Investment Rating - The industry investment rating is maintained at "Overweight" [1] Core Views - Vaccine companies are achieving breakthroughs in internationalization and research and development, while the pressure for winter epidemic prevention continues to highlight the need for effective measures [4][9] - The vaccine industry is transitioning from scale expansion to innovation-driven growth, with supply-demand imbalances and homogenized competition causing short-term challenges, but the long-term outlook remains positive due to supportive policies, increasing demand, and technological advancements [9][28] Summary by Sections Recent Developments - Zhifei Biological's subsidiary obtained a U.S. patent for an RSV vaccine, marking a significant step in its international market strategy [3] - Watson Bio's subsidiary received a marketing license for a 13-valent pneumonia vaccine in Egypt, enhancing its international presence [3] - Wuhan Institute of Biological Products achieved important progress in children's vaccine development, with two vaccines approved for clinical use [3] Market Performance - The vaccine sector saw a 1.33% increase last week, underperforming compared to other pharmaceutical sectors [5][6] - Year-to-date, the vaccine sector has experienced a cumulative decline of 5.12% [6] Valuation Metrics - The vaccine sector's PE (ttm) is 95.41X, with a PB (lf) of 1.87X, indicating a slight increase in valuation metrics compared to previous periods [7] Investment Recommendations - The vaccine industry is under pressure, with a focus on innovation and international expansion as key strategies for recovery [8] - Companies with high technical barriers and differentiated pipelines are recommended for investment, particularly those with strong research and development capabilities [9][28]

Core Insights - Tianjin has strengthened the role of enterprises in technological innovation during the "14th Five-Year Plan" period, cultivating over 12,000 technology-based SMEs and high-tech enterprises, with more than 250 high-growth "Cheetah Enterprises" [1][2] Group 1: Technological Innovation - A number of Tianjin technology companies have made breakthroughs in key areas, including Huahai Qingke, Feiteng Information, Kirin Software, Shuguang Information, CanSino, and Heyuan Biotechnology, establishing themselves as innovation benchmarks in their respective fields [1] - The city has implemented a gradient cultivation mechanism, creating a growth path for technology-based SMEs to high-tech enterprises and leading technology enterprises, supported by policies like the "Cheetah Enterprise Evaluation Method" [1] Group 2: Financial Support and Investment - Tianjin has organized over 800 key projects in 19 priority industrial sectors, with a fiscal investment of 740 million yuan, which has attracted 4.9 billion yuan from enterprises [1] - The government has established 32 innovation consortia led by technology leaders to promote deep integration of industry, academia, and research, and has supported companies like Tiandi Weiye and Kailaiying in major R&D platforms [2] - The municipal government’s guiding funds have injected financial resources into enterprises, with three innovation mother funds having established 33 sub-funds and completed 244 investments, mobilizing over 8.5 billion yuan in social capital for early-stage and hard technology sectors [2]

Core Viewpoints - The company released its Q3 2025 report, with performance meeting expectations, driven by the continued growth of the MCV series and the anticipated contribution from PCV13 [1] - The company achieved profitability in Q3 2025, with expectations for further improvement in profitability due to a rich R&D pipeline supporting long-term development [1] - The introduction of an A-share equity incentive plan in September 2025 aims to ensure long-term healthy development and attract international high-end talent [1][3] Financial Performance - For the first three quarters of 2025, the company reported revenue of 693 million yuan, a year-on-year increase of 22.13%, and a net profit attributable to shareholders of 14 million yuan, up 106.49% [1] - In Q3 2025, the company achieved revenue of 318 million yuan, a 13.07% increase year-on-year, and a net profit of 28 million yuan, up 842.28% [1] - The gross margin for the first three quarters was 80.67%, an increase of 6.47 percentage points, attributed to sales growth and cost control measures [5] Product Development and Pipeline - The MCV series generated sales of 662 million yuan in the first three quarters, a year-on-year increase of 28%, with ongoing applications for market expansion [1][2] - The company’s R&D pipeline includes various vaccines, with significant progress in clinical trials for DTcP and other products, indicating strong future growth potential [2] - The PCV13 vaccine was approved for domestic use in June 2025 and has begun vaccination efforts in over ten provinces, expected to synergize with the MCV series [1][2] Equity Incentive Plan - The A-share equity incentive plan involves granting 2.5691 million restricted shares, accounting for 1.04% of the total share capital, aimed at enhancing management and core personnel motivation [3][4] - The performance assessment for the incentive plan will focus on revenue growth and progress in R&D pipelines, aligning with the company's innovative vaccine enterprise positioning [4] Future Outlook - The company forecasts revenues of 1.047 billion yuan, 1.452 billion yuan, and 1.754 billion yuan for 2025, 2026, and 2027, respectively, with expected year-on-year growth rates of 27.0%, 38.7%, and 20.8% [6] - The net profit attributable to shareholders is projected to be 35 million yuan in 2025, with significant growth anticipated in subsequent years [6]

