New Stock Offerings - The tender offer for Shangwei New Materials (688585) is open from September 29, 2025, to October 28, 2025[1] - Zitian Tui (300280) is in the delisting adjustment period with only 2 trading days remaining until the last trading day[1] Market Alerts - Kesi Technology (688788) and Pinming Technology (688109) have recent announcements but no specific details provided[1] - Magu Technology (688448) is experiencing severe abnormal fluctuations[1] Trading Updates - Multiple companies including Dongjing (002199) and Guosheng Jinkong (002670) have announcements dated October 9, 2025, indicating ongoing trading activities[1] - Companies like Hunan Yuneng (301358) and Wanrun New Energy (688275) have announcements from October 1, 2025, indicating recent trading updates[1] Financial Disclosures - Several companies have disclosed their financial information, with specific announcements linked to their respective stock codes[1] - The report includes links to detailed announcements for various companies, providing transparency in their financial activities[1]

Core Viewpoint - The company, Borui Pharmaceutical, plans to issue H-shares and list on the Hong Kong Stock Exchange to accelerate its international strategy, enhance overseas financing capabilities, and improve its capital strength and competitiveness [1][4]. Financial Performance - In the first half of 2025, the company's revenue was approximately 537.44 million, a decrease of 18.28% year-on-year, while net profit dropped by 83.85% to 17.17 million [3][4]. - The company has faced a continuous decline in revenue and net profit since 2022, with a significant drop in core raw material drug business and ongoing challenges in its innovative drug pipeline [4][5]. Business Challenges - The raw material drug business, which contributes over 75% of revenue, has seen a revenue decline of 19.30% year-on-year, leading to overall performance pressure [6][8]. - Key products, particularly antiviral and antifungal raw materials, have experienced sharp revenue declines due to market competition and changing demand trends [5][6]. R&D and Financial Strain - R&D expenses surged to 348 million in the first half of 2025, representing 64.83% of revenue, indicating a heavy investment in innovation at the cost of cash flow [9][10]. - The company is under significant cash flow pressure, with net cash flow from operating activities down 24.87% and cash reserves reduced by 22.46% year-on-year [8][9]. Strategic Moves - The H-share issuance is seen as a critical step to alleviate short-term debt pressure and support the transition from a raw material-focused business to an innovation-driven model [11][12]. - The funds raised will be directed towards upgrading core raw material business technology and expanding the innovative drug pipeline, aiming for a dual goal of optimizing capital structure and upgrading business structure [11].

Group 1 - The company announced plans to issue H-shares and list on the Hong Kong Stock Exchange to enhance its international strategy and overseas business layout [1] - The funds raised from the H-share issuance will be used for R&D activities, expanding production lines, strategic investments and acquisitions, and general corporate purposes [1] - The company appointed Ernst & Young as the auditing firm for the H-share issuance [1] Group 2 - In the first half of 2025, the company reported revenue of 537 million yuan, a year-on-year decrease of 18.28%, and a net profit attributable to shareholders of 17.17 million yuan, down 83.85% [2] - The company's R&D expenditure as a percentage of revenue increased by 43.12 percentage points compared to the same period last year, driven by a focus on R&D for GLP-1 innovative drugs and inhalation formulations [2] - The company plans to raise up to 500 million yuan through a private placement, with the actual controller subscribing at a price of 22.56 yuan per share [2]

博瑞生物医药（苏州）股份有限公司 2025 年第一次临时股东大会会议资料 博瑞生物医药（苏州）股份有限公司 2025 年第一次临时股东大会会议资料 二〇二五年十月 第 1页/共 37页 | 议案 27 | | --- | | 关于预计日常关联交易额度的议案 35 | | --- | 博瑞生物医药（苏州）股份有限公司 2025 年第一次临时股东大会会议资料 2025 年第一次临时股东大会会议须知 为维护全体股东的合法权益，确保股东大会会议秩序和议事效率，保证股东 大会的顺利召开，根据《中华人民共和国公司法》（以下简称"《公司法》"） 《中华人民共和国证券法》（以下简称"《证券法》"）《上市公司股东会规则》 以及《博瑞生物医药（苏州）股份有限公司章程》（以下简称"《公司章程》"） 和博瑞生物医药（苏州）股份有限公司（以下简称"公司"、"上市公司"或"博 瑞医药"）《股东大会议事规则》等有关规定，特制定 2025 年第一次临时股东 大会会议须知： 一、 为保证本次大会的严肃性和正常秩序，切实维护股东及股东代理人 （以下统称"股东"）的合法权益，除出席会议的股东、公司董事、监事、高级 管理人员、见证律师及董事会邀请的 ...

