Group 1 - The second academic conference on bioreactor engineering and biomanufacturing was held in Shanghai, focusing on cutting-edge technologies and industry development in the field [1] - East China University of Science and Technology aims to seize opportunities in the biomanufacturing sector, enhancing research in fine chemicals, electronic chemicals, and new energy [1] - Advanced biomanufacturing is recognized as a disruptive technology that transcends traditional disciplines, necessitating a new foundational development logic [1][2] Group 2 - Bioreactors are identified as the "core engine" of biomanufacturing, with next-generation intelligent bioreactors expected to facilitate the efficient conversion of synthetic biology achievements [1] - The importance of bioreactor engineering in the industrialization of synthetic biology outcomes is emphasized, calling for enhanced collaboration between industry, academia, and research [1] - Key figures in the field discussed various topics, including the development of synthetic biology, the application of core materials in biopharmaceutical innovation, and the upgrade of the health industry driven by food and medicine integration [2]

项目进展 | 湖 北 微琪 【SynBioCon】 获 悉， 近日，关于 湖北微琪 年产3万吨合成生物PHA可降解材料绿色智能制造项目 （一期）竣工验收公示。 年产3万吨合成生物PHA可降解材料绿色智能制造项目，其产品为生物基可降解材料——聚羟基脂肪 酸酯类聚合物（即PHA），项目分两期建设， 一期建设年产10000吨PHA生产装置，二期建设年产 20000吨PHA生产装置。 建设性质：新建 一期项目实际总投资：34000万元 建设内容：项目位于宜昌市猇亭区安琪生物科技园，属于新建项目，占地约200.86亩，总建筑面积约 34516平方米，环评规划主要建设发酵及提取车间、干燥车间、原材料及成品仓库等，配套建设公用 工程及研发办公综合体。 项目于2023年7月开始建设，目前项目已建成一期建设年产10000吨PHA生产装置，配套建设干燥车 间、发酵及提取车间等生产车间各1栋，内设10000t/aPHA生产装置1套；建设供电、给排水、消防等 公用工程，储罐区及危化品库等储运工程及环保工程。 一期项目生产的产品包括 PHB 和 P34HB 两个小类，且每期产品中聚-3.羟基丁酸酯(PHB)和聚-3-羟 基丁酸-4-羟 ...

Core Viewpoint - The article discusses the advancements and applications of artificial intelligence (AI) in the field of biomanufacturing, highlighting various case studies and innovations presented at the SynBioCon 2025 conference [1][44]. Group 1: AI Empowerment in Biomanufacturing - The conference featured a series of activities promoting typical application cases of AI in biomanufacturing, including forums on AI-driven innovations [1][3]. - Shanghai Zhiyu Biotechnology introduced the "ZCloud Biocomputing Platform" and "ZBot Experimental Verification Platform," achieving the production of vanillin through enzyme methods at a scale of hundreds of tons [6]. - Baidu Biotechnology has emerged as a global leader in foundational models for life sciences, showcasing their xTrimoDNA and xTrimoProtein models and applications [7]. Group 2: Innovative Technologies and Applications - Dibil Biotechnology developed an intelligent dynamic and optimization system for microbial culture, enabling real-time prediction of intracellular metabolic flux [10]. - The roundtable discussion emphasized the importance of technology empowerment, scenario innovation, and ecological collaboration to drive high-quality industrial development [13]. - A high-throughput protein engineering platform was established, leading to the discovery of a new gene editing tool with a 40% efficiency increase and the identification of two new industrial enzymes with over ten times the catalytic activity of competitors [16]. Group 3: Future Food and Agriculture - The conference included discussions on the rapid growth of the global functional sugar market and the challenges in obtaining new functional sugars due to unclear biosynthesis pathways [28]. - The research center of Yili Group focused on developing a self-controlled probiotic R&D technology system tailored to the gut microbiome characteristics of the Chinese population [30]. - The report from Henglu Biotechnology highlighted the development of human milk oligosaccharides and their potential applications, with a focus on safety assessments for production strains [32]. Group 4: Industry Trends and Innovations - The article mentions the establishment of China's first enzymatic production line for vitamin A palmitate by Xinhai Biotechnology, which has entered into strategic cooperation for product development [33]. - The report from Zhejiang University discussed the development and application of biotechnology in fine chemical production [34]. - The potential of microalgae as a sustainable food source was emphasized, showcasing advancements in microalgae protein cultivation and its nutritional benefits [43].

