Core Viewpoint - The company, Burning Stone Medical (BNR), is experiencing fluctuations in its stock price and financial performance, with a notable decrease in revenue but an increase in net profit year-over-year [1][2]. Financial Performance - As of December 31, 2024, Burning Stone Medical reported total revenue of 516 million RMB, a year-over-year decrease of 4.02% [1]. - The company recorded a net profit attributable to shareholders of -347 million RMB, which represents a year-over-year increase of 46.97% [1]. Upcoming Events - Burning Stone Medical is scheduled to disclose its Q1 2025 financial report on June 4, with the actual date subject to company announcements [2]. Company Overview - Founded in 2014, Burning Stone Medical focuses on providing clinically valuable next-generation sequencing (NGS) for precision oncology [2]. - The company holds a leading market share in tumor patient testing in China and collaborates with global anti-tumor pharmaceutical companies on biomarkers and companion diagnostics [2]. - The company received the first NGS testing kit certification from the National Medical Products Administration (NMPA) in July 2018, marking a significant milestone in the in vitro diagnostic field [2]. - Its laboratories in Guangzhou and California have obtained CLIA and CAP laboratory quality system certifications, ensuring high standards in testing [2].

Core Viewpoint - Lidman Biochemical Co., Ltd. is experiencing a decline in revenue and profit, with a significant net outflow of funds, indicating potential challenges in the market [1][2]. Company Overview - Lidman specializes in the research, production, sales, and service of in vitro diagnostic reagents, diagnostic instruments, and biochemical raw materials [1]. - The company's main products include biochemical diagnostic reagents, immunodiagnostic reagents, and automated chemiluminescence immunoassay analyzers [1]. - Lidman has received multiple accolades, including "National High-tech Enterprise" and "Beijing Specialized and Innovative Enterprise" [1]. Financial Performance - For Q1 2025, Lidman reported revenue of 78.91 million yuan, a year-on-year decrease of 16.61% [1]. - The net profit for the same period was -1.25 million yuan, reflecting a year-on-year increase in losses of 53.73% [1]. - The gross profit margin stood at 53.56% [1]. Market Position - As of May 27, Lidman's stock closed at 4.98 yuan, with a market capitalization of 2.709 billion yuan and a price-to-book ratio of 1.63 [1]. - The company has seen a net outflow of 3.4978 million yuan in principal funds on May 27, with a total outflow of 7.7543 million yuan over the past five days [1]. Industry Comparison - Lidman's PE (TTM) ratio is -36.79, while the industry average is 49.11, indicating a significant disparity in valuation metrics [2]. - The industry median PE (TTM) is 35.89, suggesting that Lidman is underperforming compared to its peers [2].

Core Insights - The article emphasizes the growing importance of clinical mass spectrometry in precision medicine, highlighting its unique advantages such as high specificity, sensitivity, and multi-parameter detection [3]. Market Overview - As of May 26, 2025, two clinical mass spectrometry instruments and twelve reagent kits have been approved. The global clinical mass spectrometry market is projected to reach $930 million by 2024, with an expected growth to $1.435 billion by 2029, reflecting a compound annual growth rate (CAGR) of 9% [3]. Clinical Applications - **Intraoperative Diagnosis of Brain Gliomas**: The article discusses the use of portable mass spectrometry for rapid identification of IDH mutations in brain gliomas, which significantly improves patient prognosis. A study conducted by a team from Fudan University and other institutions achieved a 100% accuracy rate in detecting IDH mutations in 697 samples from 260 glioma patients [4]. - **Therapeutic Drug Monitoring (TDM)**: Mass spectrometry is becoming a crucial tool in TDM, particularly for high-risk drugs like monoclonal antibodies. The nSMOL (nano-surface and molecular orientation limited) technology has enhanced specificity and sensitivity in measuring total drug concentrations, supporting personalized treatment for complex diseases [5]. Challenges and Future Directions - Despite the advancements, the transition of mass spectrometry from the laboratory to clinical settings faces challenges such as complex sample preparation, lack of standardized protocols, insufficient automation, and limitations in speed and cost. The article also mentions the importance of standard materials for ensuring accurate measurement in clinical chemistry [6].

