Group 1 - Kintor Pharmaceutical (科济药业-B) shares rose over 7%, currently up 6.39% at HKD 19.98, with a trading volume of HKD 10.51 million [1] - The company announced it will present clinical data for CT0596 at the 67th American Society of Hematology (ASH) annual meeting [1] - On September 20, the National Healthcare Security Administration announced the completion of expert review for the first version of the commercial insurance innovative drug catalog, with Kintor's CAR-T drug, Sai Ke Ze, among five CAR-T drugs that passed the review, potentially entering this year's basic medical insurance and commercial insurance innovative drug catalog [1]

Group 1 - The core point of the article is that Kintor Pharmaceutical (科济药业-B) has seen a stock price increase of over 7%, currently trading at 19.98 HKD with a transaction volume of 10.51 million HKD [1] - Kintor Pharmaceutical announced that it will present clinical data for CT0596 at the 67th American Society of Hematology (ASH) annual meeting [1] - On September 20, the National Healthcare Security Administration announced the completion of expert review for the first version of the commercial insurance innovative drug catalog, with Kintor's CAR-T drug, Sai Ke Ze, among five CAR-T drugs that passed the review, potentially entering the basic medical insurance catalog and commercial insurance innovative drug catalog this year [1]

Core Insights - Company Kintor Pharmaceutical (科济药业-B) announced that it will present clinical data for CT0596, a BCMA-targeted allogeneic CAR-T cell candidate, at the 67th American Society of Hematology Annual Meeting [1] - CT0596 is developed on the company's proprietary THANK-u Plus platform and is currently undergoing investigator-initiated clinical trials for relapsed/refractory multiple myeloma (R/R MM) and plasma cell leukemia (PCL) [1] - The candidate has shown promising safety and efficacy signals, with CAR-T cell expansion observed across all predefined dose groups [1] - The company plans to explore CT0596 in other plasma cell tumors and autoimmune diseases driven by autoreactive plasma cells [1] - An IND application for CT0596 is expected to be submitted in the second half of 2025 [1]

Core Viewpoint - Company Kintor Pharmaceutical (科济药业-B) is set to present clinical data for its CAR-T cell therapy candidate CT0596 at the 67th American Society of Hematology Annual Meeting, with further details to be released on November 3, 2025 [1] Group 1: Product Information - CT0596 is a universal CAR-T cell therapy targeting BCMA, developed on the company's proprietary THANK-u Plus™ platform [1] - The therapy is currently undergoing investigator-initiated clinical trials for relapsed/refractory multiple myeloma (R/R MM) and plasma cell leukemia (PCL) [1] - Initial results indicate promising safety and efficacy signals, with CAR-T cell expansion observed across all predefined dose groups [1] Group 2: Future Plans - In addition to R/R MM, the company plans to explore CT0596 in other plasma cell tumors and autoimmune diseases driven by autoreactive plasma cells [1] - The company anticipates submitting an IND application for CT0596 in the second half of 2025 [1]

香港交易及結算所有限公司、香港聯合交易所有限公司及香港中央結算有限公司對本公告的內 容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任 何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 科濟藥業是一家生物製藥公司，專注於開發創新CAR-T細胞療法，以滿足未滿足 的臨床需求，包括但不限於血液惡性腫瘤、實體瘤及自身免疫性疾病。科濟藥業 建立了從靶點發現、臨床前研究、產品臨床開發到商業規模生產的CAR-T細胞研 究與開發的端到端能力。科濟藥業通過自主研發新技術以及擁有全球權益的產品 管線，以解決現有CAR-T細胞療法的挑戰，比如提高安全性、提高治療實體瘤的 療效和降低治療成本等。科濟藥業的使命是成為全球生物製藥領域的領導者，為 全球癌症及其他疾病的患者提供創新和差異化的細胞療法，使癌症及其他疾病可 治癒。 1 CARsgen Therapeutics Holdings Limited 科濟藥業控股有限公司 （於開曼群島註冊成立的有限公司） （股份代號：2171） 自願公告 於2025年ASH年會上呈列的CT0596的研究成果更新 本公告由科濟藥業控股有限公司（「本公司」 ...

Group 1 - Zijin Mining International (02259) has been included in the Hang Seng Composite Index, effective from October 16, 2025, following the rapid inclusion rules [1] - The rapid inclusion mechanism allows new stocks to be added if their market capitalization ranks in the top 10% of existing constituents on their first trading day [1] - Other companies such as Aux Group (02580), Chery Automobile (09973), and FWD Group (01828) are also expected to be included in the Hang Seng Composite Index based on similar criteria [1] Group 2 - Companies like Silver Noble Pharma-B (02591), Zhonghui Biotech-B (02627), and others have shown good performance and may warrant attention for future market performance [2] - The company Extreme Intelligence-W (02590), listed on July 9, 2023, must meet additional standards for dual-class shares to be eligible for inclusion in the Hong Kong Stock Connect [2]