Core Points - The company held its second extraordinary general meeting of shareholders in 2025, where all proposed resolutions were approved without any rejections [2][4][8] Meeting Details - The meeting was convened by the board of directors and chaired by Dr. Xuefeng Yu, utilizing a combination of on-site and online voting methods, complying with relevant laws and regulations [2][3] - All seven current directors and three supervisors attended the meeting, along with the board secretary and other executives [3] Resolutions Passed - The following key resolutions were approved: - Cancellation of the supervisory board and amendments to the Articles of Association [4] - Approval of the rules for shareholder meetings and board meetings [4][5] - Revision of various corporate governance systems, including fundraising management, related party transaction management, external guarantee decision-making, external investment management, and independent non-executive director work systems [5] - Use of surplus reserves to offset losses, with a total of CNY 1,450,342,128.90 allocated from surplus reserves and capital reserves [5][9] Legal Compliance - The meeting was witnessed by lawyers from Beijing Jingtian & Gongcheng Law Firm, confirming that the meeting's procedures and voting results were legally valid [7] Notification to Creditors - The company announced its intention to use capital reserves to offset losses and informed creditors of their rights to claim debts within specified timeframes [11][12]

Core Viewpoint - 康希诺生物 has elected new independent non-executive directors during the extraordinary general meeting, indicating a shift in governance structure [2] Group 1: Board Elections - 左敏 and 纪雪峰 have been elected as independent non-executive directors of the third board [2] Group 2: Committee Adjustments - Following the extraordinary general meeting, the board has decided to adjust the composition of its committees, effective from November 27, 2025, until the term of the third board ends [2] - The Audit Committee will be chaired by 张耀樑, with members 纪雪峰 and 李志成 [2] - The Compensation and Assessment Committee will be chaired by 左敏, including members 张耀樑, 纪雪峰, 李志成, and 博士 Xuefeng YU [2] - The Nomination Committee will be chaired by 纪雪峰, with members 左敏 and 博士 Xuefeng YU [2]

Core Points - 康希诺生物 announced the election of Mr. Zuo Min and Ms. Ji Xuefeng as independent non-executive directors of the third board of directors [1] - Following the extraordinary general meeting, the company’s board of directors resolved to adjust the composition of its committees, effective from November 27, 2025, until the term of the third board of directors expires [1] Committee Composition - Audit Committee: Mr. Zhang Yaoliang (Chairman), Ms. Ji Xuefeng, Mr. Li Zhicheng [1] - Remuneration and Assessment Committee: Mr. Zuo Min (Chairman), Mr. Zhang Yaoliang, Ms. Ji Xuefeng, Mr. Li Zhicheng, Dr. Xuefeng Yu [1] - Nomination Committee: Ms. Ji Xuefeng (Chairman), Mr. Zuo Min, Dr. Xuefeng Yu [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部 或任何部分內容所產生或因依賴該等內容而引致的任何損失承擔任何責任。 CanSino Biologics Inc. 康希諾生物股份公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6185） 海外監管公告 本 公 告 乃 康 希 諾 生 物 股 份 公 司（「本公司」）根 據 香 港 聯 合 交 易 所 有 限 公 司 證 券 上 市規則第13.10B條而發表。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 發 的《康 希 諾 生 物 股 份 公 司 關 於 使 用 公 積 金 彌 補 虧 損 通 知 債 權 人 的 公 告》，僅 供 參 閱。 承董事會命 康希諾生物股份公司 Xuefeng YU 董事長 香港，2025年11月27日 於 本 公 告 日 期，本 公 司 董 事 會 包 括 執 行 董 事Xuefeng YU博 士、Shou Bai CHAO博 士及王靖女士；非執行董事李志成先生；以及獨立非執行董事張耀樑先生、左敏 先生及 ...

