Group 1: R&D Progress - DR10624 has shown strong lipid-lowering effects and safety in Phase II clinical trials, with results presented at the AHA Scientific Sessions 2025. It has been included as a breakthrough therapy for severe hypertriglyceridemia by the CDE in January 2026 [1][2] - HDM1002, an oral GLP-1 receptor agonist, has completed patient enrollment for its Phase III trial in weight management, with top-line data expected in Q3 2026. The study has shown good overall safety without liver enzyme elevation [3] - HDM2005 has reported positive preliminary results in Phase I trials for mantle cell lymphoma and classical Hodgkin lymphoma, and is also undergoing trials for diffuse large B-cell lymphoma and solid tumors [4] Group 2: Upcoming Data Releases - Key data releases expected in 2026 include: - HDM1002 weight management Phase III top-line data - HDM1005 weight management Phase III 40-week data - HDM2005 solid tumor Phase I preliminary data - DR10624 for MASLD/MASH Phase II top-line data [5] Group 3: New Product Approvals and Market Outlook - The company anticipates new drug approvals in 2026, including edaravone tablets and various biosimilars, which are expected to enhance revenue contributions [6][7] - The innovative products, such as Ailaha® and Huijiaojing®, are projected to maintain rapid growth due to their clinical value and market strategies [9] Group 4: Industrial Microbiology and Pet Medicine - The industrial microbiology sector is expected to continue its rapid growth, supported by expanding overseas markets and commercialized products [12] - The HDM7006 project for managing obesity in cats is addressing a significant market gap, with a reported obesity rate of 28.1% among pet cats in China. This product is positioned as a safe and effective GLP-1/GIP dual-target weight management solution [16] Group 5: Strategic Collaborations and Licensing - The company is actively pursuing licensing agreements for its self-developed products and is optimistic about future collaborations [8] - A strategic partnership with MC2 for skincare products aims to leverage innovative technology for daily skin care solutions in the Greater China region [14][15]

Group 1: Small Nucleic Acid Business - The company's small nucleic acid business primarily includes phosphoramidite monomers and GalNAc delivery systems, with the capability to provide modified monomer processes to meet diverse customer needs [2][3] - Pricing for small nucleic acid monomers varies based on customer requirements, including different segments, quantities, and stages [3] - The company began its small nucleic acid business layout in 2024, driven by overseas agency promotion and technical cooperation [3] Group 2: Supply Chain and Production Capacity - MNC suppliers generally do not change key material suppliers easily due to the need for global registration and product process validation [3] - The company's production capacity is expected to meet the demands of small nucleic acid business as fundraising projects gradually release capacity [3] Group 3: Stem Cell Projects - The company has made progress in its cell therapy projects, including the completion of GMP facility design, installation, and validation for heart and brain infarction projects [3] - Technical transfers for umbilical cord mesenchymal stem cells have been completed, establishing seed, master, and working cell banks, along with method development and validation for analysis [3] Group 4: Investor Relations Activity - The investor relations activity took place on January 14, 2026, from 10:30 to 11:30 in the company meeting room, involving various investment firms [2] - The activity did not involve the disclosure of any undisclosed significant information [3]

Group 1 - The core business of the company currently focuses on small nucleic acids, specifically phosphoramidite monomers and GalNAc delivery systems [1] - The pricing for different monomers and delivery systems varies, with delivery systems being priced higher than monomers [1]

Group 1: Company Overview and Business Focus - Chengda Pharmaceutical Co., Ltd. is expanding its small nucleic acid business through CDMO services, currently entering the MNC supply chain but with low order volume [2] - The company has established a stable quality system and possesses the necessary equipment and technology for production [3] Group 2: MNC Supplier Considerations - MNCs prioritize supplier qualifications and compliance management over price sensitivity, focusing on product quality and stable supply [3] - Changing key material suppliers is complex for MNCs due to global registration requirements, necessitating revalidation of processes and global submissions [3] Group 3: Production Capacity and Collaborations - The company’s fundraising projects are gradually releasing capacity to meet varying customer order sizes and stages [3] - Chengda has partnered with Chiron Pharma, Inc. for collaborative development on myocardial infarction and cerebral infarction projects, with significant progress in facility setup and technology transfer [3]

Summary of Jiuzhou Pharmaceutical Conference Call Company Overview - **Company**: Jiuzhou Pharmaceutical - **Industry**: CDMO (Contract Development and Manufacturing Organization) Key Points and Arguments Financial Performance - Jiuzhou Pharmaceutical reported a revenue growth of **42%** in the first three quarters of 2025, driven by sales growth and improved gross margins [2][3] - Operating cash flow increased by over **100%**, reaching **1.34 billion RMB**, due to timely collection of payments [2][3] - For Q3 2025, the company achieved a net profit of **220 million RMB**, a **42%** year-on-year increase, attributed to sales growth and higher product margins [3] Market Trends and Industry Outlook - The CDMO industry is expected to rebound starting Q4 2024, influenced by a declining interest rate cycle and improved investment environment [2][7] - Jiuzhou Pharmaceutical's **80%** of orders come from overseas, with strong business certainty from major clients [7] - The Japanese and Korean markets are projected to maintain a growth rate of **30%** over the next 1-2 years, while the U.S. market is expected to see contract amounts grow by over **30%** [2][7] Production Capacity and Utilization - New factory capacity utilization exceeded expectations, with the Taizhou factory operating at near full capacity with **17 projects** simultaneously [2][6] - The company plans to maintain a stable expense ratio for the year, with a slight decrease in R&D expense ratio anticipated [2][14] Product Development and Pipeline - The company has introduced over **30** high-value projects in the formulation sector, with **22** projects in the generic drug pipeline, of which **8** have been approved and **9** submitted for approval [4][9] - The Taizhou factory is expected to start production in November 2025, with an annual capacity of **800 kg**, and **30-40%** of this capacity already has confirmed orders [8] Strategic Initiatives - Jiuzhou Pharmaceutical is focusing on enhancing collaboration with core clients and actively expanding its customer base [2][3] - The company is also pursuing mergers and acquisitions to establish overseas commercial production bases [4][13][16] Challenges and Risks - The raw material prices have seen a decline, but an improvement is expected in Q4 2025 [4][15] - The company faces challenges in the raw material sector due to domestic overcapacity and intense competition, leading to price fluctuations [15] Future Plans - Capital expenditure for 2025 is projected to be controlled within **1 billion RMB**, with a focus on talent acquisition in emerging fields such as peptides and small molecules [17] - Jiuzhou Pharmaceutical aims to establish high-automation overseas commercial bases, with an estimated project scale of **100 million USD** [20] Asset Impairment - The company anticipates no significant changes in asset impairment for 2025, maintaining overall stability [21] Additional Important Information - Jiuzhou Pharmaceutical has established a strong presence in the Japanese market, being a core supplier to over half of the top ten pharmaceutical companies [13] - The company is actively working on expanding its capabilities in the peptide and small nucleic acid sectors, with plans for mid-scale production capacity [8][12]