29][33]. Group 5: Financial Considerations - Despite receiving $35 million from the previous collaboration, the funds are insufficient to cover the long-term costs of global clinical development for the two drugs [30][31]. - 宜明昂科-B has reported continuous losses from 2023 to 2025, with increasing R&D expenditures, indicating significant financial pressure moving forward [30][31].

Core Viewpoint - Yiming Anke-B (01541) has received approval from the National Medical Products Administration of China for clinical trials of IMM01 (Tadapaxip) for the treatment of atherosclerosis, which has positively impacted its stock price [1][4]. Group 1: Company Developments - Yiming Anke's stock price increased by 9.28% to HKD 6.71, with a trading volume of HKD 12.32 million [1][4]. - The company holds global intellectual property and commercialization rights for IMM01 (Tadapaxip), with a patent family that includes authorized patents in China, the United States, Japan, and the European Union [1][4]. Group 2: Research and Development Insights - Guoyuan International reported that the company has regained global rights for IMM2510 and IMM27M, which will accelerate its overseas clinical research and development pace [1][4]. - Clinical data for IMM2510 is reported to be excellent, with good safety and significant differentiation advantages [1][4]. - The company has a rich R&D pipeline, enhancing its risk resistance, with promising clinical efficacy data for the CD47CD20 dual antibody (IMM0306), which is expected to become a key drug in the autoimmune field [1][4]. - The company is recognized as a global innovator in CD47 fusion proteins, with broad application prospects in oncology, autoimmune diseases, and cardiovascular fields [1][4]. - The current market capitalization is only HKD 2.7 billion, indicating a significant undervaluation, and it is recommended to pay close attention to the company [1][4].

Group 1 - The stock of Yiming Anke-B (01541.HK) rose over 10% in early trading, currently up 8.63% at HKD 6.67 [1] - The trading volume reached HKD 11.1965 million [1]

Core Viewpoint - Yiming Anke-B (01541) has seen a significant stock price increase following the approval from the National Medical Products Administration of China for clinical trials of IMM01 (Tadapaxip) for atherosclerosis treatment [1] Group 1: Company Developments - Yiming Anke has received approval for clinical trials of IMM01 (Tadapaxip) for treating atherosclerosis, holding global intellectual property and commercialization rights for this drug [1] - The company possesses a patent family for IMM01, with authorized patents in China, the United States, Japan, and the European Union [1] Group 2: Market Analysis - Guoyuan International's report indicates that the company has regained global rights for IMM2510 and IMM27M, which will accelerate the pace of global development [1] - Clinical data for IMM2510 is reported to be excellent, with good safety and significant differentiation advantages [1] - The company is recognized as a global innovator in CD47 fusion proteins, with a rich pipeline and promising applications in oncology, autoimmune diseases, and cardiovascular fields [1] - The current market capitalization is only 2.7 billion HKD, indicating a significant undervaluation, and the company is recommended for active monitoring [1]