非经营性资金占用及其他关联资金往来情况 目 录 1、 专项审计报告 2、 附表 委托单位： 审计单位： 联系电话： IDC 汇总表的专项审计报告 关于康希诺生物股份公司 为了更好地理解康希诺 2024 年度控股股东、实际控制人及其他关联方资金占用情况,后 附的汇总表应当与已审财务报表一并阅读。 本说明仅作为康希诺向证券监管机构呈报 2024 年度控股股东、实际控制人及其他关联方 资金占用情况之用,不得用作任何其他目的。 atsu Lert 德勒华永会计师 口 引 中国注册会计师 (特殊普通合伙) 关于康希诺生物股份公司 控股股东、实际控制人及其他关联方资金占用情况的专项说明 德师报(函)字(25)第 Q00340 号 康希诺生物股份公司董事会: 我们接受委托,依据中国注册会计师审计准则审计了康希诺生物股份公司(以下简称"康希 诺")2024年12月31日合并及母公司资产负债表,2024年度合并及母公司利润表、合并及母公 司现金流量表、合并及母公司股东权益变动表以及相关财务报表附注(以下合称"财务报表"), 并于 2025年 3月25 日签发了德师报(审)字(25)第 P03280 号无保留意见的审计报告。 根 ...

按照公司上市地监管规则和《康希诺生物股份公司章程》《对外担保决策制 度》的相关规定，为满足康希诺生物股份公司（以下简称"公司"）合并报表范 围内下属子公司的经营发展需要，公司及全资子公司康希诺生物（上海）有限公 司拟在 2025 年度对下属子公司康希诺（上海）生物科技有限公司、康希诺（上 海）生物研发有限公司提供合计累计不超过人民币 1 亿元的担保。 相关担保事项以正式签署的担保文件为准，授权期限为本次董事会审议通过 之日起 12 个月内。 公司拟提请董事会授权董事长在上述额度及决议有效期内行使担保决策权、 签署相关文件等事宜，具体事项由公司财务管理中心负责组织实施。 截至本公告披露日，公司对外担保的总额为 46,802.36 万元，占公司最近一 期经审计净资产和总资产的比例分别为 9.53%和 5.88%，全部为公司全资子公司 康希诺生物（上海）有限公司为其控股子公司康希诺（上海）生物科技有限公司 提供担保。公司无逾期担保，无涉及诉讼的担保。 特此公告。 康希诺生物股份公司董事会 证券代码：688185 证券简称：康希诺 公告编号：2025-010 康希诺生物股份公司 关于 2025 年度对外担保预计的公告 ...

证券代码：688185 证券简称：康希诺 公告编号：2025-007 康希诺生物股份公司 第三届监事会第六次会议决议公告 本公司监事会及全体监事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、监事会会议召开情况 康希诺生物股份公司（以下简称"公司"）第三届监事会第六次会议于 2025 年 3 月 25 日在公司会议室以现场及通讯的方式召开，会议通知已于会议召开 10 日前以电子邮件形式送达全体监事。本次会议由监事会主席肖治召集，应到监事 3 人，实到监事 3 人。会议的召集、召开和表决程序符合《中华人民共和国公司 法》等法律法规及规范性文件和《康希诺生物股份公司章程》（以下简称"《公 司章程》"）的规定，合法有效。 二、监事会会议审议情况 经与会监事审议，逐项表决，形成决议如下： （一）《关于 2024 年度监事会工作报告的议案》 表决结果：同意 3 票，反对 0 票，弃权 0 票。 该议案尚需提交公司股东大会审议。 （二）《关于 2024 年年度报告及摘要的议案》 表决结果：同意 3 票，反对 0 票，弃权 0 票。 具体内容详见公司于同 ...

