Group 1: Market Overview - The pharmaceutical and biotechnology index decreased by 0.14% from December 15 to December 19, outperforming the ChiNext and CSI 300 indices [1][23] - The total trading volume in the pharmaceutical sector was 389.82 billion yuan, accounting for 4.49% of the total trading volume in the Shanghai and Shenzhen markets, which is below the average of 7.12% since 2013 [1][38] - The pharmaceutical sector ranked 18th in terms of weekly performance among all industries during the same period [1][25] Group 2: Sector Analysis - The recent lack of significant industrial catalysts has led to a muted beta effect in the sector, but many stocks have entered a value range, indicating potential for a rebound [2][59] - The "reward economy" theme has positively influenced certain pharmaceutical companies, particularly those linked to Ant Group and related retail channels [2][59] - Strong performance was noted in CXO, small nucleic acids, and certain innovative drugs, driven by specific stock factors such as BD expectations and overseas mapping [2][59] Group 3: In Vivo CAR-T Developments - In vivo CAR-T technology is expected to address the accessibility issues of CAR-T therapies, potentially lowering treatment costs and making it available as a shelf product [4][12] - Major pharmaceutical companies are actively investing in in vivo CAR-T, with business development (BD) transactions exceeding 5 billion USD, indicating its strategic importance [4][16] - Clinical data presented at the 2025 ASH meeting showed promising results for in vivo CAR-T therapies, with high rates of minimal residual disease (MRD) negativity in patients [4][19] Group 4: Future Outlook - The company maintains a positive outlook on innovation, international expansion, and turnaround opportunities in the pharmaceutical sector, focusing on BD 2.0, small nucleic acids, and supply chains as key investment areas [3][22] - The upcoming 2026 potential catalysts include the publication of the commercial insurance innovation drug directory and the commercialization of targeted CAR-T therapies [21][22] - Domestic companies are rapidly advancing in the in vivo CAR-T space, with several candidates in early clinical stages, indicating a growing competitive landscape [22][22]

Core Insights - The health care sector has several oversold stocks that present potential buying opportunities for undervalued companies [1] Group 1: Oversold Stocks - Insmed Inc (NASDAQ:INSM) has an RSI value of 26.8, with a recent stock price of $198.46, and has experienced a 2% decline over the past month [7] - Tempus AI Inc (NASDAQ:TEM) also has an RSI value of 26.8, with shares closing at $64.62 after a 13% drop in the last five days [7] - Legend Biotech Corp (NASDAQ:LEGN) has the lowest RSI value at 19.1, with a stock price of $21.42, reflecting a 27% decrease over the past month [7]

Core Insights - The health care sector has several oversold stocks that present potential buying opportunities for undervalued companies [1] Group 1: Oversold Stocks - Insmed Inc (NASDAQ:INSM) has an RSI value of 26.8, with a recent stock price of $198.46, and has experienced a 2% decline over the past month [7] - Tempus AI Inc (NASDAQ:TEM) also has an RSI value of 26.8, with shares closing at $64.62 after a 13% drop in the last five days [7] - Legend Biotech Corp (NASDAQ:LEGN) has the lowest RSI value at 19.1, with a stock price of $21.42, reflecting a 27% decline over the past month [7]

Company Updates - Legend Biotech Corporation will present the latest company updates at the 44th Annual J.P. Morgan Healthcare Conference on January 14, 2026, at 9:00 a.m. PT [1] - The live webcast of the presentation will be accessible through the Investor Relations section of Legend's website, with a replay available approximately 48 hours later [2] Company Overview - Legend Biotech is the largest standalone cell therapy company with over 2,900 employees and is a pioneer in cancer treatment innovations [3] - The company is leading the CAR-T cell therapy revolution with its product CARVYKTI, a one-time treatment for relapsed or refractory multiple myeloma, developed in collaboration with Johnson & Johnson [3] - Legend Biotech aims to maximize patient access and therapeutic potential of CARVYKTI while driving future innovations across its pipeline of advanced cell therapy modalities [3]

Core Insights - Legend Biotech Corp (NASDAQ:LEGN) is recognized as a strong investment opportunity by Wall Street analysts, with RBC Capital maintaining an Outperform rating and a price target of $74 [1][2]. Group 1: Company Performance - The company’s multiple myeloma treatment, CARVYKTI, has shown impressive efficacy, achieving over 50 months of median progression-free survival in patients, which is significantly better than competitors [2]. - Legend Biotech has treated over 9,000 patients globally with CARVYKTI, which is currently approved for adults with relapsed or refractory multiple myeloma [2][4]. - The company has demonstrated remarkable revenue growth of 74.75% over the past 12 months, indicating strong financial performance [3]. Group 2: Market Position and Future Prospects - RBC Capital believes that the current share price does not fully reflect the company's potential to maintain market share, supported by a robust pipeline of products [3]. - The firm anticipates that Legend Biotech will continue to experience strong growth and near-term profitability due to its successful product offerings and market strategies [3].

