Group 1 - Southbound funds net bought HKD 717 million in Hong Kong stocks on June 9, with notable net purchases in companies like Innovent Biologics (HKD 1.125 billion), Meituan (HKD 1.046 billion), and Li Auto (HKD 452 million) [1] - Tencent Holdings saw a significant net sell-off of HKD 2.141 billion, marking a continuous seven-day net sell totaling HKD 8.05292 billion [1] - Meituan has experienced a continuous net buy for 16 days, accumulating a total of HKD 17.52673 billion [1] Group 2 - Innovent Biologics' stock rose by 8% to HKD 79 per share, driven by positive clinical data presented at the ASCO annual meeting [5] - Goldman Sachs upgraded Innovent Biologics' risk-adjusted sales forecast for IBI363 from USD 1.4 billion to USD 3.2 billion, anticipating its market launch in 2028 [5] - Tencent Holdings' stock slightly increased by 0.58% to HKD 518 per share, with the company repurchasing 968,000 shares at prices ranging from HKD 513 to HKD 520.5 [5] Group 3 - Xiaomi Group's stock rose by 1.98% to HKD 54.15 per share, with over 250,000 units of the Xiaomi SU7 delivered [5]

Summary of Key Points Core Viewpoint - The Hong Kong stock market experienced significant net inflows from northbound capital, with a total net buy of 717 million HKD on June 9, 2023, indicating strong investor interest in certain stocks, particularly in the innovative pharmaceutical sector and local businesses like Meituan [1][2]. Group 1: Northbound Capital Inflows and Outflows - Northbound capital had a net buy of 12.47 billion HKD through the Shenzhen Stock Connect and a net sell of 5.3 billion HKD through the Shanghai Stock Connect [1]. - The stocks with the highest net inflows included Xinda Bio (01801), Meituan-W (03690), and Li Auto-W (02015) [1]. - The stocks with the highest net outflows were Tencent (00700), Xiaomi Group-W (01810), and Alibaba-W (09988) [1]. Group 2: Active Stocks and Their Performance - Meituan-W (03690) saw a net buy of 10.46 billion HKD, supported by strong fundamentals and a solid merchant base [5]. - Xinda Bio (01801) received a net buy of 7.73 billion HKD, benefiting from favorable developments in the pharmaceutical sector [4]. - Alibaba-W (09988) and Tencent (00700) faced significant net sells of 9.39 billion HKD and 21.41 billion HKD, respectively, due to concerns over capital expenditures and cloud revenue growth [6]. Group 3: Sector Trends and Insights - The innovative pharmaceutical sector is gaining traction, with Xinda Bio, Shiyao Group, and Sanofi Pharmaceutical receiving substantial net buys, reflecting a positive outlook for domestic innovative drugs [4]. - The automotive sector showed mixed results, with Li Auto-W (02015) gaining 4.52 billion HKD while Xiaomi Group-W (01810) faced a net sell of 14.52 billion HKD, indicating ongoing challenges in the industry [5]. - The banking sector, represented by China Bank (03988), attracted a net buy of 326.7 million HKD, driven by stable fundamentals and dividend attractiveness [6].

Group 1 - Morgan Stanley raised the target price for Innovent Biologics (01801.HK) from HKD 74 to HKD 84, maintaining an "Overweight" rating [1] - The increase in target price is attributed to upcoming catalysts and updates following the American Society of Clinical Oncology (ASCO) meeting [1] - The positive data on overall survival for IBI363 presented at the ASCO conference is expected to drive further stock performance [1] Group 2 - Morgan Stanley anticipates that the drug MaShidu will receive approval in China within 1 to 2 months, potentially providing additional stock options [1] - The sales forecast for IBI363 has been raised by approximately 95% post-ASCO meeting, along with an increase in pipeline valuation [1] - The firm holds a moderate sales expectation for MaShidu in 2025 [1]

5 June 2025 | 12:27AM HKT Innovent Biologics (1801.HK): ASCO 2025 take: Encouraging survival benefit of IBI363; Better understanding of POC hinges on RCT data As noted in our previous ASCO2025 notes (preview, abstract takeaway), Innovent orally presented the updated ph1 data of IBI363 (PD-1/IL-2α-bias BsAb) in NSCLC, CRC, and melanoma, which we view as incrementally positive for ORR/PFS compared to abstract, with particular highlight on the encouraging survival benefit (OS data debut) in IO-treated squamous ...