万孚生物：近日，万孚生物与腾讯健康在北京正式签署战略合作协议，双方将携手打造更具智能化、精 准化的体外诊断和健康服务体系。 ...

IPO Review and Registration Progress - Four new IPO applications were accepted last week, with the first IPO on the Shanghai main board this year being Longyu Group, which aims to raise 700 million yuan [2][3] - Longyu Group's main business involves zirconium products, special nylon products, and fine chemical products, with over 70% of revenue coming from zirconium products, although its gross margin is declining [2][3] - The company reported revenues of 1.669 billion yuan in 2022, 1.607 billion yuan in 2023, and 1.637 billion yuan in 2024, with net profits of 257 million yuan, 188 million yuan, and 205 million yuan respectively [3] - Shenglong Co., a large molybdenum company, plans to raise 1.53 billion yuan and reported a revenue of 2.864 billion yuan in 2024, a 46.3% increase year-on-year [3] - Two new IPOs were accepted on the Beijing Stock Exchange: Peicheng Technology and Kanghua Co., with Peicheng's revenue declining by 4.02% in 2024 [3][4] Upcoming IPOs - Three companies, Zhigao Machinery, Shichang Co., and Hai'an Rubber, are scheduled for IPO meetings this week, with Hai'an Rubber aiming to raise 2.952 billion yuan [5][6] - Hai'an Rubber's revenue growth has significantly slowed, with a revenue increase of only 2.19% in 2024 compared to previous years [6] - Zhigao Machinery plans to raise 395 million yuan, while Shichang Co. aims for 171 million yuan [7] New Stock Subscription and Listing Dynamics - Three new stocks are scheduled for subscription this week, with a total expected fundraising of 1.332 billion yuan [10] - Youyou Green Energy plans to issue shares at 89.6 yuan each, aiming to raise approximately 941 million yuan, exceeding its original target by 34% [10] - The company reported a revenue of 1.497 billion yuan in 2024, an 8.85% increase, but a net profit decline of 4.6% [10] - Jiao Da Tie Fa aims to raise 168 million yuan, while Ying Shi Innovation plans to raise 464 million yuan for their respective projects [11] Policy and Regulatory Developments - The China Securities Association updated the list of D-class sponsor representatives, adding eight new names from various securities firms [13] - The Ministry of Finance announced administrative penalties against several securities evaluation institutions and asset appraisers following quality checks [14] - The Shenzhen Stock Exchange is focusing on supporting the computing chip industry through reforms and enhancing the service system from "IP" to "IPO" [15]

沛城科技是定位于锂电新能源行业的局部电路增值服务商，公司是国家高新技术企业、国家级专精特 新"小巨人"企业。沛城科技2023年度和2024年度经审计的归属于母公司股东的净利润（扣除非经常性损 益前后孰低数）分别为1.13亿元和9229.64万元。 5月22日，康华股份和沛城科技上市申请均获北交所受理。北交所官网显示，5月以来已有联川生物、瑞 尔竞达、康华股份和沛城科技4家公司加入北交所受理队伍。 康华股份是一家以病原体检测为核心，覆盖六大产品线的综合性体外诊断企业，公司曾荣获"国家级专 精特新'小巨人'企业""国家知识产权优势企业""山东省制造业单项冠军产品企业"等荣誉称号。 2022年至2024年，康华股份实现营业收入分别为14.8亿元、7.39亿元、7.28亿元，实现净利润分别为2.7 亿元、6983.52万元、1.25亿元。2024年康华股份营业收入同比下降1.48%，净利润同比增长79.09%。 康华股份本次计划公开发行股票数量不超过1.2亿股，拟募集资金5.62亿元，其中，2.67亿元用于多场景 智能检验分析仪器及精准诊断试剂研发及产业化项目，9810.94万元用于金标层析平台试剂（含居家检 测类） ...