Group 1 - The core point of the news is that Borui Pharmaceutical (688166.SH) is facing significant stock price pressure, leading to a share reduction by a major shareholder and a subsequent share buyback announcement [1][2] - As of September 26, 2025, the shareholder Advanced Manufacturing Industry Investment Fund reduced its holdings by 5.301792 million shares, accounting for 1.25% of the total share capital, with a total value of approximately 440 million yuan [1] - The company's stock price has dropped nearly 50% from its peak of 122.59 yuan on August 6, 2025, to a closing price of 59.44 yuan on September 29, 2025 [1] Group 2 - In the first half of 2025, the company reported operating revenue of 537 million yuan, a year-on-year decline of 18.28% [2] - The net profit attributable to shareholders was only 17.1732 million yuan, down 83.85% year-on-year, primarily due to decreased demand and pricing for its key product, Oseltamivir, amid changing flu trends and intensified market competition [2] - The decline in net profit was also influenced by high base effects from last year's temporary demand for high-margin antifungal raw materials, as well as increased depreciation costs from the conversion of construction in progress [2]

Group 1 - A total of 21 companies were investigated by institutions on September 29, with 14 companies specifically targeted by funds [1] - The most popular company among funds was Yongzhen Co., with 26 funds participating in the investigation [1] - Other notable companies included Borui Pharmaceutical and Ruixin Microelectronics, attracting 23 and 18 funds respectively [1] Group 2 - The companies investigated belong to various sectors, with the pharmaceutical and biological industry having the highest representation, featuring 4 companies [1] - The total market capitalization of the investigated companies included 1 company with a market cap over 500 billion and 7 companies with a market cap below 100 billion [1] - The market performance of the investigated stocks showed that 8 out of 14 companies increased in value over the past 5 days, with Shengda Resources, Weiteou, and Fangsheng Pharmaceutical leading with increases of 15.07%, 14.42%, and 8.62% respectively [1] Group 3 - Among the funds participating in the investigations, 6 stocks experienced net inflows over the past 5 days, with Fangsheng Pharmaceutical receiving a net inflow of 119 million [2] - Other companies with significant net inflows included Shengda Resources and Jinshi Resources, with net inflows of 108 million and 41.28 million respectively [2] - A detailed list of companies investigated includes their respective fund participation, latest closing prices, and recent performance metrics [2]

Group 1 - In the past five trading days, a total of 222 companies were investigated by institutions, with significant interest in companies like Siwei Technology, Borui Pharmaceutical, and Xinlitai [1][2] - Among the companies investigated, 41 received attention from more than 20 institutions, with Siwei Technology being the most popular, attracting 92 institutions [1][2] - The types of institutions involved in the investigations included 194 securities companies, 145 fund companies, and 74 private equity firms, indicating a strong interest from the securities sector [1] Group 2 - In terms of investigation frequency, two companies, Hu Dian Co. and Ice Wheel Environment, were investigated three times, indicating high interest [2] - Out of the stocks investigated by more than 20 institutions, 13 saw net inflows of funds, with Jucheng Co. receiving the highest net inflow of 297 million yuan [2] - Among the stocks investigated, 24 experienced price increases, with Jucheng Co. leading with a rise of 36.31%, while 17 saw declines, with Borui Pharmaceutical dropping by 27.33% [2][3] Group 3 - The investigation data included various companies across different sectors, with notable mentions such as Siwei Technology (92 institutions), Borui Pharmaceutical (80 institutions), and Xinlitai (78 institutions) [2][3] - The latest closing prices and percentage changes for these companies were also highlighted, showing significant volatility in the market [2][3] - The data provided a comprehensive overview of institutional interest and market performance, reflecting the dynamic nature of the investment landscape [2][3]

