香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦 不發表任何聲明，並明確表示，概不會對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的 任何損失承擔任何責任。 Zai Lab Limited 再鼎醫藥有限公司 * （於開曼群島註冊成立的有限公司） （股份代號：9688） 本公司根據香港上市規則將刊發的中期業績與本公司先前公佈並向證交會提交的業績相同，惟香 港上市規則規定須披露的若干附加資料以及本公司業績從美國公認會計準則至國際財務報告準則 的對賬結果除外。 承董事會命 再鼎醫藥有限公司 董事、董事長兼首席執行官 杜瑩 香港，2025 年 8 月 13 日 於本公告日期，本公司董事會包括董事杜瑩博士；以及獨立董事 John Diekman 博士、 Richard Gaynor 博士、 梁頴宇女士、 William Lis 先生、 Scott W. Morrison 先生、 Leon O. Moulder, Jr. 先生、 Michel Vounatsos 先生及 Peter Wirth 先生。 * 僅供識別 審核委員會行動通告 再鼎醫藥有限公司（「本公司」）董 ...

格隆汇8月13日｜再鼎医药(ZLAB.US)盘前涨3.44%，报35.49美元。中金发研报指，国家医保局发布基 本医疗保险、生育保险和工伤保险药品目录以及商保创新药目录调整初步形式审查公告，534个药品通 过初步形式审查，预期当局启动双目录机制，可为医保形成清晰分工，基本医保目录覆盖临床必需的基 础药品，而商保创新目录则重点纳入未被医保覆盖、但具有重大临床价值的高价值药品。 中金指，医保托底加上商保扩容，预料将鼓励商业保险公司通过创新药投资基金等多种方式，为创新药 研发提供稳定的长期投资，培育支持创新药的耐心资本，有利于具创新性和临床价值的高价值创新药落 地，创新药料将商保应用积累数据、增加临床渗透及提升潜在市场价值空间。该行建议关注再鼎医药等 股票。(格隆汇) | ZLAB 再鼎医药 | | 03 | | --- | --- | --- | | 34.310 ↓ -0.350 -1.01% | | 收盘价 08/12 16:00 美东 | | 35.490 ↑ 1.180 +3.44% | | 盘前价 08/13 04:24 美乐 | | 雪 5 24 华 S 9 8 目 ♥ | | ● 快捷交易 | | ...

Group 1 - The Hong Kong stock market showed strong performance on August 13, with the Hang Seng Index rising by 1.88% and the Hang Seng Tech Index increasing by 2.35%, particularly driven by the healthcare sector [1] - The Hong Kong Innovative Drug 50 ETF (513780) closed up by 3.38% with a turnover rate exceeding 18% and a transaction volume of over 400 million yuan, indicating strong investor interest [1] - Notably, the Hong Kong Innovative Drug 50 ETF (513780) experienced a net inflow of 1.07 billion yuan over the past 15 trading days, and it has gained over 92% year-to-date as of August 12 [1] Group 2 - The National Healthcare Security Administration announced the preliminary review results for the 2025 medical insurance directory and commercial insurance innovative drug directory, with 534 drugs passing the basic medical insurance directory review and 121 drugs passing the commercial insurance innovative drug directory review [2] - High-priced innovative drugs, including CAR-T therapies, are seeking inclusion in the commercial insurance innovative drug directory, indicating a push for diversified payment methods for innovative drugs [2] - Analysts suggest that the rise of innovative drugs is sustainable, recommending attention to companies with rich pipeline layouts, high-potential single innovative drugs, and leading technology platforms in the sector [2]

智通财经APP讯，再鼎医药(09688)发布公告，于2025年8月12日，该公司根据股权激励计划发行684.43 万股。 （原标题：再鼎医药(09688)根据股权激励计划发行684.43万股） ...

Group 1 - The company, Zai Lab (09688.HK), announced the issuance of 6.84429 million new ordinary shares on August 12, 2025 [1] - The shares will be held by a trustee to fulfill the share awards and options granted to executive directors under the equity incentive plans disclosed in 2015, 2017, 2022, and 2024 [1]

Core Viewpoint - Zai Ding Pharmaceutical (09688) announced the issuance of 6.8443 million shares under its equity incentive plan, scheduled for August 12, 2025 [1] Group 1 - The company is implementing an equity incentive plan to issue shares [1] - The total number of shares to be issued is 6.8443 million [1] - The issuance date is set for August 12, 2025 [1]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 再鼎醫藥有限公司 呈交日期： 2025年8月12日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 09688 | 說明 | 普通股 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不 ...

Investment Rating - The report maintains a "Buy" rating for the company, with a target price adjusted to USD 46 for the US stock and HKD 36 for the Hong Kong stock, reflecting potential upside of +35% and +18% respectively [5][13]. Core Insights - The company's Q2 2025 performance was below expectations, primarily due to lower-than-expected revenues from key products Aigamod and Zelek, as well as a decline in gross margin [1][2]. - Total revenue for Q2 2025 was USD 110 million, including product net revenue of USD 109 million, which represents a year-over-year increase of 9.0% but is significantly below market expectations [2]. - The net loss narrowed to USD 40.73 million, a decrease of 49.3% year-over-year, but still fell short of internal forecasts [2]. - The report highlights that Aigamod's sales were USD 26.5 million in Q2 2025, showing a year-over-year increase of 14.3%, but the growth rate has slowed compared to previous quarters [3]. - Zelek's revenue was only USD 41 million, down 8.8% year-over-year, attributed to increased competition from generic drugs [3]. Financial Performance Summary - The company maintained its full-year guidance for 2025, projecting total revenue between USD 560 million and USD 590 million, with expectations of significant growth in the second half of the year [4]. - The report anticipates that Aigamod will benefit from new treatment guidelines, potentially leading to a recovery in sales growth [4]. - The company is expected to face challenges in achieving its revenue targets, with projected growth rates of 63%-77% year-over-year and 59%-73% quarter-over-quarter for the second half of 2025 [4]. - Key catalysts for growth include updates on the promising pipeline product ZL-1310 and potential approvals for other drugs in the pipeline [4][12]. Market Data - The current stock price is USD 34.1, with a 52-week range of USD 16.0 to USD 44.3, and a total market capitalization of USD 3.747 billion [5]. - The average daily trading volume over the past three months is USD 32 million [5].

