证券代码：688621 证券简称：阳光诺和 公告编号：2025-050 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： ? 是否涉及差异化分红送转：是 ? 每股分配比例 每股现金红利0.163 元（含税） ? 相关日期 股权登记日 除权（息）日 现金红利发放日 北京阳光诺和药物研究股份有限公司2024年年度权 益分派实施公告 一、 通过分配方案的股东大会届次和日期 本次利润分配方案经公司2025 年 4 月 29 日的2024年年度股东大会审议通过。 二、 分配方案 截至股权登记日下午上海证券交易所收市后，在中国证券登记结算有限责任 公司上海分公司（以下简称"中国结算上海分公司"）登记在册的本公司全体股东。 根据《上市公司股份回购规则》《上海证券交易所上市公司自律监管指引第 7 号——回购股份》等有关规定，上市公司回购专用账户中的股份，不享有股东会 表决权、利润分配、公积金转增股本、认购新股和可转换公司债券等权利。 故公司回购专用证券账户持有的股份不参与本次权益分派。 （1）本次差异化分红方案 经公司 202 ...

致：北京阳光诺和药物研究股份有限公司 北京市天元律师事务所（以下简称本所）接受北京阳光诺和药物研究股份有 限公司（以下简称公司或阳光诺和）的委托，就公司 2024 年度利润分配方案所 涉及的差异化事项（以下简称本次差异化分红）出具本法律意见。 本所及经办律师依据《中华人民共和国公司法》（以下简称《公司法》）、《中 华人民共和国证券法》（以下简称《证券法》）、《律师事务所从事证券法律业务管 理办法》《上海证券交易所上市公司自律监管指引第 7 号——回购股份》（以下简 称《回购股份指引》）等法律、法规、《北京阳光诺和药物研究股份有限公司章程》 （以下简称《公司章程》）及本法律意见出具日以前已经发生或者存在的事实， 按照律师行业公认的业务标准、道德规范和勤勉尽责的精神，出具本法律意见。 北京市天元律师事务所 关于北京阳光诺和药物研究股份有限公司 差异化分红事项之 专项法律意见 北京市天元律师事务所 北京市西城区金融大街 35 号国际企业大厦 A 座 509 单元 邮编：100033 北京市天元律师事务所 关于北京阳光诺和药物研究股份有限公司 差异化分红事项之专项法律意见 京天股字（2025）第 328 号 基于上述 ...

证券代码：688621 证券简称：阳光诺和 公告编号：2025-050 北京阳光诺和药物研究股份有限公司2024年年度权 益分派实施公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 每股现金红利0.163 元（含税） 相关日期 | 股权登记日 | 除权（息）日 | 现金红利发放日 | | --- | --- | --- | | 2025/6/10 | 2025/6/11 | 2025/6/11 | 一、 通过分配方案的股东大会届次和日期 本次利润分配方案经公司2025 年 4 月 29 日的2024年年度股东大会审议通过。 二、 分配方案 1. 发放年度：2024年年度 2. 分派对象： 截至股权登记日下午上海证券交易所收市后，在中国证券登记结算有限责任 公司上海分公司（以下简称"中国结算上海分公司"）登记在册的本公司全体股东。 是否涉及差异化分红送转：是 每股分配比例 的议案》，公司 2024 年度以实施权益分派股权登记日登记的总股本扣减公司回购 专用证券账户中股份为基数分配利润，向全体股东每 10 股 ...

Investment Rating - The report assigns a "Buy" rating for the stock of Sunshine Nuohuo (688621) based on its strong clinical data and commercial potential of STC007 [1]. Core Viewpoints - The successful Phase II clinical trial results for STC007 indicate significant pain relief efficacy compared to placebo and comparable to the positive control drug, Tramadol [2][3]. - The opioid market presents substantial growth opportunities, with KOR agonists like STC007 showing advantages over traditional MOR agonists, including reduced side effects and addiction risks [4][5]. - The company is undergoing a business transformation, focusing on a "R&D services + pipeline cultivation + new quality industrial chain" model, which is expected to enhance its market valuation [6][7]. Summary by Sections Clinical Trial Results - STC007 demonstrated superior pain relief in postoperative patients, with significant reductions in pain scores compared to both placebo and Tramadol [2]. - The safety profile of STC007 is favorable, with common side effects being lower than those of Tramadol [3]. Market Potential - The opioid market in China has grown from 193.58 billion in 2019 to 233.68 billion in 2023, indicating a robust demand for pain management solutions [3]. - KOR agonists are positioned to address unmet needs in pain management without the adverse effects associated with traditional opioids [4]. Business Transformation - The company aims to integrate R&D services with a robust pipeline of innovative and improved drugs, enhancing its competitive edge [6]. - Plans to acquire Langyan Life Sciences will strengthen the company's production capabilities and ensure stable supply chains [7]. Financial Projections - Revenue is projected to grow from 1.29 billion in 2025 to 1.78 billion by 2027, with net profit expected to increase from 204 million to 300 million in the same period [8][9]. - The report anticipates a gradual improvement in EPS, with estimates of 1.82 yuan in 2025 and 2.68 yuan in 2027, reflecting a positive outlook for the company's financial health [9].