信达生物 20250608 摘要 363 项目的数据表现优异。在混合组（剂量为 1~1.5 毫克）中，中位总生存期 （OS）达到 15.3 个月，而 12 个月 OS 率也显示出积极预期。鳞癌组数据显示， 该品种疗效在研品种中表现突出，中位无进展生存期（mPFS）达到 9.3 个月。 此外，高剂量组（3 毫克）的未来 OS 水平预期较高，这些数据表明 363 在非 Q&A 信达生物在创新药领域的最新进展是什么？ 信达生物近期在创新药领域取得了显著进展，特别是在 PD-1/CTLA-4 双抗 363 项目上。该项目目前在黑色素瘤、非小细胞肺癌和结直肠癌等适应症上积 累了大量数据，成功率较高。2025 年 1 月，信达生物与 Kakao 合作启动了黑 色素瘤的临床试验。363 项目作为 first in class 品种，其机制有效性和特异性 激活免疫系统的潜力得到了临床前研究和 ASCO 会议上的数据验证。 为什么 PD-1 类药物值得关注？ PD-1 类药物因其广泛的适应症拓展能力而备受关注，特别是在非小细胞肺癌 （NSCLC）中的应用。全球范围内，NSCLC 占据 PD-1 销售比例最高，大约 为 43%。 ...

Investment Rating - The investment rating for the company is "Buy" with a target price of 95.42 HKD, compared to the last closing price of 74.25 HKD [1][10]. Core Views - The report highlights that the clinical data for IBI363, a dual-specific antibody fusion protein, has exceeded expectations in treating advanced non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and melanoma [3][4][5][6]. - The company is expected to see significant revenue growth, with projected revenues of 94.22 billion HKD in 2024, increasing to 207.91 billion HKD by 2027, reflecting a growth rate of 51.82% in 2024 and 31.60% in 2027 [11][15]. Summary by Sections Company Overview - The total share capital is 1.65 billion shares, with a total market capitalization of 1,225 billion HKD [2]. - The company has a strong pipeline with multiple important developments expected in 2025, including approvals for various treatments [9]. Clinical Data - IBI363 showed a median progression-free survival (mPFS) of 9.3 months and a 12-month overall survival (OS) rate of 70.9% in patients with immune-resistant lung squamous cell carcinoma [4]. - In CRC patients, IBI363 demonstrated a median overall survival (mOS) of 16.1 months, indicating a significant improvement over existing treatment options [5]. - For melanoma, IBI363 achieved an mPFS of 5.7 months, with ongoing trials comparing it to pembrolizumab in treatment-naive patients [6]. Financial Projections - The company is projected to achieve a net profit of 6.23 billion HKD in 2025, with a significant increase to 30.77 billion HKD by 2027, reflecting a net profit growth rate of 132.26% in 2027 [11][15]. - The earnings per share (EPS) is expected to rise from -0.06 HKD in 2024 to 1.87 HKD in 2027 [11][15]. Valuation - The valuation methods used include DCF and NPV, resulting in a target market value of 1,574 billion HKD, which corresponds to the target stock price of 95.42 HKD [10].

Investment Rating - The investment rating for the company is "Buy" with a target price of HKD 84.00, indicating a potential upside of 16.2% from the current price of HKD 72.30 [4][14]. Core Insights - The early data for IBI363 in lung cancer is encouraging, revealing a significant market opportunity. The target price has been raised due to the inclusion of IBI363 in the valuation model, with an estimated peak sales potential of approximately USD 1.5 billion by 2028 [2][7]. - The company plans to initiate a Phase III registration study for IBI363 in squamous NSCLC patients who have failed prior PD-(L)1 therapy, having received breakthrough therapy designation from CDE [7][10]. Financial Overview - Revenue projections show a strong growth trajectory, with expected revenues of RMB 6,206 million in 2023, increasing to RMB 17,071 million by 2027, representing a compound annual growth rate (CAGR) of 36.2% from 2023 to 2024 and 20.0% from 2026 to 2027 [3][15]. - The net profit is projected to turn positive in 2025, with an estimated net profit of RMB 751 million, growing to RMB 3,242 million by 2027 [3][15]. - The earnings per share (EPS) is expected to improve significantly, moving from a loss of RMB 0.66 in 2023 to a profit of RMB 1.97 by 2027 [3][15]. Clinical Data Highlights - IBI363 demonstrated an overall response rate (ORR) of 26-37% in squamous NSCLC patients, with a median progression-free survival (PFS) of 5.5-9.3 months and a median overall survival (OS) exceeding 15.3 months [7][8]. - In the non-squamous NSCLC cohort, the ORR was 24% with a median PFS of 5.6 months, indicating the drug's potential effectiveness in a challenging treatment landscape [7][9]. Market Potential - The report highlights a significant unmet need in the second-line treatment for I/O resistant NSCLC patients, with current therapies showing an ORR of less than 20% and median PFS/OS of less than 4 months/12 months [7][10]. - The global sales for PD-(L)1 drugs are projected to exceed USD 40 billion in 2024, underscoring the substantial market opportunity for effective therapies like IBI363 [7].