Core Viewpoint - Shandong Kanghua Biological Medical Technology Co., Ltd. has received approval for its IPO on the Beijing Stock Exchange, aiming to raise 562 million yuan for various projects related to in vitro diagnostics and smart testing instruments [3]. Company Overview - Founded on September 26, 1996, Kanghua is a comprehensive in vitro diagnostic enterprise focusing on pathogen detection, with six major product lines [3]. - The company’s legal representative is Yang Zhiting, and it has a registered capital of 360 million yuan [3]. IPO Details - The IPO aims to raise 562 million yuan for projects including the development and industrialization of smart testing instruments, rapid test kits, core raw materials for in vitro diagnostics, e-commerce and brand promotion, and overseas marketing network construction [3]. Financial Performance - Projected revenues for 2022, 2023, and 2024 are 1.48 billion yuan, 739 million yuan, and 728 million yuan, respectively [4]. - Net profits for the same years are expected to be 270 million yuan, 69.9 million yuan, and 125 million yuan, with gross profit margins of 55.4%, 65.31%, and 66.68% [3][4]. Shareholder Structure - As of the date of the prospectus, the actual controllers of Kanghua are Yang Zhiting, Wang Aixiang, and Yang Fan, collectively holding 90.07% of the shares [4].

Core Viewpoint - MIRXES-B, a company focused on RNA technology, successfully listed on the Hong Kong Stock Exchange on May 23, with an initial price of 23.3 HKD, experiencing a significant opening increase of 24.89% to reach 29 HKD, and closing at 29.9 HKD, resulting in a total market capitalization of 82.62 billion HKD [1][2]. Company Overview - MIRXES-B was founded in 2014 in Singapore by Zhu Xingfen, Zhou Lihan, and Zou Ruiyang, focusing on developing blood-based miRNA testing kits for early disease detection globally [3][4]. - The company's core product, GASTROClearTM, is the first and only regulatory-approved molecular IVD product for gastric cancer screening, characterized by its non-invasive, rapid, and convenient features [3][4]. Financial Performance - The company reported revenues of 17.76 million USD, 24.18 million USD, and 20.28 million USD for the years 2022, 2023, and 2024, respectively, with gross profits of 9.33 million USD, 13.58 million USD, and 8.89 million USD during the same period [5]. - However, the company also faced increasing losses, reported at 56.20 million USD, 69.57 million USD, and 92.21 million USD for the same years [5]. Investment and Funding - The IPO attracted significant cornerstone investors, including Beijing Xunrui and Evergreen Gate, who collectively subscribed to shares worth 57.92 million USD, with Beijing Xunrui investing 50 million USD and Evergreen Gate investing 7.92 million USD [3]. - Notably, Sun Tongyu, former president of Taobao, played a crucial role in the company's funding, having invested 4 million SGD (approximately 2.8 million USD) in 2016 and later participating in a 30 million USD Series B funding round [4]. - Following the IPO, Sun Tongyu's stake in MIRXES-B is valued at approximately 1.839 billion HKD, reflecting a 7x return on investment [4].

