Core Viewpoint - The Hong Kong Stock Connect innovative drug sector is experiencing a rebound, with significant trading activity and price increases among leading innovative drug companies, indicating a shift in the market dynamics for innovative pharmaceuticals in China [1][3]. Group 1: Market Performance - On December 23, the Hong Kong Stock Connect innovative drug ETF (520880) reached a peak increase of 1.53% and recorded over 1.4 billion yuan in trading volume [1]. - Leading companies in the innovative drug sector, such as CSPC Pharmaceutical Group, saw stock price increases exceeding 5%, while others like 3SBio and Hengrui Medicine rose over 2% [1]. Group 2: Investment Insights - Analysts from Zhongtai Securities noted that the current innovative drug market differs from the 2019-2021 period, as it has transitioned from narrative to actual performance, with trading volumes hitting new highs, reflecting a leap in China's innovative capabilities [1]. - Changjiang Securities emphasized that the innovative drug sector is entering a new cycle of policy support, suggesting a focus on high-quality innovative drug assets with strong overseas potential [3]. Group 3: ETF Characteristics - The Hong Kong Stock Connect innovative drug ETF (520880) tracks the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which has three unique advantages: it exclusively includes innovative drug companies, has a high concentration of leading firms (over 72% in the top ten), and employs measures to control risks associated with less liquid stocks [3][4]. - The ETF's current market price is close to its initial listing price, presenting a potential value opportunity for investors [3]. Group 4: Composition and Strategy - The top ten holdings of the Hong Kong Stock Connect innovative drug ETF account for 72.57% of the total weight, showcasing significant dominance by leading companies in the sector [4]. - For investors seeking to mitigate volatility while still focusing on innovative drugs, alternative ETFs that include a mix of traditional Chinese medicine and innovative drugs are available, providing a balanced investment approach [4].

截至收盘，恒生港股通创新药指数、中证港股通医药卫生综合指数均下跌0.8%，中证生物科技主题指数下跌0.4%，中证创新药产业指数、沪深300医药卫生 指数均下跌0.3%。资金逆势布局，恒生创新药ETF（159316）全天净申购达2200万份。Wind数据显示，该ETF近期持续受资金关注，上周合计"吸金"超1亿 元。 中泰证券表示，本轮创新药行情区别于2019-2021年，在于创新药出海从"叙事"进入真正兑现阶段，交易金额屡创新高，反映的是中国创新能力 从"量"到"质"的跃迁。同时，国内政策端持续全链条支持创新药，首次增设商保目录，打开了支付空间。 跟踪中证港股通医药卫生综合指数 该指数聚焦港股医疗卫生行 业龙头,由50只医疗器械 、生物药品、化学药及其它 医药卫生行业的港股通股票 组成。 该指数聚焦A股创新药龙头, 由不超过50只主营业务涉 及创新药研发的公司股票 组成,汇聚A股创新药主力 车。 �日 该指数涨跌 -0.3% 生物科技ETF - 日石十七 米F 0月 00 == = -0.8% 取示中川二物代汉王赵馆蚁 该指数聚焦A股生物科技龙 头,由不超过50只业务涉 及基因诊断、生物制药、血 液制品及其它人 ...

Group 1 - The Hong Kong innovative drug industry is experiencing a strong recovery, with significant revenue and profit growth expected in the first half of 2025, driven by accelerated overseas expansion, commercialization, and policy support [1] - The Hong Kong innovative drug index has risen by 108.64% since the beginning of the year, outperforming the Hang Seng Composite Index by 79.70 percentage points, according to Wanlian Securities [1] - Companies with differentiated technology platforms, strong business development (BD) expectations, and those involved in emerging disease areas like Alzheimer's and GLP-1 drugs are recommended for attention in the second half of the year [1] Group 2 - Several innovative drug companies reported impressive mid-year results for 2025, with BeiGene achieving revenue of 17.518 billion yuan, a year-on-year increase of 46.03%, and a net profit of 450 million yuan, compared to a net loss of 2.877 billion yuan in the same period last year [1] - WuXi AppTec in the CXO sector reported a 20.64% year-on-year increase in revenue and a 101.92% increase in net profit attributable to shareholders for the first half of 2025 [1] - Policy changes are expected to further shorten the clinical review and approval times for innovative drugs, enhancing the sector's development [1] Group 3 - As of September 4, 2025, the Hong Kong innovative drug ETF (513120) has seen a decline of 2.70%, while it has increased by 7.80% over the past week [2] - The top ten weighted stocks in the index account for 70.79%, including leading innovative drug companies such as CanSino Biologics, Innovent Biologics, and BeiGene [2] - The latest scale of the Hong Kong innovative drug ETF reached 21.56 billion yuan, marking a new high since its inception, with a net inflow of 32.8559 million yuan [2] Group 4 - The Hong Kong innovative drug ETF (513120) closely tracks the China Securities Hong Kong Innovative Drug Index and allows T+0 trading, enhancing liquidity and capital efficiency for investors [3]

Core Viewpoint - The recent surge in the innovative drug market is driven by three main factors: policy support, improved liquidity, and positive performance indicators [1][2][3] Group 1: Policy Support - The implementation of the "Full Chain Support for Innovative Drug Development" plan in 2024 establishes a systematic support framework for the innovative drug industry, emphasizing the collaboration of pricing mechanisms, medical insurance payments, and commercial insurance [1] - The acceleration of the inclusion of innovative drugs into the medical insurance list and the establishment of a fast track for negotiations significantly shorten the post-launch volume cycle [1] - Continuous promotion of priority review and approval policies has led to record approvals, with 11 innovative drugs approved in a single day on May 29, marking a five-year high for the same period [1] Group 2: Improved Liquidity - After enduring difficult times, innovative drug companies are now entering a harvest season, aided by the anticipated interest rate cuts in the U.S. in 2024, which will facilitate financing and reduce costs [2] - Many companies that faced cash flow issues between 2019 and 2021 are now achieving milestone results in drug development [2] - By 2025, China's innovative drugs are expected to enter a "golden period" for overseas expansion, with transaction amounts and numbers reaching historical highs [2] Group 3: Performance Indicators - Chinese pharmaceutical companies showcased impressive performances at the ASCO conference, contributing 73 oral presentations, with 11 selected for "Latest Breakthrough Abstracts," covering cutting-edge fields like tumor immunology and ADC [2] - The successful overseas strategies of innovative drug companies not only generate cash flow through upfront payments and milestone revenues but also enhance brand influence through international multi-center clinical trials [2] - The innovative drug ETF has been a market leader from the beginning of the year, reflecting the positive impact of policy, liquidity, and performance improvements [3]