CanSino Biologics Inc. 康希諾生物股份公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6185） | Xuefeng YU博 士 | （主席、執行董事） | | --- | --- | | Shou Bai CHAO博 士 | （執行董事） | | 王靖女士 | （執行董事） | | 李志成先生 | （非執行董事） | | 張耀樑先生 | （獨立非執行董事） | | 左敏先生 | （獨立非執行董事） | | 紀雪峰女士 | （獨立非執行董事） | 董事會設立三個委員會。下表載列各董事會成員在該等委員會所擔任的職位。 | | 董事委員會 | 審計委員會 | 薪酬與 | | | 提名委員會 | | --- | --- | --- | --- | --- | --- | --- | | 董 事 | | | 考核委員會 | | | | | Xuefeng YU博 士 | | | 成 | 員 | 成 | 員 | | Shou Bai CHAO博 | 士 | | | | | | | 王靖女士 | | | | | | | | 李志成先生 | | 成 員 | 成 | 員 | | | | 張 ...

康希諾生物股份公司 章 程 中 國 • 天 津 – 1 – | 第一章 | 總 | | 則 | 3 | | --- | --- | --- | --- | --- | | 第二章 | | | 經營宗旨及範圍 | 5 | | 第三章 | 股 | | 份 | 5 | | 第一節 | | | 股份發行 | 5 | | 第二節 | | | 股份增減和回購 | 7 | | 第三節 | | | 股份轉讓 | 8 | | 第四章 | | | 股東和股東會 | 9 | | 第一節 | | | 股東的一般規定 | 9 | | 第二節 | | | 控股股東和實際控制人 | 13 | | 第三節 | | | 股東會的一般規定 | 14 | | 第四節 | | | 股東會的召集 | 18 | | 第五節 | | | 股東會的提案與通知 | 19 | | 第六節 | | | 股東會的召開 | 21 | | 第七節 | | | 股東會的表決和決議 | 24 | | 第五章 | | 董事會 | | 29 | | 第一節 | | | 董 事 | 29 | | 第二節 | | | 董事會 | 33 | | 第三節 | | | 獨立董事 | 4 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部 或任何部分內容所產生或因依賴該等內容而引致的任何損失承擔任何責任。 CanSino Biologics Inc. 康希諾生物股份公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6185） 2025年第二次臨時股東大會 的投票表決結果； 修訂公司章程； 選舉獨立非執行董事； 及 調整董事會下設各委員會的組成 臨時股東大會的投票表決結果 董 事 會 謹 此 宣 佈，於2025年11月27日（星 期 四）舉 行 的 臨 時 股 東 大 會 上 提 呈 的 決議的投票表決結果。所有決議均於臨時股東大會上以投票表決方式獲正式 通過。第4.01項及第4.02項決議按累積投票制方式進行表決。 修訂公司章程 根 據 臨 時 股 東 大 會 的 投 票 表 決 結 果，董 事 會 謹 此 宣 佈，公 司 章 程 已 獲 修 訂， 自2025年11月27日起生效。 選舉獨立非執行董事 於臨時股東大會上，左敏先生及紀雪峰女士獲選舉為第三屆董事會獨立非執 行董事。 調整董事會下設 ...