Summary of the Earnings Call for Yifan Pharmaceutical Company Overview - **Company**: Yifan Pharmaceutical - **Key Product**: Yili Shu (Recombinant Human Follicle Stimulating Hormone-Fc Fusion Protein Injection) Industry Insights - **Market Dynamics**: The domestic market for Yili Shu has seen significant growth after entering the medical insurance system, with sales expected to double in 2025 compared to 2024, driven primarily by the domestic market [2][3] - **International Market**: In the U.S., Yili Shu is promoted by Acrotech, with initial orders indicating a shipment volume of over 40,000 units in 2025, which is double the original expectations [2][4] Financial Performance - **Cash Flow**: Yifan Pharmaceutical maintained a net operating cash flow of over 500 million yuan in 2024, despite slightly lower-than-expected performance [2][6] - **Sales Projections**: The company anticipates a significant increase in sales for Yili Shu, with a projected shipment volume of 270,000 units in 2024 and over 500 million yuan in net sales [2][3] Product Development and Strategy - **New Product Launches**: The company plans to launch new products, including synthetic biology applications, in Q4 2025, aiming to reduce production costs by at least 50% [4][12] - **Sales Model Transition**: Yifan Pharmaceutical is considering shifting from a distribution model to a direct sales model for certain products, which could enhance market share over the next few years [18] Market Challenges and Opportunities - **Sales Strategy Adjustments**: The sales of Dinggan Cross-linked Sodium Hyaluronate (Yili Kang) fell short of expectations in 2024, but a significant increase in shipments is anticipated in 2025 [16][17] - **Competitive Landscape**: The company has a favorable window to establish market strategies as long-acting products are limited in the market for the next few years [19] Collaborations and Partnerships - **Aptech Collaboration**: Yifan has signed an agreement with Aptech, which is optimistic about the on-body device development, potentially increasing market share in the U.S. [8][9] - **Milestone Payments**: The company expects to receive approximately $2 million in milestone payments upon the U.S. market launch of Yili Shu, with additional payments tied to sales milestones [9] Future Outlook - **Growth Projections**: The company is optimistic about achieving over 3 billion yuan in sales and over 300 million yuan in net profit if market expectations are met [27] - **R&D Pipeline**: Yifan is advancing several early-stage R&D products, including a first-in-class product and interleukin therapies, with potential IND applications in 2025 [26] Conclusion - **Overall Sentiment**: Yifan Pharmaceutical is positioned for growth with a strong focus on product launches, market expansion, and strategic partnerships, while navigating challenges in sales and market competition [28]

Investment Rating - The report assigns a "Buy-A" investment rating for the company, with a target price of 15.00 CNY for the next six months [5]. Core Insights - The company is gradually becoming an international innovative pharmaceutical enterprise, with its innovative pipeline entering a harvest period, focusing on large molecules, small molecules, and traditional Chinese medicine [10][30]. - The company has made significant progress in its research and development pipeline, particularly with its product Yilishu, which has been approved for sale in 34 countries, including China, the US, and the EU [30][46]. - The company expects to achieve a net profit of 609 million CNY in 2025, with a year-on-year growth of 57.8% [7][72]. Summary by Sections 1. Company Overview - The company focuses on research and innovation in the pharmaceutical health sector, with a diverse product pipeline in areas such as hematological oncology, inflammation, metabolism, dermatology, gynecology, and pediatrics [10]. - The controlling shareholder, Cheng Xianfeng, holds 42.85% of the company's shares [13]. 2. Large Molecule Innovative Drugs - The company has made progress in its research pipeline, with Yilishu being a new generation G-CSF long-acting preparation that has been approved in multiple countries [30][33]. - The domestic market is expected to see rapid sales growth for Yilishu due to a commercial cooperation agreement with Zhengda Tianqing [50]. - The global G-CSF drug market is projected to grow steadily, with the company having established sales in 34 countries [51][54]. 3. Small Molecule Drugs - The company has differentiated its product offerings in the small molecule drug sector, focusing on unique and specialized products [57]. - Sales of small molecule drugs have shown significant growth, with revenue increasing from 453 million CNY in 2021 to 887 million CNY in 2023 [59]. 4. Traditional Chinese Medicine - The company has a wide range of traditional Chinese medicine products, with several exclusive varieties that contribute to steady growth in this segment [60][61]. - Revenue from traditional Chinese medicine increased from 643 million CNY in 2021 to 934 million CNY in 2023 [68]. 5. Raw Material Business - The company maintains a leading position in the vitamin B5 (calcium pantothenate) market, with stable demand expected to drive growth [65]. - The price of calcium pantothenate is currently at a historical low, with limited downside risk [69]. 6. Profit Forecast and Valuation Analysis - The company is projected to achieve revenues of 60.42 billion CNY, 70.30 billion CNY, and 81.29 billion CNY from 2025 to 2027, with corresponding net profits of 6.09 billion CNY, 7.40 billion CNY, and 8.88 billion CNY [72].

