Core Viewpoint - The article discusses the usage, storage, dietary considerations, and potential side effects of the GLP-1 receptor agonist drug Semaglutide, emphasizing the importance of proper administration and nutrition for users [2][3][4][6]. Usage Guidelines - Initial dosage of Semaglutide should start at 0.25 mg weekly, gradually increasing as per medical advice, with a maximum single dose of 1 mg [2]. - Oral Semaglutide should be taken before breakfast with no more than 120 ml of water, and patients should wait at least 30 minutes before consuming food or other medications [2][5]. - The injectable form is administered subcutaneously once a week, with recommended sites being the abdomen, outer thigh, and upper arm [2][5]. Storage Conditions - Oral Semaglutide is more flexible in storage and does not require refrigeration, while unopened injectable Semaglutide must be stored in a refrigerator (2°C-8°C) and can be kept at room temperature (below 30°C) for up to 6 weeks after first use [3]. Monitoring and Side Effects - Regular blood sugar monitoring is essential during Semaglutide use, with necessary dosage adjustments made under medical supervision [4]. - Gastrointestinal side effects such as nausea, vomiting, and diarrhea may occur, particularly in the initial treatment phase, but often lessen over time [4]. Dietary Considerations - Users of Semaglutide should focus on nutrient-dense foods, ensuring adequate intake of quality protein, fiber, and hydration, while considering the potential for nutrient deficiencies due to reduced food intake [6][10]. - A balanced meal plate should include protein, vegetables, and starches, tailored to individual health conditions and preferences [9][10]. Foods to Avoid - High-fat foods, especially fried and heavily oil-based dishes, should be avoided as they may cause gastrointestinal discomfort [12]. - Foods high in trans fats and saturated fats, such as full-fat dairy and red meats, can exacerbate gastrointestinal issues and affect drug efficacy [12]. - High-sugar foods and refined carbohydrates should be limited to prevent blood sugar spikes, particularly for diabetic patients [14]. - Alcohol consumption should be minimized as it can aggravate digestive issues and increase the risk of hypoglycemia [15]. Positive Body Composition Changes - A study involving 241 patients showed that those who lost weight while using Semaglutide experienced positive changes in body composition, including reductions in visceral fat area and liver volume, which are beneficial for metabolic health [16][17].

Core Points - The article discusses the usage guidelines and considerations for Semaglutide and other GLP-1 receptor agonists, emphasizing the importance of proper administration, dietary adjustments, and monitoring for side effects [2][4][5][6][7]. Administration Guidelines - Semaglutide should start at a low dose of 0.25 mg weekly, gradually increasing as per medical advice, with a maximum single injection not exceeding 1 mg [2]. - The oral form of Semaglutide should be taken before breakfast with no more than 120 ml of water, and patients should wait at least 30 minutes before consuming food or other medications [2][6]. - For the injectable form, recommended sites include the abdomen, outer thigh, and upper arm, using a new sterile needle for each injection [4]. Storage Conditions - The oral formulation is more flexible in storage and does not require refrigeration, while unopened injectable Semaglutide must be stored in a refrigerator (2°C-8°C) and can be kept at room temperature for up to 6 weeks after first use [4]. Monitoring and Side Effects - Regular blood sugar monitoring is essential during Semaglutide use, with necessary dose adjustments made under medical supervision [5]. - Gastrointestinal side effects such as nausea, vomiting, and diarrhea may occur, particularly in the initial treatment phase, but often lessen over time [5]. Dietary Considerations - Users of Semaglutide should focus on nutrient-dense foods, ensuring adequate intake of quality proteins, fibers, and vitamins to mitigate potential nutrient deficiencies due to reduced food intake [9][10]. - A balanced meal plate should include 85-113g of protein, 170g of non-starchy vegetables, and 85g of starch, with recommendations for protein shakes if balanced meals are challenging [10]. Foods to Avoid - High-fat foods, especially fried and heavily oily dishes, should be avoided as they can exacerbate gastrointestinal discomfort [12]. - Foods high in trans fats and saturated fats, such as full-fat dairy and red meats, can worsen gastrointestinal issues and affect drug efficacy [12]. - High-sugar foods and refined carbohydrates should be strictly limited to prevent blood sugar spikes, particularly for diabetic patients [14]. Positive Health Outcomes - Research indicates that all body composition changes from Semaglutide use are beneficial, contributing to heart metabolic health, with reductions in visceral fat and improvements in liver density observed in weight loss groups [17].

Core Viewpoint - The article emphasizes the importance of a balanced diet and nutritional management for individuals using GLP-1 receptor agonists like semaglutide for weight loss, highlighting that medication alone is insufficient for effective weight management [4][6]. Group 1: Nutritional Considerations - Users of semaglutide should focus on the nutritional density of their food, as rapid weight loss can lead to a decrease in muscle mass [6][7]. - It is crucial for users to ensure adequate intake of high-quality protein, fiber, and hydration, while considering the potential need for multivitamins to address nutritional gaps [7][9]. - A balanced plate should include approximately 85-113g of protein, 170g of non-starchy vegetables, and 85g of starch, although many users may struggle to achieve this balance [7][9]. Group 2: Foods to Avoid - High-fat foods, especially fried and heavily oil-based dishes, should be avoided as they can cause gastrointestinal discomfort during semaglutide use [9][11]. - Foods high in trans fats and saturated fats, such as full-fat dairy and red meats, can exacerbate digestive issues and affect medication efficacy [9][11]. - High-sugar foods, including desserts and sugary beverages, should be strictly limited to prevent blood sugar fluctuations, particularly for diabetic patients [9][11]. - High-sodium foods and refined carbohydrates should also be minimized to reduce health risks, especially for those with type 2 diabetes [11][12]. - Alcohol consumption is discouraged as it can aggravate digestive problems and increase the risk of hypoglycemia [12].

Core Viewpoint - The article discusses the launch of the weight loss drug Semaglutide (brand name: Novo Nordisk) in China and emphasizes the importance of a holistic approach to weight loss that includes dietary changes alongside medication use [1][3]. Group 1: Drug Overview and Usage - Semaglutide was officially launched in China on November 17, leading to an increase in consultations at weight loss and endocrinology clinics [1]. - The use of weight loss medications requires standardized management, as relying solely on drugs is insufficient for effective weight loss [1][3]. Group 2: Nutritional Considerations - Users of Semaglutide should focus on the nutritional density of their food, as rapid weight loss can lead to a decrease in muscle mass [3][4]. - It is crucial for users to ensure adequate intake of high-quality protein, fiber, and hydration, as well as to consider taking multivitamins to address potential nutritional gaps [5][4]. Group 3: Recommended Dietary Practices - A balanced plate should include protein, vegetables, and starches tailored to individual health conditions and preferences [5]. - Specific recommendations include consuming 85-113g of protein, 170g of non-starchy vegetables, and 85g of starch per meal, although many users may struggle to achieve this balance [5]. Group 4: Foods to Avoid - High-fat foods, such as fried items and those cooked in heavy oils, should be avoided as they can cause gastrointestinal discomfort, especially when using Semaglutide [7]. - Foods high in trans fats and saturated fats, such as full-fat dairy and red meats, can exacerbate digestive issues and affect the drug's efficacy [7]. - High-sugar foods and refined carbohydrates should be limited, as they can lead to blood sugar spikes and interfere with the medication's effects [10][9]. - Alcohol consumption should be minimized or avoided due to its potential to aggravate digestive problems and increase the risk of hypoglycemia [11].