Core Insights - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) was held in Ningbo, featuring over 60 experts and executives sharing more than 40 presentations on various topics related to bio-manufacturing and green chemistry [2][4]. Group 1: Conference Overview - The conference included four main sessions: macro forum on bio-manufacturing, green chemistry and new materials, AI applications in bio-manufacturing, and future food & agriculture [2]. - Additional activities included a youth forum, high-level discussions on bio-manufacturing, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2]. Group 2: Keynote Highlights - Zhang Xian'en, Dean of the Synthetic Biology Institute at Shenzhen University, emphasized the rapid development of synthetic biology over the past decade, highlighting AI's role in overcoming the complexity of biological systems [10][11]. - Chen Luoping, Director of the Electronic Information Research Institute, noted that AI in bio-manufacturing presents opportunities for significant advancements, particularly in enzyme design and strain construction, despite existing challenges such as data scarcity and algorithm limitations [12][13]. Group 3: Technological Innovations - Chen Haibin, Vice President of Ningbo Enzyme Bioengineering Co., discussed the company's transition from technological innovation to product innovation, achieving industrial-scale production of small organic acids and bio-based nylon [15]. - Feng Yan, a professor at Shanghai Jiao Tong University, presented breakthroughs in enzyme molecular design and gene editing, which enhance the bio-synthesis of high-value compounds [19]. Group 4: Green Chemistry and New Materials - Wang Dan from Chongqing University addressed the bottlenecks in bio-synthesis of polyamide materials and shared advancements in developing key monomers for industrial applications [23]. - Li Zhen, co-founder of Suzhou Polygen Biotech, highlighted the company's use of straw as a raw material for producing bio-based succinic acid at a scale that is cost-competitive with petrochemical products [28]. Group 5: Industry Collaboration and Future Directions - The conference featured a signing ceremony for a joint laboratory between Shenzhen University and Ningbo Enzyme Bioengineering Co., aimed at fostering collaboration in synthetic biology research [6]. - The high-level discussions focused on the future trends of bio-manufacturing, technological innovation, and industry chain collaboration, aiming for high-quality development in the synthetic biology sector [56].

工业和信息化部新闻宣传中心主任张学军在发布会上表示，近年来，伴随生物制造领域科技创新的加速 突破、政策体系的逐步完善、产业要素的持续投入，我国生物制造发展跑出"加速度"，原创性研究成果 不断涌现、成果产业化步伐持续加快、代表性行业企业竞相发展，生物制造领域的科技创新对新产业 （300832）、新模式、新动能的催生带动作用显著增强。在此背景下，本次论坛以"生机无限制引未 来"为主题，以"推动生物制造领域科技创新和产业创新融合发展"为宗旨，内容丰富，亮点纷呈：设定 了"1+3+N"的活动架构，包含1场开幕式暨主论坛，3场平行会议，N项特色活动。其中，开幕式暨主论 坛将围绕"科技创新引领现代化产业体系建设"目标，邀请一批顶尖学者和创新企业家分享真知灼见，发 布一批生物制造领域创新发展的最新成果，展示一批行业各方的创新实践和成功经验；平行会议方面， 面向生物制造领域科技创新和产业创新融合发展的三个重点方向，将策划举办合成生物学技术创新会 议、生物制造产业转化促进会议以及新兴技术赋能合成生物学创新会议；特色活动方面，本次论坛将突 出科技创新引领、助力产业宣传普及、展现常德地方产业特色，推出生物制造领域颠覆性创新成果、成 ...

Core Viewpoint - The 2025 China Biomanufacturing Technology Innovation Forum aims to promote the integration of technological and industrial innovation in the biomanufacturing sector, highlighting its potential to lead the Fourth Industrial Revolution and transform traditional manufacturing and agriculture [1][3]. Group 1: Forum Overview - The forum will take place from September 25 in Changde, Hunan, lasting for two days, with the theme "Unlimited Vitality Leads the Future" [1]. - The event is structured around "1+3+N," which includes one opening ceremony and main forum, three parallel sessions, and multiple special activities [3]. Group 2: Key Activities - The main forum will focus on "Technological Innovation Leading the Construction of a Modern Industrial System," featuring top scholars and innovative entrepreneurs sharing insights and showcasing the latest achievements in biomanufacturing [3]. - Parallel sessions will cover three key areas: synthetic biology technology innovation, biomanufacturing industry transformation, and the integration of emerging technologies like AI with biomanufacturing [3]. Group 3: Special Activities - The forum will highlight disruptive innovations in biomanufacturing and share successful case studies, along with a "Biomanufacturing Industry Science Popularization Report" to enhance public understanding [4]. - Special activities will also include showcasing Changde's local industrial capabilities and inviting investment in biomanufacturing [4]. Group 4: Changde's Biomanufacturing Landscape - Changde has a solid foundation in biomanufacturing, with a mature innovation chain and significant policy support, making it a reference point for innovation exploration [5]. - The synthetic biomanufacturing industry in Changde has seen a remarkable growth rate of 23.5% from January to July this year [5]. - A new local regulation to promote the development of the synthetic biomanufacturing industry was approved, marking a significant step in institutionalizing policy benefits [5].