Financial Performance - The company reported a net loss for the period, continuing its trend of not achieving profitability since its listing [3]. - The company reported a revenue of RMB 1.2 billion for the fiscal year 2024, representing a 15% increase compared to the previous year [14]. - The company achieved operating revenue of RMB 846,338,072.24 in 2024, a year-on-year increase of 137.01% [25]. - The net loss attributable to shareholders of the listed company was RMB 378,884,001.37, a decrease in loss of 74.45% compared to the previous year [25]. - The total assets at the end of 2024 were RMB 7,958,132,235.38, a decrease of 14.60% year-on-year [25]. - The basic earnings per share for 2024 was -RMB 1.53, compared to -RMB 6.01 in 2023 [24]. - The gross margin for the current fiscal year is reported at 60%, maintaining a stable level compared to last year [22]. - The total net profit from non-recurring items for 2024 was RMB 62,366,451.62, compared to RMB 128,356,172.58 in 2023 [31]. Research and Development - The company continues to focus on research and development of new products and technologies, although specific financial metrics are not provided in the current report [3]. - The R&D department is focusing on the development of a new mRNA vaccine, with an expected completion date for clinical trials in Q3 2024 [17]. - The company has allocated RMB 300 million for research and development in the upcoming year, a 30% increase from the previous budget [20]. - Research and development expenses accounted for 60.35% of operating revenue, a decrease of 124.95 percentage points from the previous year [24]. - The company has established five major technology platforms for vaccine research and development, enhancing its competitive product portfolio [72]. - The company has received 7 new patents during the reporting period, bringing the total number of granted patents to 57 [78]. - The company is focusing on the development of high-quality vaccine products to replace imports in developed markets, with specific products like MCV2 and MCV4 showing promising safety and immunogenicity [165]. Market Expansion and Strategy - The company plans to expand its market presence in Southeast Asia, targeting a 25% increase in market share by the end of 2025 [18]. - The company projects a revenue growth of 10% for the next fiscal year, driven by new product launches and market expansion strategies [16]. - The company is advancing its internationalization efforts, targeting Southeast Asia, the Middle East, North Africa, and South America for the commercialization of its quadrivalent meningococcal conjugate vaccine MCV4, which received registration in Indonesia in December 2024 [40]. - The company is exploring new strategies for market expansion and product development to enhance its competitive position in the vaccine industry [138]. - The company is actively expanding its product pipeline with various vaccines in different clinical stages, including those for meningitis and tuberculosis [45]. Corporate Governance - The board of directors confirmed the absence of any profit distribution plan or capital reserve transfer to increase share capital for the reporting period [5]. - The company has not disclosed any special arrangements regarding corporate governance [5]. - The company has established a governance structure that complies with regulatory requirements, ensuring effective operation and accountability [173]. - The company has proposed a profit distribution plan for the year 2023, which is currently under review [175]. - The company has not reported any changes in the governance structure of its red-chip architecture during the reporting period [176]. Risk Factors and Financial Management - The company has identified significant risk factors that may adversely affect its operations, as detailed in the management discussion section [3]. - The company is exposed to financial risks, including currency exchange risks related to overseas operations and potential asset impairment risks [96]. - The company has implemented strict risk control measures for derivative trading, ensuring that the scale and direction of trades match the hedged foreign exchange assets [157]. - The company is committed to improving operational efficiency through resource focus and cost control measures [170]. Product Development and Clinical Trials - The company is conducting Phase I clinical trials for a recombinant shingles vaccine in Canada, utilizing adenovirus vector technology to stimulate both cellular and humoral immunity, with production adhering to international quality standards [39]. - The company has completed Phase I clinical trials for PBPV (pneumococcal vaccine) with positive preliminary results [45]. - The company is advancing multiple vaccine projects, including a recombinant polio vaccine currently in clinical trials in Indonesia [84]. - The company has received acceptance for the drug registration application of PCV13, a 13-valent pneumococcal conjugate vaccine, indicating progress in its R&D pipeline [139]. Sales and Marketing - The company has established partnerships with three major healthcare organizations to enhance distribution channels and improve vaccine accessibility [23]. - The sales revenue from the two meningococcal conjugate vaccines reached approximately 793.79 million RMB, representing a year-on-year growth of 41.31% [35]. - The company is enhancing its corporate governance framework to align with best practices in the industry [181]. - The company is expanding its market presence in Asia, aiming to increase market share by 15% over the next two years [185]. Operational Efficiency - The company has optimized resource allocation, leading to a decrease in management and research expenses, and improved operational efficiency [26]. - The company reported a significant reduction in lease liabilities by 92.76% to ¥12,675,754.57 due to the exclusion of a subsidiary from consolidation [128]. - The company is committed to advancing the commercialization of existing products while maintaining significant investment in R&D for future pipeline products [93]. - The company has seen a trend of decreasing procurement amounts from the top five suppliers since 2023, indicating a diversification in supplier relationships [119]. Shareholder Engagement - The company held its first extraordinary shareholders' meeting of 2024 on February 21, where the third board of directors and the third supervisory board were elected [180]. - The company has proposed to revise its shareholder dividend return plan for the next three years (2023-2025) [1]. - The company has not reported any dissenting votes on the proposals presented at the shareholders' meeting, indicating strong shareholder support [175].