Core Viewpoint - Mirxes Holding Company Limited (referred to as "Mirxes") has successfully listed on the Hong Kong Stock Exchange, with its share price rising significantly on the first day of trading, reflecting strong market interest in its innovative cancer screening technology [1][2]. Company Overview - Mirxes, founded in 2014 and headquartered in Singapore, specializes in RNA technology, focusing on non-invasive blood-based microRNA (miRNA) diagnostic kits for early disease detection, particularly cancer [1][5]. - The company has launched its first product, GASTROClear™, which is the world's first and only approved molecular diagnostic IVD product for gastric cancer screening [5]. IPO Details - The IPO involved a global offering of 46.62 million shares, representing 16.87% of the total shares post-IPO, with a pricing of HKD 23.30 per share, raising approximately HKD 1.086 billion [1]. - The public offering was oversubscribed by 25.51 times, while the international offering saw a subscription rate of 0.98 times [2]. Product Pipeline - As of May 2025, Mirxes has one core product (GASTROClear™), two other commercialized products (LUNGClear™ and Fortitude™), and six candidates in preclinical stages [3]. - GASTROClear™ has received CE certification in 2017 and FDA breakthrough device designation in 2023, with clinical trials in China showing promising results [5][10]. Financial Performance - The company reported revenues of USD 17.76 million, USD 24.19 million, and USD 20.28 million for the years 2022, 2023, and 2024, respectively, while incurring net losses of USD 56.20 million, USD 69.57 million, and USD 92.21 million during the same period [7][8]. - Despite increasing revenues, the company has faced continuous losses, indicating challenges in achieving profitability [7]. Market Valuation - As of the closing on May 23, the market capitalization of Mirxes was approximately HKD 82.90 billion, translating to a price-to-sales (P/S) ratio of about 52 times based on projected 2024 revenues [9]. - The valuation is heavily reliant on future revenue expectations, particularly from GASTROClear™ and other products in the pipeline [9][10]. Future Outlook - The company's future valuation will depend on the commercialization speed of GASTROClear™ and the potential of its multi-cancer pipeline [12]. - Approval from China's National Medical Products Administration (NMPA) for GASTROClear™ is anticipated in the first half of 2025, which could significantly impact the company's market position [10][12].

Group 1 - China Communication Technology Co., Ltd. won a total of 11 important rail transit projects with a total bid amount of approximately 3.789 billion yuan, accounting for 11.67% of the company's audited revenue for 2024 [1] - New Chai Co., Ltd. plans to use no more than 500 million yuan of idle funds to purchase low-risk financial products to improve fund efficiency [2] - Qingshan Paper Industry's controlling shareholder intends to restructure and inject assets into Fujian Provincial Industrial Holding Group [3] Group 2 - BWS hired Liu Xiaodan as Senior Vice President, effective immediately [4] - Huakang Clean won a bid for a purification project at the Tengzhou Medical and Health Center, with a bid price of 60.2394 million yuan [6] - Silver Dragon Co., Ltd. announced that several executives plan to reduce their holdings by a total of no more than 550,000 shares due to personal financial needs [8] Group 3 - Intercontinental Oil & Gas plans to invest 848 million USD in the South Basra Integrated Project in Iraq, holding a 67% stake [13] - Huatai Dain's subsidiary received a drug registration certificate for sodium valproate oral solution, used for treating epilepsy [14] - Hainan Mining's 20,000-ton battery-grade lithium hydroxide project has achieved full-process connectivity and produced qualified products [29] Group 4 - Roman Co., Ltd.'s subsidiary won a significant overseas project in Saudi Arabia with a bid amount of approximately 200 million yuan [30] - Measurement Co., Ltd. completed a capital reduction for its subsidiary, optimizing resource allocation [31] - Guodian Nanzi plans to increase capital by 45 million yuan for its wholly-owned subsidiary to meet market expansion needs [32] Group 5 - Eighty Billion Space plans to repurchase shares with a total amount not less than 50 million yuan and not exceeding 100 million yuan [33] - Tianyin Electromechanical's director plans to reduce holdings of no more than 0.25% of the company's shares [34] - Hailier's subsidiary passed environmental protection acceptance for its agricultural chemical preparation project [35] Group 6 - Kelong Pharmaceutical's subsidiary will present innovative drug research results at the ASCO annual meeting [36] - Zhonghong Medical's subsidiary received medical device registration certificates for enteral nutrition pumps and injection pumps [37] - Luyou Pharmaceutical received a drug registration certificate for amlodipine besylate tablets, used for hypertension [39]