GENERATIVE AI DRUG CREATION 2026 J.P. MORGAN HEALTHCARE CONFERENCE GENERATIVE AI DRUG CREATION Disclaimers COPYRIGHT© 2026 ABSCI CORPORATION | ALL RIGHTS RESERVED 2 FORWARD - LOOKING STATEMENTS Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expres ...

Company Overview - Proactive provides fast, accessible, informative, and actionable business and finance news content to a global investment audience [2] - The news team operates from key finance and investing hubs including London, New York, Toronto, Vancouver, Sydney, and Perth [2] Expertise and Focus Areas - The company specializes in medium and small-cap markets while also covering blue-chip companies, commodities, and broader investment stories [3] - Proactive delivers news and insights across various sectors including biotech and pharma, mining and natural resources, battery metals, oil and gas, crypto, and emerging digital and EV technologies [3] Technology Adoption - Proactive is recognized for its forward-looking approach and enthusiastic adoption of technology to enhance workflows [4] - The company utilizes automation and software tools, including generative AI, while ensuring all content is edited and authored by humans [5]

Summary of Magnite FY Conference Call (January 14, 2026) Company Overview - **Company**: Magnite (NasdaqGS:MGNI) - **Industry**: Digital Advertising Technology - **Position**: Largest independent sell-side advertising platform, focusing on programmatic monetization across digital, video, and connected TV channels [6][10] Key Points and Arguments Customer Wins and Revenue Growth - Magnite has secured partnerships with major global streamers such as Disney, Netflix, Warner Bros. Discovery, and Paramount, which are expected to drive revenue growth as these companies expand internationally [10][11] - The company is well-positioned to benefit from the increasing adoption of programmatic advertising in international markets, particularly as traditional markets open up to programmatic solutions [12] Shift in Advertising Dynamics - There is a notable trend of data moving from Demand-Side Platforms (DSPs) to Supply-Side Platforms (SSPs), which is seen as a power shift in the advertising ecosystem [17][41] - Advertisers are increasingly looking to keep their valuable data closer to home, opting to work with Magnite rather than relying solely on DSPs [19][20] - This shift is expected to enhance efficiency and reduce overall take rates in the advertising ecosystem, potentially saving advertisers 300 to 500 basis points [32][27] DV+ Performance and Future Outlook - The DV+ segment has shown resilience and is performing better than neutral, with expectations of continued growth despite challenges in the open web [59][60] - Approximately 40% of the DV+ business is exposed to the open web, which is facing structural changes due to shifts in consumer behavior and search engine dynamics [66][60] Impact of Political Advertising - Magnite anticipates significant revenue from political advertising, estimating around $10 billion in midterm election spending, with the company expecting to capture a substantial portion of that [50][53] AI and Technology Integration - Magnite is investing in AI to streamline ad tech processes, aiming to simplify the complex landscape of digital advertising [118][120] - The company is positioned to leverage AI advancements, although immediate revenue impacts are not expected until 2026 [119] Regulatory Environment and Market Share - The ongoing litigation against Google for monopolistic practices could present opportunities for Magnite, with potential revenue gains estimated at $50 million for every 1% market share gained from Google [128][145] - Current estimates place Google's market share in digital advertising at approximately 60%, with Magnite holding mid- to high-single digits [145][146] Additional Insights - The trend of exclusive partnerships with companies like Pinterest and Spotify is expected to enhance Magnite's revenue streams and create deeper integrations, leading to increased stickiness and long-term relationships [104][108] - The company is adapting to the evolving landscape of digital advertising, focusing on building customized tech stacks for clients while maintaining a take rate model [100][108] Conclusion Magnite is strategically positioned to capitalize on the growth of programmatic advertising, the shift in data dynamics, and the potential regulatory changes in the digital advertising landscape. The company's focus on exclusive partnerships and technological integration, along with its resilience in the DV+ segment, suggests a positive outlook for future revenue growth.

