康希诺公告，2025年上半年营业收入3.82亿元，同比增长26.00%。归属于上市公司股东的净亏损 1348.54万元，上年同期净亏损2.25亿元。研发投入占营业收入的比例48.03%，减少33.82个百分点。 ...

Group 1 - The overall number of vaccine batch approvals in the first half of 2025 is 1,629, representing a year-on-year decrease of 17% [1] - Certain vaccines, such as rabies and HPV vaccines, have seen significant growth in batch approvals, while others like polio, meningitis, and measles-mumps-rubella vaccines have experienced substantial declines [1] - Several key vaccines have received approval for market launch in the first half of the year, including CanSino's PCV13 and Wantai's 9-valent HPV vaccine [1] Group 2 - Multiple products are currently in the review stage for market approval, including Zhifei's PCV15 and MCV4, as well as Kangtai's IPV and quadrivalent influenza vaccines [1] - It is anticipated that sales of certain products in the second half of 2025 may improve year-on-year, driven by new product launches contributing to revenue growth [1] - The ongoing development of innovative vaccine pipelines and expectations for external licensing are areas of interest, along with the implications of recent equity changes in some companies and the potential impact of new shareholders [1]

Summary of Key Points from the Conference Call Company Overview - The conference call discusses 康希诺 (CanSino), a biopharmaceutical company specializing in vaccine development and commercialization. Industry Insights - The vaccine market is expected to expand significantly, particularly for products like MCV4 and PCV13, driven by rising demand and economic recovery in China. Key Products and Developments 1. **MCV4 Vaccine** - MCV4 vaccine shows superior immunogenicity and durability in children under two compared to traditional vaccines, with sales projected to grow from 560 million CNY in 2023 to over 1 billion CNY in 2024 [2][3][5] - It has received expert consensus recommendation and is expected to replace existing meningococcal vaccines [2][3] 2. **PCV13 Vaccine** - PCV13 utilizes multi-component and dual-carrier technology, aiming to produce higher specificity antibodies in infants and address immune suppression issues from co-administration with other vaccines [2][3][6] - The overall market for PCV13 was nearly 7 billion CNY in 2022, making it the top vaccine in China that year [3][6] 3. **PDP1 Pneumococcal Vaccine** - PDP1 is in Phase I clinical trials, demonstrating good safety and high antibody levels, with potential to cover over 98% of pneumococcal strains [2][4][7] - It shows broad-spectrum efficacy and public health value [4][7] 4. **DPTCP Vaccine** - The DPTCP vaccine is developed to meet the increasing demand for a more durable and safer pertussis vaccine, utilizing a purified antigen approach [2][4][8] - This vaccine is positioned to replace older generation vaccines and imported pentavalent vaccines [4][9] 5. **VLP Polio Vaccine** - The VLP (Virus-Like Particle) polio vaccine is in Phase I clinical trials and has received funding from the Gates Foundation and WHO, offering high safety and immunogenicity [2][10] - It avoids the risks associated with traditional oral and inactivated polio vaccines [10] 6. **Shingles Vaccine** - CanSino is developing a shingles vaccine using adenovirus vector technology, with clinical trials ongoing in Canada [2][11] - Preliminary data indicates that its immunogenicity is comparable to GSK's Shingrix, which has a high adverse event rate [11] Market Position and Future Outlook - CanSino is positioned as the third domestic and fourth overall listed vaccine company in China, with significant market share potential in the expanding PCV market [4][6] - The company is focused on global market expansion and innovation in vaccine development, with a strong pipeline of products that leverage advanced technologies [2][12] - Investors are encouraged to pay attention to companies like CanSino that possess advanced R&D capabilities and differentiated product offerings in the healthcare sector [3][12]

Group 1 - The Shanghai Composite Index fell by 0.46% to close at 3666.44 points, while the Hang Seng Index decreased by 0.37% to 25519.32 points [1] - CanSino Biologics has an AH premium of 88.3%, ranking 35th among AH shares. The A-share closed at 83.93 yuan, down 1.33%, and the H-share closed at 48.76 HKD, down 0.77% [1] - CanSino Biologics, founded in 2009 in China, focuses on providing innovative, high-quality, and accessible vaccines for the prevention and treatment of infectious diseases. The company's mission is to offer innovative and quality vaccines globally, aiming for "innovation without end, a world without epidemics" [1] Group 2 - CanSino Biologics is listed on both the Hong Kong Stock Exchange (H-share, stock code 6185.HK) and the Shanghai Stock Exchange's STAR Market (A-share, stock code 688185), making it the first "A+H" vaccine stock since the launch of the STAR Market in China [1]

Group 1 - The Shanghai Composite Index rose by 0.5% to close at 3665.92 points, while the Hang Seng Index increased by 0.25% to 24969.68 points [1] - CanSino Biologics has an AH premium of 91.3%, ranking 35th among AH shares. The A-shares closed at 82.5 yuan, down 3.06%, and the H-shares closed at 47.08 HKD, down 6.96% [1] - CanSino Biologics, founded in 2009 in China, focuses on providing innovative, high-quality, and accessible vaccines for the prevention and treatment of infectious diseases, positioning itself as a leading high-tech biopharmaceutical company [1] Group 2 - The company's mission is to provide innovative, high-quality, and accessible vaccines globally, aiming for the vision of "Innovation without end, a world without epidemics" [1] - CanSino Biologics is listed on both the Hong Kong Stock Exchange (H shares, stock code 6185.HK) and the Shanghai Stock Exchange's STAR Market (A shares, stock code 688185), being the first "A+H" vaccine stock since the launch of the STAR Market [1]