Core Insights - Legend Biotech Corporation announced long-term clinical data for CARVYKTI, showing a median progression-free survival (mPFS) of 50.4 months in triple-class-exposed relapsed/refractory multiple myeloma patients after a single infusion, marking one of the longest PFS outcomes for BCMA-targeted CAR-T therapy in this population [1][8][12] Group 1: Clinical Data and Efficacy - The CARTITUDE-1 and CARTITUDE-4 studies demonstrated that patients treated with CARVYKTI earlier in their treatment journey exhibited stronger immune fitness and a more immunocompetent tumor microenvironment, correlating with longer PFS [3][4][12] - At a median follow-up of 33.6 months, patients with standard-risk cytogenetics in the CARVYKTI arm achieved a 30-month PFS rate of 71.0%, compared to 43.2% in the standard-of-care arm [7][8] - Notably, all patients who achieved minimal residual disease (MRD)-negative complete response at 12 months following CARVYKTI infusion remained progression-free at 30 months [9] Group 2: Safety and Adverse Events - Among patients receiving CARVYKTI, cytokine release syndrome (CRS) occurred in 84% of cases, with a median time to onset of 7 days and resolution in 82% of patients [20][22] - Neurologic toxicities, including Immune Effector Cell-associated Neurotoxicity Syndrome (ICANS), occurred in 24% of patients, with a median time to onset of 10 days [25][28] - Hypogammaglobulinemia was reported in 36% of patients, with 93% experiencing laboratory IgG levels below 500 mg/dL after infusion [52][53] Group 3: Company Overview and Future Directions - Legend Biotech is a leader in cell therapy, particularly with CARVYKTI, which has been approved for treating relapsed or refractory multiple myeloma [64][65] - The company is focused on expanding patient access and therapeutic potential of CARVYKTI while driving innovation across its pipeline of cell therapy modalities [71]

Core Insights - Legend Biotech has been awarded the Foreign Investor of the Year at the 2025 Flanders International Business Awards, recognizing its significant contributions to the region's biotech sector [1][2] - The company has made a €165 million joint investment with Johnson & Johnson to expand its manufacturing facility in Ghent, enhancing its position as a major CAR-T manufacturing center in Europe [3][4] Company Growth and Operations - Since starting operations in Ghent in 2022, Legend Biotech's workforce has grown from 2 to over 1,000 employees, representing 66 nationalities, with plans for further hiring in the coming years [4] - The Ghent facility, along with the nearby Obelisc site, serves as the European hub for clinical and commercial supply of cell therapies across the EMEA region [3] Strategic Partnerships and Ecosystem - Legend Biotech's growth is closely linked to the strength of the Flemish biotech ecosystem, supported by partnerships with Flanders Investment & Trade (FIT) and collaborations with research institutions like VIB and Ghent University [5] - The company aims to leverage its leadership in CAR-T cell therapy to maximize patient access and drive future innovations in cell therapy modalities [6]

Investment Rating - The report maintains a "Buy" rating for Sands China (1928) with a target price of HKD 25.11, reflecting a potential upside of 27.9% from the current price [2][8]. Core Insights - Sands China's new promotional strategies are beginning to show results, with expectations for continued market share and EBITDA growth [5][7]. - The company reported a net revenue of USD 1.9 billion for Q3 2025, recovering to 90% of 2019 levels, with a year-on-year growth of 7.3% and a quarter-on-quarter growth of 6.1% [5]. - The adjusted EBITDA for Q3 2025 increased by 2.7% year-on-year and 6.2% quarter-on-quarter to USD 600 million, recovering to 80% of 2019 levels [5][7]. Summary by Sections Company Research - Sands China (1928) is rated "Buy" with a target price of HKD 25.11, reflecting a 12x EV/EBITDA for 2025 [2][8]. - The company’s market share in the gaming sector has rebounded to 25.4%, with a year-on-year increase of 0.5% and a quarter-on-quarter increase of 1.4% [5][7]. Financial Performance - Q3 2025 net profit increased by 1.5% year-on-year and 27.1% quarter-on-quarter to USD 270 million [5]. - The company holds approximately USD 1.13 billion in cash, with net debt reduced by USD 150 million to USD 5.79 billion [5][7]. Market Dynamics - The VIP segment saw a year-on-year decline of 16.3%, while the mass market segment grew by 12.1% year-on-year, indicating a shift in customer preferences [5][6]. - The company is benefiting from the full service of the Londoner project and new promotional strategies, which are expected to enhance market share and EBITDA further [7][8]. Other Key Points - The report highlights the importance of the new strategies and the expected growth in EBITDA to reach USD 2.7-2.8 billion in the short term [7]. - Sands China has repurchased USD 340 million worth of shares, increasing its ownership stake to 74.76% [7].

Core Insights - Allka Research has over two decades of experience in investment, focusing on uncovering undervalued assets in various sectors including ETFs, commodities, technology, and pharmaceuticals [1] - The company adopts a conservative investment approach, aiming to deliver substantial returns and strategic insights to clients [1] - Allka Research is committed to simplifying investment strategies, making them accessible to both seasoned investors and newcomers [1] - The mission of Allka Research includes sharing knowledge through Seeking Alpha, providing thought-provoking analyses and informed perspectives [1] - The goal is to inspire confidence in readers and foster a community of informed investors capable of navigating the financial markets effectively [1] Company Overview - Allka Research is recognized for its dedication to identifying lucrative investment opportunities [1] - The company emphasizes a commitment to empowering individuals financially through education and strategic insights [1] - Allka Research aims to demystify investing, contributing to a better understanding of market complexities [1]

Core Insights - Allka Research has over two decades of experience in investment, focusing on identifying undervalued assets in ETFs, commodities, technology, and pharmaceutical sectors [1] - The company emphasizes a conservative investment approach, aiming to deliver substantial returns and strategic insights to clients [1] - Allka Research is committed to simplifying investment strategies, making them accessible to both seasoned and novice investors [1] - The mission of Allka Research includes sharing knowledge and analyses through Seeking Alpha, fostering a community of informed investors [1] Company Overview - Allka Research is recognized for its dedication to uncovering lucrative investment opportunities [1] - The firm aims to empower individuals financially by providing thought-provoking analyses and informed perspectives [1] - The company seeks to demystify investing, inspiring confidence among its readers [1]