CanSino Biologics Inc. 香港交易及結算所有限公司及香港聯合交易所有限公司對本通告的內容概不負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本通告全部 或任何部分內容所產生或因依賴該等內容而引致的任何損失承擔任何責任。 康 希 諾 生 物 股 份 公 司（「本公司」）董 事（「董 事」）會（「董事會」）謹 此 宣 佈，董 事 會 會 議將於2025年3月25日（星 期 二）舉 行，藉 以（其 中 包 括）考 慮 及 批 准 本 公 司 及 其 附 屬公司截至2024年12月31日 止 年 度 的 全 年 業 績 及 其 發 佈，以 及 考 慮 建 議 派 發 年 度 股 息（如 有）。 承董事會命 康希諾生物股份公司 Xuefeng YU 董事長 香港，2025年3月12日 於本通告日期，本公司董事會包括執行董事Xuefeng YU博士、Shou Bai CHAO博 士 及王靖女士；非執行董事李志成先生；以及獨立非執行董事桂水發先生、劉建忠 先生及張耀樑先生。 康希諾生物股份公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6185） 董事會會議通告 ...

证券研究报告 2025 年 03 月 07 日 湘财证券研究所 公司研究 康希诺（688185.SH） MCV4 商业化进展顺利，带动公司营收快速增长 相关研究： 1. 《以创新为核心，由Biotech转 型为Biopharma》 20241216 近十二个月公司表现 % 1 个月 3 个月 12 个月 相对收益 1 -10 6 绝对收益 3 -10 18 -40% -30% -20% -10% 0% 10% 20% 30% 40% 50% 康希诺 沪深300 注：相对收益与沪深 300 相比 分析师：许雯 证书编号：S0500517110001 Tel：021-50293534 Email：xw3315@xcsc.com 地址：上海市浦东新区银城路88号 中国人寿金融中心10楼 公司发布2024年度业绩快报。2024年实现营收8.46亿元，同比增长137.01%； 实现归母净利润-3.79 亿元，亏损幅度显著收窄（去年同期-14.83 亿元）；EPS 为-1.53 元/股（去年同期-6.01 元/股）。 核心要点： ❑ 受益于 MCV4 商业化的快速推进，公司营收实现快速增长 公司目前已上市产品共五款，其中 ...

证券研究报告 2025 年 03 月 07 日 湘财证券研究所 公司研究 康希诺（688185.SH） MCV4 商业化进展顺利，带动公司营收快速增长 相关研究： 1. 《以创新为核心，由Biotech转 型为Biopharma》 20241216 近十二个月公司表现 % 1 个月 3 个月 12 个月 相对收益 1 -10 6 绝对收益 3 -10 18 -40% -30% -20% -10% 0% 10% 20% 30% 40% 50% 康希诺 沪深300 注：相对收益与沪深 300 相比 分析师：许雯 证书编号：S0500517110001 Tel：021-50293534 Email：xw3315@xcsc.com 地址：上海市浦东新区银城路88号 中国人寿金融中心10楼 公司发布2024年度业绩快报。2024年实现营收8.46亿元，同比增长137.01%； 实现归母净利润-3.79 亿元，亏损幅度显著收窄（去年同期-14.83 亿元）；EPS 为-1.53 元/股（去年同期-6.01 元/股）。 核心要点： 公司的研发管线及产品布局体现出其较强的研发创新能力。强产品力、成 功的商业化模式、丰富的在研 ...

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年2月28日 狀態: 新提交 致：香港交易及結算所有限公司 呈交日期: 2025年3月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06185 | 說明 | H 股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 132,670,900 | RMB | | 1 RMB | | 132,670,900 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 132,670,900 | RMB | | 1 RMB | | 132,670,900 | | 2. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 ( ...

Financial Performance - Total revenue for 2024 reached ¥846,338,072.24, a year-on-year increase of 137.01%[4] - Net loss attributable to shareholders decreased to ¥378,884,001.37, a reduction of 74.45% compared to the previous year[6] - The company reported a significant reduction in operating losses by 80.62% and total losses by 80.74%[9] - The basic earnings per share improved to -¥1.53, compared to -¥6.01 in the previous year[4] Assets and Liabilities - Total assets at the end of the reporting period were ¥7,958,132,235.38, a decrease of 14.60% year-on-year[4] Research and Development - Research and development expenses decreased significantly, contributing to improved operational efficiency[7] - The company focused on commercializing the ACYW135 meningococcal polysaccharide conjugate vaccine, which is the only four-valent meningococcal vaccine in the Chinese market[6] Operational Efficiency - The company optimized resource allocation and implemented cost-reduction measures, leading to a notable decrease in asset impairment losses[7] - The sales channel for the meningococcal vaccine was continuously developed, resulting in increased market penetration and sales volume[9] Risk Management - The company emphasizes the importance of monitoring investment risks as the financial data is preliminary and unaudited[10]