Market Overview - The A-share market experienced an overall increase on May 29, with the Shanghai Composite Index closing at 3363.45 points, up 0.7%, the Shenzhen Component Index at 10127.2 points, up 1.24%, and the ChiNext Index at 2012.55 points, up 1.37%. The North Star 50 Index rose by 2.73%. Total trading volume reached 12136.01 billion yuan, an increase of 1795.28 billion yuan compared to the previous trading day [1]. Capital Flow - The net inflow of main funds in the A-share market was 74.33 billion yuan, with an opening net outflow of 19.58 billion yuan and a closing net inflow of 23.89 billion yuan [2]. - The net inflow for the CSI 300 was 12.91 billion yuan, while the ChiNext saw a net inflow of 42.65 billion yuan, and the STAR Market experienced a net outflow of 17.3 billion yuan [4]. Sector Performance - Among the 23 sectors, the computer industry led with a net inflow of 191.73 billion yuan, followed by the electronics sector with 124.39 billion yuan, and the pharmaceutical and biological sector with 112.04 billion yuan. The non-bank financial sector saw a net inflow of 47.51 billion yuan, while the communication sector had 34.87 billion yuan [6][7]. - The sectors with the largest net outflows included food and beverage with -21.56 billion yuan, basic chemicals with -12.02 billion yuan, and banking with -8.89 billion yuan [7]. Individual Stock Activity - The stock with the highest net inflow was Shanzhi Gaoke, with 7.11 billion yuan [8]. - Institutional investors showed significant interest in several stocks, with Wangzi New Materials receiving a net buy of 41.11 million yuan, and Sifang Precision receiving 36.17 million yuan [11][12]. Institutional Focus - Recent institutional ratings highlighted several stocks, including Huichuan Technology with a target price of 73.00 yuan, indicating an upside potential of 8.83%, and Longying Precision with a target price of 24.70 yuan, suggesting a 19.73% upside [14].

Investment Rating - The report assigns a "Buy-A" investment rating for the company, with a target price of 15.00 CNY for the next six months [5]. Core Insights - The company is transitioning into an international innovative pharmaceutical enterprise, with its innovative pipeline gradually entering a harvest period [10]. - The company has made significant progress in its large molecule innovative drugs, particularly with the product Yilishu, which has received approval for sale in 34 countries [30][54]. - The small molecule drug segment focuses on differentiation through a strategy of "small, sharp, and special," with a stable growth in sales [59]. - The traditional Chinese medicine segment has a wide range of products, including several exclusive varieties, contributing to steady growth [62]. Summary by Sections 1. Company Overview - The company focuses on research and innovation in the pharmaceutical health sector, with a diverse product pipeline in various therapeutic areas [10]. - The controlling shareholder holds 42.85% of the company's shares, indicating strong ownership [13]. 2. Large Molecule Innovative Drugs - The company has made advancements in its research pipeline, with Yilishu being a key product that has received approvals in multiple countries [30]. - The domestic market strategy includes a commercial partnership with Zhengda Tianqing to enhance sales [51]. - The global market for G-CSF drugs is expected to grow, with the company positioned to benefit from this trend [52]. 3. Small Molecule Drugs - The company has established a differentiated product layout in the small molecule drug sector, focusing on key products that have shown stable sales growth [59]. 4. Traditional Chinese Medicine - The company has a broad layout in traditional Chinese medicine, with several exclusive products contributing to its revenue growth [62]. 5. Raw Material Business - The company maintains a leading position in the vitamin B5 market, with stable demand expected to drive growth [67]. 6. Profit Forecast and Valuation Analysis - The company is projected to achieve revenues of 60.42 billion CNY, 70.30 billion CNY, and 81.29 billion CNY from 2025 to 2027, with corresponding net profits of 6.09 billion CNY, 7.40 billion CNY, and 8.88 billion CNY [74].