Policy Developments - The Ministry of Industry and Information Technology, along with two other departments, announced the initiation of the 2025 high-end medical equipment promotion application project [1] Drug and Device Approvals - Baicheng Pharmaceutical received clinical trial approval for its innovative drug BIOS-0623-Z4, aimed at treating cancer pain in adults, with no similar drugs currently on the market [2] - Heng Rui Medicine's subsidiary received approval for clinical trials of HRS-2129, targeting diabetic peripheral neuropathic pain and osteoarthritis pain, with a total R&D investment of approximately 112 million yuan [3] - Borui Pharmaceutical obtained FDA approval for the clinical trial of BGM1812 injection for overweight or obesity treatment, with no similar products approved globally [4] Capital Market - Hangzhou Yaojiasu Medical Isotope Technology Co., Ltd. announced the completion of several million yuan in angel round financing, aimed at expanding its core team and advancing technology development [5] Industry Events - The National Medical Insurance Administration has identified and addressed multiple cases of abnormal data, enhancing the regulatory capabilities of medical insurance data [7] - Xiangyu Medical signed a cooperation agreement with Zhejiang Provincial People's Hospital to establish a clinical research ward for brain-machine interfaces [8] - A micro "lung chip" with an embedded immune system was developed by researchers from Georgia Tech and Vanderbilt University, potentially revolutionizing disease research [9] Public Opinion Alerts - Shenqi Pharmaceutical faced a significant stock drop after being ordered to rectify issues related to the misappropriation of 44.83 million yuan in sales fees, leading to regulatory actions [10]

Group 1 - Yinglian Co., Ltd. expects a net profit of 34.5 million to 37.5 million yuan for the first three quarters of 2025, representing a year-on-year increase of 1531% to 1673% [1] - China CNR Corporation signed major contracts totaling approximately 54.34 billion yuan, accounting for 22% of its expected revenue for 2024 [1] - Shengmei Shanghai reported a total order amount of 9.072 billion yuan, a year-on-year increase of 34.1% [2] Group 2 - Fulian Precision plans to increase capital in its subsidiary Jiangxi Shenghua with a total investment of 35.63 billion yuan, which is expected to constitute a major asset restructuring [3] - Aimeike has obtained a drug registration certificate for Minoxidil topical solution, which is used for treating male pattern baldness [4] - Guolin Technology is planning to acquire 91.07% of Kailianjie’s equity for cash, which is expected to constitute a major asset restructuring [5] Group 3 - Baicheng Co. plans to purchase 55% of Shanghai Canxi Engineering Equipment Co. and will suspend trading of its stock starting September 30, 2025 [6][7] - Diaowei is planning to acquire equity in Rongpai Semiconductor and has suspended trading of its stock [8] - Xiatun New Energy signed a strategic cooperation framework agreement with Zhongwei Co. to establish a long-term partnership in the supply chain for solid-state lithium battery materials [9] Group 4 - Lingyi Zhi Manufacturing is planning to issue H-shares and list on the Hong Kong Stock Exchange to enhance its international strategy [10] - Baicheng Pharmaceutical received clinical trial approval for its innovative drug BIOS-0623-Z4, which targets cancer pain treatment [11] - Weide Information announced a preliminary transfer price of 40.33 yuan per share, representing a 26% discount to its closing price [12] Group 5 - Huayou Cobalt's subsidiary signed contracts with LGES for the supply of 76,000 tons of ternary precursor materials and 88,000 tons of ternary cathode materials from 2026 to 2030 [13] - Hubei Energy signed a cooperation agreement with the Xiangyang Municipal Government to invest 26.7 billion yuan in clean energy projects [14]

Core Viewpoint - The company, Borui Pharmaceutical, has received approval from the U.S. FDA to initiate Phase I clinical trials for BGM1812 injection aimed at treating overweight or obesity [2] Group 1 - The announcement was made on the evening of September 29 [2] - The approval marks a significant step for the company in the development of treatments for obesity [2]