新京报贝壳财经讯（记者陈维城）8月21日，记者在2025中国生物制造科技创新论坛新闻发布会上获 悉，本次论坛以"生机无限 制引未来"为主题，将于9月25日在湖南常德正式开幕，论坛为期2天，将探 讨合成生物与生物制造领域研究的最新进展，分享生物制造前沿成果，探讨加快科技成果转化的实现路 径。 工业和信息化部新闻宣传中心主任张学军表示，近年来，伴随生物制造领域科技创新的加速突破、政策 体系的逐步完善、产业要素的持续投入，我国生物制造发展跑出"加速度"，原创性研究成果不断涌现、 成果产业化步伐持续加快、代表性行业企业竞相发展，生物制造领域的科技创新对新产业（300832）、 新模式、新动能的催生带动作用显著增强。 清华大学合成与系统生物学中心秘书长吴赴清提到，生物制造是科技创新和产业创新融合发展的重要领 域，具备引领第四次工业革命的潜力，将会带来重构传统制造业的生产模式、替代传统天然产物的获取 方式、颠覆传统农业的种养殖模式等一系列重大变革。 据悉，本次论坛设定了"1+3+N"的活动架构，包含1场开幕式暨主论坛，3场平行会议，N项特色活动。 开幕式暨主论坛将围绕"科技创新引领现代化产业体系建设"目标，发布一批生物制 ...

平行会议方面，面向生物制造领域科技创新和产业创新融合发展的三个重点方向，策划举办合成生物学技术创新会议，邀请生 物制造领域专家学者等围绕行业创新趋势热点进行分享交流；策划举办生物制造产业转化促进会议，邀请创新企业家、科技服 务业机构代表等围绕生物制造领域产业成果转化路径、所需平台要素等进行交流对接；策划举办新兴技术赋能合成生物学创新 会议，邀请人工智能、智能制造等领域专家及企业家分享探讨人工智能等新兴技术与生物制造融合发展的新场景、新模式、新 方向。 21世纪经济报道见习记者冉黎黎 北京报道 2025年政府工作报告提出，建立未来产业投入增长机制，培育生物制造等未来产业。8月21日，2025中国生物制造科技创新论坛 新闻发布会召开，发布会上介绍，2025中国生物制造科技创新论坛将于9月25日在湖南常德正式开幕，为期2天，论坛主题为"生 机无限 制引未来"。论坛以"推动生物制造领域科技创新和产业创新融合发展"为宗旨，设定了"1+3+N"的活动架构，包含1场开 幕式暨主论坛，3场平行会议，N项特色活动。 "生物制造是科技创新和产业创新融合发展的重要领域，具备引领第四次工业革命的潜力，将会带来重构传统制造业的生产模 ...

（HMOs）/2'-岩藻糖基乳糖（2'-FL) 嘉必优是中国最早关注和投入HMOs研发的企业之一，自2012年起启动合成生物学技术合成HMOs项 目。嘉必优通过CRISPR联合转座等基因编辑策略对底盘细胞进行遗传改良，将HMOs合成线路整合至 底盘细胞基因组上，使得产物表达更加稳定，并通过代谢流分析，找出关键限速步骤，进一步提升产 量。 为了实现高效的HMOs生物制造，嘉必优采用了代谢工程改造、工程化技术集成等多种先进的技术工 艺，加速HMOs产品产业化。嘉必优2'-FL通过大肠杆菌工程菌株发酵生产，遗传操作背景清晰，生物安 全性高；通过理性设计及突变文库构建、高通量筛选的组合策略，筛选出对底物具有高特异性的关键 酶，减少了副产物的生成， 较大幅度提升了产品纯度和生产效率，极大的发挥了生物制造的可持续发 展优势，推进绿色生物制造研究。 【新华企业资讯8月19日】7月31日，工业和信息化部公示首批生物制造标志性产品名单，共36项产品入 选，涵盖生物材料、生物化工、生物医药等多个领域。嘉必优生物技术（武汉）股份有限公司申报的 2'-岩藻糖基乳糖（2'-FL）成功入选，标志着嘉必优的生物制造实力获国家高度认可。 | ...

Group 1 - The Ministry of Industry and Information Technology and the National Health Commission of China have launched a notice to collect innovative applications of biological manufacturing technologies in the food processing sector, focusing on areas such as food raw materials, food additives, and food and beverage manufacturing [1] - The application directions should align with the goal of building a diversified food supply system and have significant promotional value for industry development, referencing safety evaluation requirements for genetically modified microorganisms [1] - Specific conditions for the applications include: products must be developed domestically and have entered small-scale trial production or mass production; products must have sufficient research results proving their safety or have been approved in other countries for food processing; and products must meet the criteria for "three new foods" in China but have not yet been approved [1] Group 2 - Huazhong Securities has released a research report indicating that frontier research in life sciences remains active, with a global biotechnology revolution accelerating its integration into economic and social development, providing new solutions for major challenges such as health, climate change, resource security, and food security [2] - The report suggests that the biological economy is emerging as a trillion-dollar sector, highlighting the potential for significant investment opportunities in this field [2]