氘恩扎鲁胺的销售策略围绕"医学-市场-准入-销售"四轮驱动模式展开。医学策略包括建立新标准和积累 真实世界数据；市场策略精准定位并强调疗效及安全性优势；销售策略采取差异化的自营+招商双轨 制，覆盖9个主要省份自营，21个省份通过CSO合作推广；市场准入与医保策略计划通过2025年国谈纳 入医保。 截至2025年6月6日收盘，海创药业（688302）报收于50.66元，较上周的51.0元下跌0.67%。本周，海创 药业6月3日盘中最高价报52.0元。6月6日盘中最低价报45.8元。海创药业当前最新总市值50.16亿元，在 化学制药板块市值排名88/150，在两市A股市值排名2933/5148。 本周关注点 机构调研要点 6月3日电话会议 公司在2016年开始蛋白降解技术的探索，目前拥有成熟的PROTC及分子胶技术平台。HP518是国内首个 进入临床试验阶段的口服R PROTC在研药物，中国Ⅱ期临床试验已于2024年12月完成首例受试者入 组，预计今年年底将获得部分Ⅱ期数据。 HP515是一种THR-β激动剂，与GLP-1R激动剂联用能扩大脂肪流失而不减少肌肉。临床前数据显示， HP515与司美格鲁肽联用能进一步 ...

Core Viewpoint - Cancer remains a significant challenge in modern society, with a new revolutionary technology, targeted protein degradation, offering potential solutions for previously "undruggable" targets [1][2]. Group 1: Targeted Protein Degradation Technology - PROTAC (Proteolysis Targeting Chimeras) is an emerging therapeutic strategy that targets and degrades proteins associated with cancer and other diseases, with approximately 3,000 proteins linked to these conditions, but only about 700 are currently druggable [2][3]. - PROTAC operates by briefly binding to the target protein and directing it to the cell's natural degradation system, allowing for efficient and sustained effects with minimal dosage [2][3]. - The mechanism of PROTAC is described as "capture-release," which allows for the complete elimination of pathogenic proteins, addressing multiple disease-causing pathways [2]. Group 2: Clinical Trials and Developments - Since 2019, at least 30 PROTACs have entered clinical trials, primarily targeting cancer, with three PROTACs currently in Phase III trials for breast cancer, prostate cancer, and leukemia [3][4]. - The first PROTAC to enter Phase III trials is vepdegestrant, developed by Arvinas and Pfizer, which has shown to extend disease-free survival in patients with a specific breast cancer mutation compared to standard anti-estrogen therapies [3]. - Other PROTACs in Phase III trials target the androgen receptor in metastatic prostate cancer and the BTK enzyme in chronic lymphocytic leukemia, addressing issues of drug resistance in advanced cancers [3]. Group 3: Limitations and Future Prospects - Despite the promising potential of PROTACs, they face limitations, such as difficulty in targeting membrane-embedded proteins and the risk of unintended degradation of other proteins [4]. - The first approval of a PROTAC is anticipated to be a significant milestone, likely targeting an already druggable cancer-related protein, while true breakthroughs would involve previously untargeted proteins [4]. - Molecular glue is emerging as another potential protein degradation agent, which operates differently from PROTAC by altering the surface of ubiquitin ligases to facilitate protein degradation without direct binding [5].