Core Viewpoint - The Chinese innovative pharmaceutical industry is transitioning from imitation-based innovation to original innovation, and there is a strong emphasis on expanding into emerging overseas markets to achieve high-quality development [1][2]. Group 1: Industry Insights - Since the reform of the drug review and approval system in 2015, China's innovative drugs have entered a rapid development phase [1]. - Experts at the "Future Path of Chinese New Drugs (T20+)" conference suggested that collaboration among various stakeholders is essential to accelerate the internationalization of innovative drugs [1]. - The potential market in developing countries is significant due to their large populations, and China's innovative drugs are seen as high-quality and affordable alternatives [1]. Group 2: Company Initiatives - Companies like BeiGene, China Biologic Products, and CanSino Biologics are taking proactive steps to promote their innovative drugs in developing countries, contributing to global health challenges such as infectious diseases and chronic illnesses [1]. - A new alliance called the "Emerging Market New Drug Product Export Alliance" was established to facilitate experience sharing and collaborative efforts in promoting products to more countries [2].

Investment Rating - The industry investment rating is maintained at "Overweight" [3][10][29] Core Viewpoints - The vaccine industry is experiencing significant innovation breakthroughs both domestically and internationally, with multiple companies achieving clinical trial approvals for new vaccines [2][6][10] - The industry is currently facing performance pressure due to supply-demand imbalances, with high competition leading to price declines for some products [10][29] - Long-term prospects remain positive, driven by policy support, increasing demand due to aging populations, and ongoing technological advancements in vaccine development [11][31] Summary by Sections Recent Developments - Watson Bio's mRNA vaccine for respiratory syncytial virus (RSV) has received clinical trial approval, marking a significant step in domestic vaccine innovation [5][6] - The first phase trial of China's Tian Tan strain HIV vaccine has been successfully completed, indicating progress in HIV vaccine research [5][6] - Pfizer reported a 10% revenue growth in Q2 2025, exceeding market expectations, with significant contributions from its anticoagulant and COVID-19 products [5][6] Market Performance - The vaccine sector saw a slight decline of 0.44% last week, while the overall pharmaceutical sector dropped by 0.84% [7][8] - The vaccine industry has shown a cumulative increase of 0.96% since the beginning of 2025, indicating a recovery trend [7][8] Valuation Metrics - The vaccine sector's price-to-earnings (PE) ratio is 80.76X, with a recent decrease of 0.33X, while the price-to-book (PB) ratio stands at 1.96X [9][10] - The PE ratio is within the 48.20% percentile since 2013, indicating a relatively high valuation compared to historical data [9][10] Investment Recommendations - The report suggests focusing on companies with strong innovation capabilities and differentiated products, recommending companies like CanSino and Kanghua Bio [10][31] - The long-term outlook emphasizes the importance of innovation and international expansion as key drivers for growth in the vaccine industry [10][31]

承董事會命 康希諾生物股份公司 Xuefeng YU 董事長 香港，2025年8月6日 （股份代號：6185） 董事會會議通告 康 希 諾 生 物 股 份 公 司（「本公司」）董 事（「董 事」）會（「董事會」）謹 此 宣 佈，董 事 會 會 議將於2025年8月20日（星 期 三）舉 行，藉 以（其 中 包 括）考 慮 及 批 准 本 公 司 及 其 附 屬公司截至2025年6月30日止六個月的中期業績及其發佈，以及考慮建議派發中 期 股 息（如 有）。 香港交易及結算所有限公司及香港聯合交易所有限公司對本通告的內容概不負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本通告全部 或任何部分內容所產生或因依賴該等內容而引致的任何損失承擔任何責任。 CanSino Biologics Inc. 康希諾生物股份公司 （於中華人民共和國註冊成立的股份有限公司） 於本通告日期，本公司董事會包括執行董事Xuefeng YU博士、Shou Bai CHAO博 士 及王靖女士；非執行董事李志成先生；以及獨立非執行董事桂水發先生、劉建忠 先生及張耀樑先生。 ...

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 康希諾生物股份公司 呈交日期: 2025年8月6日 FF301 II. 已發行股份及/或庫存股份變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06185 | 說明 | H 股 | | | | | | | | 已發行股份（不包括庫存股份）數目 | | 庫存股份數目 | | 已發行股份總數 | | | 上月底結存 | | | 132,670,900 | | 0 | | 132,670,900 | | 增加 / 減少 (-) | | | 0 | | 0 | | | | 本月底結存 | | | 132,670,900 | | 0 | | 132,670,900 | | 2. 股份分類 | 普通股 | 股份類別 | A | 於香港聯交所上市 (註 ...

8月6日，上证指数涨0.45%，收报3633.99点，恒生指数涨0.03%，收报24910.63点。 康希诺AH溢价达85.6%，位居AH股溢价率第40位。当日收盘，康希诺A股报88.48元，涨幅6.13%，H股 报52.05港元，上涨9.21%。 *注：AH股是指同时在A股和港股上市的公司，溢价（A/H）越大，说明H股相比A股越便宜。 本文源自：金融界 作者：行情君 资料显示，康希诺生物股份公司2009年成立于中国,以在世界范围内提供预防和治疗感染类疾病的解决 方案为己任,专注于创新、优质、可及的人用疫苗的研发、生产和商业化,是行业领先的高科技生物制品 企业。康希诺生物的使命始终是"为全球提供创新、优质、可及的疫苗",以达到"创新不止,世界无疫"的 企业愿景。公司已登陆香港联交所主板H股(股票代码6185.HK)和上海证券交易所科创板A股(股票代码 688185),是中国科创板开板以来首支"A+H"疫苗股。 ...