Core Viewpoint - Zai Ding Pharma reported a total revenue of $110 million for Q2 2025, reflecting a 9% year-over-year growth, with management reaffirming the annual revenue guidance and targeting a positive Non-GAAP operating profit by Q4 2025. However, the market reacted negatively, with a significant drop in stock prices, raising questions about underlying concerns in the financial report and potential investment opportunities [1][2][3]. Revenue Performance - The company achieved a total revenue of $110 million in Q2 2025, marking a 9% increase year-over-year, and a 10% increase when adjusted for constant exchange rates [2]. - Management reiterated the annual revenue guidance, indicating a sustainable growth outlook [2]. Market Concerns - The revenue growth has raised market concerns, particularly regarding the performance of the PARPi product line, which saw a 9.75% decline in sales year-over-year, leading to skepticism about the annual revenue guidance of $560 million to $590 million [3][4]. - Despite the challenges faced by the PARPi products, there are signs of marginal improvement in sales for the second half of the year [4]. Product Performance - The sales of the flagship product, Egamod, increased significantly by 46% quarter-over-quarter, reaching a historical high in patient usage, although year-over-year growth remains modest [5]. - The company plans to submit a market application for a pre-filled subcutaneous injection of Egamod in 2025, which will enhance its market position with three administration methods [5]. New Growth Drivers - New products such as Niu Zai Le and Ding You Le contributed to a 30% year-over-year growth in "other businesses," indicating a strengthening pipeline [6]. Global Pipeline Development - Zai Ding Pharma is advancing its "dual reporting in China and the U.S." strategy, with several global pipeline candidates entering critical stages [10]. - Notable candidates include ZL-1310 for small cell lung cancer and ZL-1503 for atopic dermatitis, both showing promising clinical results [11]. Financial Health - The company reported a Q2 2025 operating loss of $54.9 million, a 28% year-over-year reduction, with adjusted losses narrowing by 37% to $34.2 million, indicating improved financial health [13]. - With cash reserves of $832.3 million, the company is well-positioned to support business expansion and R&D efforts [13]. Market Sentiment - Despite stock price declines, there was a significant inflow of capital into the stock, suggesting some investors are adopting a "buy the dip" strategy [9]. - The overall market sentiment remains optimistic due to the company's global pipeline and clear path to profitability, which may lead to a revaluation of the stock [15].

Summary of Conference Call Notes Company and Industry Overview - **Company**: 赛领医药 (Sailin Pharmaceuticals) - **Industry**: Biopharmaceuticals, focusing on autoimmune diseases and oncology treatments Key Points and Arguments Product Developments - **艾佳莫德 (Eijamode)**: - Currently has a penetration rate of only 10% in the Chinese market for Myasthenia Gravis (MG) treatment, with significant growth potential due to new guidelines recommending its use for early and diverse patient populations [2][17] - Achieved a cumulative target rate of 73% and a first-cycle target rate of 40% in clinical settings, indicating strong efficacy [3][17] - Plans to enhance market education and increase hospital coverage to boost penetration [4][17] - **ZL1,310**: - Demonstrated a high overall response rate (ORR) of 67% in second-line small cell lung cancer patients, with a 79% ORR in the 1.6 mg dosage group [2][7] - Received FDA fast track designation and is expected to initiate global registration clinical trials in the second half of the year [7][12] - **Z21,503**: - A bispecific antibody for atopic dermatitis showing promising preclinical data for itch and inflammation relief, with plans to submit a global IND application in the second half of the year [2][8] - **Bemarituzumab**: - Positive results in a global Phase III study for first-line gastric cancer, with plans to submit for market approval within six months [2][9] Financial Performance - **Q2 2025 Financials**: - Total revenue reached $110 million, a 9% year-over-year increase, with Eijamode revenue growing by 46% quarter-over-quarter [3][12] - Cash reserves exceeded $830 million, supporting business expansion and R&D investments [4][12] Market Dynamics - **Competition**: - Zele's sales revenue decreased in Q2 due to changes in competitive landscape but is expected to stabilize in the second half of the year [4][6] - New product **顶优乐 (Dingyoule)** received positive feedback but faced supply constraints, which the company is actively addressing [6][23] Future Outlook - **Growth Projections**: - Eijamode is projected to become a blockbuster product with peak sales potential of 7 billion RMB, driven by increasing market acceptance and new indications [18][19] - Zele is expected to recover and grow in market share, particularly in the ovarian cancer treatment segment [21][22] - **Clinical Trials and Approvals**: - Plans to submit multiple IND applications and initiate key clinical trials for various products, including those targeting autoimmune diseases and cancers [12][10][11] Strategic Initiatives - **AI Integration**: - The company plans to utilize AI platforms for patient management and to enhance treatment adherence [5][17] - **Market Education**: - A focus on educating healthcare providers and patients about new treatment guidelines and product benefits to increase adoption rates [4][17] Additional Important Information - The company is actively expanding its product pipeline and exploring collaborations to enhance its market position [15][34] - The competitive landscape for small cell lung cancer treatments is intensifying, with multiple products entering late-stage trials [26][27] - The company is preparing for the commercialization of new therapies, including those for IGA nephropathy and thyroid eye disease, with significant market potential [32][33]