Investment Rating - The report assigns a "Buy" rating for the company based on its strong clinical trial results and potential for commercialization [1]. Core Viewpoints - The company has achieved significant milestones with its STC007 injection, which has shown superior pain relief compared to placebo and comparable efficacy to positive control drug Tramadol [2][3]. - The opioid market presents vast opportunities, with KOR agonists like STC007 offering advantages over traditional MOR opioids, such as reduced risk of respiratory depression and addiction [4][5]. - The company is in a critical phase of business transformation, focusing on a comprehensive R&D service model, pipeline cultivation, and a new quality industrial chain [6][7]. Summary by Sections Clinical Trial Results - STC007 has completed its Phase II clinical trial for postoperative pain, demonstrating significant pain relief in moderate to severe cases compared to placebo and Tramadol [2][3]. - The safety profile of STC007 is favorable, with common side effects being lower than those of Tramadol [3]. Market Potential - The opioid market in China has grown from 193.58 billion in 2019 to 233.68 billion in 2023, indicating a robust demand for effective pain management solutions [3]. - The successful market entry of similar KOR agonists validates the commercial viability of STC007, enhancing its market prospects [5]. Business Transformation Strategy - The company aims to build a "R&D service + pipeline cultivation + new quality industrial chain" model, enhancing its operational capabilities and market positioning [6]. - The acquisition of Langyan Life Sciences is expected to strengthen the company's production capabilities and ensure stable product quality and supply [7]. Financial Projections - Revenue is projected to grow from 1.29 billion in 2025 to 1.78 billion in 2027, with net profit expected to increase from 204 million to 300 million in the same period [8][9]. - The company’s EPS is forecasted to rise from 1.82 in 2025 to 2.68 in 2027, reflecting strong earnings growth [9].

证券代码：688621 证券简称：阳光诺和 公告编号：2025-049 北京阳光诺和药物研究股份有限公司 自愿披露关于 STC007 注射液治疗腹部手术后疼痛 II 期临床试验数据的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 近日，北京阳光诺和药物研究股份有限公司（以下简称"公司"或"阳光诺 和"）全资子公司成都诺和晟泰生物科技有限公司（以下简称"诺和晟泰"）自 主研发的 STC007 注射液（项目代号"STC007"）治疗腹部手术后的中、重度 疼痛的 II 期临床试验达成预期目标。现将相关情况公告如下： （一）基本情况 药品名称：STC007 注射液 主要研发阶段：II 期临床试验 临床试验通知书受理号：CXHL2200494 国 （二）STC007 临床试验情况 试验名称：一项初步评估 STC007 注射液治疗腹部手术后疼痛的有效性、安 全性和药代动力学特征的随机、双盲、安慰剂/阳性对照Ⅱ期临床研究。 受试者数量：156 例 研究目的：评估 STC007 注射液用于择期全身麻醉下行腹部腔镜手术受试者 术后镇痛 ...

Core Viewpoint - The clinical trial of STC007 injection for treating moderate to severe postoperative abdominal pain has met its expected goals, indicating potential for effective pain management in this area [1] Group 1: Clinical Trial Results - The Phase II clinical trial was conducted by Chengdu Nuoheshengtai Biotechnology Co., Ltd., a wholly-owned subsidiary of the company, in collaboration with Huazhong University of Science and Technology [1] - A total of 156 subjects were involved in the trial across 20 research centers nationwide [1] - STC007 injection showed significant improvement in postoperative pain scores within 0-24 hours compared to the placebo group [1] - When compared to Tramadol hydrochloride injection, STC007 also demonstrated effective pain relief during movement for moderate to severe postoperative pain patients [1] Group 2: Safety and Tolerability - The overall safety and tolerability of STC007 injection were reported to be good [1] - No new safety signals were identified during the trial, and no serious adverse events occurred [1]

