Summary of Zai Lab's Conference Call Company Overview - **Company**: Zai Lab - **Focus Areas**: Oncology and Immunology - **Key Product**: Zosi, a DLL3-targeted antibody-drug conjugate (ADC) Key Points on Zosi Development - **Clinical Trials**: - Initiated a global phase three trial for Zosi in second-line small cell lung cancer (SCLC) and expanding into first-line SCLC and neuroendocrine carcinomas (NECs) [2][5][18] - Zosi has shown a 68% overall response rate (ORR) in second-line patients at a dose of 1.6 mg/kg and an 80% ORR in patients with untreated brain metastases [4][14] - The median duration of response is 6.1 months across all doses [15] - **Safety Profile**: - Zosi demonstrated a low rate of grade three treatment-related adverse events at 13%, significantly lower than other ADCs [12] - No treatment discontinuations due to toxicity were reported [16] - **Patient Population**: - The trial includes heavily pretreated patients, with over 90% having received prior anti-PD-L1 or PD-1 therapy [11] - Approximately one-third of patients had brain metastases, which is significant given the poor prognosis associated with this condition [11][52] Market Context and Competitive Landscape - **Urgent Need for New Therapies**: - SCLC accounts for about 15% of lung cancer cases, with over 370,000 new cases annually worldwide [6] - Current treatment options are limited and often associated with high toxicity and poor long-term outcomes [7][8] - **Positioning Against Competitors**: - Zosi is positioned as a chemotherapy-sparing option, which could enhance its appeal in the first-line treatment setting [26][34] - The competitive landscape includes Imdeltra, which is expected to become a front-line agent, but Zosi's rapid onset of action and favorable safety profile may provide a competitive edge [25][34] Future Development Plans - **Upcoming Trials**: - A randomized phase two study is ongoing to optimize dose selection, with plans for a pivotal study in the front-line setting in 2026 [19][48] - Zai Lab is also exploring combination strategies with other agents to enhance Zosi's efficacy [58] - **Regulatory Strategy**: - Zai Lab aims for accelerated approval based on response and durability of response, with a potential filing in 2027 [23][41] - The FDA has agreed on the focus doses of 1.2 and 1.6 mg/kg for the pivotal trial [45] Additional Insights - **Brain Metastasis Efficacy**: - Zosi has shown promising results in patients with brain metastases, with an 80% response rate, highlighting its potential for treating this challenging aspect of SCLC [52][54] - **Long-term Vision**: - Zai Lab is committed to reshaping the treatment paradigm for SCLC and NECs, with a focus on delivering innovative therapies that improve patient outcomes [19][60] Conclusion - Zai Lab is advancing Zosi as a potential best-in-class treatment for SCLC, with a strong emphasis on safety, efficacy, and rapid development timelines. The company is well-positioned to address significant unmet needs in oncology, particularly in challenging patient populations.

Core Viewpoint - The company, Zai Lab (09688.HK), announced that its board's audit committee will review and approve the unaudited quarterly performance for the third quarter ending September 30, 2025, on November 6, 2025, in accordance with US GAAP and SEC regulations [1] Group 1 - The board's audit committee is scheduled to meet on November 6, 2025 [1] - The meeting will focus on the unaudited quarterly results for the three and nine months ending September 30, 2025 [1] - The results will be prepared in compliance with US GAAP and applicable SEC rules [1]

Zai Lab Limited 再鼎醫藥有限公司 * （於開曼群島註冊成立的有限公司） （股份代號：9688） 審核委員會行動通告及 2025 年第三季度業績公告的發佈日期 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦 不發表任何聲明，並明確表示，概不會對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的 任何損失承擔任何責任。 在第三季度業績獲批准及發佈後，本公司管理層計劃在 2025 年 11 月 6 日（星期四，美國東部時間） 上午 8:00/2025 年 11 月 6 日（星期四，香港時間）下午 9:00 舉行現場業績電話會議及網絡直播，以討 論第三季度業績並回答提問。有意參會人士可透過本公司網站 http://ir.zailaboratory.com 參與網絡直播。 所有參與者均須於電話會議前透過下文提供的連結完成線上登記流程。登記後，參與者將收到提供撥 號詳情的確認郵件。 網絡直播登記連結： https://edge.media-server.com/mmc/p/svanah67 拨入登記連結：https://register-conf.med ...