Investment Rating - The investment rating for the company is "Buy" with a target price of HKD 84.00, indicating a potential upside of 16.2% from the current closing price of HKD 72.30 [4][14]. Core Insights - The early clinical data for IBI363 in lung cancer is encouraging, revealing a significant market opportunity. The target market for IBI363 is characterized as a "blue ocean" due to limited existing treatment options for first-line I/O resistant NSCLC patients [2][7]. - The report projects that IBI363 could achieve peak sales of approximately USD 1.5 billion by 2028, based on a conservative estimate of capturing around 10% of the post-PD-(L)1 treatment market with a 40% success rate [7][10]. - The financial forecasts show substantial revenue growth, with expected revenues increasing from RMB 6,206 million in 2023 to RMB 17,071 million by 2027, reflecting a compound annual growth rate (CAGR) of 36.2% from 2023 to 2024 and 20.0% from 2026 to 2027 [3][15]. Financial Overview - Revenue projections for the company are as follows: RMB 6,206 million in 2023, RMB 9,422 million in 2024, RMB 11,782 million in 2025, RMB 14,231 million in 2026, and RMB 17,071 million in 2027, with year-on-year growth rates of 36.2%, 51.8%, 25.1%, 20.8%, and 20.0% respectively [3][15]. - The net profit is expected to turn positive in 2025, reaching RMB 751 million, and further increasing to RMB 3,242 million by 2027 [3][15]. - The earnings per share (EPS) is projected to improve from a loss of RMB 0.66 in 2023 to a profit of RMB 1.97 by 2027 [3][15]. Clinical Data Highlights - IBI363 demonstrated an overall response rate (ORR) of 26-37% in squamous NSCLC patients, with a median progression-free survival (PFS) of 5.5-9.3 months and a median overall survival (OS) exceeding 15.3 months [7][8]. - In the EGFR wild-type non-squamous NSCLC cohort, the ORR was 24% with a median PFS of 5.6 months [7][9]. - The safety profile of IBI363 is reported to be manageable, with the most common grade 3 adverse events being joint pain and rash [7].

Core Viewpoint - The 2025 ASCO Annual Meeting will showcase significant research achievements of domestic innovative drugs, highlighting their potential in oncology treatment [1] Group 1: Innovative Drug Highlights - Several innovative drug molecules with first-in-class or best-in-class potential will present data, including IBI363 from Innovent Biologics, SKB264 from Kelun-Biotech, and others [1] - IBI363 is the world's first next-generation IO dual antibody designed with IL 2α bias, showing promising efficacy in treating IO-resistant tumors such as NSCLC, melanoma, and CRC [2] Group 2: Clinical Data and Efficacy - In a Phase I clinical study, IBI363 demonstrated an overall response rate (ORR) of 43.3% and a disease control rate (DCR) of 90.0% in squamous NSCLC patients at a 3 mg/kg dosage, with a median progression-free survival (mPFS) of 7.3 months [2] - For adenocarcinoma patients previously treated with PD-(L)1 therapy, the 3 mg/kg group showed an ORR of 76.0% and a DCR of 90.0%, with an mPFS of 4.2 months [2] Group 3: Comparative Efficacy - IBI363 exhibited significant clinical activity in IO-resistant lung squamous and adenocarcinoma patients, outperforming existing therapies such as docetaxel and various immune combination treatments [3] Group 4: Colorectal Cancer Potential - IBI363 also shows promise in late-line CRC treatment, with clinical studies indicating an overall survival (OS) of 16.1 months for patients treated with IBI363 monotherapy [5][6] - Compared to standard treatments like TAS-102 combined with bevacizumab, IBI363 demonstrated superior survival outcomes in patients with worse baseline characteristics [6]

Core Viewpoint - Zhongyin International has raised the target price for Innovent Biologics (01801.HK) to HKD 82 and maintains a "Buy" rating following positive data updates on IBI363 presented at the ASCO conference [1] Financial Projections - The revenue forecasts for Innovent Biologics for 2025, 2026, and 2027 have been increased to RMB 11.4 billion, RMB 14.2 billion, and RMB 17.9 billion respectively [1] Regulatory Developments - The US FDA has granted Fast Track designation for IBI363 for the treatment of advanced non-small cell lung cancer and melanoma, while the National Medical Products Administration has awarded it Breakthrough Therapy designation [1] Clinical Trials - The company plans to initiate two Phase III clinical trials in the second half of the year [1]