Group 1: Market Performance - Major indices experienced a strong rebound, with the Shanghai Composite Index rising by 0.7%, Shenzhen Component Index by 1.24%, and ChiNext Index by 1.37% [2] - Over 4,200 stocks in the two markets saw gains, with a total trading volume of approximately 1.19 trillion yuan [2] Group 2: Digital Currency and Software Sector - The digital currency and software sectors led the market rally, with notable stocks like Lakala (300773.SZ) and Sifang Jingchuang (300468.SZ) hitting the daily limit with a 20% surge [2] - New Guodu (300130.SZ) rose over 14%, while Feitian Chengxin (300386.SZ) and Shenzhou Information (000555.SZ) also saw significant increases of 12.84% and 10%, respectively [2] Group 3: Autonomous Driving and Intelligent Connected Vehicles - Stocks related to autonomous driving and intelligent connected vehicles surged, with companies like Fulongma (603686.SH) and Jintour Environment (001230.SZ) hitting the daily limit [3] - A strategic cooperation agreement was signed between Xiaoma Zhixing and Guangzhou Public Transport Group, focusing on autonomous vehicle services [3] Group 4: Innovative Pharmaceuticals - The innovative pharmaceutical sector remains active, with companies like Sanofi Guojian (688336.SH) rising over 12% [4][3] - The sector is supported by policy backing, global competitiveness, and improving fundamentals, with a focus on "innovation + internationalization" [4] Group 5: Automotive Sector - The automotive sector showed strong performance, with Jinlong Automobile (600686.SH) and Dongfeng Co. (600006.SH) both increasing by 10% [5] - The launch of new models by XPeng and supportive government policies in Fujian province are contributing factors to the sector's growth [5] Group 6: Weak Sectors - The precious metals and food processing sectors experienced declines, with companies like Western Gold (601069.SH) and Laiyifen (603777.SH) seeing significant drops [5]

Core Viewpoint - The company has approved the 2025 Restricted Stock Incentive Plan and conducted a self-examination regarding insider trading among those privy to the plan's information, confirming compliance with regulations and no insider trading activities [1][6][4]. Group 1: Incentive Plan Approval - The company held its 19th meeting of the second board and the 4th meeting of the Compensation and Assessment Committee on May 12, 2025, where the 2025 Restricted Stock Incentive Plan was approved [1]. - The plan was developed in accordance with relevant laws and regulations, ensuring confidentiality and proper registration of insiders [1][6]. Group 2: Insider Trading Self-Examination - The company conducted a self-examination of insider trading activities among individuals privy to the incentive plan's information during the six months prior to its public disclosure [2]. - Two individuals were found to have traded the company's stock during the self-examination period, but their actions were based on publicly available information, and there was no evidence of insider trading [4][5]. - The company confirmed that all other insiders did not engage in any stock trading during the self-examination period, ensuring compliance with regulations [5][6]. Group 3: Shareholder Meeting - The company held its second extraordinary general meeting on May 28, 2025, where all proposed resolutions, including those related to the incentive plan, were approved without any objections [9][11]. - The meeting was conducted in accordance with legal and regulatory requirements, with all board members present [10][13].

证券代码：688621 证券简称：阳光诺和 公告编号：2025-047 北京阳光诺和药物研究股份有限公司 关于公司 2025 年限制性股票激励计划内幕信息知情 人买卖公司股票情况的自查报告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 2025 年 5 月 12 日，北京阳光诺和药物研究股份有限公司（以下简称"公司" 或"阳光诺和"）召开第二届董事会第十九次会议、第二届薪酬与考核委员会第 四次会议，审议通过了《关于<北京阳光诺和药物研究股份有限公司 2025 年限制 性股票激励计划（草案）>及其摘要的议案》等议案，具体内容详见公司于 2025 年 5 月 13 日在上海证券交易所网站（www.sse.com.cn）上披露的相关公告。 根据《上海证券交易所科创板股票上市规则》《上市公司股权激励管理办法》 （以下简称"《管理办法》"）《科创板上市公司自律监管指南第 4 号—股权激 励信息披露》等法律、法规和规范性文件以及公司章程有关规定，公司对 2025 年限制性股票激励计划（以下简称"本次激励计划"）采取了充分必要的保密措 ...