- 1 - (A) 人數。委員會應由至少三名成員組成。 (B) 獨立性。委員會的每名成員均應符合納斯達克全球市場（「納斯達克」）及香 港聯合交易所有限公司證券上市規則（「香港上市規則」）的適用獨立性 要求，並符合「獨立董事」的資格。 (C) 主席。除非主席由董事會委任，否則委員會成員應通過委員會全體成員的 多數票指定一名主席。主席應領導委員會，包括制定會議議程、主持會議、 分配小組委員會任務及代表委員會向董事會報告。 (D) 關於成員資格的決定。委員會的成員應由董事會委任並可由董事會酌情罷 免。董事會將至少每年評估是否符合上述成員資格要求。 再鼎醫藥有限公司董事會 提名及企業管治委員會章程 （於2025年10月22日獲董事會採納） I. 宗旨和權限。 再鼎醫藥有限公司（「公司」）董事會（「董事會」）下設的提名及企業管治委員會（「委 員會」）的宗旨是履行董事會授予有關企業管治及董事提名的職責。 II. 組成。 III. 程序和管理。 (A) 董事會和委員會事務；企業管治。 (1) 董事提名人選。委員會應按董事會批准的標準物色有資格成為董事會成 員的人士，接收並審查有關合格人士的提名及審查首席執行官提出的推 薦； ...

Core Viewpoint - The Hong Kong stock market's innovative drug sector is experiencing a decline, with the Hong Kong Stock Connect Innovative Drug ETF (520880) dropping over 3.5% as of the report, indicating a potential buying opportunity for investors despite the downturn [1] Group 1: Market Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has seen a trading volume exceeding 200 million yuan, continuing to exhibit high premiums in the market [1] - The innovative drug sector faced a significant drop recently, with the ETF attracting over 75 million yuan in a single day, totaling over 120 million yuan in the last four days [1] Group 2: Recent Developments - The ESMO 2025 conference recently showcased positive data for several core projects of Chinese innovative drugs [1] - On October 22, Innovent Biologics announced a global strategic partnership with Takeda Pharmaceutical worth 11.4 billion USD, setting a record for the value of business development (BD) transactions in China's innovative drug sector, involving three product rights and pipeline development [1] Group 3: Future Outlook - Huafu Securities suggests that the recent adjustments in the Hong Kong innovative drug sector may present a significant opportunity for investment in late October [1] - The long-term outlook remains positive for companies with commercialization capabilities and rich pipelines, particularly in BioPharma, potential BD targets, and cutting-edge technology [1] - The innovative drug industry is expected to benefit from interest rate cuts, with performance anticipated to improve, and the end-of-year BD period may act as a catalyst for growth [1] Group 4: Index Composition - The Hong Kong Stock Connect Innovative Drug ETF (520880) and its linked fund (025220) passively track the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which includes top ten weighted stocks such as BeiGene, China Biologic Products, Innovent Biologics, and others [1]

Core Insights - Zai Lab Limited announced a late-breaking abstract featuring new data from its global Phase 1 clinical trial evaluating zocilurtatug pelitecan (zoci), previously known as ZL-1310 [1] - The abstract has been selected for an oral presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, scheduled for October 22-26, 2025, in Boston, Massachusetts [1] Company Summary - Zai Lab Limited is actively involved in clinical trials for zocilurtatug pelitecan, indicating ongoing research and development efforts in the oncology sector [1] - The selection of the abstract for oral presentation highlights the significance of the trial results and the company's commitment to advancing cancer therapeutics [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | | | 致：香港交易及結算所有限公司 公司名稱: 再鼎醫藥有限公司 呈交日期: 2025年10月6日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09688 | 說明 | 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 5,000,000,000 | USD | | 0.000006 | USD | | 30,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 5,000,000,000 | USD | | 0.000006 | USD | | 30,000 | 本月底法定/註冊股本總額： USD 30,000 F ...

Core Viewpoint - Zai Ding Pharmaceutical (09688) announced the grant of stock options and restricted stock units as part of its 2024 equity incentive plan, indicating a focus on employee retention and motivation through equity compensation [1] Summary by Category Stock Options - The company granted stock options to one grantee for a total of 25,000 American Depositary Shares (ADS) [1] Restricted Stock Units - Additionally, the company awarded restricted stock units to seven grantees involving a total of 32,200 ADS [1]

Core Viewpoint - Zai Ding Pharmaceutical (09688) announced the grant of stock options and restricted stock units as part of its 2024 equity incentive plan, indicating a focus on employee retention and motivation through equity compensation [1] Group 1 - The company granted a total of 25,000 American Depositary Shares (ADS) stock options to one grantee [1] - Additionally, the company awarded a total of 32,200 restricted stock units (RSUs) to seven grantees [1] - The grants are set to take effect on October 1, 2025, Eastern Time [1]

Core Viewpoint - The company announced the grant of stock options and restricted stock units as part of its 2024 equity incentive plan, indicating a focus on employee retention and motivation [1] Group 1: Stock Options and Restricted Stock Units - The company granted a total of 25,000 American Depositary Shares (ADS) stock options to one grantee [1] - Additionally, the company awarded a total of 32,150 restricted stock units (RSUs) to seven grantees [1] - The grants are set to take effect on October 1, 2025, Eastern Time [1]