Core Viewpoint - Global pharmaceutical companies are facing a difficult choice: invest billions in building factories in the U.S. or bear up to 100% tariff costs on imported drugs [1][2] Tariff Policy Impact - The U.S. tariff policy aims to push pharmaceutical companies to relocate production to the U.S. and encourage investment in domestic manufacturing [2] - Following the tariff announcement, Hong Kong pharmaceutical stocks experienced declines, indicating market concerns about the changes [2] - Approximately 80% of generic drug active pharmaceutical ingredients (APIs) and some high-value finished drugs in the U.S. are reliant on imports, highlighting the need for domestic production [2] Consequences for Pharmaceutical Companies - Companies without U.S. manufacturing facilities will face significant losses due to the 100% tariff, potentially doubling the end-user prices of imported drugs [4] - For example, a European company's cancer drug costing $100 per treatment could rise to $200 due to tariffs, forcing companies to either absorb losses or increase prices [4] - Companies dependent on single overseas production sites must urgently evaluate alternatives, such as accelerating U.S. factory construction or seeking non-U.S. production options [4] Global Pharmaceutical Landscape - The tariff policy is expected to accelerate the shift of pharmaceutical distribution networks, with Indian pharmaceutical companies likely to benefit, potentially capturing nearly 50% of global generic drug revenue by 2030 [6] - European pharmaceutical companies are also expressing concerns about the risk of industry migration from Europe to the U.S. due to the tariffs [6] Impact on Chinese Pharmaceutical Companies - The tariff announcement is expected to have a limited impact on Chinese pharmaceutical companies, primarily affecting patented drugs, and the operational feasibility of the policy is uncertain [7] - Chinese companies need to enhance risk awareness to address potential challenges arising from geopolitical tensions and regulatory changes [7] - The U.S. foreign investment review process is expanding to include healthcare, which may affect Chinese companies regardless of their listing status [7][9] Market Dynamics and Listing Trends - The attractiveness of the U.S. stock market for innovative pharmaceutical companies is diminishing compared to Hong Kong, as regulatory hurdles increase for Chinese biotech firms seeking U.S. listings [10] - The Hong Kong market has become more appealing for mainland biotech companies, with significant fundraising activity observed in 2023 [12][14] - The introduction of a confidential listing application process in Hong Kong has allowed companies to avoid early public disclosures, enhancing their competitive positioning [14] Future Outlook - The geopolitical environment is complex, but the Chinese pharmaceutical industry is expected to leverage its strengths in drug development and commercialization [16] - China's drug approval activity is increasing, with a projected rise in the share of Chinese drugs in U.S. FDA approvals from 4% in 2024 to 35% by 2040 [12]

Core Viewpoint - Global pharmaceutical companies face a challenging decision: invest billions in building factories in the U.S. or bear up to 100% tariff costs on imported drugs [1][2] Tariff Policy and Market Impact - The U.S. will impose new tariffs starting October 1, including a 100% tariff on patented and branded drugs, significantly increasing import costs [1][2] - The policy aims to encourage pharmaceutical companies to relocate production to the U.S., reducing reliance on overseas supply chains and creating local jobs [2][4] - Capital markets reacted negatively, with Hong Kong pharmaceutical stocks experiencing declines, indicating market concerns over the tariff implications [2] Industry Response and Strategic Adjustments - Companies reliant on single overseas production bases must urgently evaluate alternatives, such as accelerating factory construction in the U.S. or seeking non-U.S. production options [3] - The tariff policy is expected to accelerate the shift of pharmaceutical distribution networks globally, with Indian pharmaceutical companies potentially benefiting from this transition [4] Implications for Chinese Pharmaceutical Companies - The impact of the tariff on Chinese pharmaceutical companies is expected to be limited, primarily affecting patented drugs, with operational challenges in implementing the policy [5] - Increased scrutiny on foreign investments in the healthcare sector by the U.S. could pose challenges for Chinese companies, particularly regarding data transfer regulations and compliance [6][7] Market Trends and Future Projections - The trend of Chinese innovative drugs gaining approval in the U.S. is expected to rise, with projections indicating that by 2040, Chinese drugs could account for 35% of new drug approvals by the FDA [8] - The Hong Kong market has become increasingly attractive for Chinese biotech companies, with significant fundraising activity observed in 2023 [8][9] Regulatory Environment and Listing Challenges - Recent regulatory changes in Hong Kong have made it easier for biotech companies to list, with a notable increase in the number of companies opting for confidential submissions [9][10] - The U.S. investment review mechanisms pose additional challenges for biotech companies seeking to attract capital, particularly in sensitive technology sectors [7][11]

Core Viewpoint - Pharmaceutical stocks are under pressure following the announcement of new tariffs on imported pharmaceutical products by U.S. President Trump, which could significantly impact the industry [1] Group 1: Stock Performance - Companies such as 科济药业-B (02171) saw a decline of 5.11%, trading at 18.37 HKD [1] - 康宁杰瑞制药-B (09966) dropped by 3.48%, with a trading price of 12.22 HKD [1] - 维亚生物 (01873) fell by 3.52%, now priced at 2.47 HKD [1] - 泰格医药 (300347) (03347) decreased by 3.1%, trading at 45.6 HKD [1] Group 2: Tariff Announcement - Starting October 1, the U.S. will impose a 100% tariff on all brands and patented pharmaceutical products [1] - Trump indicated that these tariffs will not apply to companies that build factories in the U.S., defining such facilities as "under construction" [1] Group 3: Policy Context - Trump's administration has focused on "lowering drug prices" and "supply chain repatriation" as key themes in its policies affecting the pharmaceutical industry this year [1]

Group 1 - Pharmaceutical stocks are under pressure, with notable declines: 科济药业-B down 5.11% to 18.37 HKD, 康宁杰瑞制药-B down 3.48% to 12.22 HKD, 维亚生物 down 3.52% to 2.47 HKD, and 泰格医药 down 3.1% to 45.6 HKD [1] - On September 25, President Trump announced a new round of high tariffs on various imported products, including a 100% tariff on all brands and patented pharmaceutical products starting October 1 [1] - The tariffs will not apply to companies that build factories in the U.S., defined by Trump as "under construction" [1] Group 2 - Trump's policies this year have focused on the pharmaceutical industry, with key themes being "lower drug prices" and "supply chain repatriation" [1]