Core Insights - Google is introducing a new AI tool called Personal Intelligence that integrates information from various apps like Gmail and Google Photos to provide personalized responses in its chatbot [1][3] - The feature aims to enhance reasoning capabilities within the Gemini app, allowing it to provide proactive insights by understanding context without explicit instructions [2][3] Product Features - Personal Intelligence will initially be available to Google AI Pro and AI Ultra subscribers in the U.S. and will be integrated into Google's search tool "AI Mode" in the future [4] - The feature will be off by default, and Google is seeking user feedback during its beta phase to improve functionality [4] Competitive Landscape - This development positions Google against competitors like OpenAI and Apple, with Apple also integrating AI features into its systems, including a major upgrade to Siri [3] - Gemini 3's ability to reason across user data is a key differentiator in the competitive generative AI market [3] Limitations and User Guidance - The beta version of Personal Intelligence may still contain errors, and users are encouraged to provide feedback [4] - The AI aims to avoid making assumptions on sensitive topics like health and will only discuss such data if prompted by the user [5] - Google clarifies that its AI models are not trained directly on personal data from Gmail or Google Photos but use limited information to enhance functionality over time [6]

Summary of Mountain's Conference Call Company Overview - **Company**: Mountain - **Industry**: Connected Television (CTV) Advertising - **CEO**: Mark Douglas - **Founded**: 2009 - **Key Focus**: Performance-driven advertising solutions for small and medium businesses (SMBs) on internet-connected televisions [1][5][11] Core Points and Arguments Market Position and Growth - Mountain has pioneered the concept of "Performance TV," allowing SMBs to leverage television advertising, which was traditionally dominated by large brands [5][11] - 97% of Mountain's customers have never advertised on TV before, indicating a significant market opportunity [6][12] - The company aims for consistent growth and to increase its share of wallet from customers, which currently averages between 12% to 15% of their overall media budget [12][141] Technology and Innovation - Mountain positions itself as a Demand-Side Platform (DSP) but is compared by customers to platforms like Meta and Google rather than traditional DSPs [8][12] - The company is heavily investing in technology, including generative AI for ad targeting and creative processes, which has reduced the time to launch campaigns from 45 days to less than a week [16][18][27] - Quick Frame AI, a new platform, allows customers to create TV ads quickly and affordably, with over 5,000 users already logged in [24][29] Customer Insights and Trends - Customers are becoming more knowledgeable about the potential of CTV advertising, moving from early adopters to mainstream acceptance [38] - The demand for targeted and measurable advertising is increasing, with SMBs recognizing the value of being on platforms like Bravo and Disney+ [38][39] Supply and Pricing Dynamics - Mountain has direct partnerships with major streaming services, excluding Netflix, which is expected to join soon [41][42] - The company reports stable pricing and growing inventory availability, with access to approximately 4 million impressions per second [63][64] - New ad formats, such as pause ads, are being well-received by customers, contributing to the overall growth of the CTV market [46][52] Competitive Landscape - Mountain does not currently see significant competition from larger players like Amazon in the SMB market, as their offerings are tailored to different customer needs [90][93] - The company believes its unique focus on SMBs and its established technology for targeting and creative gives it a competitive edge [70][72] Additional Important Insights - The international market for CTV is still developing, presenting future growth opportunities for Mountain [55] - The company is exploring the integration of social media influencers into its advertising strategy, recognizing the crossover potential between social media and television [115][117] - Mountain's approach to performance marketing is distinct, focusing on immediate sales attribution rather than delayed reporting, which is critical for SMBs [93][96] This summary encapsulates the key points discussed during the conference call, highlighting Mountain's strategic direction, technological advancements, market positioning, and competitive landscape.

Core Insights - Wayfair is making a significant investment in artificial intelligence to enhance the online shopping experience for home goods, partnering with Google to develop the Universal Commerce Protocol [1][4] - The new protocol will enable a seamless checkout experience, allowing customers to purchase Wayfair products directly through Google's AI Mode and the Gemini app while maintaining Wayfair's control over pricing and customer support [2][4] - Wayfair's existing AI initiatives, such as the Muse discovery tool and the Discover tab in its mobile app, aim to improve product navigation for customers, reflecting the company's focus on personalization in a high-consideration purchase category [3][5] Financial Performance - Wayfair reported a 9% increase in revenue and over 70% year-over-year growth in adjusted EBITDA for the third quarter, indicating that its investments in technology are yielding positive results [5]

Group 1 - Proactive provides fast, accessible, informative, and actionable business and finance news content to a global investment audience [1] - The news team covers medium and small-cap markets, as well as blue-chip companies, commodities, and broader investment stories [2] - Proactive focuses on sectors including biotech and pharma, mining and natural resources, battery metals, oil and gas, crypto, and emerging digital and EV technologies [2] Group 2 - Proactive is committed to adopting technology to enhance workflows and improve content delivery [3] - The company utilizes automation and software tools, including generative AI, while ensuring all content is edited and authored by humans [4]