Group 1 - The National Vaccine and Biotechnology Index (980015) has seen a strong increase of 2.39% as of May 29, 2025, with notable gains in constituent stocks such as Zhaoyan New Drug (603127) up 9.99%, Yifan Pharmaceutical (002019) up 9.17%, and Dizhe Pharmaceutical (688192) up 8.73% [1] - The Biovaccine ETF (159657) rose by 2.28%, with the latest price reported at 0.63 yuan [2] - The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting will take place from May 30 to June 3, 2025, in Chicago, showcasing the development of oncology research in China, with over 70 studies from Chinese scholars selected for presentation [2] Group 2 - The top ten weighted stocks in the National Vaccine and Biotechnology Index (980015) as of April 30, 2025, include Fosun Pharma (600196), Changchun High-tech (000661), and others, collectively accounting for 63.18% of the index [3] - The Biovaccine ETF closely tracks the National Vaccine and Biotechnology Index, which consists of 50 companies involved in the biotechnology industry, reflecting the overall performance of quality listed companies in the sector [2]

Core Viewpoint - The company Yifan Pharmaceutical has successfully completed the first shipment of its innovative drug F-627 to the U.S. market, marking a significant milestone in its international expansion [1] Group 1: Product Launch - F-627, also known as Ryzneuta, is the world's first third-generation long-acting G-CSF drug for increasing white blood cell counts [1] - The drug has received approval for sale in multiple regions, including China, the U.S., the EU, and Brazil [1] Group 2: Market Expectations - Based on current order conditions, the company anticipates shipping approximately 40,000 units overseas by 2025 [1] - The drug has been successfully included in China's medical insurance directory following negotiations in 2023 [1]

Core Viewpoint - The announcement details the pledge and release of shares by Cheng Xianfeng, the controlling shareholder of Yifan Pharmaceutical Co., Ltd, indicating changes in shareholding structure and potential implications for the company's stock performance [2][4]. Share Pledge Details - Cheng Xianfeng pledged 5.24% of his shares, amounting to 2.14% of the company's total share capital, starting from May 25, 2025 [2]. - The pledge was made to China Galaxy Securities Co., Ltd [2]. Share Release Details - Cheng Xianfeng released 22,000,000 shares, which represents 4.43% of his total holdings and 1.81% of the company's total share capital, effective from May 27, 2025 [2]. - The shares were also released from pledge to China Galaxy Securities Co., Ltd [2]. Cumulative Pledge Situation - As of the announcement date, Cheng Xianfeng and his concerted actors have a total of pledged shares, with the cumulative pledged amount being significant [2]. - The report indicates the proportion of pledged shares relative to total holdings and the company's total share capital [2][4].

证券代码：002019 证券简称：亿帆医药 公告编号：2025-036 亿帆医药股份有限公司 关于控股股东部分股份质押及解除质押的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 三、股东股份累计被质押的情况 截至本公告披露日，程先锋先生及其一致行动人所持股份质押情况如下： | 股东名称 | 持股数 量 | 持股比 | 累计质押 数量 | 占其所 持股份 | | 已质押股份情况 | | 未质押股份情况 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | | | 占公司总 | 已质押股份 | 占已质 | 未质押股份 | 占未质 | | | | 例 | | | 股本比例 | 限售和冻结 | 押股份 | 限售和冻结 | 押股份 | | | （股） | | （股） | 比例 | | | | | | | | | | | | | 数量（股） | 比例 | 数量（股） | 比例 | | 程先锋 | 496,526, | 40.82 | 69,500,00 | 14.00% | ...

Group 1 - The company has approved a cash dividend distribution plan for the year 2024, proposing to distribute 1 RMB per 10 shares to all shareholders, totaling approximately 121.64 million RMB [1][2] - The distribution will be based on the company's total share capital of 1,216,390,085 shares, excluding repurchased shares, with adjustments made if the total share capital changes before the distribution [1][2] - The dividend tax rates will vary for different types of shareholders, with specific provisions for Hong Kong investors and domestic investors holding different classes of shares [1][2] Group 2 - The record date for the dividend distribution is set for May 28, 2025, and the ex-dividend date is May 29, 2025 [2] - The distribution will be directly credited to the shareholders' accounts through their custodial securities companies or other custodial institutions [2] - The company assumes all legal responsibilities and consequences for any insufficient cash dividends distributed [2]

035 证券代码：002019 证券简称：亿帆医药 公告编号：2025- 4、本次实施分派方案距股东会审议通过的时间未超过两个月。 二、权益分派方案 本公司2024年年度权益分派方案为：以公司现有总股本剔除已回购股份0股 后的1,216,390,085股为基数，向全体股东每10股派1.000000元人民币现金（含税； 扣税后，通过深股通持有股份的香港市场投资者（特别说明：请上市公司根据自 身是否属于深股通标的证券，确定权益分派实施公告保留或删除该类投资者）、 境外机构（含QFII、RQFII）以及持有首发前限售股的个人和证券投资基金每10 股派0.900000元；持有首发后限售股、股权激励限售股及无限售流通股的个人股 息红利税实行差别化税率征收，本公司暂不扣缴个人所得税，待个人转让股票时， 根据其持股期限计算应纳税额【注】；持有首发后限售股、股权激励限售股及无 亿帆医药股份有限公司 2024年年度权益分派实施公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 亿帆医药股份有限公司（以下简称"公司"）2024年年度权益分派方案已获 2025年5月20日召开的2 ...