Summary of Perion Network FY Conference Call Company Overview - **Company**: Perion Network (NasdaqGS:PERI) - **Industry**: Digital Advertising Technology - **CEO**: Tal assumed the role in 2023, previously led CodeFuel search advertising business, focusing on market share and revenue growth [3][5] Core Business and Strategy - **Market Position**: Perion aims to address inefficiencies in digital advertising, where $1 trillion is spent annually, by creating a centralized platform for advertisers [5][6] - **Perion One**: A new product that integrates various advertising channels into a single platform, optimizing budget allocation across different channels [7][20] - **Performance Focus**: Shifted all products to be performance-driven, enhancing advertiser retention by ensuring measurable results [25][31] - **Outmax**: An AI-driven algorithm that optimizes ad campaigns in real-time, reportedly improving yield by up to 40% on the same budget [11][35] Financial Performance and Growth - **CTV Growth**: Achieved 75% growth in CTV in Q3, compared to a 14% market growth, indicating strong performance in this segment [35][36] - **Revenue Model**: Maintains a take rate based on ad spending, similar to models used by Google and Meta, with potential for volume discounts as budgets increase [82][86] - **Buyback Program**: Announced a $200 million buyback program, reflecting confidence in the company's valuation and cash generation capabilities [97][98] Product Development and Market Trends - **Dynamic Creative Optimization (DCO)**: Utilizes DCO to enhance ad performance, particularly in out-of-home advertising, by tailoring messages based on real-time data [80][81] - **Retail Media**: Recognizes the growing importance of out-of-home advertising as a performance channel, linking it to retail media strategies [80][81] - **Self-Service Initiatives**: Plans to introduce more self-service options for small and medium businesses, leveraging GenAI for ease of use [32][93] Challenges and Future Outlook - **Market Positioning**: Acknowledges the need to pivot away from traditional Open Web advertising due to changing consumer behavior and competition from walled gardens [122][123] - **Long-Term Goals**: Aims for significant growth in 2027, focusing on scaling operations and enhancing product offerings [100][101] - **Customer Acquisition**: Currently relies on major agencies for customer acquisition but plans to simplify the process for smaller businesses in the future [91][94] Key Takeaways - Perion Network is transforming its business model to focus on performance-driven advertising solutions, leveraging AI technology to optimize ad spend and improve results for advertisers [5][11][25] - The company is experiencing significant growth in CTV and is actively working to integrate out-of-home advertising into its performance metrics [35][80] - Future strategies include expanding self-service capabilities and enhancing the overall user experience for advertisers, particularly in the SMB segment [32][93]

Company Overview - Proactive is a financial news and online broadcast organization that provides fast, accessible, informative, and actionable business and finance news content to a global investment audience [2] - The company operates across six offices on three continents, including key financial hubs such as London, New York, Toronto, Vancouver, Sydney, and Perth [2] Content Production - Proactive's editorial team produces approximately 50,000 pieces of real-time news, feature articles, and filmed interviews annually [1] - The content covers a wide range of topics, including medium and small-cap markets, blue-chip companies, commodities, biotech and pharma, mining and natural resources, battery metals, oil and gas, crypto, and emerging digital and EV technologies [3] Technology Utilization - Proactive is committed to adopting technology to enhance its content creation and workflow processes [4] - The company utilizes automation and software tools, including generative AI, while ensuring that all published content is edited and authored by humans [5]

Core Insights - The partnership between Nvidia Corp. and Eli Lilly And Co. is a significant collaboration aimed at transforming drug development, which is currently undervalued by the market [1][4]. Partnership Overview - Nvidia and Eli Lilly have established a $1 billion partnership to reduce drug discovery costs by up to 70% [2]. - This initiative is designed to enhance the speed of drug creation by integrating Nvidia's "lab-in-the-loop" model, which replaces traditional human-paced iterations [2]. Technological Advancements - The partnership aims to shift failures from physical labs to software simulations, potentially increasing research throughput by nearly 100 times [3]. - Nvidia's next-generation Vera Rubin architecture and BioNeMo platform are being utilized to transform computing into essential pharmaceutical infrastructure [6]. Market Sentiment - Despite the groundbreaking potential of the Nvidia and Eli Lilly alliance, the market is largely ignoring it, focusing instead on short-term fluctuations in other sectors [4][5]. - The current market environment is described as "irritable" and overly focused on retail stocks, which detracts from recognizing the long-term value of generative AI in healthcare [5]. Performance Metrics - As of 2026, shares of Eli Lilly have increased by only 0.04%, while Nvidia's shares have declined by 2.07% year-to-date [7]. - Eli Lilly shows a stronger price trend over short, medium, and long terms, despite a poor value ranking [7]. - Nvidia maintains a stronger price trend over medium and long terms but shows a weak trend in the short term, with a solid quality ranking [8].